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  1. AU="Jiang, Cui"
  2. AU="Suresh, Vinod"
  3. AU="Monferrer, Dominique"
  4. AU="John Tam"
  5. AU="Yi, Rong"
  6. AU="Bhandary, R P"
  7. AU="Merkebu, Jerusalem"
  8. AU="Han, Junhyek"
  9. AU="Muneoka, Yusuke"
  10. AU="Griggs, Lisa"
  11. AU="Klauck, Sabine M"
  12. AU="Turton, James A"
  13. AU="Patel, Abhijit A"
  14. AU="Shankowsky, Heather A"
  15. AU="Płóciennik, Przemysław"
  16. AU="Marchesi, Pietro"
  17. AU="Kim Je Hyoung"
  18. AU="Huber, Ingrid"
  19. AU="Hasuko, K."
  20. AU="Yao, Weigen"
  21. AU="Huang, Xiao-Fan"
  22. AU=Zuo Chuantian
  23. AU="Varchetta, Veronica"
  24. AU="Zhang, Lingye"
  25. AU="Venko, Katja"
  26. AU="Kasthuri, Thirupathi"
  27. AU="Pirtskhalava, Tamar"
  28. AU="Saridakis, E N"
  29. AU="Vithana, Eranga N"
  30. AU="Suárez-Lledó, M"
  31. AU="Olivo-Marston, Susan"
  32. AU="Denise P Momesso"
  33. AU="Obrecht-Sturm, Denise"

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  1. Artikel: Influence of initial check, information exchange, final accuracy check, reaction information nursing on the psychology of elderly with lung cancer.

    Jiang, Cui / Ma, Jing / He, Wen / Zhang, Hai-Ying

    World journal of clinical cases

    2024  Band 12, Heft 4, Seite(n) 737–745

    Abstract: Background: As one of the fatal diseases with high incidence, lung cancer has seriously endangered public health and safety. Elderly patients usually have poor self-care and are more likely to show a series of psychological problems.: Aim: To ... ...

    Abstract Background: As one of the fatal diseases with high incidence, lung cancer has seriously endangered public health and safety. Elderly patients usually have poor self-care and are more likely to show a series of psychological problems.
    Aim: To investigate the effectiveness of the initial check, information exchange, final accuracy check, reaction (IIFAR) information care model on the mental health status of elderly patients with lung cancer.
    Methods: This study is a single-centre study. We randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January 2022. These elderly patients with lung cancer were randomly divided into two groups, with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care protocol. The differences in psychological distress, anxiety and depression, life quality, fatigue, and the locus of control in psychology were compared between these two groups, and the causes of psychological distress were analyzed.
    Results: After the intervention, Distress Thermometer, Hospital Anxiety and Depression Scale (HADS) for anxiety and the HADS for depression, Revised Piper's Fatigue Scale, and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group (
    Conclusion: The IIFAR information care model can help elderly patients with lung cancer by reducing their anxiety and depression, psychological distress, and fatigue, improving their tendencies on the locus of control in psychology, and enhancing their life qualities.
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v12.i4.737
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  2. Artikel: Predictive and Prognostic Role of Peripheral Blood T-Cell Subsets in Triple-Negative Breast Cancer.

    Li, Meng / Xu, Junnan / Jiang, Cui / Zhang, Jingyan / Sun, Tao

    Frontiers in oncology

    2022  Band 12, Seite(n) 842705

    Abstract: Background: Triple-negative breast cancer (TNBC), as a highly aggressive and metastatic tumor, can still not contain the medical needs. It has become an urgent problem to develop prognostic markers further and realize precision medicine. The predictive ... ...

    Abstract Background: Triple-negative breast cancer (TNBC), as a highly aggressive and metastatic tumor, can still not contain the medical needs. It has become an urgent problem to develop prognostic markers further and realize precision medicine. The predictive and prognostic significance of peripheral blood lymphocytes, as well as the clinicopathological factors affecting them, were explored in the present study.
    Methods: The clinicopathological data of 278 patients with TNBC were collected and analyzed retrospectively. Peripheral blood lymphocytes (pBL) and blood routine indexes before treatment were quantified by flow cytometry analysis. Progression-free survival (PFS) and overall survival (OS) were analyzed by the Kaplan-Meier curve and Cox hazard proportion regression model. The associations between hematologic parameters and treatment response and clinicopathological characteristics were estimated by the Mann-Whitney test and Spearman test.
    Results: Compared with all blood routine indexes, only a significant correlation between better treatment efficacy and higher peripheral CD4 +/CD8 + ratio of TNBC patients was observed (P=0.059), particularly those treated with chemotherapy combined with immune checkpoint inhibitors (P=0.048). Among the pBL subsets, CD4 + T lymphocyte was the only independent factor that could predict the prognosis of metastatic TNBC. Patients presenting higher values of peripheral CD4 + T lymphocytes showed longer PFS (median PFS 9 months vs. 5 months; HR =0.65, 95%CI: 0.440-0.973, P = 0.032) and OS (median OS 31 months vs. 16 months; HR=0 .63, 95%CI: 0.417-0.940, P< 0.01). Especially CD4+ was found predictive for prognosis in TNBC patients who received chemotherapy (P<0.05). Finally, the older age, higher clinical stage, and more advanced treatment lines were related to the lower level of CD4 +. The older age and having received neoadjuvant therapy were related to the lower CD4 +/CD8 + ratio (P<0.05).
    Conclusion: The baseline CD4+/CD8+ cell ratio in peripheral blood is associated with therapeutic response, especially for chemotherapy combined with immunotherapy. Peripheral CD4+ cells can steadily predict all clinical outcomes for patients with mTNBC, and this clinical prognosis prediction is significantly related to chemotherapy. Peripheral CD4+ and CD4+/CD8+ are both closely associated with clinicopathological parameters.
    Sprache Englisch
    Erscheinungsdatum 2022-02-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.842705
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Molecular targeted therapy and immunotherapy in advanced hepatocellular carcinoma

    Yun-Long Zhang / Xin-Jiang Cui / Hui Xing / Hou-Fa Ning / Peng Dong / Guang-Zhi Wang

    Annals of Medicine, Vol 55, Iss

    a systematic review and Bayesian network meta-analysis based on randomized controlled trials

    2023  Band 2

    Abstract: AbstractObjective The aim of this study was to compare and rank different targeted therapies or immunotherapies for advanced hepatocellular carcinoma based on efficacy.Methods A systematic search of the PubMed, EMBASE, and Cochrane Library databases was ... ...

    Abstract AbstractObjective The aim of this study was to compare and rank different targeted therapies or immunotherapies for advanced hepatocellular carcinoma based on efficacy.Methods A systematic search of the PubMed, EMBASE, and Cochrane Library databases was conducted. All systematic treatment regimens that reported comparisons with sorafenib were included in this analysis. The primary outcome measures were overall survival (OS) and progression-free survival (PFS), and other outcome measures included the objective response rate (ORR) and safety analysis according to reported treatment-related adverse events.Results A total of 29 RCTs involving 13376 patients were included in the analysis, including 10 single-agent therapies and 17 combination therapies. Compared with sorafenib, sintilimab plus IBI305 (HR: 0.57, 95% CI: 0.43-0.75), camrelizumab plus rivoceranib (HR: 0.62, 95% CI: 0.49-0.78), and atezolizumab plus bevacizumab (HR: 0.66, 95% CI: 0.52-0.83) ranked in the top three in terms of OS.Conclusions PD-1/PD-L1 inhibitors combined with anti-vascular endothelial growth factor (anti-VEGF)-targeting drugs have shown better therapeutic effects in the systematic treatment of patients with advanced hepatocellular carcinoma, and the combination of targeted and immune therapy modes should be further developed.
    Schlagwörter Molecular targeted therapy ; immunotherapy ; hepatocellular carcinoma ; meta-analysis ; Bayesian ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Taylor & Francis Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Chinese herbal medicine for immune infertility: A protocol for systematic review and meta-analysis.

    Jiang, Cui / Wang, Zhaodi / Yuan, Shiqing / Jiang, Yong / Ye, Ying

    Medicine

    2021  Band 100, Heft 5, Seite(n) e24248

    Abstract: Background: Infertility is a reproductive disorder caused by multiple causes and is an adverse event of reproductive health for couples in the reproductive period. Women who do not avoid sex for at least 12 months and are not pregnant are said to be ... ...

    Abstract Background: Infertility is a reproductive disorder caused by multiple causes and is an adverse event of reproductive health for couples in the reproductive period. Women who do not avoid sex for at least 12 months and are not pregnant are said to be infertile. 10% to 20% of infertility is caused by immune factors. At present, there is no unified diagnostic standard for immunological infertility. Clinically, it is considered that abnormal ovulation and reproductive system function of women are excluded, and no obvious pathogenic factors occur; routine examination of male semen is normal, but there is evidence of anti-reproductive immunity, thus causing infertility is immunological infertility. Traditional Chinese medicine (TCM) has a long history of treating infertility and has remarkable curative effect. It plays an important role in the treatment of gynecological and obstetrical diseases in China. The purpose of this study is to evaluate the efficacy and safety of traditional Chinese medicine for the treatment of immune infertility.
    Method: we searched the literature from following databases: Cochrane Library, PubMed, China Biomedical Literature Database (CB), EMBASE, Chinese Journal of Science and Technology (VIP), China National Knowledge Infrastructure Database (CNKI) and Wanfang Database were searched. All the databases mentioned above will be searched from the start date to the latest version. A manual search of all references to the included trials, published randomized controlled trials (RCTs) whether blind or unblind, any languages and length of follow up were included. Treatments included Chinese medicinal herbs (single or compound). Controlls were placebo and western medicine, or no intervention. Key outcomes will include pregnancy rates, the efficiency of Chinese herbal medicine (at least one negative antibody for infertility), birth rates (the ratio of the number of pregnant women giving birth to their babies normally after herbal treatment to the total number of patients treated), recurrence rate and safety index. Two evaluators independently retrieved and extracted data and import it into Endnote X8. Then they conduct methodological evaluation on the quality of the included studies, and meta-analysis was conducted with RevMan 5.3 and Stata 13.0 software. We will use the Cochrane risk analysis tool to assess the risk of bias. Differences will be resolved by consensus or through the participation of third parties. All analysis will be performed based on the Cochrane Handbook for Systematic Reviews of Interventions.
    Results: The purpose of this study is to evaluate the efficacy and safety of traditional Chinese herb medicine in the treatment of immune infertility.
    Conclusion: This meta-analysis can provide evidence for clinicians to help patients make better choices.
    Trial registration number: INPLASY2020120073.
    Mesh-Begriff(e) Drug Monitoring/methods ; Drugs, Chinese Herbal/pharmacology ; Female ; Humans ; Infertility, Female/immunology ; Infertility, Female/therapy ; Meta-Analysis as Topic ; Monitoring, Immunologic/methods ; Pregnancy ; Pregnancy Rate ; Research Design ; Systematic Reviews as Topic ; Treatment Outcome
    Chemische Substanzen Drugs, Chinese Herbal
    Sprache Englisch
    Erscheinungsdatum 2021-02-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000024248
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Sonneradon A Extends Lifespan of

    Jiang, Shu / Jiang, Cui-Ping / Cao, Pei / Liu, Yong-Hong / Gao, Cheng-Hai / Yi, Xiang-Xi

    Marine drugs

    2022  Band 20, Heft 1

    Abstract: Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of ... ...

    Abstract Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of mangrove
    Mesh-Begriff(e) Aging/drug effects ; Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Aquatic Organisms ; Caenorhabditis elegans/metabolism ; Fruit ; Geroscience ; Lythraceae ; Mitochondria/metabolism ; Models, Animal ; Signal Transduction/drug effects ; Somatomedins/metabolism
    Chemische Substanzen Antioxidants ; Somatomedins
    Sprache Englisch
    Erscheinungsdatum 2022-01-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20010059
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Corrigendum to "Shaoyao decoction restores the mucus layer in mice with DSS-induced colitis by regulating Notch signaling pathway" [J. Ethnopharmacol. 308 (2023) 116258].

    Fang, Yu-Xi / Liu, You-Qian / Hu, Yi-Min / Yang, Yuan-Yuan / Zhang, Dong-Jian / Jiang, Cui-Hua / Wang, Jian-Hua / Zhang, Jian

    Journal of ethnopharmacology

    2023  Band 316, Seite(n) 116726

    Sprache Englisch
    Erscheinungsdatum 2023-06-13
    Erscheinungsland Ireland
    Dokumenttyp Published Erratum
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116726
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  7. Artikel ; Online: Shaoyao decoction restores the mucus layer in mice with DSS-induced colitis by regulating Notch signaling pathway.

    Fang, Yu-Xi / Liu, You-Qian / Hu, Yi-Min / Yang, Yuan-Yuan / Zhang, Dong-Jian / Jiang, Cui-Hua / Wang, Jian-Hua / Zhang, Jian

    Journal of ethnopharmacology

    2023  Band 308, Seite(n) 116258

    Abstract: Ethnopharmacological relevance: Restoring the mucus layer is a potential strategy for treating ulcerative colitis (UC). Previous studies reported that a Chinese medicine formula Shaoyao Decoction (SYD) effectively improved UC. However, the role and ... ...

    Abstract Ethnopharmacological relevance: Restoring the mucus layer is a potential strategy for treating ulcerative colitis (UC). Previous studies reported that a Chinese medicine formula Shaoyao Decoction (SYD) effectively improved UC. However, the role and mechanism of SYD in restoring the mucus layer are still vague.
    Aim of the study: This study aimed to research the therapeutical effects and unravel the involved mechanism of SYD on DSS-evoked UC.
    Materials and methods: First, the constituents of SYD were detected by UPLC-QTOF-MS/MS. Then, the DSS-induced UC model was introduced to investigate the pharmacologic action and molecular mechanism of SYD on UC. Pharmacodynamic indicators were assessed including body weight, colon length, ulcerations, disease activity index (DAI), inflammatory cytokines and histological parameters. To investigate the integrality and functions of the mucous layer, AB-PAS stain and UEA-1 stain were used to evaluate the completeness of mucous layer, as well as the maturation of goblet cells (GCs). The bacterial invasion was detected by fluorescence in situ hybridization. As to mechanism exploration, the expressions of Notch/Hes1 pathway were investigated by using agonists in lipopolysaccharides (LPS) -stimulated LS174T cell.
    Results: After modeling in mice, SYD remarkedly ameliorated the symptoms of mouse colitis, the expression of pro-inflammatory factors declined, and increased IL-10 expression was observed in SYD-treated mice. Besides, SYD repaired the structure of the mucus layer and prevented bacterial invasion. Mechanism investigation discovered that SYD promoted GCs differentiation by inhibiting the Notch pathway, which was consistent with the results in LPS-challenged LS174 cell.
    Conclusions: These findings demonstrated that SYD could restore the mucus layer to prevent UC via suppressing the Notch signaling pathway, which provided evidences for the UC treatment of SYD in the clinic.
    Mesh-Begriff(e) Animals ; Mice ; Tandem Mass Spectrometry ; Lipopolysaccharides/pharmacology ; In Situ Hybridization, Fluorescence ; Drugs, Chinese Herbal/pharmacology ; Colitis/drug therapy ; Colitis, Ulcerative/drug therapy ; Colon ; Signal Transduction ; Mucus/metabolism ; Dextran Sulfate ; Mice, Inbred C57BL ; Disease Models, Animal
    Chemische Substanzen Lipopolysaccharides ; Drugs, Chinese Herbal ; Dextran Sulfate (9042-14-2)
    Sprache Englisch
    Erscheinungsdatum 2023-02-17
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116258
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Sonneradon A Extends Lifespan of Caenorhabditis elegans by Modulating Mitochondrial and IIS Signaling Pathways

    Jiang, Shu / Jiang, Cui-Ping / Cao, Pei / Liu, Yong-Hong / Gao, Cheng-Hai / Yi, Xiang-Xi

    Marine drugs. 2022 Jan. 08, v. 20, no. 1

    2022  

    Abstract: Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of mangrove Sonneratia apetala, showed remarkable antiaging ... ...

    Abstract Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of mangrove Sonneratia apetala, showed remarkable antiaging activity. However, the role of SDA in antiaging remains unclear. In this article, we studied the function of SDA in antiaging by using the animal model Caenorhabditis elegans. Results showed that SDA inhibited production of reactive oxygen species (ROS) by 53%, and reduced the accumulation of aging markers such as lipids and lipofuscins. Moreover, SDA also enhanced the innate immune response to Pseudomonas aeruginosa infection. Genetic analysis of a series of mutants showed that SDA extended the lifespan of the mutants of eat-2 and glp-1. Together, this effect may be related to the enhanced resistance to oxidative stress via mitochondrial and insulin/insulin-like growth factor-1 signaling (IIS) pathways. The results of this study provided new evidence for an antiaging effect of SDA in C. elegans, as well as insights into the implication of antiaging activity of SDA in higher organisms.
    Schlagwörter Caenorhabditis elegans ; Pseudomonas aeruginosa ; Sonneratia apetala ; animal models ; anti-aging properties ; genetic analysis ; glucagon-like peptide 1 ; innate immunity ; longevity ; mitochondria ; oxidative stress ; reactive oxygen species ; risk
    Sprache Englisch
    Erscheinungsverlauf 2022-0108
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20010059
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Flavonoid extracts of Citrus aurantium L. var. amara Engl. Promote browning of white adipose tissue in high-fat diet-induced mice.

    Lin, Song-Xia / Yang, Chun / Jiang, Ru-Shan / Wu, Chao / Lang, Deng-Qin / Wang, Ya-Li / Li, Xiao-Yi / Jiang, Cui-Ping / Liu, Qiang / Shen, Chun-Yan

    Journal of ethnopharmacology

    2024  Band 324, Seite(n) 117749

    Abstract: Ethnopharmacological relevance: Obesity has become a public burden worldwide due to its booming incidence and various complications, and browning of white adipose tissue (WAT) is recognized as a hopeful strategy to combat it. Blossom of Citrus aurantium ...

    Abstract Ethnopharmacological relevance: Obesity has become a public burden worldwide due to its booming incidence and various complications, and browning of white adipose tissue (WAT) is recognized as a hopeful strategy to combat it. Blossom of Citrus aurantium L. var. amara Engl. (CAVA) is a popular folk medicine and dietary supplement used for relieving dyspepsia, which is recorded in the Chinese Materia Medica. Our previous study showed that blossom of CAVA had anti-obesity potential, while its role in browning of WAT was still unclear.
    Aim of the study: This study aimed to characterize the constituents in flavonoids from blossom of CAVA (CAVAF) and to clarify the anti-obesity capacities especially the effects on browning of WAT.
    Materials and methods: Gradient ethanol eluents from blossom of CAVA were obtained by AB-8 macroporous resin. 3T3-L1 cells and pancreatic lipase inhibition assay were employed to investigate the potential anti-obesity effects in vitro. HPLC and UPLC/MS assays were performed to characterize the chemical profiles of different eluents. Network pharmacology and molecular docking assays were used to reveal potential anti-obesity targets. Furthermore, high-fat diet (HFD)-induced mice were constructed to explore the anti-obesity actions and mechanisms in vivo.
    Results: 30% ethanol eluents with high flavonoid content and great inhibition on proliferation of 3T3-L1 preadipocytes and pancreatic lipase activity were regarded as CAVAF. 19 compounds were identified in CAVAF. Network pharmacology analysis demonstrated that AMPK and PPARα were potential targets for CAVAF in alleviating obesity. Animal studies demonstrated that CAVAF intervention significantly decreased the body weight, WAT weight, serum TG, TC and LDL-C levels in HFD-fed obese mice. HFD-induced insulin resistance and morphological changes in WAT and brown adipose tissue were also markedly attenuated by CAVAF treatment. CAVAF supplementation potently inhibited iWAT inflammation by regulating IL-6, IL-1β, TNF-α and IL-10 mRNA expression in iWAT of mice. Furthermore, the gene expression levels of thermogenic markers including Cyto C, ATP synthesis, Cidea, Cox8b and especially UCP1 in iWAT of mice were significantly up-regulated by CAVAF administration. CAVAF intervention also markedly increased the expression levels of PRDM16, PGC-1α, SIRT1, AMPK-α1, PPARα and PPARγ mRNA in iWAT of mice.
    Conclusion: CAVAF treatment significantly promoted browning of WAT in HFD-fed mice. These results suggested that flavonoid extracts from blossom of CAVA were probably promising candidates for the treatment of obesity.
    Mesh-Begriff(e) Mice ; Animals ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Diet, High-Fat/adverse effects ; AMP-Activated Protein Kinases/metabolism ; Molecular Docking Simulation ; PPAR alpha ; Adipose Tissue, White ; Obesity/metabolism ; Ethanol/pharmacology ; Citrus/chemistry ; RNA, Messenger ; Lipase ; Mice, Inbred C57BL
    Chemische Substanzen Flavonoids ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; PPAR alpha ; Ethanol (3K9958V90M) ; RNA, Messenger ; Lipase (EC 3.1.1.3)
    Sprache Englisch
    Erscheinungsdatum 2024-01-14
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117749
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Chemical Composition and Antibacterial and Antiulcerative Colitis Activities of Essential Oil from Pruni Semen.

    Wang, Ya-Li / Lang, Deng-Qin / Wu, Chao / Chen, Qi-Cong / Lin, Song-Xia / Li, Xiao-Yi / Liu, Qiang / Jiang, Cui-Ping / Shen, Chun-Yan

    Journal of agricultural and food chemistry

    2024  Band 72, Heft 2, Seite(n) 1096–1113

    Abstract: This study was sought to investigate the chemical composition and antibacterial and antiulcerative colitis (UC) effects of essential oil from Pruni Semen (PSEO). A GC-MS assay showed that the major compounds in PSEO were products of amygdalin hydrolysis, ...

    Abstract This study was sought to investigate the chemical composition and antibacterial and antiulcerative colitis (UC) effects of essential oil from Pruni Semen (PSEO). A GC-MS assay showed that the major compounds in PSEO were products of amygdalin hydrolysis, which possessed great antibacterial and anti-inflammatory potential.
    Mesh-Begriff(e) Mice ; Animals ; Oils, Volatile/chemistry ; Proto-Oncogene Proteins c-akt/genetics ; Semen/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Molecular Docking Simulation ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/metabolism ; Anti-Bacterial Agents/pharmacology ; Colitis, Ulcerative/chemically induced ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Mice, Inbred C57BL ; Colon/metabolism
    Chemische Substanzen Oils, Volatile ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Anti-Bacterial Agents ; Dextran Sulfate (9042-14-2)
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c06442
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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