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  1. Article: MicroRNAs with Multiple Targets of Immune Checkpoints, as a Potential Sensitizer for Immune Checkpoint Inhibitors in Breast Cancer Treatment.

    Zhou, Huiling / Jia, Wentao / Lu, Lingeng / Han, Rui

    Cancers

    2023  Volume 15, Issue 3

    Abstract: Breast cancer is the most common cancer type and the leading cause of cancer-associated mortality in women worldwide. In recent years, immune checkpoint inhibitors (ICIs) have made significant progress in the treatment of breast cancer, yet there are ... ...

    Abstract Breast cancer is the most common cancer type and the leading cause of cancer-associated mortality in women worldwide. In recent years, immune checkpoint inhibitors (ICIs) have made significant progress in the treatment of breast cancer, yet there are still a considerable number of patients who are unable to gain lasting and ideal clinical benefits by immunotherapy alone, which leads to the development of a combination regimen as a novel research hotspot. Furthermore, one miRNA can target several checkpoint molecules, mimicking the therapeutic effect of a combined immune checkpoint blockade (ICB), which means that the miRNA therapy has been considered to increase the efficiency of ICIs. In this review, we summarized potential miRNA therapeutics candidates which can affect multiple targets of immune checkpoints in breast cancer with more therapeutic potential, and the obstacles to applying miRNA therapeutically through the analyses of the resources available from a drug target perspective. We also included the content of "too many targets for miRNA effect" (TMTME), combined with applying TargetScan database, to discuss adverse events. This review aims to ignite enthusiasm to explore the application of miRNAs with multiple targets of immune checkpoint molecules, in combination with ICIs for treating breast cancer.
    Language English
    Publishing date 2023-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Targeting tumor-derived exosome-mediated premetastatic niche formation: The metastasis-preventive value of traditional Chinese medicine.

    Jia, Wentao / Yuan, Jiaying / Cheng, Binbin / Ling, Changquan

    Cancer letters

    2023  Volume 567, Page(s) 216261

    Abstract: Tumor-derived exosome (TDE)-mediated premetastatic niche (PMN) formation is a potential mechanism underlying the organotropic metastasis of primary tumors. Traditional Chinese medicine (TCM) has shown considerable success in preventing and treating tumor ...

    Abstract Tumor-derived exosome (TDE)-mediated premetastatic niche (PMN) formation is a potential mechanism underlying the organotropic metastasis of primary tumors. Traditional Chinese medicine (TCM) has shown considerable success in preventing and treating tumor metastasis. However, the underlying mechanisms remain elusive. In this review, we discussed PMN formation from the perspectives of TDE biogenesis, cargo sorting, and TDE recipient cell alterations, which are critical for metastatic outgrowth. We also reviewed the metastasis-preventive effects of TCM, which act by targeting the physicochemical materials and functional mediators of TDE biogenesis, regulating the cargo sorting machinery and secretory molecules in TDEs, and targeting the TDE-recipient cells involved in PMN formation.
    MeSH term(s) Humans ; Exosomes/pathology ; Medicine, Chinese Traditional ; Tumor Microenvironment ; Cell Communication ; Neoplasms/drug therapy ; Neoplasms/prevention & control ; Neoplasms/pathology ; Neoplasm Metastasis/pathology
    Language English
    Publishing date 2023-06-09
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2023.216261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
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  3. Article ; Online: The role of dysregulated mRNA translation machinery in cancer pathogenesis and therapeutic value of ribosome-inactivating proteins.

    Jia, Wentao / Yuan, Jiaying / Li, Shu / Cheng, Binbin

    Biochimica et biophysica acta. Reviews on cancer

    2023  Volume 1878, Issue 6, Page(s) 189018

    Abstract: Dysregulated protein synthesis is a hallmark of tumors. mRNA translation reprogramming contributes to tumorigenesis, which is fueled by abnormalities in ribosome formation, tRNA abundance and modification, and translation factors. Not only malignant ... ...

    Abstract Dysregulated protein synthesis is a hallmark of tumors. mRNA translation reprogramming contributes to tumorigenesis, which is fueled by abnormalities in ribosome formation, tRNA abundance and modification, and translation factors. Not only malignant cells but also stromal cells within tumor microenvironment can undergo transformation toward tumorigenic phenotypes during translational reprogramming. Ribosome-inactivating proteins (RIPs) have garnered interests for their ability to selectively inhibit protein synthesis and suppress tumor growth. This review summarizes the role of dysregulated translation machinery in tumor development and explores the potential of RIPs in cancer treatment.
    MeSH term(s) Humans ; Ribosome Inactivating Proteins/genetics ; Ribosome Inactivating Proteins/therapeutic use ; Ribosome Inactivating Proteins/metabolism ; Ribosomes/genetics ; Protein Biosynthesis ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Tumor Microenvironment
    Chemical Substances Ribosome Inactivating Proteins (EC 3.2.2.22)
    Language English
    Publishing date 2023-11-07
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2918802-7
    ISSN 1879-2561 ; 0304-419X
    ISSN (online) 1879-2561
    ISSN 0304-419X
    DOI 10.1016/j.bbcan.2023.189018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7162: Show issues Location:
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  4. Book ; Thesis: Purification and identification of p92

    Jia, Wentao

    a sequence specific nuclear factor interactig with the enhancer of the human papillomavirus type 18 (HPV 18)

    2000  

    Author's details vorgelegt von Wentao Jia
    Language English
    Size 106 Bl., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 2000
    HBZ-ID HT013240711
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 MB 368 order for loan Magazin

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  5. Article ; Online: Does distorted allocation of capital factors inhibit green technology innovation in Chinese cities? An empirical analysis based on spatial effect

    Yao, Siling / Yu, Shenghua / Jia, Wentao

    Environ Sci Pollut Res. 2023 Feb., v. 30, no. 7 p.19234-19249

    2023  

    Abstract: Distorted allocation of capital factors will lead to the loss of capital market-based soil as the background support for green technology innovation, which will not be able to climb up the value chain and eventually become an economic “colony.” This ... ...

    Abstract Distorted allocation of capital factors will lead to the loss of capital market-based soil as the background support for green technology innovation, which will not be able to climb up the value chain and eventually become an economic “colony.” This study empirically investigates the relationship between distorted capital factor allocation and green technology innovation using data from 2005 to 2018 for prefecture-level cities in China. The empirical results show that the distortion of capital factor allocation not only has a significant inhibiting effect on green technology innovation in the city, but also hinders the development of green technology innovation in neighboring cities. Mechanism test analysis suggests that there is negative impact via generating mismatch, crowding out, and rent-seeking effects. Further research shows that the effect of distorted capital factor allocation on urban green technology innovation is more influential in the eastern and western regions. The conclusions of this study have important practical significance for optimizing the rational allocation of factor resources, promoting green technology innovation, and achieving high-quality economic growth.
    Keywords capital ; economic development ; empirical research ; soil ; supply chain ; sustainable technology ; technology ; China
    Language English
    Dates of publication 2023-02
    Size p. 19234-19249.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-23419-5
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  6. Article ; Online: Does distorted allocation of capital factors inhibit green technology innovation in Chinese cities? An empirical analysis based on spatial effect.

    Yao, Siling / Yu, Shenghua / Jia, Wentao

    Environmental science and pollution research international

    2022  Volume 30, Issue 7, Page(s) 19234–19249

    Abstract: Distorted allocation of capital factors will lead to the loss of capital market-based soil as the background support for green technology innovation, which will not be able to climb up the value chain and eventually become an economic "colony." This ... ...

    Abstract Distorted allocation of capital factors will lead to the loss of capital market-based soil as the background support for green technology innovation, which will not be able to climb up the value chain and eventually become an economic "colony." This study empirically investigates the relationship between distorted capital factor allocation and green technology innovation using data from 2005 to 2018 for prefecture-level cities in China. The empirical results show that the distortion of capital factor allocation not only has a significant inhibiting effect on green technology innovation in the city, but also hinders the development of green technology innovation in neighboring cities. Mechanism test analysis suggests that there is negative impact via generating mismatch, crowding out, and rent-seeking effects. Further research shows that the effect of distorted capital factor allocation on urban green technology innovation is more influential in the eastern and western regions. The conclusions of this study have important practical significance for optimizing the rational allocation of factor resources, promoting green technology innovation, and achieving high-quality economic growth.
    MeSH term(s) China ; Cities ; Economic Development ; Technology
    Language English
    Publishing date 2022-10-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-23419-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article: Using Traditional Chinese Medicine to Treat Hepatocellular Carcinoma by Targeting Tumor Immunity.

    Jia, Wentao / Wang, Lina

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 9843486

    Abstract: As the leading cause of cancer-related death, hepatocellular carcinoma (HCC) threatens human health and limited treatments are available to cure the disease efficiently and effectively. The particularly immunotolerant environment of the liver lowers the ... ...

    Abstract As the leading cause of cancer-related death, hepatocellular carcinoma (HCC) threatens human health and limited treatments are available to cure the disease efficiently and effectively. The particularly immunotolerant environment of the liver lowers the efficacy of current therapies in patients with advanced HCC. Traditional Chinese medicine (TCM) is gathering increasing interest due to the immunoregulatory properties of certain compounds. In advanced HCC, TCM can restore immunosurveillance to promote antitumor effects in several ways, including the upregulation of immunostimulatory factors and the downregulation of immunosuppressive factors. The characteristic multitarget regulation of TCM compounds may provide new insights regarding effective HCC immunotherapies. Here, we review the immunoregulatory potency of TCMs for treating HCC and explain how individual TCM drugs and complex formulas remodel the immune environment in various cell- and cytokine-dependent manners.
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/9843486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  8. Article ; Online: Design and collaborative optimization method of multilayer coatings to correct polarization aberration of optical systems.

    Jia, Wentao / He, Wenjun / Li, Yahong / Fu, Yuegang / Zhang, Lei

    Optics express

    2022  Volume 30, Issue 17, Page(s) 30611–30622

    Abstract: Multilayer coatings induce a significant polarization aberration in optical systems with high numerical aperture (NA) and wide field of view, which will cause wavefront distortion and imaging degradation. Studies have used low-polarization coatings (LPC) ...

    Abstract Multilayer coatings induce a significant polarization aberration in optical systems with high numerical aperture (NA) and wide field of view, which will cause wavefront distortion and imaging degradation. Studies have used low-polarization coatings (LPC) design to reduce the coating-induced polarization aberration. However, the polarization aberration caused by LPC remain evident in systems with large incident angles and many coated surfaces. In this paper, a hybrid optimization algorithm (HOA) is proposed to enhance the design accuracy of LPC. Based on the HOA, a collaborative optimization method is developed to simultaneously design coatings with different polarization properties for multiple surfaces, which can correct polarization aberration by mutual compensation between the coated surfaces and other optical elements in a single system. Finally, a high NA lithographic lens is simulated as an example to verify the collaborative optimization method. The simulation demonstrates that this method is superior to conventional methods. This research provides a new way to correct the polarization aberration and is applicable to any systems coated with multilayer coatings.
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.464633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Role of Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and the Value of Traditional Chinese Medicine Treatment.

    Jia, Wentao / Liang, Shufang / Cheng, Binbin / Ling, Changquan

    Frontiers in oncology

    2021  Volume 11, Page(s) 763519

    Abstract: Invasion and metastasis are the main reasons for the high mortality of liver cancer, which involve the interaction of tumor stromal cells and malignant cells. Cancer-associated fibroblasts (CAFs) are one of the major constituents of tumor stromal cells ... ...

    Abstract Invasion and metastasis are the main reasons for the high mortality of liver cancer, which involve the interaction of tumor stromal cells and malignant cells. Cancer-associated fibroblasts (CAFs) are one of the major constituents of tumor stromal cells affecting tumor growth, invasion, and metastasis. The heterogeneous properties and sources of CAFs make both tumor-supporting and tumor-suppression effects possible. The mechanisms for CAFs in supporting hepatocellular carcinoma (HCC) progression can be categorized into upregulated aggressiveness and stemness, transformed metabolism toward glycolysis and glutamine reductive carboxylation, polarized tumor immunity toward immune escape of HCC cells, and increased angiogenesis. The tumor-suppressive effect of fibroblasts highlights the functional heterogenicity of CAF populations and provides new insights into tumor-stromal interplay mechanisms. In this review, we introduced several key inflammatory signaling pathways in the transformation of CAFs from normal stromal cells and the heterogeneous biofunctions of activated CAFs. In view of the pleiotropic regulation properties of traditional Chinese medicine (TCM) and heterogeneous effects of CAFs, we also introduced the application and values of TCM in the treatment of HCC through targeting CAFs.
    Language English
    Publishing date 2021-11-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.763519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Local Phase Segregation Induced by Ion Milling in 2:17-Type Sm-Co Based Magnets.

    Song, Xin / Liu, Yao / Jia, Wentao / Li, Jian / Liu, Xiaolian / Zhao, Lizhong / Yuan, Tao / Ma, Tianyu

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 12

    Abstract: Transmission electron microscopy (TEM) is indispensable to reveal the cellular nanostructure of the 2:17-type Sm-Co based magnets which act as the first choice for high-temperature magnet-associated devices. However, structural deficiencies could be ... ...

    Abstract Transmission electron microscopy (TEM) is indispensable to reveal the cellular nanostructure of the 2:17-type Sm-Co based magnets which act as the first choice for high-temperature magnet-associated devices. However, structural deficiencies could be introduced into the TEM specimen during the ion milling process, which would provide misleading information to understand the microstructure-property relationship of such magnets. In this work, we performed a comparative investigation of the microstructure and microchemistry between two TEM specimens prepared under different ion milling conditions in a model commercial magnet Sm
    Language English
    Publishing date 2023-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16124378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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