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Artikel ; Online: B-Cell Receptor Repertoire: Recent Advances in Autoimmune Diseases.

Wang, Qian / Feng, Delong / Jia, Sujie / Lu, Qianjin / Zhao, Ming

Clinical reviews in allergy & immunology

2024 Band 66, Heft 1, Seite(n) 76–98

Abstract: In the field of contemporary medicine, autoimmune diseases (AIDs) are a prevalent and debilitating group of illnesses. However, they present extensive and profound challenges in terms of etiology, pathogenesis, and treatment. A major reason for this is ... ...

Abstract	In the field of contemporary medicine, autoimmune diseases (AIDs) are a prevalent and debilitating group of illnesses. However, they present extensive and profound challenges in terms of etiology, pathogenesis, and treatment. A major reason for this is the elusive pathophysiological mechanisms driving disease onset. Increasing evidence suggests the indispensable role of B cells in the pathogenesis of autoimmune diseases. Interestingly, B-cell receptor (BCR) repertoires in autoimmune diseases display a distinct skewing that can provide insights into disease pathogenesis. Over the past few years, advances in high-throughput sequencing have provided powerful tools for analyzing B-cell repertoire to understand the mechanisms during the period of B-cell immune response. In this paper, we have provided an overview of the mechanisms and analytical methods for generating BCR repertoire diversity and summarize the latest research progress on BCR repertoire in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), multiple sclerosis (MS), and type 1 diabetes (T1D). Overall, B-cell repertoire analysis is a potent tool to understand the involvement of B cells in autoimmune diseases, facilitating the creation of innovative therapeutic strategies targeting specific B-cell clones or subsets.
Mesh-Begriff(e)	Humans ; Autoimmune Diseases ; Arthritis, Rheumatoid ; Lupus Erythematosus, Systemic ; B-Lymphocytes ; Receptors, Antigen, B-Cell ; Sjogren's Syndrome
Chemische Substanzen	Receptors, Antigen, B-Cell
Sprache	Englisch
Erscheinungsdatum	2024-03-09
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	1239045-8
ISSN	1559-0267 ; 1080-0549
ISSN (online)	1559-0267
ISSN	1080-0549
DOI	10.1007/s12016-024-08984-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Gut-tropic T cells and extra-intestinal autoimmune diseases.

Wu, Yutong / Wang, Qiaolin / Jia, Sujie / Lu, Qianjin / Zhao, Ming

Autoimmunity reviews

2024 , Seite(n) 103544

Abstract: Gut-tropic T cells primarily originate from gut-associated lymphoid tissue (GALT), and gut-tropic integrins mediate the trafficking of the T cells to the gastrointestinal tract, where their interplay with local hormones dictates the residence of the ... ...

Abstract	Gut-tropic T cells primarily originate from gut-associated lymphoid tissue (GALT), and gut-tropic integrins mediate the trafficking of the T cells to the gastrointestinal tract, where their interplay with local hormones dictates the residence of the immune cells in both normal and compromised gastrointestinal tissues. Targeting gut-tropic integrins is an effective therapy for inflammatory bowel disease (IBD). Gut-tropic T cells are further capable of entering the peripheral circulatory system and relocating to multiple organs. There is mounting evidence indicating a correlation between gut-tropic T cells and extra-intestinal autoimmune disorders. This review aims to systematically discuss the origin, migration, and residence of gut-tropic T cells and their association with extra-intestinal autoimmune-related diseases. These discoveries are expected to offer new understandings into the development of a range of autoimmune disorders, as well as innovative approaches for preventing and treating the diseases.
Sprache	Englisch
Erscheinungsdatum	2024-04-09
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2024.103544
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Macrophage: Key player in the pathogenesis of autoimmune diseases.

Yang, Shuang / Zhao, Ming / Jia, Sujie

Frontiers in immunology

2023 Band 14, Seite(n) 1080310

Abstract: The macrophage is an essential part of the innate immune system and also serves as the bridge between innate immunity and adaptive immune response. As the initiator and executor of the adaptive immune response, macrophage plays an important role in ... ...

Abstract	The macrophage is an essential part of the innate immune system and also serves as the bridge between innate immunity and adaptive immune response. As the initiator and executor of the adaptive immune response, macrophage plays an important role in various physiological processes such as immune tolerance, fibrosis, inflammatory response, angiogenesis and phagocytosis of apoptotic cells. Consequently, macrophage dysfunction is a vital cause of the occurrence and development of autoimmune diseases. In this review, we mainly discuss the functions of macrophages in autoimmune diseases, especially in systemic lupus erythematosus (SLE), rheumatic arthritis (RA), systemic sclerosis (SSc) and type 1 diabetes (T1D), providing references for the treatment and prevention of autoimmune diseases.
Mesh-Begriff(e)	Humans ; Autoimmune Diseases/etiology ; Macrophages ; Arthritis, Rheumatoid ; Diabetes Mellitus, Type 1/etiology ; Lupus Erythematosus, Systemic
Sprache	Englisch
Erscheinungsdatum	2023-02-14
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1080310
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Gut immune microenvironment and autoimmunity.

Wang, Qiaolin / Lu, Qianjin / Jia, Sujie / Zhao, Ming

International immunopharmacology

2023 Band 124, Heft Pt A, Seite(n) 110842

Abstract: A variety of immune cells or tissues are present in the gut to form the gut immune microenvironment by interacting with gut microbiota, and to maintain the gut immune homeostasis. Accumulating evidence indicated that gut microbiota dysbiosis might break ... ...

Abstract	A variety of immune cells or tissues are present in the gut to form the gut immune microenvironment by interacting with gut microbiota, and to maintain the gut immune homeostasis. Accumulating evidence indicated that gut microbiota dysbiosis might break the homeostasis of the gut immune microenvironment, which was associated with many health problems including autoimmune diseases. Moreover, disturbance of the gut immune microenvironment can also induce extra-intestinal autoimmune disorders through the migration of intestinal pro-inflammatory effector cells from the intestine to peripheral inflamed sites. This review discussed the composition of the gut immune microenvironment and its association with autoimmunity. These findings are expected to provide new insights into the pathogenesis of various autoimmune disorders, as well as novel strategies for the prevention and treatment against related diseases.
Sprache	Englisch
Erscheinungsdatum	2023-08-27
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110842
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Artikel ; Online: Modified Lichong decoction intervenes in colorectal cancer by modulating the intestinal flora and the Wnt/β-catenin signaling pathway.

Liu, Longhui / Zhao, Mengmeng / Lang, Xiaomeng / Jia, Sujie / Kang, Xin / Liu, Yue / Liu, Jianping

Journal of cancer research and clinical oncology

2024 Band 150, Heft 5, Seite(n) 234

Abstract: Background: The pathogenesis and treatment of colorectal cancer (CRC) continue to be areas of ongoing research, especially the benefits of traditional Chinese medicine (TCM) in slowing the progression of CRC. This study was conducted to investigate the ... ...

Abstract	Background: The pathogenesis and treatment of colorectal cancer (CRC) continue to be areas of ongoing research, especially the benefits of traditional Chinese medicine (TCM) in slowing the progression of CRC. This study was conducted to investigate the effectiveness and mechanism of action of modified Lichong decoction (MLCD) in inhibiting CRC progression. Methods: We established CRC animal models using azoxymethane/dextran sodium sulfate (AOM/DSS) and administered high, medium, or low doses of MLCD or mesalazine (MS) for 9 weeks to observe MLCD alleviation of CRC. The optimal MLCD dose group was then subjected to metagenomic and RNA sequencing (RNA-seq) to explore the differentially abundant flora and genes in the control, model and MLCD groups. Finally, the mechanism of action was verified using WB, qRT‒PCR, immunohistochemistry and TUNEL staining. Results: MLCD inhibited the progression of CRC, and the optimal effect was observed at high doses. MLCD regulated the structure and function of the intestinal flora by decreasing the abundance of harmful bacteria and increasing that of beneficial bacteria. The differentially expressed genes were mainly associated with the Wnt/β-catenin pathway and the cell cycle. Molecular biology analysis indicated that MLCD suppressed the Wnt/β-catenin pathway and the epithelial-mesenchymal transition (EMT), inhibited abnormal cell proliferation and promoted intestinal epithelial cell apoptosis. Conclusion: MLCD mitigated the abnormal growth of intestinal epithelial cells and promoted apoptosis, thereby inhibiting the progression of CRC. This inhibition was accomplished by modifying the intestinal microbiota and disrupting the Wnt/β-catenin pathway and the EMT. Therefore, MLCD could serve as a potential component of TCM prescriptions for CRC treatment.
Mesh-Begriff(e)	Wnt Signaling Pathway/drug effects ; Gastrointestinal Microbiome/drug effects ; Animals ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/metabolism ; Drugs, Chinese Herbal/pharmacology ; Mice ; Humans ; Male ; Apoptosis/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Cell Proliferation/drug effects ; Dextran Sulfate ; beta Catenin/metabolism ; Disease Models, Animal
Chemische Substanzen	Drugs, Chinese Herbal ; Dextran Sulfate (9042-14-2) ; beta Catenin
Sprache	Englisch
Erscheinungsdatum	2024-05-06
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-024-05763-w
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: RFX1 regulates foam cell formation and atherosclerosis by mediating CD36 expression.

Yang, Shuang / Min, Xiaoli / Hu, Longyuan / Zheng, Meiling / Lu, Shuang / Zhao, Ming / Jia, Sujie

International immunopharmacology

2024 Band 130, Seite(n) 111751

Abstract: Background and aims: Atherosclerosis (AS) is a continuously low-grade inflammatory disease, and monocyte-derived macrophages play a vital role in AS pathogenesis. Regulatory factor X1 (RFX1) has been reported to participate in differentiation of various ...

Abstract	Background and aims: Atherosclerosis (AS) is a continuously low-grade inflammatory disease, and monocyte-derived macrophages play a vital role in AS pathogenesis. Regulatory factor X1 (RFX1) has been reported to participate in differentiation of various cells. Our previous report showed that RFX1 expression in CD14 Methods: We explored the effects of RFX1 on oxidation low lipoprotein (ox-LDL)-stimulated foam cell formation and CD36 expression by increasing or silencing Rfx1 expression in mouse peritoneal macrophages (PMAs). The ApoE Results: Our results demonstrate that RFX1 expression was significantly reduced in ox-LDL induced foam cells and negatively correlated with lipid uptake in macrophages. Besides, Rfx1 deficiency in myeloid cells aggravated atherosclerotic lesions in ApoE Conclusions: The reduction of RFX1 expression in macrophages is a vital determinant for foam cell formation and the initiation of AS, proving a potential novel approach for the treatment of AS disease.
Mesh-Begriff(e)	Animals ; Humans ; Mice ; Apolipoproteins E/metabolism ; Atherosclerosis/metabolism ; Foam Cells/cytology ; Foam Cells/metabolism ; Lipoproteins, LDL/metabolism ; Regulatory Factor X1/metabolism ; CD36 Antigens/metabolism
Chemische Substanzen	Apolipoproteins E ; Lipoproteins, LDL ; Regulatory Factor X1 ; RFX1 protein, human ; Rfx1 protein, mouse ; Cd36 protein, mouse ; CD36 Antigens
Sprache	Englisch
Erscheinungsdatum	2024-02-24
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111751
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Systemic lupus erythematosus is associated with the risk of coeliac disease: a Mendelian randomisation study.

Wang, Qiaolin / Jia, Sujie / Lu, Qianjin / Zhao, Ming

Autoimmunity

2022 Band 56, Heft 1, Seite(n) 2250103

Abstract: As an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated until now. We performed a two-sample Mendelian randomisation study to ... ...

Abstract	As an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated until now. We performed a two-sample Mendelian randomisation study to evaluate the relationship between SLE and CeD, and found that SLE can significantly increase the risk of CeD, suggesting the association between SLE and abnormal intestinal immune microenvironment.
Mesh-Begriff(e)	Humans ; Celiac Disease/complications ; Celiac Disease/epidemiology ; Celiac Disease/genetics ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/genetics ; Autoimmune Diseases
Sprache	Englisch
Erscheinungsdatum	2022-03-18
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1025450-x
ISSN	1607-842X ; 0891-6934
ISSN (online)	1607-842X
ISSN	0891-6934
DOI	10.1080/08916934.2023.2250103
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Reasonable drug analysis of Listeria monocytogenes meningitis related to mantle cell lymphoma.

Zhu, Guang-Xuan / Jia, Su-Jie

Journal of infection and public health

2019 Band 12, Heft 5, Seite(n) 744–747

Abstract: We report a case of Listeria meningitis related to mantle cell lymphoma. A clinical pharmacist adjusted repeatedly the patient's anti-infective therapeutic regimen by analyzing the pharmacologic and pharmacokinetic characteristics of antibacterial drugs ( ...

Abstract	We report a case of Listeria meningitis related to mantle cell lymphoma. A clinical pharmacist adjusted repeatedly the patient's anti-infective therapeutic regimen by analyzing the pharmacologic and pharmacokinetic characteristics of antibacterial drugs (such as cefotaxime, meropenem, etc.) due to the patient's repeated fever during hospitalization. To the best of our knowledge, this is the first case of Listeria meningitis related to mantle cell lymphoma treated successfully with meropenem reported in China. This case aims to optimize the anti-infection treatment regimen of Listeria meningitis and to provide a reference for clinicians and clinical pharmacists to use drugs rationally.
Mesh-Begriff(e)	Anti-Bacterial Agents/therapeutic use ; China ; Drug Therapy, Combination ; Fever/drug therapy ; Fever/microbiology ; Humans ; Listeria monocytogenes/drug effects ; Lymphoma, Mantle-Cell/complications ; Lymphoma, Mantle-Cell/microbiology ; Male ; Meningitis, Listeria/diagnosis ; Meningitis, Listeria/drug therapy ; Meropenem/therapeutic use ; Middle Aged ; Thienamycins/therapeutic use ; Treatment Outcome
Chemische Substanzen	Anti-Bacterial Agents ; Thienamycins ; Meropenem (FV9J3JU8B1)
Sprache	Englisch
Erscheinungsdatum	2019-05-10
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ISSN	1876-035X
ISSN (online)	1876-035X
DOI	10.1016/j.jiph.2019.04.010
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Celecoxib-induced drug fever: A rare case report and literature review.

Xiao, Jing / Jia, Su-Jie / Wu, Cui-Fang

Journal of clinical pharmacy and therapeutics

2021 Band 47, Heft 3, Seite(n) 402–406

Abstract: What is known and objective: Drug fever is frequently misdiagnosed, especially during concurrent infection. Celecoxib causes various adverse effects; however, celecoxib-induced drug fever is rarely reported.: Case summary: A 32-year-old man presented ...

Abstract	What is known and objective: Drug fever is frequently misdiagnosed, especially during concurrent infection. Celecoxib causes various adverse effects; however, celecoxib-induced drug fever is rarely reported. Case summary: A 32-year-old man presented with pyrexia after 17 days of celecoxib therapy, which was reintroduced following 3-day total drug cessation. His fever recurred after this unsuspected rechallenge, which aided in the ultimate identification of the offending drug. A Naranjo Score of 8 led us to infer that drug fever was "probably" caused by celecoxib. What is new and conclusion: This is the first report of celecoxib-induced drug fever, aimed at assisting its diagnosis, particularly with rarely suspected causative drugs.
Mesh-Begriff(e)	Adult ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Celecoxib/adverse effects ; Cyclooxygenase 2 Inhibitors/adverse effects ; Fever/chemically induced ; Humans ; Male ; Pyrazoles/adverse effects ; Sulfonamides/adverse effects
Chemische Substanzen	Anti-Inflammatory Agents, Non-Steroidal ; Cyclooxygenase 2 Inhibitors ; Pyrazoles ; Sulfonamides ; Celecoxib (JCX84Q7J1L)
Sprache	Englisch
Erscheinungsdatum	2021-07-20
Erscheinungsland	England
Dokumenttyp	Case Reports ; Review
ZDB-ID	639006-7
ISSN	1365-2710 ; 0269-4727
ISSN (online)	1365-2710
ISSN	0269-4727
DOI	10.1111/jcpt.13490
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Aberrant H3K4me3 modification of immune response genes in CD4

Feng, Delong / Zhao, Hongjun / Wang, Qian / Wu, Jiali / Ouyang, Lianlian / Jia, Sujie / Lu, Qianjin / Zhao, Ming

International immunopharmacology

2024 Band 130, Seite(n) 111748

Abstract: Background: Increasing evidence has highlighted the significant role of histone modifications in pathogenesis of systemic lupus erythematosus (SLE). However, few studies have comprehensively analyzed trimethylation of histone H3 lysine 4 (H3K4me3) ... ...

Abstract	Background: Increasing evidence has highlighted the significant role of histone modifications in pathogenesis of systemic lupus erythematosus (SLE). However, few studies have comprehensively analyzed trimethylation of histone H3 lysine 4 (H3K4me3) features at specific immune gene loci in SLE patients. Methods: We conducted H3K4me3 chromatin immunoprecipitation sequencing (ChIP-seq) on CD4 Results: we identified 147 downregulated and 2701 upregulated H3K4me3 peaks in CD4 Conclusion: Our study uncovers dysregulated H3K4me3 modification patterns in immune response genes loci, which also exhibit downregulated DNA methylation and higher mRNA expression in CD4
Mesh-Begriff(e)	Humans ; CD4-Positive T-Lymphocytes/immunology ; Chromatin/metabolism ; Chromatin Immunoprecipitation ; DNA Methylation ; Histones/metabolism ; Immunity/genetics ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/immunology
Chemische Substanzen	Chromatin ; histone H3 trimethyl Lys4 ; Histones
Sprache	Englisch
Erscheinungsdatum	2024-03-02
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111748
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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