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Article: Risk Factors and Predictive Nomogram for Carbapenem-Resistant

Chu, Xinmin / Ning, Lijuan / Fang, Yuting / Jia, Hengmin / Wang, Meng

2024 Volume 17, Page(s) 41–49

Abstract: Background: This study determined risk factors for Carbapenem-resistant Klebsiella pneumoniae (CRKP)in children admitted to a grade 3 first-class general hospital and developed an individualized line graph predictive model.: Methods: The clinical ... ...

Abstract	Background: This study determined risk factors for Carbapenem-resistant Klebsiella pneumoniae (CRKP)in children admitted to a grade 3 first-class general hospital and developed an individualized line graph predictive model. Methods: The clinical data of 185 children infected with Klebsiella pneumoniae from January 2015 to December 2019 were analyzed retrospectively. Patients were grouped according to carbapenem resistance: CRKP group (50 cases) and CSKP (carbapenem-sensitive Klebsiella pneumoniae) group (135 cases). Risk factors for CRKP in children were screened by logistic regression analysis. The predictive model was established using R software and validated using the Bootstrap method. Results: Age (odds ratio [OR]=0.104, 95% confidence interval [CI]: 0.026-0.408), intensive care unit admission (OR =2.829, 95% CI: 1.138-7.030), mechanical ventilation (OR =7.510, 95% CI: 3.140-17.961), surgery history (OR =5.005, 95% CI: 1.507-16.618) and glucocorticoid (OR =0.235, 95% CI: 0.099-0.557) were independent risk factors for CRKP in children (P < 0.05), The total risk score of each factor was 362.5, and the risk rate was 0.1-0.9. In receiver-operating characteristic curve analysis, the area under the curve of CRKP predicted by the total risk score was 0.872 (95% CI=0.844-0.901; P < 0.001). The correction curve indicated that the consistency between the observed value and the predicted value was good. Discussion and conclusion: This study successfully established a model based on the risk factors, with high accuracy and good predictive value for CRKP in children. Hospitals should take necessary preventive measures against the risk factors for drug-resistant bacteria, such as optimizing the configuration of ICU space, timely isolation of infected children, and adequate disinfection of ICU equipment. Which may reduce CRKP infection rate.
Language	English
Publishing date	2024-01-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S437742
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Fabrication of Antimicrobial Multilayered Nanofibrous Scaffolds-Loaded Drug

Liu, Qi / Jia, Hengmin / Ouyang, Wenchong / Mu, Yan / Wu, Zhengwei

Frontiers in bioengineering and biotechnology

2021 Volume 9, Page(s) 755777

Abstract: Nanofibers prepared by biobased materials are widely used in the field of biomedicine, owing to outstanding biocompatibility, biodegradable characters, and excellent mechanical behavior. Herein, we fabricated multilayered nanofibrous scaffolds in order ... ...

Abstract	Nanofibers prepared by biobased materials are widely used in the field of biomedicine, owing to outstanding biocompatibility, biodegradable characters, and excellent mechanical behavior. Herein, we fabricated multilayered nanofibrous scaffolds in order to improve the performance of drug delivery. The composite layer-by-layer scaffolds were incorporated by hydrophobic poly(l-lactic acid) (PLA): polycaprolactone (PCL) and hydrophilic poly(vinyl alcohol) (PVA) nanofibers
Language	English
Publishing date	2021-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2021.755777
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Article ; Online: The Value of Combination Analysis of Tumor Biomarkers for Early Differentiating Diagnosis of Lung Cancer and Pulmonary Tuberculosis.

Jia, Hengmin / Zhang, Liang / Wang, Baolong

Annals of clinical and laboratory science

2019 Volume 49, Issue 5, Page(s) 645–649

Abstract: Objective: Distinguishing early lung cancer from pulmonary tuberculosis is difficult. Biomarkers have been applied to tumor diagnoses widely. However, the ability for tumor biomarkers to uniquely identify either lung cancer or pulmonary tuberculosis ... ...

Abstract	Objective: Distinguishing early lung cancer from pulmonary tuberculosis is difficult. Biomarkers have been applied to tumor diagnoses widely. However, the ability for tumor biomarkers to uniquely identify either lung cancer or pulmonary tuberculosis remains controversial. Methods: The retrospective analysis of patients hospitalized with suspected pathological tissue mass in their thoracic cage, found via imaging, was conducted. The levels of tumor biomarkers CEA, NSE, CYFRA21-1, Pro-GRP, and SCC-Ag were measured and compared in patients with defined lung cancer (N=235) and pulmonary tuberculosis (N=224), respectively. Results: In the study, Serum CEA, NSE, CYFRA21-1, Pro-GRP, and SCC-Ag levels were significantly higher in the lung cancer group than in the pulmonary tuberculosis group ( Conclusion: The combination of CEA, CYFRA21-1, and NSE possesses better values for identifying lung cancer patients who are at a high risk of being misdiagnosed for pulmonary tuberculosis.
MeSH term(s)	Aged ; Biomarkers, Tumor/blood ; Diagnosis, Differential ; Early Detection of Cancer ; Female ; Humans ; Lung Neoplasms/blood ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Male ; Middle Aged ; ROC Curve ; Reproducibility of Results ; Sensitivity and Specificity ; Tuberculosis, Pulmonary/blood ; Tuberculosis, Pulmonary/diagnosis
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2019-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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Article: Design and production of environmentally degradable quaternary ammonium salts

Zhang, Xiaolong / Kong, Hongtao / Zhang, Xuepeng / Jia, Hengmin / Ma, Xiuxia / Miao, Hui / Mu, Yan / Zhang, Guoqing

Green chemistry. 2021 Aug. 31, v. 23, no. 17

2021

Abstract: Quaternary ammonium compounds (QACs) are a class of cationic surfactants routinely used for the disinfection of industries, institutions and households, and have seen a sharp increase in use during the COVID-19 pandemic. However, current commercial QACs ... ...

Abstract	Quaternary ammonium compounds (QACs) are a class of cationic surfactants routinely used for the disinfection of industries, institutions and households, and have seen a sharp increase in use during the COVID-19 pandemic. However, current commercial QACs consist of only stable chemical bonds such as C–N, C–C, and C–H, which makes their natural degradation rather difficult. Recent studies suggest that emerging negative environmental impacts, such as systemic antibiotics resistance and toxicity to living organisms, are directly associated with prolonged exposure to QACs. Here we report a new class of QAC which contains relatively volatile chemical functional groups such as ester and thioether bonds. Degradation kinetics in aqueous solutions suggests that the stability of these QACs depends not only on their intrinsic hydrophobicity but also on external environmental factors such as pH, temperature and ion presence. The microbicidal effects of QACs containing carbon chains with various lengths were also tested, one of which, named “Ephemora”, is highly active against a broad spectrum of microbes including fungi, bacteria and viruses, for instance, methicillin-resistant Staphylococcus aureus (MRSA). The easy synthesis and purification of Ephemora starting from inexpensive commercially available reagents, together with its excellent antimicrobial activity and ability to degrade in natural waters over time, make its large-scale commercial production possible.
Keywords	COVID-19 infection ; antimicrobial properties ; carbon ; disinfection ; green chemistry ; hydrophobicity ; methicillin-resistant Staphylococcus aureus ; pH ; quaternary ammonium compounds ; temperature ; toxicity ; volatile compounds
Language	English
Dates of publication	2021-0831
Size	p. 6548-6554.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/d1gc01525g
Database	NAL-Catalogue (AGRICOLA)

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Article: LncRNA EPIC1 promotes tumor angiogenesis via activating the Ang2/Tie2 axis in non-small cell lung cancer

Hou, Yanjiao / Jia, Hengmin / Cao, Yanhong / Zhang, Shuang / Zhang, Xiaolei / Wei, Pingping / Xie, Jun / Dong, Wenqian / Wang, Baolong

Life sciences. 2021 Feb. 15, v. 267

2021

Abstract: Non-small cell lung cancer (NSCLC) is considered a highly fatal tumor. Importantly, angiogenesis is critical for tumor progression. Long non-coding RNAs (lncRNAs), which are untranslatable, control cell functions through different pathways. lncRNA EPIC1 ... ...

Abstract	Non-small cell lung cancer (NSCLC) is considered a highly fatal tumor. Importantly, angiogenesis is critical for tumor progression. Long non-coding RNAs (lncRNAs), which are untranslatable, control cell functions through different pathways. lncRNA EPIC1 has been reported to promote cell viability, cell cycle progression, and invasion. However, the relationship between EPIC1 and tumor angiogenesis remains an enigma. We explored the role of EPIC1 in tumor angiogenesis in NSCLC.First, EPIC1 expression was analyzed using the GEPIA database and was further verified using qPCR in tumor tissues from patients with NSCLC and NSCLC cell lines. Next, EPIC1 function was detected using loss-of-function and gain-of-function assays. Moreover, EdU staining, flow cytometry, and channel formation assays were performed to assess HUVEC proliferation and channel the formation in the NSCLC-HUVEC transwell co-culture system.EPIC1 expression was significantly upregulated in NSCLC tissues and cell lines. Furthermore, the overexpression of EPIC1 in NSCLC cells stimulated HUVEC channel formation and proliferation by activating Ang2/Tie2 signaling, and the opposite results were obtained when EPIC1 was silenced in NSCLC cells. The density of new blood vessels was simultaneously increased by EPIC1 overexpression in vivo, using CAM angiogenesis model and a nude mouse tumor model. Finally, all these experimental findings could be established in the samples from patients with NSCLC. We postulate that EPIC1 promotes tumor angiogenesis by activating the Ang2/Tie2 axis in NSCLC.Elucidating the molecular and cellular mechanisms of EPIC1 in tumor angiogenesis provides a novel perspective on NSCLC clinical therapy.
Keywords	angiogenesis ; blood ; cell cycle ; cell viability ; coculture ; databases ; flow cytometry ; gain-of-function mutation ; loss-of-function mutation ; lung neoplasms ; mice ; models ; neoplasm progression ; therapeutics
Language	English
Dates of publication	2021-0215
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-light
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118933
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: LncRNA EPIC1 promotes tumor angiogenesis via activating the Ang2/Tie2 axis in non-small cell lung cancer.

Hou, Yanjiao / Jia, Hengmin / Cao, Yanhong / Zhang, Shuang / Zhang, Xiaolei / Wei, Pingping / Xie, Jun / Dong, Wenqian / Wang, Baolong

Life sciences

2020 Volume 267, Page(s) 118933

Abstract: Aims: Non-small cell lung cancer (NSCLC) is considered a highly fatal tumor. Importantly, angiogenesis is critical for tumor progression. Long non-coding RNAs (lncRNAs), which are untranslatable, control cell functions through different pathways. lncRNA ...

Abstract	Aims: Non-small cell lung cancer (NSCLC) is considered a highly fatal tumor. Importantly, angiogenesis is critical for tumor progression. Long non-coding RNAs (lncRNAs), which are untranslatable, control cell functions through different pathways. lncRNA EPIC1 has been reported to promote cell viability, cell cycle progression, and invasion. However, the relationship between EPIC1 and tumor angiogenesis remains an enigma. We explored the role of EPIC1 in tumor angiogenesis in NSCLC. Materials and methods: First, EPIC1 expression was analyzed using the GEPIA database and was further verified using qPCR in tumor tissues from patients with NSCLC and NSCLC cell lines. Next, EPIC1 function was detected using loss-of-function and gain-of-function assays. Moreover, EdU staining, flow cytometry, and channel formation assays were performed to assess HUVEC proliferation and channel the formation in the NSCLC-HUVEC transwell co-culture system. Key findings: EPIC1 expression was significantly upregulated in NSCLC tissues and cell lines. Furthermore, the overexpression of EPIC1 in NSCLC cells stimulated HUVEC channel formation and proliferation by activating Ang2/Tie2 signaling, and the opposite results were obtained when EPIC1 was silenced in NSCLC cells. The density of new blood vessels was simultaneously increased by EPIC1 overexpression in vivo, using CAM angiogenesis model and a nude mouse tumor model. Finally, all these experimental findings could be established in the samples from patients with NSCLC. We postulate that EPIC1 promotes tumor angiogenesis by activating the Ang2/Tie2 axis in NSCLC. Significance: Elucidating the molecular and cellular mechanisms of EPIC1 in tumor angiogenesis provides a novel perspective on NSCLC clinical therapy.
MeSH term(s)	Angiopoietin-2/genetics ; Angiopoietin-2/metabolism ; Animals ; Carcinoma, Non-Small-Cell Lung/blood supply ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Cell Survival/physiology ; Chick Embryo ; Databases, Genetic ; Disease Models, Animal ; Heterografts ; Human Umbilical Vein Endothelial Cells ; Humans ; Lung Neoplasms/blood supply ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Receptor, TIE-2/genetics ; Receptor, TIE-2/metabolism ; Signal Transduction
Chemical Substances	Angiopoietin-2 ; RNA, Long Noncoding ; Receptor, TIE-2 (EC 2.7.10.1) ; TEK protein, human (EC 2.7.10.1)
Language	English
Publishing date	2020-12-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118933
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Real-time measurements of airborne biologic particles using fluorescent particle counter to evaluate microbial contamination: results of a comparative study in an operating theater.

Dai, Chunyang / Zhang, Yan / Ma, Xiaoling / Yin, Meiling / Zheng, Haiyang / Gu, Xuejun / Xie, Shaoqing / Jia, Hengmin / Zhang, Liang / Zhang, Weijun

American journal of infection control

2015 Volume 43, Issue 1, Page(s) 78–81

Abstract: Background: Airborne bacterial contamination poses a risk for surgical site infection, and routine surveillance of airborne bacteria is important. Traditional methods for detecting airborne bacteria are time consuming and strenuous. Measurement of ... ...

Abstract	Background: Airborne bacterial contamination poses a risk for surgical site infection, and routine surveillance of airborne bacteria is important. Traditional methods for detecting airborne bacteria are time consuming and strenuous. Measurement of biologic particle concentrations using a fluorescent particle counter is a novel method for evaluating air quality. The current study was to determine whether the number of biologic particles detected by the fluorescent particle counter can be used to indicate airborne bacterial counts in operating rooms. Methods: The study was performed in an operating theater at a university hospital in Hefei, China. The number of airborne biologic particles every minute was quantified using a fluorescent particle counter. Microbiologic air sampling was performed every 30 minutes using an Andersen air sampler (Pusong Electronic Instruments, Changzhou, China). Correlations between the 2 different methods were analyzed by Pearson correlation coefficients. Results: A significant correlation was observed between biologic particle and bacterial counts (Pearson correlation coefficient = 0.76), and the counting results from 2 methods both increased substantially between operations, corresponding with human movements in the operating room. Conclusion: Fluorescent particle counters show potential as important tools for monitoring bacterial contamination in operating theatres.
MeSH term(s)	Air Microbiology ; China ; Environmental Monitoring/methods ; Hospitals, University ; Humans ; Microbiological Techniques/methods ; Operating Rooms
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2014.10.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1773: Show issues

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Article ; Online: Outbreak of carbapenemase-producing Klebsiella pneumoniae neurosurgical site infections associated with a contaminated shaving razor used for preoperative scalp shaving.

Dai, Yuanyuan / Zhang, Chengfang / Ma, Xiaoling / Chang, Wenjiao / Hu, Shoukui / Jia, Hengmin / Huang, Jiaxiang / Lu, Huaiwei / Li, Hua / Zhou, Shusheng / Qiu, Guangkuo / Liu, Jiaqin

American journal of infection control

2014 Volume 42, Issue 7, Page(s) 805–806

Abstract: Between July 5 and 21, 2011, an outbreak of neurosurgical site infections with carbapenemase-producing Klebsiella pneumonia occurred in a tertiary care hospital. The outbreak affected 7 patients. The subsequent investigation revealed that a barber's ... ...

Abstract	Between July 5 and 21, 2011, an outbreak of neurosurgical site infections with carbapenemase-producing Klebsiella pneumonia occurred in a tertiary care hospital. The outbreak affected 7 patients. The subsequent investigation revealed that a barber's contaminated shaving razor may have caused the carbapenemase-producing Klebsiella pneumonia outbreak. Standardized skin preparation performed by registered nurses using sterilized instruments should be emphasized.
MeSH term(s)	Adult ; Aged ; Bacterial Proteins/secretion ; Child ; Child, Preschool ; Disease Outbreaks ; Equipment and Supplies/microbiology ; Female ; Humans ; Klebsiella Infections/epidemiology ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/enzymology ; Klebsiella pneumoniae/isolation & purification ; Male ; Neurosurgical Procedures/adverse effects ; Preoperative Care/methods ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/microbiology ; Tertiary Care Centers ; Young Adult ; beta-Lactamases/secretion
Chemical Substances	Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2014.03.023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Risk Factors and Predictive Nomogram for Carbapenem-Resistant

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Article: Fabrication of Antimicrobial Multilayered Nanofibrous Scaffolds-Loaded Drug

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Article ; Online: The Value of Combination Analysis of Tumor Biomarkers for Early Differentiating Diagnosis of Lung Cancer and Pulmonary Tuberculosis.

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Article: Design and production of environmentally degradable quaternary ammonium salts

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Article: LncRNA EPIC1 promotes tumor angiogenesis via activating the Ang2/Tie2 axis in non-small cell lung cancer

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Article ; Online: LncRNA EPIC1 promotes tumor angiogenesis via activating the Ang2/Tie2 axis in non-small cell lung cancer.

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Article ; Online: Real-time measurements of airborne biologic particles using fluorescent particle counter to evaluate microbial contamination: results of a comparative study in an operating theater.

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Article ; Online: Outbreak of carbapenemase-producing Klebsiella pneumoniae neurosurgical site infections associated with a contaminated shaving razor used for preoperative scalp shaving.

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