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  1. Article ; Online: An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria

    David Lubkowicz / Nicholas G Horvath / Michael J James / Pasquale Cantarella / Lauren Renaud / Christopher G Bergeron / Ron B Shmueli / Cami Anderson / Jian‐Rong Gao / Caroline B Kurtz / Mylene Perreault / Mark R Charbonneau / Vincent M Isabella / David L Hava

    Molecular Systems Biology, Vol 18, Iss 3, Pp n/a-n/a (2022)

    2022  

    Abstract: Abstract Enteric hyperoxaluria (EH) is a metabolic disease caused by excessive absorption of dietary oxalate leading to the formation of chronic kidney stones and kidney failure. There are no approved pharmaceutical treatments for EH. SYNB8802 is an ... ...

    Abstract Abstract Enteric hyperoxaluria (EH) is a metabolic disease caused by excessive absorption of dietary oxalate leading to the formation of chronic kidney stones and kidney failure. There are no approved pharmaceutical treatments for EH. SYNB8802 is an engineered bacterial therapeutic designed to consume oxalate in the gut and lower urinary oxalate as a potential treatment for EH. Oral administration of SYNB8802 leads to significantly decreased urinary oxalate excretion in healthy mice and non‐human primates, demonstrating the strain's ability to consume oxalate in vivo. A mathematical modeling framework was constructed that combines in vitro and in vivo preclinical data to predict the effects of SYNB8802 administration on urinary oxalate excretion in humans. Simulations of SYNB8802 administration predict a clinically meaningful lowering of urinary oxalate excretion in healthy volunteers and EH patients. Together, these findings suggest that SYNB8802 is a promising treatment for EH.
    Keywords engineered bacteria ; enteric hyperoxaluria ; in silico modeling ; oxalate ; synthetic biology ; Biology (General) ; QH301-705.5 ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Asymmetric double donor-π-acceptor dyes based on phenothiazine and carbazole donors for dye-sensitized solar cells

    Zhu, Bo-ye / Liang Wu / Qin Ye / Jian-rong Gao / Liang Han

    Tetrahedron. 2017,

    2017  

    Abstract: Four organic dyes with asymmetric double donor-π-acceptor system were designed, synthesized and utilized in dye-sensitized solar cells (DSSCs), where phenothiazine and carbazole were introduced as double donors, butyl or octyl chain as the linker and ... ...

    Abstract Four organic dyes with asymmetric double donor-π-acceptor system were designed, synthesized and utilized in dye-sensitized solar cells (DSSCs), where phenothiazine and carbazole were introduced as double donors, butyl or octyl chain as the linker and cyanoacetic acid or rhodanine acetic acid as the electron acceptor. The design of double donor-π-acceptor system contributes to a distinctive increase of the molar extinction coefficient and benefits light-harvesting capability of these dyes. Due to superior electron injection efficiency, CPC-series dyes with cyanoacetic acid acceptor exhibit broader IPCE spectra and high IPCE responsive value compared with rhodanine-3-acetic acid acceptor, leading to higher JSC. Long alkyl chain favors antiaggregation effect and low charge recombination rate is observed for dyes with octyl chain which display higher VOC than those with butyl chain. Among four dyes, dye with octyl chain and cyanoacetic acid acceptor exhibits the highest short-circuit photocurrent density (9.64 mA cm−2) and open-circuit photovoltage (720 mV), leading to the best overall power conversion efficiency of 4.76%.
    Keywords acetic acid ; chemical reactions ; chemical structure ; dyes ; phenothiazine ; photovoltaic cells ; volatile organic compounds
    Language English
    Size p. .
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2017.09.018
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: The AIEE properties and solid state fluorescence of 3-indolyl-4-indazolyl maleimide compounds: Synthesis and fluorescence characteristics

    Zhu, Bo-ye / Jian-rong Gao / Liang Han / Qing Ye / Yu-Jin Li

    Tetrahedron. 2017 Mar. 23, v. 73

    2017  

    Abstract: A range of 3-indolyl-4-indazolyl maleimide fluorescent compounds, including 2a, 2b, 2c, 3a and 3b, were synthesized efficiently. In different organic dissolvents, the photo-physical performance was checked, either in the aggregated state or in the solid ... ...

    Abstract A range of 3-indolyl-4-indazolyl maleimide fluorescent compounds, including 2a, 2b, 2c, 3a and 3b, were synthesized efficiently. In different organic dissolvents, the photo-physical performance was checked, either in the aggregated state or in the solid state. When being in solid and in solution state, these fluorescent compounds showed high fluorescent intensity, indicating a highest fluorescence quantum efficiency of 45% accompanying a large Stokes Shift longer than 100 nm in toluene. Also, they can carry out a phenomenon of aggregation-induced emission enhancement (AIEE). TDDFT and DFT calculations were used to confirm the experimental findings.
    Keywords chemical reactions ; chemical structure ; fluorescence ; toluene
    Language English
    Dates of publication 2017-0323
    Size p. 1602-1610.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2017.02.003
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  4. Article: Rational design and synthesis of 3-heteroaromatics coumarin molecules with unusual solution and solid dual efficient luminescence

    Zhou, Zi-chun / An-na Zheng / Yan-hong Cui / Zhang-qi Lin / Wen-jie Niu / Yong-jian Zhang / Jian-rong Gao / Yu-jin Li

    Tetrahedron. 2019 May 24, v. 75, no. 21

    2019  

    Abstract: 3-Imidazolyl coumarin molecules were synthesized under solvent-free condition and the optical properties both in solution and the solid state were determined. The compounds showed dual efficient luminescence, which were blue fluorescence with the highest ...

    Abstract 3-Imidazolyl coumarin molecules were synthesized under solvent-free condition and the optical properties both in solution and the solid state were determined. The compounds showed dual efficient luminescence, which were blue fluorescence with the highest fluorescence quantum yield being more than 0.9 and also exhibited favorable yellow solid-state fluorescence. Additionally, by using density functional theory (DFT) and time-dependent DFT (TD-DFT) calculation, all structures were optimized and the associated optical performances showed similar results as the experimental results.
    Keywords chemical reactions ; chemical structure ; coumarin ; density functional theory ; fluorescence ; optical properties
    Language English
    Dates of publication 2019-0524
    Size p. 2958-2964.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2019.04.034
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  5. Article ; Online: Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

    Daniel S. Leventhal / Anna Sokolovska / Ning Li / Christopher Plescia / Starsha A. Kolodziej / Carey W. Gallant / Rudy Christmas / Jian-Rong Gao / Michael J. James / Andres Abin-Fuentes / Munira Momin / Christopher Bergeron / Adam Fisher / Paul F. Miller / Kip A. West / Jose M. Lora

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 15

    Abstract: Synthetic biology can be used to create rationally designed living therapeutics. Here the authors engineer E. coli Nissle to target STING activation in antigen presenting cells for the treatment of solid tumors and demonstrate preclinical activity in ... ...

    Abstract Synthetic biology can be used to create rationally designed living therapeutics. Here the authors engineer E. coli Nissle to target STING activation in antigen presenting cells for the treatment of solid tumors and demonstrate preclinical activity in murine models.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

    Daniel S. Leventhal / Anna Sokolovska / Ning Li / Christopher Plescia / Starsha A. Kolodziej / Carey W. Gallant / Rudy Christmas / Jian-Rong Gao / Michael J. James / Andres Abin-Fuentes / Munira Momin / Christopher Bergeron / Adam Fisher / Paul F. Miller / Kip A. West / Jose M. Lora

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 15

    Abstract: Synthetic biology can be used to create rationally designed living therapeutics. Here the authors engineer E. coli Nissle to target STING activation in antigen presenting cells for the treatment of solid tumors and demonstrate preclinical activity in ... ...

    Abstract Synthetic biology can be used to create rationally designed living therapeutics. Here the authors engineer E. coli Nissle to target STING activation in antigen presenting cells for the treatment of solid tumors and demonstrate preclinical activity in murine models.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: A novel turn off fluorescent sensor for Fe(III) and pH environment based on coumarin derivatives: the fluorescence characteristics and theoretical study

    Hua, Chao-jun / Hao Zheng / Jian-rong Gao / Kan Zhang / Ming Xin / Yu-jin Li

    Tetrahedron. 2016,

    2016  

    Abstract: In this work, a novel coumarin fluorescent sensor for Fe3+ and the pH change in DMSO was successfully prepared, and the spectra properties of the sensor a and especially its activity to metal ions, were also investigated This sensor showed an extreme ... ...

    Abstract In this work, a novel coumarin fluorescent sensor for Fe3+ and the pH change in DMSO was successfully prepared, and the spectra properties of the sensor a and especially its activity to metal ions, were also investigated This sensor showed an extreme selectivity and sensitivity to Fe3+ compared with other competing metal ions through fluorescence quenching in DMSO, which formed a 2:1 complex with Fe3+ and displayed fluorescent quenching. Furthermore, the binding mechanism was studied by the binding stoichiometry and DFT calculation, and the quenching mechanism was also confirmed by Mulliken's charge distribution which was calculated by quantum chemistry.
    Keywords chemical reactions ; chemical structure ; coumarin ; dimethyl sulfoxide ; fluorescence ; iron ; metal ions ; pH ; stoichiometry
    Language English
    Size p. .
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2016.08.023
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  8. Article: Iodine-promoted oxidative coupling reaction: a simple and efficient process to access imidazo[1,2-a]pyridines from 2-aminopyridines and chalcones

    Xing, Meng-Ming / Chao Shen / Jian-Hong Jia / Jian-Rong Gao / Ming Xin / Yu-Jin Li

    Tetrahedron. 2016 July 21, v. 72

    2016  

    Abstract: A unique and efficient approach has been developed for the synthesis of substituted imidazo[1,2-a]pyridines with aminopyridines and chalcones via a one-pot I2-induced aerobic oxidative coupling. The reported reaction proceeded though a tandem Michael ... ...

    Abstract A unique and efficient approach has been developed for the synthesis of substituted imidazo[1,2-a]pyridines with aminopyridines and chalcones via a one-pot I2-induced aerobic oxidative coupling. The reported reaction proceeded though a tandem Michael addition followed by an intramolecular oxidative amination with high regioselectivity, yields and good functional group tolerance.
    Keywords chalcones ; chemical reactions ; chemical structure ; pyridines
    Language English
    Dates of publication 2016-0721
    Size p. 4201-4204.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2016.05.052
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  9. Article: CuSO4-mediated decarboxylative C–N cross-coupling of aromatic carboxylic acids with amides and anilines

    Sheng, Wei-Jian / Jian-Rong Gao / Meng Xu / Qing Ye / Ren-Rong Liu / Wu-Bin Yu / Yi-Xia Jia

    Tetrahedron letters. 2015 Jan. 21, v. 56, no. 4

    2015  

    Abstract: CuSO4-mediated decarboxylative C–N cross-coupling of aromatic carboxylic acid with amide has been developed, leading to N-arylamides in modest to excellent yields. Anilines bearing electron-withdrawing substituents could also couple efficiently with ... ...

    Abstract CuSO4-mediated decarboxylative C–N cross-coupling of aromatic carboxylic acid with amide has been developed, leading to N-arylamides in modest to excellent yields. Anilines bearing electron-withdrawing substituents could also couple efficiently with aromatic carboxylic acids to give diarylamines in good to excellent yields.
    Keywords amides ; carboxylic acids ; chemical structure ; cross-coupling reactions
    Language English
    Dates of publication 2015-0121
    Size p. 599-601.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2014.12.085
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  10. Article: Nickel-catalyzed intramolecular addition of vinyl or aryl bromides to ketoamides

    He, Jun-Qing / Cheng Chen / Jian-Rong Gao / Meng Xu / Ren-Rong Liu / Wu-Bin Yu / Yi-Xia Jia / Yu-Jin Li

    Tetrahedron letters. 2014 Apr. 23, v. 55, no. 17

    2014  

    Abstract: A nickel-catalyzed intramolecular addition of vinyl or aryl bromides to ketoamides has been developed. The reactions proceeded efficiently with Ni(bpy)Br2 as a catalyst and zinc powder as reducing agent, affording 3-hydroxypyrrolidinones, 3- ... ...

    Abstract A nickel-catalyzed intramolecular addition of vinyl or aryl bromides to ketoamides has been developed. The reactions proceeded efficiently with Ni(bpy)Br2 as a catalyst and zinc powder as reducing agent, affording 3-hydroxypyrrolidinones, 3-hydroxyoxindoles, and dihydroquinolinones as important heterocyclic compounds in good to excellent yields.
    Keywords catalysts ; chemical reactions ; chemical structure ; heterocyclic compounds ; nickel ; organobromine compounds ; reducing agents ; zinc
    Language English
    Dates of publication 2014-0423
    Size p. 2805-2808.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2014.03.069
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