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Article ; Online: Construction and Application of Polygenic Risk Scores in Autoimmune Diseases.

Khunsriraksakul, Chachrit / Markus, Havell / Olsen, Nancy J / Carrel, Laura / Jiang, Bibo / Liu, Dajiang J

2022 Volume 13, Page(s) 889296

Abstract: Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with autoimmune diseases and provided unique mechanistic insights and informed novel treatments. These individual genetic variants on their own typically ... ...

Abstract	Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with autoimmune diseases and provided unique mechanistic insights and informed novel treatments. These individual genetic variants on their own typically confer a small effect of disease risk with limited predictive power; however, when aggregated (e.g.,
MeSH term(s)	Autoimmune Diseases/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study/methods ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/genetics ; Risk Factors
Language	English
Publishing date	2022-06-27
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.889296
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Article ; Online: Association between maternal erythrocyte PUFAs during pregnancy and neurodevelopment in children at 2 years of age: a birth cohort study.

Liu, Nan / He, Yannan / Zhao, Feng / Li, Xiaoxu / Chen, Yujing / Jiang, Bibo / Wei, Min / Li, Duo / Cai, Li

Food & function

2023 Volume 14, Issue 17, Page(s) 7938–7945

Abstract: ... ...

Abstract	Background
MeSH term(s)	Pregnancy ; Female ; Humans ; Cohort Studies ; Fatty Acids, Unsaturated ; Eicosapentaenoic Acid
Chemical Substances	Fatty Acids, Unsaturated ; Eicosapentaenoic Acid (AAN7QOV9EA)
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo01853a
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Article ; Online: The effects of organic food on human health: a systematic review and meta-analysis of population-based studies.

Jiang, Bibo / Pang, Jinzhu / Li, Junan / Mi, Lijuan / Ru, Dongmei / Feng, Jingxi / Li, Xiaoxu / Zhao, Ai / Cai, Li

Nutrition reviews

2023

Abstract: Context: Although the nutritional composition of organic food has been thoroughly researched, there is a dearth of published data relating to its impact on human health.: Objective: This systematic review aimed to examine the association between ... ...

Abstract	Context: Although the nutritional composition of organic food has been thoroughly researched, there is a dearth of published data relating to its impact on human health. Objective: This systematic review aimed to examine the association between organic food intake and health effects, including changes in in vivo biomarkers, disease prevalence, and functional changes. Data sources: PubMed, EMBASE, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched from inception through Nov 13, 2022. Data extraction: Both observational and interventional studies conducted in human populations were included, and association between level of organic food intake and each outcome was quantified as "no association," "inconsistent," "beneficial correlation/harmful correlation," or "insufficient". For outcomes with sufficient data reported by at least 3 studies, meta-analyses were conducted, using random-effects models to calculate standardized mean differences. Data analysis: Based on the included 23 observational and 27 interventional studies, the association between levels of organic food intake and (i) pesticide exposure biomarker was assessed as "beneficial correlation," (ii) toxic metals and carotenoids in the plasma was assessed as "no association," (iii) fatty acids in human milk was assessed as "insufficient," (iv) phenolics was assessed as "beneficial", and serum parameters and antioxidant status was assessed as "inconsistent". For diseases and functional changes, there was an overall "beneficial" association with organic food intake, and there were similar findings for obesity and body mass index. However, evidence for association of organic food intake with other single diseases was assessed as "insufficient" due to the limited number and extent of studies. Conclusion: Organic food intake was found to have a beneficial impact in terms of reducing pesticide exposure, and the general effect on disease and functional changes (body mass index, male sperm quality) was appreciable. More long-term studies are required, especially for single diseases. Systematic review registration: PROSPERO registration no. CRD42022350175.
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	82067-2
ISSN	1753-4887 ; 0029-6643
ISSN (online)	1753-4887
ISSN	0029-6643
DOI	10.1093/nutrit/nuad124
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Article ; Online: The Associations of Prenatal Exposure to Fine Particulate Matter and Its Chemical Components with Allergic Rhinitis in Children and the Modification Effect of Polyunsaturated Fatty Acids: A Birth Cohort Study.

Chen, Yujing / Guo, Cuihua / Chung, Ming Kei / Yi, Quanying / Wang, Xin / Wang, Yuxuan / Jiang, Bibo / Liu, Yu / Lan, Minyan / Lin, Lizi / Cai, Li

Environmental health perspectives

2024 Volume 132, Issue 4, Page(s) 47010

Abstract: Background: Polyunsaturated fatty acids (PUFAs) have been shown to protect against fine particulate matter : Objectives: We aimed to investigate the association of prenatal exposure to : Methods: This prospective birth cohort study involved 657 ... ...

Abstract	Background: Polyunsaturated fatty acids (PUFAs) have been shown to protect against fine particulate matter Objectives: We aimed to investigate the association of prenatal exposure to Methods: This prospective birth cohort study involved 657 mother-child pairs from Guangzhou, China. Prenatal exposure to residential Results: Approximately Conclusion: Prenatal exposure to
MeSH term(s)	Humans ; Female ; Child, Preschool ; Pregnancy ; Particulate Matter/analysis ; Cohort Studies ; Air Pollutants/analysis ; Prenatal Exposure Delayed Effects/chemically induced ; Prospective Studies ; Fatty Acids, Unsaturated/analysis ; Rhinitis, Allergic/chemically induced ; China ; Air Pollution/analysis ; Environmental Exposure/analysis
Chemical Substances	Particulate Matter ; Air Pollutants ; Fatty Acids, Unsaturated
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP13524
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Article ; Online: Infant Formulas With Partially or Extensively Hydrolyzed Milk Proteins for the Prevention of Allergic Diseases: A Systematic Review and Meta-Analysis of Clinical Trials.

Li, Xiaoxu / He, Tingchao / Duan, Sufang / Liang, Jinghong / Feng, Gang / Li, Fang / Shen, Zhenyu / Ye, Wenhui / Liu, Biao / Jiang, Bibo / Chen, Yujing / Liu, Nan / Szeto, Ignatius Man-Yau / Cai, Li

Advances in nutrition (Bethesda, Md.)

2024 Volume 15, Issue 5, Page(s) 100217

Abstract: Despite the widely recommended usage of partially hydrolyzed formula (PHF) or extensively hydrolyzed formula (EHF) of milk protein for preventing allergic diseases (ADs), clinical studies have been inconclusive regarding their efficacy compared with that ...

Abstract	Despite the widely recommended usage of partially hydrolyzed formula (PHF) or extensively hydrolyzed formula (EHF) of milk protein for preventing allergic diseases (ADs), clinical studies have been inconclusive regarding their efficacy compared with that of cow's milk formula (CMF) or breast milk (BM). We aimed to systematically evaluate the effects of PHF or EHF compared with those of CMF or BM on risk of ADs (cow's milk allergy, allergic rhinitis, eczema, asthma, wheeze, food allergy, and sensitization) in children. We searched PubMed, Embase, Cochrane Library, and Web of Science for clinical trials published from inception to 21 October, 2022. We used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to grade the strength of evidence. Overall, 24 trials (10,950 infants) were included, 17 of which specifically included high-risk infants. GRADE was low for the evidence that, compared with CMF, infants early fed with EHF had lower risk of cow's milk allergy at age 0-2 y [relative risk (RR): 0.62; 95% CI: 0.39, 0.99]. Moderate evidence supported that PHF and EHF reduced risk of eczema in children aged younger or older than 2 y, respectively (RR: 0.71; 95% CI: 0.52, 0.96; and RR: 0.79; 95% CI: 0.67, 0.94, respectively). We also identified moderate systematic evidence indicating that PHF reduced risk of wheeze at age 0-2 y compared with CMF (RR: 0.50; 95% CI: 0.29, 0.85), but PHF and EHF increased the risk compared with BM (RR: 1.61; 95% CI: 1.11, 2.31; and RR: 1.64; 95% CI: 1.26, 2.14). Neither PHF nor EHF had significant effects on other ADs in children of any age. In conclusion, compared with CMF, PHF, or EHF had different preventive effect on cow's milk allergy, eczema, and wheeze. Compared with BM, both PHF and EHF may increase risk of wheeze but not other ADs. Given that most trials included only high-risk infants, more research on non-high-risk infants is warranted before any generalization is attempted. This protocol was registered at PROSPERO as CRD42022320787.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2583634-1
ISSN	2156-5376 ; 2156-5376
ISSN (online)	2156-5376
ISSN	2156-5376
DOI	10.1016/j.advnut.2024.100217
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Article: Synthesis and Impurity Research of 2-Thioadenosine Monohydrate

Xiang, Jing-Jing / Jiang, Bi-Bo / Sun, Wen-Qing / Zhang, Fu-Li / Yu, Jun

Pharmaceutical Fronts

2023 Volume 05, Issue 02, Page(s) e84–e90

Abstract: 2-Thioadenosine monohydrate (: 1: is a vital intermediate in the synthesis of cangrelor. However, its industrial-scale preparation process and the analysis of the impurities formed during this process remained largely unknown. Herein, cangrelor was ... ...

Abstract	2-Thioadenosine monohydrate ( 1: is a vital intermediate in the synthesis of cangrelor. However, its industrial-scale preparation process and the analysis of the impurities formed during this process remained largely unknown. Herein, cangrelor was synthesized from oxidate adenosine, and the key step involved in the synthesis of compound 1: from intermediate 5: The effects of key synthesis parameters that influenced the reaction, including reaction temperature and time, were discussed. Moreover, four process-related impurities were purified, synthesized, and identified via nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The process can be utilized to produce 1: on a kilogram scale, with a high-performance liquid chromatography purity of 98.0%. The study sheds light on and helps drug manufacturers further understand the formation process of impurities in the preparation of cangrelor.
Keywords	cangrelor ; 2-thioadenosine monohydrate ; a kilogram scale ; impurities
Language	English
Publishing date	2023-05-24
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2628-5096 ; 2628-5088
ISSN (online)	2628-5096
ISSN	2628-5088
DOI	10.1055/s-0043-1768692
Database	Thieme publisher's database

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Article: Testing for Stationarity at High Frequency

Jiang, Bibo / Lu, Ye / Park, Joon Y

Journal of econometrics. 2019 Sept. 25,

2019

Abstract: The high frequency behavior of the KPSS test, which is most commonly used to test for stationarity, is analyzed in a continuous time framework. Our asymptotics show that the test has no discriminatory power at high frequency: It either always rejects ... ...

Abstract	The high frequency behavior of the KPSS test, which is most commonly used to test for stationarity, is analyzed in a continuous time framework. Our asymptotics show that the test has no discriminatory power at high frequency: It either always rejects stationarity or has no nontrivial power at high frequency. The test becomes valid at high frequency only when the bandwidth of its long-run variance estimate is chosen suitably in our framework. We also analyze the residual-based KPSS test for cointegration.
Keywords	econometric models ; economic analysis ; economic theory ; variance
Language	English
Dates of publication	2019-0925
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	1460617-3
ISSN	0304-4076
ISSN	0304-4076
DOI	10.1016/j.jeconom.2019.09.004
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Association Between Subjective Cognitive Decline and Social and Emotional Support in US Adults.

Weng, Xingran / George, Daniel R / Jiang, Bibo / Wang, Li

American journal of Alzheimer's disease and other dementias

2020 Volume 35, Page(s) 1533317520922392

Abstract: Subjective cognitive decline (SCD) has been linked to Alzheimer's Disease in the literature. However, little is known about whether SCD is associated with social/emotional support (SES). To investigate this association, this study utilized the 2015 and ... ...

Abstract	Subjective cognitive decline (SCD) has been linked to Alzheimer's Disease in the literature. However, little is known about whether SCD is associated with social/emotional support (SES). To investigate this association, this study utilized the 2015 and 2016 Behavioral Risk Factor Surveillance System data. A study population of 17206 participants aged 45 years and older who responded to both the Emotional Support and Life Satisfaction survey module and the Cognition Decline survey module were included. Of this study population, 11.22% had SCD, and 21.83% reported insufficient SES. A much higher percentage of those with insufficient SES experienced SCD compared to those with sufficient SES (21.15% vs 8.45%,
MeSH term(s)	Aged ; Alzheimer Disease/epidemiology ; Alzheimer Disease/psychology ; Behavioral Risk Factor Surveillance System ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/psychology ; Emotions ; Female ; Humans ; Male ; Marital Status ; Middle Aged ; Social Interaction ; Surveys and Questionnaires ; White People
Language	English
Publishing date	2020-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1283069-0
ISSN	1938-2731 ; 0895-5336 ; 1082-5207 ; 1533-3175
ISSN (online)	1938-2731
ISSN	0895-5336 ; 1082-5207 ; 1533-3175
DOI	10.1177/1533317520922392
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Article ; Online: Seqminer2: an efficient tool to query and retrieve genotypes for statistical genetics analyses from biobank scale sequence dataset.

Yang, Lina / Jiang, Shuang / Jiang, Bibo / Liu, Dajiang J / Zhan, Xiaowei

Bioinformatics (Oxford, England)

2021 Volume 36, Issue 19, Page(s) 4951–4954

Abstract: Summary: Here, we present a highly efficient R-package seqminer2 for querying and retrieving sequence variants from biobank scale datasets of millions of individuals and hundreds of millions of genetic variants. Seqminer2 implements a novel variant- ... ...

Abstract	Summary: Here, we present a highly efficient R-package seqminer2 for querying and retrieving sequence variants from biobank scale datasets of millions of individuals and hundreds of millions of genetic variants. Seqminer2 implements a novel variant-based index for querying VCF/BCF files. It improves the speed of query and retrieval by several magnitudes compared to the state-of-the-art tools based upon tabix. It also reimplements support for BGEN and PLINK format, which improves speed over alternative implementations. The improved efficiency and comprehensive support for popular file formats will facilitate method development, software prototyping and data analysis of biobank scale sequence datasets in R. Availability and implementation: The seqminer2 R package is available from https://github.com/zhanxw/seqminer. Scripts used for the benchmarks are available in https://github.com/yang-lina/seqminer/blob/master/seqminer2%20benchmark%20script.txt. Supplementary information: Supplementary data are available at Bioinformatics online.
MeSH term(s)	Biological Specimen Banks ; Genotype ; Humans ; Software
Language	English
Publishing date	2021-07-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btaa628
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Article ; Online: Association between maternal gestational diabetes and allergic diseases in offspring: a birth cohort study.

Chen, Yu-Jing / Lin, Li-Zi / Liu, Zhao-Yan / Wang, Xin / Karatela, Shamshad / Wang, Yu-Xuan / Peng, Shan-Shan / Jiang, Bi-Bo / Li, Xiao-Xu / Liu, Nan / Jing, Jin / Cai, Li

World journal of pediatrics : WJP

2023 Volume 19, Issue 10, Page(s) 972–982

Abstract: Background: Previous studies have linked gestational diabetes (GDM) with allergies in offspring. However, the effect of specific glucose metabolism metrics was not well characterized, and the role of polyunsaturated fatty acids (PUFAs), a modifier of ... ...

Abstract	Background: Previous studies have linked gestational diabetes (GDM) with allergies in offspring. However, the effect of specific glucose metabolism metrics was not well characterized, and the role of polyunsaturated fatty acids (PUFAs), a modifier of metabolism and the immune system, was understudied. We aimed to investigate the association between maternal GDM and allergic diseases in children and the interaction between glucose metabolism and PUFAs on allergic outcomes. Methods: This prospective cohort study included 706 mother-child dyads from Guangzhou, China. Maternal GDM was diagnosed via a 75-g oral glucose tolerance test (OGTT), and dietary PUFAs were assessed using a validated food frequency questionnaire. Allergic disease diagnoses and the age of onset were obtained from medical records of children within three years old. Results: Approximately 19.4% of women had GDM, and 51.3% of children had any allergic diseases. GDM was positively associated with any allergic diseases (hazard ratio [HR] 1.40; 95% confidence interval (CI) 1.05-1.88) and eczema (HR 1.44; 95% CI 1.02-1.97). A unit increase in OGTT after two hours (OGTT-2 h) glucose was associated with an 11% (95% CI 2%-21%) higher risk of any allergic diseases and a 17% (95% CI 1-36%) higher risk of food allergy. The positive associations between OGTT-2 h glucose and any allergic diseases were strengthened with decreased dietary a-linolenic acid (ALA) and increased n-6 PUFAs, linoleic acid (LA), LA/ALA ratio, and n-6/n-3 PUFA ratio. Conclusions: Maternal GDM was adversely associated with early-life allergic diseases, especially eczema. We were the first to identify OGTT-2 h glucose to be more sensitive in inducing allergy risk and that dietary PUFAs might modify the associations.
MeSH term(s)	Pregnancy ; Female ; Humans ; Child, Preschool ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/epidemiology ; Cohort Studies ; Prospective Studies ; Hypersensitivity/epidemiology ; Eczema ; Glucose
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-023-00710-0
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