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  1. Article ; Online: Monoterpene indole alkaloids from

    Wei, Quan-Hao / Zhang, Jin-Ping / Lu, Zhi-Yuan / Jia, Xian-Hui / Zhao, Xiao-Dong / Wang, Zhi-Wei / Wang, Xiao-Jing

    Natural product research

    2023  , Page(s) 1–8

    Abstract: Two new monoterpene indole alkaloids, Eleganine A ( ...

    Abstract Two new monoterpene indole alkaloids, Eleganine A (
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2261070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New cyclic C-geranylflavanones isolated from Paulownia fortunei fruits with their anti-proliferative effects on three cancer cell lines.

    Xiao, Cheng-Mei / Li, Jun / Kong, Ling-Tao / Xia, Lu-Yao / Shi, Ling-Xia / Zhao, Chao-Yue / Tang, Wen-Zhao / Jia, Xian-Hui

    Fitoterapia

    2023  Volume 168, Page(s) 105542

    Abstract: Seven new C-geranylated flavanones, fortunones F - L (1-7), were isolated from the fresh mature fruits of Paulownia fortunei (Seem.) Hemsl. Their structures were determined by extensive spectroscopic data interpretation (UV, IR, HRMS, NMR, and CD). These ...

    Abstract Seven new C-geranylated flavanones, fortunones F - L (1-7), were isolated from the fresh mature fruits of Paulownia fortunei (Seem.) Hemsl. Their structures were determined by extensive spectroscopic data interpretation (UV, IR, HRMS, NMR, and CD). These new isolated compounds were all with a cyclic side chain modified from the geranyl group. Among them, compounds 1-3 all possessed a dicyclic geranyl modification, which was described firstly for Paulownia C-geranylated flavonoids. All the isolated compounds were subjected to the cytotoxic assay on human lung cancer cell A549, mouse prostate cancer cell RM1 and human bladder cancer cell T24, respectively. Results indicated A549 cell line was more sensitive to C-geranylated flavanones than the other two cancer cell lines and compounds 1, 7 and 8 exhibited potential anti-tumor effects (IC
    MeSH term(s) Animals ; Mice ; Humans ; Fruit/chemistry ; Molecular Structure ; Flavanones/pharmacology ; Flavanones/chemistry ; Flavonoids/chemistry ; Cell Line ; Neoplasms/drug therapy
    Chemical Substances Flavanones ; Flavonoids
    Language English
    Publishing date 2023-05-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2023.105542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Monoterpene indole alkaloids from the roots of Alstonia rupestris and their anti-inflammatory activity.

    Wang, Zhi-Wei / Zhang, Jin-Ping / Wei, Quan-Hao / Lu, Zhi-Yuan / Jia, Xian-Hui / Zhao, Xiao-Dong / Wang, Xiao-Jing

    Fitoterapia

    2023  Volume 171, Page(s) 105689

    Abstract: Four new monoterpene indole alkaloids (1-4) together with twelve known alkaloids (5-16) were isolated from the roots of Alstonia rupestris. Compound 1 was the first example of ... ...

    Abstract Four new monoterpene indole alkaloids (1-4) together with twelve known alkaloids (5-16) were isolated from the roots of Alstonia rupestris. Compound 1 was the first example of C
    MeSH term(s) Alstonia/chemistry ; Monoterpenes/pharmacology ; Monoterpenes/chemistry ; Molecular Structure ; Indole Alkaloids/pharmacology ; Indole Alkaloids/chemistry ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry
    Chemical Substances Monoterpenes ; Indole Alkaloids ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-09-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2023.105689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1873: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Two new dicyclic C-geranylflavanones isolated from Paulownia fortunei and their cytotoxicity

    Liu, Wei-guo / Xiao, Cheng-mei / Li, Jun / Wu, Su-ying / Zhang, Wen-chao / Kong, Ling-tao / Tang, Wen-Zhao / Jia, Xian-hui

    Phytochemistry Letters. 2023 Apr., v. 54 p.97-100

    2023  

    Abstract: Two novel dicyclic C-geranylated flavanones, fortunones D (1) and E (2), were isolated from the fresh mature fruits of Paulownia fortunei (Seem.) Hemsl. Their structures were elucidated by the extensive spectroscopic data analyses (UV, HRMS NMR, and CD). ...

    Abstract Two novel dicyclic C-geranylated flavanones, fortunones D (1) and E (2), were isolated from the fresh mature fruits of Paulownia fortunei (Seem.) Hemsl. Their structures were elucidated by the extensive spectroscopic data analyses (UV, HRMS NMR, and CD). Each of these two isolated compounds possessed an unusual dicyclic geranyl group. Compounds 1 was more sensitive to human lung cancer cell A549 and exhibited potential anti-tumor effect (IC₅₀ = 9.72 μM).
    Keywords Paulownia fortunei ; antineoplastic activity ; cytotoxicity ; flavanones ; humans ; lung neoplasms ; neoplasm cells ; spectral analysis ; Paulownia fortunei (Seem.) Hemsl ; Dicyclic C-geranylflavanones ; Fortunones D and E ; Human lung cancer cell A549
    Language English
    Dates of publication 2023-04
    Size p. 97-100.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2023.02.001
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Paulownia C

    Cheng, Chun-Lei / Jia, Xian-Hui / Xiao, Cheng-Mei / Tang, Wen-Zhao

    Phytochemistry reviews : proceedings of the Phytochemical Society of Europe

    2019  Volume 18, Issue 3, Page(s) 549–570

    Abstract: ... ...

    Abstract Paulownia
    Keywords covid19
    Language English
    Publishing date 2019-06-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2065661-0
    ISSN 1572-980X ; 1568-7767
    ISSN (online) 1572-980X
    ISSN 1568-7767
    DOI 10.1007/s11101-019-09614-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids

    Jia, Xian-hui / Zhao, Huan-xin / Du, Cheng-lin / Tang, Wen-zhao / Wang, Xiao-Jing

    Phytochemistry reviews. 2021 Aug., v. 20, no. 4 p.845-868

    2021  

    Abstract: Naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids (PIAs and PQAs) are two small groups of herbal metabolites sharing a similar pentacyclic structure with a highly oxygenated phenanthrene moiety fused with a saturated or an ... ...

    Abstract Naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids (PIAs and PQAs) are two small groups of herbal metabolites sharing a similar pentacyclic structure with a highly oxygenated phenanthrene moiety fused with a saturated or an unsaturated N-heterocycle (indolizidine/quinolizidine moieties). Natural PIAs and PQAs only could be obtained from finite plant families (such as Asclepiadaceae, Lauraceae and Urticaceae families, etc.). Up to date, more than one hundred natural PIAs, while only nine natural PQAs had been described. PIA and PQA analogues have been applied to the development of potent anticancer agents all along because of their excellent cytotoxic activity. However, in the last two decades, other great biological properties, such as anti-inflammatory and antiviral activities were revealed successively by different pharmacological assays. Especially because of their potent antiviral activity against coronavirus (TGEV, SARS CoV and MHV) and tobacco mosaic virus, PIA and PQA analogues have attracted much pharmaceutical attention again, some of them have been used to present interesting targets for total or semi synthesis, and structure–activity relationship (SAR) study for the development of antiviral agents. In this review, natural PIA and PQA analogues obtained in the last two decades with their herbal origins, key spectroscopic characteristics for structural identification, biological activity with possible SARs and application prospects were systematically summarized. We hope this paper can stimulate further investigations on PIA and PQA analogues as an important source for potential drug discovery.
    Keywords Apocynaceae ; Lauraceae ; Tobacco mosaic virus ; Urticaceae ; antiviral properties ; cytotoxicity ; indolizidines ; metabolites ; moieties ; phenanthrenes ; plant biochemistry ; spectroscopy ; structure-activity relationships
    Language English
    Dates of publication 2021-08
    Size p. 845-868.
    Publishing place Springer Netherlands
    Document type Article ; Online
    Note Review
    ZDB-ID 2065661-0
    ISSN 1572-980X ; 1568-7767
    ISSN (online) 1572-980X
    ISSN 1568-7767
    DOI 10.1007/s11101-020-09723-3
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Flavanones from the fruit extract of Paulownia fortunei

    Liu, Hui / Jia, Xian-hui / Wang, Hong-cheng / Xiao, Cheng-mei / Du, Cheng-lin / Tang, Wen-zhao

    Phytochemistry letters. 2021 June, v. 43

    2021  

    Abstract: Two new prenylated flavanonols, named as fortunones A (1) and B (2), and one new geranylated flavanone, named as fortunones C (3), were isolated from the fruits of Paulownia fortunei (Seem.) Hemsl. Their structures were elucidated distinctly according to ...

    Abstract Two new prenylated flavanonols, named as fortunones A (1) and B (2), and one new geranylated flavanone, named as fortunones C (3), were isolated from the fruits of Paulownia fortunei (Seem.) Hemsl. Their structures were elucidated distinctly according to their UV, MS, NMR, and CD spectra. Structural modifications on prenyl and geranyl groups in these isolated compounds were uncommon for Paulownia flavanones. Only compounds 1 and 3 showed weak antioxidant effect on human umbilical vein endothelial cells injury induced by H₂O₂.
    Keywords Paulownia fortunei ; antioxidant activity ; flavanones ; fruit extracts
    Language English
    Dates of publication 2021-06
    Size p. 196-199.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2021.04.009
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids.

    Jia, Xian-Hui / Zhao, Huan-Xin / Du, Cheng-Lin / Tang, Wen-Zhao / Wang, Xiao-Jing

    Phytochemistry reviews : proceedings of the Phytochemical Society of Europe

    2020  Volume 20, Issue 4, Page(s) 845–868

    Abstract: Naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids (PIAs and PQAs) are two small groups of herbal metabolites sharing a similar pentacyclic structure with a highly oxygenated phenanthrene moiety fused with a saturated or an ... ...

    Abstract Naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids (PIAs and PQAs) are two small groups of herbal metabolites sharing a similar pentacyclic structure with a highly oxygenated phenanthrene moiety fused with a saturated or an unsaturated
    Keywords covid19
    Language English
    Publishing date 2020-09-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2065661-0
    ISSN 1572-980X ; 1568-7767
    ISSN (online) 1572-980X
    ISSN 1568-7767
    DOI 10.1007/s11101-020-09723-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Paulownia C-geranylated flavonoids: their structural variety, biological activity and application prospects

    Cheng, Chun-lei / Jia, Xian-hui / Xiao, Cheng-mei / Tang, Wen-zhao

    Phytochemistry reviews. 2019 June, v. 18, no. 3

    2019  

    Abstract: Paulownia species, especially their flowers and fruits, are traditionally used in Chinese herbal medicines for the treatment of infectious diseases. C-geranylated flavonoids were found to be the major special metabolites in Paulownia flowers and fruits, ... ...

    Abstract Paulownia species, especially their flowers and fruits, are traditionally used in Chinese herbal medicines for the treatment of infectious diseases. C-geranylated flavonoids were found to be the major special metabolites in Paulownia flowers and fruits, and 76 C-geranylated flavonoids had been isolated and characterized thus far. Structural variations in Paulownia C-geranylated flavonoids are mainly due to the complicated structural modifications in their geranyl substituents. These natural compounds have attracted much attention because of their various biological activities, including antioxidation, anti-inflammation, cytotoxic activity and various enzymatic inhibitions, etc. Among them, diplacone, a major Paulownia component, was considered to have promise for applications in medicine. This paper summarizes the information from current publications on Paulownia C-geranylated flavonoids, with a focus on their structural variety, key spectroscopic characteristics, biological activity with structure–activity relationships and application prospects. We hope that this paper will stimulate further investigations of Paulownia species and this kind of natural product.
    Keywords Paulownia ; cytotoxicity ; flavonoids ; flowers ; fruits ; herbal medicines ; infectious diseases ; medicine ; metabolites ; spectral analysis ; structure-activity relationships ; covid19
    Language English
    Dates of publication 2019-06
    Size p. 549-570.
    Publishing place Springer Netherlands
    Document type Article
    Note Review
    ZDB-ID 2065661-0
    ISSN 1572-980X ; 1568-7767
    ISSN (online) 1572-980X
    ISSN 1568-7767
    DOI 10.1007/s11101-019-09614-2
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Three new C-geranylated flavonoids from Paulownia catalpifolia T. Gong ex D.Y. Hong seeds with their inhibitory effects on xanthine oxidase

    Xiao, Cheng-mei / Jia, Xian-hui / Du, Hong-fang / Zhao, Huan-xin / Du, Cheng-lin / Tang, Wen-zhao / Wang, Xiao-Jing

    Phytochemical Society of Europe Phytochemistry letters. 2020 Apr., v. 36 p.162-165

    2020  

    Abstract: Three new C-geranylated flavonoids named as paucatalinones L (1), M (2), and N (3) were isolated from the seeds of Paulownia catalpifolia T. Gong ex D.Y. Hong. Their structures were determined by means of UV, IR, MS, NMR and CD techniques. Among them, ... ...

    Abstract Three new C-geranylated flavonoids named as paucatalinones L (1), M (2), and N (3) were isolated from the seeds of Paulownia catalpifolia T. Gong ex D.Y. Hong. Their structures were determined by means of UV, IR, MS, NMR and CD techniques. Among them, paucatalinone N (3) was the fifth C-geranylflavone derivative obtained from Paulownia genus, and its geranyl variation was firstly displayed in Paulownia C-geranylated flavonoids. Moreover, Compounds 1 and 3 showed good inhibitory effects on xanthine oxidase.
    Keywords Paulownia ; flavonoids ; nuclear magnetic resonance spectroscopy ; seeds ; xanthine oxidase ; Paulownia catalpifolia T. Gong ex D.Y. Hong ; C-geranylated flavonoids ; Paucatalinones L, M and N
    Language English
    Dates of publication 2020-04
    Size p. 162-165.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2020.02.002
    Database NAL-Catalogue (AGRICOLA)

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