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Article ; Online: A General Group-Protection Synthesis Strategy to Fabricate Covalent Organic Framework Gels.

Jia, Shuping / Liu, Yujie / Hao, Liqin / Ni, Jiayu / Wang, Yanjie / Yang, Yi / Chen, Yao / Cheng, Peng / Chen, Li / Zhang, Zhenjie

Journal of the American Chemical Society

2023 Volume 145, Issue 48, Page(s) 26266–26278

Abstract: Fabricating insoluble and infusible porous materials into gels for advanced applications is of great importance but has formidable challenges. Here, we present a general, facile, and scalable protocol to fabricate covalent organic framework (COF) gels ... ...

Abstract	Fabricating insoluble and infusible porous materials into gels for advanced applications is of great importance but has formidable challenges. Here, we present a general, facile, and scalable protocol to fabricate covalent organic framework (COF) gels using a group-protection synthesis strategy. To prove the generality of this strategy, we successfully prepared 10 types of COF organohydrogels with high crystallinity, porosity, good mechanical properties, and excellent solvent and freezing resistance. Notably, these COF organohydrogels can easily transform into hydrogels, organogels, and aerogels, breaking the gaps between different types of COF gels. An in-depth mechanism investigation unveils that the group-protection strategy effectively slows down the formation rate and regulates the morphology of COFs, benefiting the formation of cross-linked nanofibers/nanosheets to produce COF gels. We also find that the hydrogen bond network formed by the organic/water binary solvent and functional groups in the COF skeletons plays a vital role in creating organohydrogels and maintaining frost resistance and solvent resistance. As an application demonstration, COF gels installed with photoresponsive azobenzene groups show excellent solar energy absorption, photothermal conversion, and water transmission performances, demonstrating great potential in solar desalination. This work enriches the synthesis toolboxes for COF gels and expands the application scope of COFs.
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c09284
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Article ; Online: Chronic intermittent hypoxia enhances glycinergic inhibition in nucleus tractus solitarius.

Jia, Shuping / Rybalchenko, Nataliya / Kunwar, Kishor / Farmer, George E / Little, Joel T / Toney, Glenn M / Cunningham, J Thomas

Journal of neurophysiology

2022 Volume 128, Issue 6, Page(s) 1383–1394

Abstract: Chronic intermittent hypoxia (CIH), an animal model of sleep apnea, has been shown to alter the activity of second-order chemoreceptor neurons in the caudal nucleus of the solitary tract (cNTS). Although numerous studies have focused on excitatory ... ...

Abstract	Chronic intermittent hypoxia (CIH), an animal model of sleep apnea, has been shown to alter the activity of second-order chemoreceptor neurons in the caudal nucleus of the solitary tract (cNTS). Although numerous studies have focused on excitatory plasticity, few studies have explored CIH-induced plasticity impacting inhibitory inputs to NTS neurons, and the roles of GABAergic and glycinergic inputs on heightened cNTS excitability following CIH are unknown. In addition, changes in astrocyte function may play a role in cNTS plasticity responses to CIH. This study tested the effects of a 7-day CIH protocol on miniature inhibitory postsynaptic currents (mIPSCs) in cNTS neurons receiving chemoreceptor afferents. Normoxia-treated rats primarily displayed GABA mIPSCs, whereas CIH-treated rats exhibited a shift toward combined GABA/glycine-mediated mIPSCs. CIH increased glycinergic mIPSC amplitude and area. This shift was not observed in dorsal motor nucleus of the vagus neurons or cNTS cells from females. Immunohistochemistry showed that strengthened glycinergic mIPSCs were associated with increased glycine receptor protein and were dependent on receptor trafficking in CIH-treated rats. In addition, CIH altered astrocyte morphology in the cNTS, and inactivation of astrocytes following CIH reduced glycine receptor-mediated mIPSC frequency and overall mIPSC amplitude. In cNTS, CIH produced changes in glycine signaling that appear to reflect increased trafficking of glycine receptors to the cell membrane. Increased glycine signaling in cNTS associated with CIH also appears to be dependent on astrocytes. Additional studies will be needed to determine how CIH influences glycine receptor expression and astrocyte function in cNTS.
MeSH term(s)	Rats ; Animals ; Solitary Nucleus/metabolism ; Receptors, Glycine/metabolism ; Rats, Sprague-Dawley ; Hypoxia ; Glycine/metabolism ; gamma-Aminobutyric Acid/metabolism ; Sleep Apnea Syndromes/metabolism ; Neural Inhibition/physiology
Chemical Substances	Receptors, Glycine ; Glycine (TE7660XO1C) ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00241.2022
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Article ; Online: Pore Geometry and Surface Engineering of Covalent Organic Frameworks for Anhydrous Proton Conduction.

Hao, Liqin / Jia, Shuping / Qiao, Xueling / Lin, En / Yang, Yi / Chen, Yao / Cheng, Peng / Zhang, Zhenjie

Angewandte Chemie (International ed. in English)

2022 Volume 62, Issue 6, Page(s) e202217240

Abstract: Developing new materials for anhydrous proton conduction under high-temperature conditions is significant and challenging. Herein, we create a series of highly crystalline covalent organic frameworks (COFs) via a pore engineering approach. We ... ...

Abstract	Developing new materials for anhydrous proton conduction under high-temperature conditions is significant and challenging. Herein, we create a series of highly crystalline covalent organic frameworks (COFs) via a pore engineering approach. We simultaneously engineer the pore geometry (generating concave dodecagonal nanopores) and pore surface (installing multiple functional groups such as -C=N-, -OH, -N=N- and -CF
Language	English
Publishing date	2022-12-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202217240
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Article ; Online: Highly Robust Microporous Metal-Organic Frameworks for Efficient Ethylene Purification under Dry and Humid Conditions.

Liu, Wansheng / Geng, Shubo / Li, Ning / Wang, Sa / Jia, Shuping / Jin, Fazheng / Wang, Ting / Forrest, Katherine A / Pham, Tony / Cheng, Peng / Chen, Yao / Ma, Jian-Gong / Zhang, Zhenjie

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 8, Page(s) e202217662

Abstract: ... Two ... ...

Abstract	Two C
Language	English
Publishing date	2023-01-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202217662
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Article ; Online: Construction of Highly Proton-Conductive Zr(IV)-Based Metal-Organic Frameworks From Pyrrolo-pyrrole-Based Linkers with a Rhombic Shape.

Li, Yiyang / Li, Xiaoteng / Jia, Shuping / Zhang, Chong / Luo, Yuxin / Lin, Zhihua / Zhao, Yonggang / Huang, Wei

Inorganic chemistry

2021 Volume 60, Issue 16, Page(s) 12129–12135

Abstract: To date, numerous zirconium cluster-based metal-organic frameworks (Zr-MOFs) with attractive physical properties have been achieved thanks to tailorable organic linkers and versatile Zr clusters. Nevertheless, in comparison with the most-used high- ... ...

Abstract	To date, numerous zirconium cluster-based metal-organic frameworks (Zr-MOFs) with attractive physical properties have been achieved thanks to tailorable organic linkers and versatile Zr clusters. Nevertheless, in comparison with the most-used high-symmetry organic linkers, low-symmetry linkers have rarely been exploited in the construction of Zr-MOFs. Despite challenges in predicting the structure and topology of the MOF, linker desymmetrization presents opportunities for the design of Zr-MOFs with unusual topologies and unexpected functionalities. Herein, we report for the first time the construction of two robust Zr-MOFs (
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.1c01336
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Article ; Online: Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation.

Jia, Shuping / Rodriguez, Miguel / Williams, Arthur G / Yuan, Joseph P

Scientific reports

2017 Volume 7, Issue 1, Page(s) 5075

Abstract: The molecular components of store-operated ... ...

Abstract	The molecular components of store-operated Ca
MeSH term(s)	Animals ; Calcium Signaling ; Carotid Arteries/metabolism ; Carotid Arteries/pathology ; Carotid Artery Injuries/metabolism ; Carotid Artery Injuries/pathology ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Gene Knockdown Techniques ; Homer Scaffolding Proteins/metabolism ; Male ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Neointima/pathology ; ORAI1 Protein/metabolism ; Protein Binding ; Rats, Sprague-Dawley ; Transient Receptor Potential Channels/metabolism
Chemical Substances	Homer Scaffolding Proteins ; ORAI1 Protein ; Transient Receptor Potential Channels
Language	English
Publishing date	2017-07-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-04747-w
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Article ; Online: Tuning the Connectivity, Rigidity, and Functionality of Two-Dimensional Zr-Based Metal-Organic Frameworks.

Jia, Shuping / Xiao, Xue / Li, Qiyang / Li, Yue / Duan, Zhigang / Li, Yiyang / Li, Xiaoteng / Lin, Zhihua / Zhao, Yonggang / Huang, Wei

Inorganic chemistry

2019 Volume 58, Issue 19, Page(s) 12748–12755

Abstract: Presented herein is a group of highly stable Zr-based metal-organic frameworks with bowl-shaped dihydroanthracene-based tetratopic linkers as building blocks. Structural analysis reveals that these frameworks are all two-dimensional but comprise three ... ...

Abstract	Presented herein is a group of highly stable Zr-based metal-organic frameworks with bowl-shaped dihydroanthracene-based tetratopic linkers as building blocks. Structural analysis reveals that these frameworks are all two-dimensional but comprise three distinct connectivities of Zr
Language	English
Publishing date	2019-09-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.9b01666
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Article: Characterization of Hair Cell-Like Cells Converted From Supporting Cells After Notch Inhibition in Cultures of the Organ of Corti From Neonatal Gerbils.

Li, Yi / Jia, Shuping / Liu, Huizhan / Tateya, Tomoko / Guo, Weiwei / Yang, Shiming / Beisel, Kirk W / He, David Z Z

Frontiers in cellular neuroscience

2018 Volume 12, Page(s) 73

Abstract: The senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Hair cells transduce mechanical stimuli into electrical activity. Loss of hair cells as a result of aging or exposure to noise and ototoxic drugs is the ... ...

Abstract	The senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Hair cells transduce mechanical stimuli into electrical activity. Loss of hair cells as a result of aging or exposure to noise and ototoxic drugs is the major cause of noncongenital hearing and balance deficits. In the ear of non-mammals, lost hair cells can spontaneously be replaced by production of new hair cells from conversion of supporting cells. Although supporting cells in adult mammals have lost that capability, neonatal supporting cells are able to convert to hair cells after inhibition of Notch signaling. We questioned whether Notch inhibition is sufficient to convert supporting cells to functional hair cells using electrophysiology and electron microscopy. We showed that pharmacological inhibition of the canonical Notch pathway in the cultured organ of Corti prepared from neonatal gerbils induced stereocilia formation in supporting cells (defined as hair cell-like cells or HCLCs) and supernumerary stereocilia in hair cells. The newly emerged stereocilia bundles of HCLCs were functional, i.e., able to respond to mechanical stimulation with mechanotransduction (MET) current. Transmission electron microscopy (TEM) showed that HCLCs converted from pillar cells maintained the pillar cell shape and that subsurface cisternae, normally observed underneath the cytoskeleton in outer hair cells (OHCs), was not present in Deiters' cells-derived HCLCs. Voltage-clamp recordings showed that whole-cell currents from Deiters' cells-derived HCLCs retained the same kinetics and magnitude seen in normal Deiters' cells and that nonlinear capacitance (NLC), an electrical hallmark of OHC electromotility, was not detected from any HCLCs measured. Taken together, these results suggest that while Notch inhibition is sufficient for promoting stereocilia bundle formation, it is insufficient to convert neonatal supporting cells to mature hair cells. The fact that Notch inhibition led to stereocilia formation in supporting cells and supernumerary stereocilia in existing hair cells appears to suggest that Notch signaling may regulate stereocilia formation and stability during development.
Language	English
Publishing date	2018-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2018.00073
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Article: Motility-associated hair-bundle motion in mammalian outer hair cells.

Jia, Shuping / He, David Z Z

Nature neuroscience

2005 Volume 8, Issue 8, Page(s) 1028–1034

Abstract: Mammalian hearing owes its remarkable sensitivity and frequency selectivity to a local mechanical feedback process within the cochlea. Cochlear outer hair cells (OHCs) function as the key elements in the feedback loop in which the fast somatic motility ... ...

Abstract	Mammalian hearing owes its remarkable sensitivity and frequency selectivity to a local mechanical feedback process within the cochlea. Cochlear outer hair cells (OHCs) function as the key elements in the feedback loop in which the fast somatic motility of OHCs is thought to be the source of cochlear amplification. An alternative view is that amplification arises from active hair-bundle movement, similar to that seen in nonmammalian hair cells. We measured voltage-evoked hair-bundle motions in the gerbil cochlea to determine if such movements were also present in mammalian OHCs. The OHCs showed bundle movement with peak responses of up to 830 nm. The movement was insensitive to manipulations that would normally block mechanotransduction in the stereocilia, and it was absent in neonatal OHCs and prestin-knockout OHCs. These findings suggest that the bundle movement originated in somatic motility and that somatic motility has a central role in cochlear amplification in mammals.
MeSH term(s)	Animals ; Cochlea/physiology ; Electric Stimulation ; Gerbillinae ; Hair Cells, Auditory/physiology ; Hair Cells, Auditory, Outer/physiology ; In Vitro Techniques ; Mice ; Mice, Knockout ; Molecular Motor Proteins ; Motion ; Patch-Clamp Techniques ; Proteins/genetics
Chemical Substances	Molecular Motor Proteins ; Pres protein, mouse ; Proteins
Language	English
Publishing date	2005-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1420596-8
ISSN	1546-1726 ; 1097-6256
ISSN (online)	1546-1726
ISSN	1097-6256
DOI	10.1038/nn1509
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Article ; Online: Prestin forms oligomer with four mechanically independent subunits.

Wang, Xiang / Yang, Shiming / Jia, Shuping / He, David Z Z

Brain research

2010 Volume 1333, Page(s) 28–35

Abstract: Prestin is the motor protein of cochlear outer hair cells (OHCs) with the unique capability of performing direct, rapid, and reciprocal electromechanical conversion. Prestin consists of 744 amino acids with a molecular mass of approximately 81.4 kDa. The ...

Abstract	Prestin is the motor protein of cochlear outer hair cells (OHCs) with the unique capability of performing direct, rapid, and reciprocal electromechanical conversion. Prestin consists of 744 amino acids with a molecular mass of approximately 81.4 kDa. The predicted membrane topology and molecular mass of a single prestin molecule appear inadequate to account for the size of intramembrane particles (IMPs) expressed in the OHC membrane. Although recent biochemical evidence suggests that prestin forms homo-oligomers, most likely as a tetramer, the oligomeric structure of prestin in OHCs remains unclear. We obtained the charge density of prestin in the gerbil OHCs by measuring their nonlinear capacitance (NLC). The average charge density (22,608 microm(-2) measured was four times the average IMP density (5686 microm(-2) reported in the freeze-fracture study. This suggests that each IMP contains four prestin molecules, based on the general notion that each prestin transfers a single elementary charge. We subsequently compared the voltage dependency and the values of slope factor of NLC and somatic motility simultaneously measured from the same OHCs to determine whether NLC and motility are fully coupled and how prestin subunits function within the tetramer. We showed that the voltage dependency and slope factors of NLC and motility were not statistically different, suggesting that NLC and motility are fully coupled. The fact that the slope factor is the same between NLC and motility suggests that each prestin monomer in the tetramer is in parallel, each interacting independently with cytoplasmic or other partners to facilitate the mechanical response.
MeSH term(s)	Animals ; Animals, Newborn ; Cell Movement/genetics ; Cells, Cultured ; Electric Capacitance ; Fourier Analysis ; Gerbillinae ; Hair Cells, Auditory, Outer/physiology ; In Vitro Techniques ; Ion Channel Gating/physiology ; Membrane Potentials/physiology ; Molecular Structure ; Nonlinear Dynamics ; Organ of Corti/cytology ; Patch-Clamp Techniques ; Physical Stimulation/methods ; Protein Subunits/chemistry ; Protein Subunits/physiology ; Proteins/chemistry ; Proteins/genetics ; Proteins/metabolism
Chemical Substances	Pres protein, Cavia porcellus ; Protein Subunits ; Proteins
Language	English
Publishing date	2010-03-27
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2010.03.070
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