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Article ; Online: Holographic Optogenetic Activation of Neurons Eliciting Locomotion in Head-Embedded Larval Zebrafish.

Jia, Xinyu / Wyart, Claire

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2707, Page(s) 125–140

Abstract: Understanding how motor circuits are organized and recruited in order to perform complex behavior is an essential question of neuroscience. Here we present an optogenetic protocol on larval zebrafish that allows spatial selective control of neuronal ... ...

Abstract	Understanding how motor circuits are organized and recruited in order to perform complex behavior is an essential question of neuroscience. Here we present an optogenetic protocol on larval zebrafish that allows spatial selective control of neuronal activity within a genetically defined population. We combine holographic illumination with the use of effective opsin transgenic lines, alongside high-speed behavioral monitoring to dissect the motor circuits of the larval zebrafish.
MeSH term(s)	Animals ; Optogenetics ; Zebrafish/genetics ; Locomotion ; Neurons ; Animals, Genetically Modified ; Larva
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3401-1_8
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Article ; Online: Exploration of the nonlinear relationship between social support and the establishment of long-term doctor-patient relationships: An empirical analysis based on virtual doctor teams.

Liu, Xuan / Jia, Xinyu

International journal of medical informatics

2023 Volume 178, Page(s) 105198

Abstract: Background: The continued development of information technology has led to the emergence of online medical consultation platforms. Online virtual doctor teams, a new model in online medical care, have received significant attention for their ability to ... ...

Abstract	Background: The continued development of information technology has led to the emergence of online medical consultation platforms. Online virtual doctor teams, a new model in online medical care, have received significant attention for their ability to provide increased social support to patients. Many scholars have explored the role of social support in doctor-patient communication, usually focusing on a linear relationship between the impact of social support on medical outcomes. In the present study, we will explore the existence of a nonlinear relationship between the two. Methods: In the present study, we use doctor teams from a leading online consultation platform in China--Haodf online (https://www.Haodf.com), as our research object. In total, 610 doctor teams and 413,778 consultation records spanning from June 2017 to November 2019 are collected and used to explore how social support supplied by doctor teams during interactive communication would affect the establishment of long-term doctor-patient relationships. We also explore the moderating role of team leadership type in this process. From the perspective of social support theory, we select representative factors of informational support and emotional support provided by doctor teams, namely, medical term use and emotional expression. We use text and sentiment analysis methods to extract social support contained in the texts of online doctor team-patient interactions and classify doctor teams into strong and weak leadership types based on leader-member status distance. Further, we used a logistic regression model to empirically analyze the nonlinear relationship between social support and long-term doctor-patient relationship establishment and the moderating effects of team leadership types in this process. Results: The present results show that inverted U-shaped relationships exist among medical term use, emotional expression, and long-term doctor-patient relationship establishment, respectively. Doctor teams with strong leadership type make the inverted U-shaped curve between medical term use and long-term doctor-patient relationship establishment flatter than teams with weak leadership type. Conclusion: In the present study, we enrich the application of social support theory in the field of online health consultation and provide suggestions for how different types of online doctor teams provide social support to patients.
MeSH term(s)	Humans ; Physician-Patient Relations ; Physicians ; Leadership ; Referral and Consultation ; Social Support
Language	English
Publishing date	2023-08-19
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1466296-6
ISSN	1872-8243 ; 1386-5056
ISSN (online)	1872-8243
ISSN	1386-5056
DOI	10.1016/j.ijmedinf.2023.105198
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Article ; Online: Tunable underwater sound absorption characteristics of 0-3 piezoelectric anechoic coating.

Jia, Xinyu / Jin, Guoyong / Wang, Xueren / Ye, Tiangui / Chen, Yukun

The Journal of the Acoustical Society of America

2024 Volume 155, Issue 1, Page(s) 156–170

Abstract: Piezoelectric composite materials (PCMs) with shunt damping circuits are used widely in hydroacoustics because of the flexible adjustability of their parameters. PCMs offer good underwater sound absorption, but shortcomings remain, such as poor low- ... ...

Abstract	Piezoelectric composite materials (PCMs) with shunt damping circuits are used widely in hydroacoustics because of the flexible adjustability of their parameters. PCMs offer good underwater sound absorption, but shortcomings remain, such as poor low-frequency sound absorption, narrow bandwidth, and a single dissipation mechanism. In this paper, the tunable underwater sound absorption of a 0-3 PCM combined with a cavity structure and shunt circuit (PCMC) is studied systematically. First, the equivalent material parameters of 0-3 PCM are derived based on the Yamada model, and then a theoretical electroacoustic model is established for solving the absorption coefficient and is mutually verified with the numerical simulation method. On this basis, the tunable absorption characteristics of the structure are analyzed. The results show that coupling the energy dissipation mechanism of 0-3 PCM with the acoustic mechanism of the cavity structure not only achieves strong absorption at lower frequencies but also enriches the absorption mode in the mid-high frequencies by connecting the shunt circuits. Moreover, the influence of piezoelectric control variables and acoustic cavity morphology characteristics on structural sound absorption performance is further explored. Finally, the acoustic performance of PCMC is improved further via shape optimization and parameter optimization.
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0024238
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Article ; Online: Improvement of thermal perceptions and physiological responses using torso heating under short-term cold exposure

Li, Sishi / Jia, Xinyu / Cao, Bin / Zhu, Yingxin

Science of the Total Environment. 2023 Sept., v. 892 p.164491-

2023

Abstract: Short-term cold exposure (<1 h) may adversely affect human thermal comfort and health. Few studies have investigated the effectiveness of body heating in providing thermal protection to the torso against sharp temperature decreases, as well as the ... ...

Abstract	Short-term cold exposure (<1 h) may adversely affect human thermal comfort and health. Few studies have investigated the effectiveness of body heating in providing thermal protection to the torso against sharp temperature decreases, as well as the optimal operation modes of torso heating equipment. In this study, 12 male subjects were acclimatised in a room at 20 °C, then exposed to a cold environment at −2.2 °C, and finally returned to the room for recovery; each phase lasted 30 min. During cold exposure, they wore uniform clothing with an electrically heated vest (EHV) operated under these modes: no heating (NH), stage-regulated heating (SH), and intermittent alternating heating (IAH). Variations in subjective perceptions, physiological responses, and temperatures set for heating were recorded during the experiments. Torso heating mitigated the adverse effects of the large temperature down-step and continuous cold exposure on thermal perception and decreased the occurrence of three symptoms: cold hands or feet, running or stuffy noses, and shivering during cold exposure. After torso heating, the same skin temperature of the non-directly heated parts corresponded to a higher local thermal sensation, which was attributed to an indirect effect of the improved overall thermal state. The IAH mode could achieve thermal comfort at a reduced energy level, and it outperformed SH in subjective perception enhancement and self-reported symptom relief at lower heating temperatures. Additionally, under the same heating setting temperatures and power capacity, it could achieve an approximately 50 % longer usage time than SH could. The results suggest that intermittent heating protocol can be an efficient way to achieve thermal comfort and energy savings for personal heating devices.
Keywords	clothing ; cold ; cold stress ; cold zones ; energy ; environment ; equipment ; heat ; humans ; males ; sensation ; skin temperature ; torso ; Thermal comfort ; Temperature steps ; Cold exposure ; Body heating ; Heated vest
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164491
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Article ; Online: Improvement of thermal perceptions and physiological responses using torso heating under short-term cold exposure.

Li, Sishi / Jia, Xinyu / Cao, Bin / Zhu, Yingxin

The Science of the total environment

2023 Volume 892, Page(s) 164491

Abstract	Short-term cold exposure (<1 h) may adversely affect human thermal comfort and health. Few studies have investigated the effectiveness of body heating in providing thermal protection to the torso against sharp temperature decreases, as well as the optimal operation modes of torso heating equipment. In this study, 12 male subjects were acclimatised in a room at 20 °C, then exposed to a cold environment at -2.2 °C, and finally returned to the room for recovery; each phase lasted 30 min. During cold exposure, they wore uniform clothing with an electrically heated vest (EHV) operated under these modes: no heating (NH), stage-regulated heating (SH), and intermittent alternating heating (IAH). Variations in subjective perceptions, physiological responses, and temperatures set for heating were recorded during the experiments. Torso heating mitigated the adverse effects of the large temperature down-step and continuous cold exposure on thermal perception and decreased the occurrence of three symptoms: cold hands or feet, running or stuffy noses, and shivering during cold exposure. After torso heating, the same skin temperature of the non-directly heated parts corresponded to a higher local thermal sensation, which was attributed to an indirect effect of the improved overall thermal state. The IAH mode could achieve thermal comfort at a reduced energy level, and it outperformed SH in subjective perception enhancement and self-reported symptom relief at lower heating temperatures. Additionally, under the same heating setting temperatures and power capacity, it could achieve an approximately 50 % longer usage time than SH could. The results suggest that intermittent heating protocol can be an efficient way to achieve thermal comfort and energy savings for personal heating devices.
MeSH term(s)	Humans ; Male ; Temperature ; Skin Temperature ; Thermosensing ; Body Temperature Regulation/physiology ; Hot Temperature ; Cold Temperature
Language	English
Publishing date	2023-05-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164491
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Article ; Online: A novel dual-pooling attention module for UAV vehicle re-identification.

Guo, Xiaoyan / Yang, Jie / Jia, Xinyu / Zang, Chuanyan / Xu, Yan / Chen, Zhaoyang

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2027

Abstract: Vehicle re-identification (Re-ID) involves identifying the same vehicle captured by other cameras, given a vehicle image. It plays a crucial role in the development of safe cities and smart cities. With the rapid growth and implementation of unmanned ... ...

Abstract	Vehicle re-identification (Re-ID) involves identifying the same vehicle captured by other cameras, given a vehicle image. It plays a crucial role in the development of safe cities and smart cities. With the rapid growth and implementation of unmanned aerial vehicles (UAVs) technology, vehicle Re-ID in UAV aerial photography scenes has garnered significant attention from researchers. However, due to the high altitude of UAVs, the shooting angle of vehicle images sometimes approximates vertical, resulting in fewer local features for Re-ID. Therefore, this paper proposes a novel dual-pooling attention (DpA) module, which achieves the extraction and enhancement of locally important information about vehicles from both channel and spatial dimensions by constructing two branches of channel-pooling attention (CpA) and spatial-pooling attention (SpA), and employing multiple pooling operations to enhance the attention to fine-grained information of vehicles. Specifically, the CpA module operates between the channels of the feature map and splices features by combining four pooling operations so that vehicle regions containing discriminative information are given greater attention. The SpA module uses the same pooling operations strategy to identify discriminative representations and merge vehicle features in image regions in a weighted manner. The feature information of both dimensions is finally fused and trained jointly using label smoothing cross-entropy loss and hard mining triplet loss, thus solving the problem of missing detail information due to the high height of UAV shots. The proposed method's effectiveness is demonstrated through extensive experiments on the UAV-based vehicle datasets VeRi-UAV and VRU.
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52225-x
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Article ; Online: Potential Candidate Molecule of Photosystem II Inhibitor Herbicide-Brassicanate A Sulfoxide.

Wang, Yu / Wang, Dong / Dong, Baozhu / Hao, Jianxiu / Jia, Xinyu / Zhou, Hongyou

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Brassicanate A sulfoxide, a secondary metabolite of broccoli, exhibited the inhibition of weed growth, but its mechanism of action on weeds remains unclear. To elucidate the mechanism by which brassicanate A sulfoxide suppresses weeds, this study ... ...

Abstract	Brassicanate A sulfoxide, a secondary metabolite of broccoli, exhibited the inhibition of weed growth, but its mechanism of action on weeds remains unclear. To elucidate the mechanism by which brassicanate A sulfoxide suppresses weeds, this study explores the interaction between brassicanate A sulfoxide and the photosystem II D1 protein through molecular docking and molecular dynamics simulations. This research demonstrates that brassicanate A sulfoxide interacts with the photosystem II D1 protein by forming hydrogen bonds with Phe-261 and His-214. The successful expression of the photosystem II D1 protein in an insect cell/baculovirus system validated the molecular docking and dynamics simulations. Biolayer interferometry experiments elucidated that the affinity constant of brassicanate A sulfoxide with photosystem II was 2.69 × 10
MeSH term(s)	Herbicides/chemistry ; Photosystem II Protein Complex/metabolism ; Molecular Docking Simulation ; Photosynthesis ; Plant Weeds/metabolism ; Sulfoxides
Chemical Substances	Herbicides ; Photosystem II Protein Complex ; Sulfoxides
Language	English
Publishing date	2024-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042400
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Article ; Online: A randomized controlled clinical trial of concentrated growth factor combined with sodium hyaluronate in the treatment of temporomandibular joint osteoarthritis.

Jia, Xin-Yu / Jing, Si-Li / Sun, Yang / Gong, Zhong-Cheng / Guo, Zhi-Chen

BMC oral health

2024 Volume 24, Issue 1, Page(s) 540

Abstract: Objective: To investigate the effect of concentrated growth factor (CGF) combined with sodium hyaluronate (SH) on temporomandibular joint osteoarthritis (TMJOA).: Methods: Sixty patients with TMJOA who were diagnosed by cone-beam computed tomography ( ...

Abstract	Objective: To investigate the effect of concentrated growth factor (CGF) combined with sodium hyaluronate (SH) on temporomandibular joint osteoarthritis (TMJOA). Methods: Sixty patients with TMJOA who were diagnosed by cone-beam computed tomography (CBCT) between March 2020 and March 2023 at the Stomatological Hospital of Xi'an Jiaotong University were randomly divided into a control group (n = 30) and an experimental group (n = 30). The patients in the experimental group were treated with CGF + SH, and those in the control group were treated with SH only. The visual analogue scale (VAS) score indicating pain in the temporomandibular joint (TMJ) area; the Helkimo Clinical Dysfunction Index (Di); and changes in condylar CBCT at the first visit and 2 weeks, 3 months and 6 months after treatment were recorded. The CBCT data of the patients in the experimental and control groups were collected, and the three-dimensional CBCT image sequences were imported into Mimics Medical 19.0 software in DICOM format for condylar reconstruction. Results: The VAS scores at 2 weeks, 3 months and 6 months after treatment were significantly lower in the experimental group than in the control group (P < 0.05), and the pain in the experimental group was significantly relieved. The Di was significantly lower in the experimental group than in the control group (P < 0.05), and the clinical function of the TMJ improved. After treatment, the CBCT score was significantly lower in the experimental group than in the control group (P < 0.05), and the condylar bone cortex was obviously repaired. Observation of the condylar bone cortex by three-dimensional reconstruction showed the same results as those obtained by CBCT. Conclusion: CGF combined with SH is effective in the treatment of TMJOA and can improve muscle pain, TMJ pain, Impaired TMJ function, Impaired range of movement, Pain on movement of the mandible and promote bone repair. The registration number (trn): ChiCTR2400082712. The date of registration: April 5, 2024.
MeSH term(s)	Humans ; Hyaluronic Acid/therapeutic use ; Hyaluronic Acid/administration & dosage ; Female ; Male ; Osteoarthritis/drug therapy ; Osteoarthritis/diagnostic imaging ; Cone-Beam Computed Tomography ; Temporomandibular Joint Disorders/drug therapy ; Temporomandibular Joint Disorders/diagnostic imaging ; Adult ; Middle Aged ; Pain Measurement ; Intercellular Signaling Peptides and Proteins/therapeutic use ; Treatment Outcome
Chemical Substances	Hyaluronic Acid (9004-61-9) ; Intercellular Signaling Peptides and Proteins
Language	English
Publishing date	2024-05-08
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-024-04258-x
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Article ; Online: Conductive interpenetrating network organohydrogels of gellan gum/polypyrrole with weather-tolerance, piezoresistive sensing and shape-memory capability.

Li, Panpan / Jia, Xinyu / Sun, Zhaolong / Tang, Jinglong / Ji, Quan / Ma, Xiaomei

International journal of biological macromolecules

2024 Volume 262, Issue Pt 2, Page(s) 130215

Abstract: To develop ecofriendly multifunctional gel materials for sustainable flexible electronic devices, composite organohydrogels of gellan gum (GG) and polypyrrole (PPy) with an interpenetrating network structure (IPN-GG/PPy organohydrogels) were developed ... ...

Abstract	To develop ecofriendly multifunctional gel materials for sustainable flexible electronic devices, composite organohydrogels of gellan gum (GG) and polypyrrole (PPy) with an interpenetrating network structure (IPN-GG/PPy organohydrogels) were developed first time, through fabrication of GG organohydrogels followed by in-situ oxidation polymerization of pyrrole inside. Combination of water with glycerol can not only impart environment-stability to GG hydrogels but promote the mechanics remarkably, with the compressive strength amplified by 1250 % from 0.02 to 0.27 MPa. Incorporation of PPy confers electrical conductivity to the GG organohydrogel as well as promoting the mechanical performance further. The maximum conductivity of the IPN-GG/PPy organohydrogels reached 1.2 mS/cm at 25 °C, and retained at 0.6 mS/cm under -20 °C and 0.56 mS/cm after 7 days' exposure in 25 °C and 60 % RH. The compression strength of that with the maximum conductivity increases by 170 % from 0.27 to 0.73 MPa. The excellent conductivity and mechanical properties endow the IPN-GG/PPy organohydrogels good piezoresistive strain/pressure sensing behavior. Moreover, the thermo-reversible GG network bestows them shape-memory capability. The multifunctionality and intrinsic eco-friendliness is favorable for sustainable application in fields such as flexible electronics, soft robotics and artificial intelligence, competent in motion recognition, physiological signal monitoring, intelligent actuation.
MeSH term(s)	Artificial Intelligence ; Polymers ; Pyrroles ; Electric Conductivity ; Hydrogels ; Weather ; Polysaccharides, Bacterial
Chemical Substances	gellan gum (7593U09I4D) ; polypyrrole (30604-81-0) ; Polymers ; Pyrroles ; Hydrogels ; Polysaccharides, Bacterial
Language	English
Publishing date	2024-02-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130215
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Article ; Online: Enhancing Fat Graft Survival via Upregulating Autophagy of Adipocytes.

Jia, Xinyu / Chai, Yimeng / Zhu, Jinglin / Zhang, Xinyu / Jiang, Chanyuan / Yin, Ningbei / Li, Facheng

Aesthetic plastic surgery

2024 Volume 48, Issue 9, Page(s) 1807–1816

Abstract: Background: Autophagy is a cellular self-protection mechanism. The upregulation of adipose-derived stem cells' (ADSCs) autophagy can promote fat graft survival. However, the effect of interfering with adipocyte autophagy on graft survival is still ... ...

Abstract	Background: Autophagy is a cellular self-protection mechanism. The upregulation of adipose-derived stem cells' (ADSCs) autophagy can promote fat graft survival. However, the effect of interfering with adipocyte autophagy on graft survival is still unknown. In addition, autophagy is involved in adipocyte dedifferentiation. We investigated the effect of autophagy on adipocyte dedifferentiation and fat graft survival. Methods: The classic autophagy regulatory drugs rapamycin (100 nM) and 3-methyladenine (3-MA; 10 mM) were used to treat adipocytes, adipocyte dedifferentiation was observed, and their effects on ADSCs were detected. In our experiments, 100 nM rapamycin, 10 mM 3-MA and saline were mixed with human adipose tissue and transplanted into nude mice. At 2, 4, 8 and 12 weeks postoperatively, the grafts were harvested for histological and immunohistochemical analysis. Results: Rapamycin and 3-MA can promote and inhibit adipocyte dedifferentiation by regulating autophagy. Both drugs can inhibit ADSC proliferation, and 10 mM 3-MA can inhibit ADSC adipogenesis. At weeks 8 and 12, the volume retention rate of the rapamycin group (8 weeks, 64.77% ± 6.36%; 12 weeks, 56.13% ± 4.73%) was higher than the control group (8 weeks, 52.62% ± 4.04%; P < 0.05; 12 weeks, 43.17% ± 6.02%; P < 0.05) and the rapamycin group had more viable adipocytes and better vascularization. Compared with the control group, the volume retention rate, viable adipocytes and vascularization of the 3-MA group decreased. Conclusions: Rapamycin can promote adipocyte dedifferentiation by upregulating autophagy to promote fat graft survival. 3-MA can inhibit graft survival, but its mechanism includes the inhibition of adipocyte dedifferentiation and ADSC proliferation and adipogenesis. No level assigned: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
MeSH term(s)	Animals ; Autophagy/drug effects ; Autophagy/physiology ; Mice ; Adipocytes/transplantation ; Graft Survival/drug effects ; Humans ; Mice, Nude ; Sirolimus/pharmacology ; Up-Regulation ; Female ; Adipose Tissue/transplantation ; Adenine/analogs & derivatives ; Adenine/pharmacology
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	532791-x
ISSN	1432-5241 ; 0364-216X
ISSN (online)	1432-5241
ISSN	0364-216X
DOI	10.1007/s00266-023-03797-y
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