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Article ; Online: Design and Preparation of Ethylene Fluorescence Probes Based on Arylolefins and Grubbs Catalysts.

Yang, Yanyan / Bian, Hongxia / Jia, Zhilong / Tu, Peng

ACS omega

2023 Volume 8, Issue 17, Page(s) 15350–15359

Abstract: To detect the plant hormone ethylene, three arylolefins were employed to react with ethylene based on olefin metathesis. In this study, three fluorescence probes were successfully prepared using a first-generation Grubbs catalyst (G-1) and arylolefin ... ...

Abstract	To detect the plant hormone ethylene, three arylolefins were employed to react with ethylene based on olefin metathesis. In this study, three fluorescence probes were successfully prepared using a first-generation Grubbs catalyst (G-1) and arylolefin with terminal vinyl groups. The probes were characterized using various techniques, including UV-vis, fluorescence, FT-IR,
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c00586
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparative Analysis of Volatile Compounds from Four Radish Microgreen Cultivars Based on Ultrasonic Cell Disruption and HS-SPME/GC-MS.

Zhong, Yuan / Jia, Zhilong / Zhou, Hailong / Zhang, Dan / Li, Guichen / Yu, Jihua

International journal of molecular sciences

2023 Volume 24, Issue 19

Abstract: The ultrasonic cell disruption method was used to efficiently extract isothiocyanates and other volatile compounds from radish microgreens. A total of 51 volatiles were identified and quantified by headspace solid-phase micro-extraction and gas ... ...

Abstract	The ultrasonic cell disruption method was used to efficiently extract isothiocyanates and other volatile compounds from radish microgreens. A total of 51 volatiles were identified and quantified by headspace solid-phase micro-extraction and gas chromatography-mass spectrometry (HS-SPME/GC-MS) in four radish microgreen cultivars, mainly including alcohols, aldehydes, isothiocyanates, sulfides, ketones, esters, terpenes, and hydrocarbons. The correlation between cultivars and volatile compounds was determined by chemometrics analysis, including principal component analysis (PCA) and hierarchical clustering heat maps. The aroma profiles were distinguished based on the odor activity value (OAV), odor contribution rate (OCR), and radar fingerprint chart (RFC) of volatile compounds. This study not only revealed the different flavor characteristics in four cultivars but also established a theoretical basis for the genetic improvement of radish microgreen flavors.
MeSH term(s)	Solid Phase Microextraction/methods ; Raphanus ; Gas Chromatography-Mass Spectrometry/methods ; Ultrasonics ; Volatile Organic Compounds/analysis ; Odorants/analysis ; Isothiocyanates/analysis
Chemical Substances	Volatile Organic Compounds ; Isothiocyanates
Language	English
Publishing date	2023-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241914988
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The active lung microbiota landscape of COVID-19 patients through the metatranscriptome data analysis.

Han, Yang / Jia, Zhilong / Shi, Jinlong / Wang, Weidong / He, Kunlun

BioImpacts : BI

2021 Volume 12, Issue 2, Page(s) 139–146

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-10-09
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2604624-6
ISSN	2228-5660 ; 2228-5652
ISSN (online)	2228-5660
ISSN	2228-5652
DOI	10.34172/bi.2021.23378
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Proteomic and clinical biomarkers for acute mountain sickness in a longitudinal cohort.

Yang, Jing / Jia, Zhilong / Song, Xinyu / Shi, Jinlong / Wang, Xiaoreng / Zhao, Xiaojing / He, Kunlun

Communications biology

2022 Volume 5, Issue 1, Page(s) 548

Abstract: Ascending to high-altitude by non-high-altitude natives is a well-suited model for studying acclimatization to extreme environments. Acute mountain sickness (AMS) is frequently experienced by visitors. The diagnosis of AMS mainly depends on a self- ... ...

Abstract	Ascending to high-altitude by non-high-altitude natives is a well-suited model for studying acclimatization to extreme environments. Acute mountain sickness (AMS) is frequently experienced by visitors. The diagnosis of AMS mainly depends on a self-questionnaire, revealing the need for reliable biomarkers for AMS. Here, we profiled 22 AMS symptom phenotypes, 65 clinical indexes, and plasma proteomic profiles of AMS via a combination of proximity extension assay and multiple reaction monitoring of a longitudinal cohort of 53 individuals. We quantified 1069 proteins and validated 102 proteins. Via differential analysis, machine learning, and functional association analyses. We found and validated that RET played an important role in the pathogenesis of AMS. With high-accuracies (AUCs > 0.9) of XGBoost-based models, we prioritized ADAM15, PHGDH, and TRAF2 as protective, predictive, and diagnostic biomarkers, respectively. Our findings shed light on the precision medicine for AMS and the understanding of acclimatization to high-altitude environments.
MeSH term(s)	ADAM Proteins ; Acute Disease ; Altitude ; Altitude Sickness/diagnosis ; Biomarkers ; Humans ; Membrane Proteins ; Proteomics
Chemical Substances	Biomarkers ; Membrane Proteins ; ADAM Proteins (EC 3.4.24.-) ; ADAM15 protein, human (EC 3.4.24.-)
Language	English
Publishing date	2022-06-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-03514-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Low-dose of caffeine alleviates high altitude pulmonary edema

Tian, Liuyang / Jia, Zhilong / Yan, Yan / Jia, Qian / Shi, Wenjie / Cui, Saijia / Chen, Huining / Han, Yang / Zhao, Xiaojing / He, Kunlun

Frontiers in pharmacology

2023 Volume 14, Page(s) 1155414

Abstract: Backgrounds: ...

Abstract	Backgrounds:
Language	English
Publishing date	2023-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1155414
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19).

Jia, Zhilong / Song, Xinyu / Shi, Jinlong / Wang, Weidong / He, Kunlun

Pathogens and disease

2020 Volume 78, Issue 4

Abstract: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world has led to a pandemic with high morbidity and mortality. However, there are no effective drugs to prevent and treat the disease. Transcriptome-based drug ... ...

Abstract	The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world has led to a pandemic with high morbidity and mortality. However, there are no effective drugs to prevent and treat the disease. Transcriptome-based drug repositioning, identifying new indications for old drugs, is a powerful tool for drug development. Using bronchoalveolar lavage fluid transcriptome data of COVID-19 patients, we found that the endocytosis and lysosome pathways are highly involved in the disease and that the regulation of genes involved in neutrophil degranulation was disrupted, suggesting an intense battle between SARS-CoV-2 and humans. Furthermore, we implemented a coexpression drug repositioning analysis, cogena, and identified two antiviral drugs (saquinavir and ribavirin) and several other candidate drugs (such as dinoprost, dipivefrine, dexamethasone and (-)-isoprenaline). Notably, the two antiviral drugs have also previously been identified using molecular docking methods, and ribavirin is a recommended drug in the diagnosis and treatment protocol for COVID pneumonia (trial version 5-7) published by the National Health Commission of the P.R. of China. Our study demonstrates the value of the cogena-based drug repositioning method for emerging infectious diseases, improves our understanding of SARS-CoV-2-induced disease, and provides potential drugs for the prevention and treatment of COVID-19 pneumonia.
MeSH term(s)	Antiviral Agents/pharmacology ; Betacoronavirus/drug effects ; Bronchoalveolar Lavage Fluid/chemistry ; COVID-19 ; Cell Degranulation/immunology ; Coronavirus Infections/drug therapy ; Drug Repositioning ; Endocytosis/immunology ; Gene Expression Profiling ; Humans ; Lysosomes/immunology ; Molecular Docking Simulation ; Neutrophil Activation/immunology ; Pandemics ; Pneumonia, Viral/drug therapy ; Ribavirin/pharmacology ; SARS-CoV-2 ; Saquinavir/pharmacology ; Transcriptome
Chemical Substances	Antiviral Agents ; Ribavirin (49717AWG6K) ; Saquinavir (L3JE09KZ2F)
Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2049-632X
ISSN (online)	2049-632X
DOI	10.1093/femspd/ftaa036
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Transcriptional landscape in rat intestines under hypobaric hypoxia.

Tian, Liuyang / Jia, Zhilong / Xu, Zhenguo / Shi, Jinlong / Zhao, XiaoJing / He, Kunlun

PeerJ

2021 Volume 9, Page(s) e11823

Abstract: Oxygen metabolism is closely related to the intestinal homeostasis environment, and the occurrence of many intestinal diseases is as a result of the destruction of oxygen gradients. The hypobaric hypoxic environment of the plateau can cause dysfunction ... ...

Abstract	Oxygen metabolism is closely related to the intestinal homeostasis environment, and the occurrence of many intestinal diseases is as a result of the destruction of oxygen gradients. The hypobaric hypoxic environment of the plateau can cause dysfunction of the intestine for humans, such as inflammation. The compensatory response of the small intestine cells to the harsh environment definitely changes their gene expression. How the small intestine cells response the hypobaric hypoxic environment is still unclear. We studied the rat small intestine under hypobaric hypoxic conditions to explore the transcriptional changes in rats under acute/chronic hypobaric hypoxic conditions. We randomly divided rats into three groups: normal control group (S), acute hypobaric hypoxia group, exposing to hypobaric hypoxic condition for 2 weeks (W2S) and chronic hypobaric hypoxia group, exposing to hypobaric hypoxic condition for 4 weeks (W4S). The RNA sequencing was performed on the small intestine tissues of the three groups of rats. The results of principal component analysis showed that the W4S and W2S groups were quite different from the control group. We identified a total of 636 differentially expressed genes, such as ATP binding cassette, Ace2 and Fabp. KEGG pathway analysis identified several metabolic and digestive pathways, such as PPAR signaling pathway, glycerolipid metabolism, fat metabolism, mineral absorption and vitamin metabolism. Cogena analysis found that up-regulation of digestive and metabolic functions began from the second week of high altitude exposure. Our study highlights the critical role of metabolic and digestive pathways of the intestine in response to the hypobaric hypoxic environment, provides new aspects for the molecular effects of hypobaric hypoxic environment on intestine, and raises further questions about between the lipid metabolism disorders and inflammation.
Language	English
Publishing date	2021-07-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.11823
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Article ; Online: Functionalized Attapulgite for the Adsorption of Methylene Blue: Synthesis, Characterization, and Adsorption Mechanism.

Zhang, Zhifang / Gui, Wenjun / Wei, Jia / Cui, Yanjun / Li, Ping / Jia, Zhilong / Kong, Peng

ACS omega

2021 Volume 6, Issue 30, Page(s) 19586–19595

Abstract: Attapulgite (denoted as APT, also called palygorskite) has been regarded as the green material in the "21st century world" and has attracted widespread attention due to its advantages of low cost, natural abundance, nontoxic nature, and environmental ... ...

Abstract	Attapulgite (denoted as APT, also called palygorskite) has been regarded as the green material in the "21st century world" and has attracted widespread attention due to its advantages of low cost, natural abundance, nontoxic nature, and environmental friendliness. However, the limited adsorption sites and surface charges of natural APT greatly hinder its application as an adsorbent in industrial fields. In this work, natural APT was modified with sodium humate (SA) via a facile one-step hydrothermal process to improve its adsorption capacity and systematically studied its ability to remove methylene blue (MB) from aqueous solutions. The effect of hydrothermal modification in the presence of SA on the microscopic structure, morphology, and physicochemical properties of APT was studied by field-emission scanning electron microscopy, Fourier transform infrared spectrometry, X-ray diffraction, and Brunauer-Emmett-Teller analyses. The adsorption properties of the modified APT toward MB were evaluated systematically. The results demonstrated that the modified APT has a high adsorption capacity of 227.27 mg/g and also shows a high removal rate up to 99.7% toward MB in a dye solution with an initial concentration of 150 mg/L, which was a 64.7% increase as compared to that of raw APT. The adsorption kinetics could be fitted to the pseudo-second-order model, while the adsorption isotherm could be well-described with the Langmuir model. It was concluded that electrostatic attraction, hydrogen-bonding interaction, and chemical association are the main driving force during the adsorption process.
Language	English
Publishing date	2021-07-21
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c02111
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19)

Jia, Zhilong / Song, Xinyu / Shi, Jinlong / Wang, Weidong / He, Kunlun

Pathogens and Disease

2020 Volume 78, Issue 4

Abstract: ABSTRACT The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world has led to a pandemic with high morbidity and mortality. However, there are no effective drugs to prevent and treat the disease. Transcriptome-based ... ...

Abstract	ABSTRACT The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world has led to a pandemic with high morbidity and mortality. However, there are no effective drugs to prevent and treat the disease. Transcriptome-based drug repositioning, identifying new indications for old drugs, is a powerful tool for drug development. Using bronchoalveolar lavage fluid transcriptome data of COVID-19 patients, we found that the endocytosis and lysosome pathways are highly involved in the disease and that the regulation of genes involved in neutrophil degranulation was disrupted, suggesting an intense battle between SARS-CoV-2 and humans. Furthermore, we implemented a coexpression drug repositioning analysis, cogena, and identified two antiviral drugs (saquinavir and ribavirin) and several other candidate drugs (such as dinoprost, dipivefrine, dexamethasone and (-)-isoprenaline). Notably, the two antiviral drugs have also previously been identified using molecular docking methods, and ribavirin is a recommended drug in the diagnosis and treatment protocol for COVID pneumonia (trial version 5–7) published by the National Health Commission of the P.R. of China. Our study demonstrates the value of the cogena-based drug repositioning method for emerging infectious diseases, improves our understanding of SARS-CoV-2-induced disease, and provides potential drugs for the prevention and treatment of COVID-19 pneumonia.
Keywords	Immunology and Allergy ; Microbiology (medical) ; General Immunology and Microbiology ; Infectious Diseases ; General Medicine ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
ISSN	2049-632X
DOI	10.1093/femspd/ftaa036
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The active lung microbiota landscape of COVID-19 patients

Han, Yang / Jia, Zhilong / Shi, Jinlong / Wang, Weidong / He, Kunlun

medRxiv

Abstract: With the outbreak of COVID-19 causing by SARS-CoV-2, the interaction between the host and SARS-CoV-2 was widely studied. However, it is unclear whether and how SARS-CoV-2 infection affects lung microflora, which contributes to COVID-19 complications. ... ...

Abstract	With the outbreak of COVID-19 causing by SARS-CoV-2, the interaction between the host and SARS-CoV-2 was widely studied. However, it is unclear whether and how SARS-CoV-2 infection affects lung microflora, which contributes to COVID-19 complications. Here, we analyzed the metatranscriptomic data of bronchoalveolar lavage fluid (BALF) of 19 COVID-19 patients and 23 healthy controls from 6 independent projects and detailed the active microbiota landscape in both healthy individuals and COVID-19 patients. The infection of SARS-CoV-2 could deeply change the lung microbiota, evidenced by the α-diversity, β-diversity and species composition analysis based on bacterial microbiota and virome. Pathogens (such as Klebsiella oxytoca causing pneumonia as well), immunomodulatory probiotics (such as Lactic Acid Bacteria and Faecalibacterium prausnitzii, a butyrate producer) and Tobacco mosaic virus (TMV) were enriched in the COVID-19 group, suggesting a severe microbiota dysbiosis. The significant correlation between Rothia mucilaginosa, TMV and SARS-CoV-2 revealed drastic inflammatory battles between the host, SARS-CoV-2 and other microbes in the lungs. Notably, TMV only existed in the COVID-19 group, while Human respirovirus 3 only existed in the healthy group. Our study provides insight into the active microbiota in the lungs of COVID-19 patients and will contribute to the understanding of the infection mechanism of SARS-CoV-2 and the treatment of the disease and complications.
Keywords	covid19
Language	English
Publishing date	2020-08-23
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.08.20.20144014
Database	COVID19

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