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  1. Article ; Online: Relationship between the impacted mandibular third molar and adjacent second molar' external root resorption by cone-bean computed tomography analysis.

    Cui, L / Jiang, E / Liu, Z / Li, J

    Medicina oral, patologia oral y cirugia bucal

    2024  Volume 29, Issue 1, Page(s) e27–e35

    Abstract: Background: The relationship between the impacted mandibular third molar (IMTM) and the external root resorption (ERR) of the mandibular second molar (MSM) was analysed with cone-beam computed tomography (CBCT). The risk factors affecting the ERR of the ...

    Abstract Background: The relationship between the impacted mandibular third molar (IMTM) and the external root resorption (ERR) of the mandibular second molar (MSM) was analysed with cone-beam computed tomography (CBCT). The risk factors affecting the ERR of the MSM were examined to provide a reference.
    Material and methods: A total of 327 patients (total: 578 teeth) admitted to the Affiliated Hospital of Yanbian University for IMTM extraction from January 2017 to December 2019 was chosen and divided according to gender and age. The correlation between the IMTM and ERR of MSM was analysed, including inclination angle, impaction direction and depth. The relationship of mandibular ascending ramus classification with ERR of MSM was also analysed. In addition, the correlation between the MTM impaction type and the severity of ERR was analysed.
    Results: The incidence of ERR of MSM in male patients was higher than in females (27.9% vs.17.6%, p = 0.018). The occurrence and the site of ERR showed statistical differences in the inclination angle [(≤20°, 3.6%) vs. (21°-40°, 27.1%) vs. (41°-60°, 27.6%) vs. (61°-80°, 25.6%) vs. (>80°, 31.7%), p <0.001], impaction direction [(Vertical, 1.1%) vs. (Mesial, 32.7%) vs. (Horizontal, 25.3%), p <0.001] and depth of MTM [(Low position, 38.6%) vs. (Median position, 32.0%) vs. (High position, 13.7%), p <0.001]. Also, there was a significant difference in the mandibular ascending ramus type [(Class I, 17.4%) vs. (Class II, 32.3%) vs. (Class III, 44.9%), p <0.001]. In addition, the severity of ERR showed statistical differences in the mesial (40.9%, p<0.05), lower impaction (54.5%, p<0.05) depth of MTM and type III of mandibular ascending ramus (63.6%, p<0.05).
    Conclusions: The inclination angle, impaction direction, and depth of MTM were the influencing factors for the occurrence and site of ERR. Also, mandibular ascending ramus type was the impact fact. For MTM with mesioangular, lower impaction, and mandibular ascending ramus with type III, the ERR of the MSM was severer.
    MeSH term(s) Female ; Humans ; Male ; Cone-Beam Computed Tomography/methods ; Mandible/diagnostic imaging ; Molar/diagnostic imaging ; Molar, Third/diagnostic imaging ; Root Resorption/epidemiology ; Tooth, Impacted/diagnostic imaging
    Language English
    Publishing date 2024-01-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2171573-7
    ISSN 1698-6946 ; 1698-4447
    ISSN (online) 1698-6946
    ISSN 1698-4447
    DOI 10.4317/medoral.26044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [How I treat myelodysplastic syndromes with allogeneic hematopoietic stem cell transplantation].

    Jiang, E L

    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

    2021  Volume 42, Issue 1, Page(s) 10–14

    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Myelodysplastic Syndromes/therapy ; Transplantation Conditioning
    Language Chinese
    Publishing date 2021-03-07
    Publishing country China
    Document type Journal Article
    ZDB-ID 2997162-7
    ISSN 0253-2727 ; 0253-2727
    ISSN (online) 0253-2727
    ISSN 0253-2727
    DOI 10.3760/cma.j.issn.0253-2727.2021.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Overcoming genetic and cellular complexity to study the pathophysiology of X-linked intellectual disabilities.

    Martinez, Dayne / Jiang, Evan / Zhou, Zhaolan

    Journal of neurodevelopmental disorders

    2024  Volume 16, Issue 1, Page(s) 5

    Abstract: X-linked genetic causes of intellectual disability (ID) account for a substantial proportion of cases and remain poorly understood, in part due to the heterogeneous expression of X-linked genes in females. This is because most genes on the X chromosome ... ...

    Abstract X-linked genetic causes of intellectual disability (ID) account for a substantial proportion of cases and remain poorly understood, in part due to the heterogeneous expression of X-linked genes in females. This is because most genes on the X chromosome are subject to random X chromosome inactivation (XCI) during early embryonic development, which results in a mosaic pattern of gene expression for a given X-linked mutant allele. This mosaic expression produces substantial complexity, especially when attempting to study the already complicated neural circuits that underly behavior, thus impeding the understanding of disease-related pathophysiology and the development of therapeutics. Here, we review a few selected X-linked forms of ID that predominantly affect heterozygous females and the current obstacles for developing effective therapies for such disorders. We also propose a genetic strategy to overcome the complexity presented by mosaicism in heterozygous females and highlight specific tools for studying synaptic and circuit mechanisms, many of which could be shared across multiple forms of intellectual disability.
    MeSH term(s) Female ; Humans ; Pregnancy ; Chromosomes, Human, X ; Genes, X-Linked/genetics ; Intellectual Disability/genetics ; Mosaicism ; X Chromosome Inactivation/genetics
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2487174-6
    ISSN 1866-1955 ; 1866-1955
    ISSN (online) 1866-1955
    ISSN 1866-1955
    DOI 10.1186/s11689-024-09517-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study.

    Zong, Kaican / Zhou, Hui / Li, Wen / Jiang, E / Liu, Yi / Li, Shiying

    Acta pharmaceutica Sinica. B

    2023  Volume 13, Issue 11, Page(s) 4655–4660

    Abstract: In our retrospective cohort study, we aim to explore whether Azvudine modifies the risk of death in COVID-19 patients. It was conducted on the medical records of patients, consecutively admitted for COVID-19 pneumonia to two hospitals in Chongqing, China. ...

    Abstract In our retrospective cohort study, we aim to explore whether Azvudine modifies the risk of death in COVID-19 patients. It was conducted on the medical records of patients, consecutively admitted for COVID-19 pneumonia to two hospitals in Chongqing, China. Based on Azvudine treatment exposure, the patients were divided into Azvudine group and non-Azvudine group. We used 1:2 ratio propensity score matching (PSM) in our study to adjust for confounding factors and differences between Azvudine and non-Azvudine groups. There were 1072 patients included in our original cohort. With 1:2 ratio PSM, the Azvudine group included 195 patients and non-Azvudine group included 390 patients. The results showed that Azvudine treatment was associated with improved in-hospital mortality in overall population (OR 0.375, 95% CI 0.225-0.623,
    Language English
    Publishing date 2023-07-13
    Publishing country Netherlands
    Document type Clinical Trial
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effect of Fipronil Exposure on Hematological Aspects of Rhesus Monkeys (

    Khan, Nazeer Hussain / Jiang, Enshe / Qureshi, Irfan Zia

    Journal of inflammation research

    2023  Volume 16, Page(s) 5755–5765

    Abstract: Background: Fipronil (FPN) is a broad-spectrum phenylpyrazole insecticide, widely used in agriculture and veterinary medicine. Published research on FPN toxicity has established the fact that its inhalation or dermal exposure may lead to very serious ... ...

    Abstract Background: Fipronil (FPN) is a broad-spectrum phenylpyrazole insecticide, widely used in agriculture and veterinary medicine. Published research on FPN toxicity has established the fact that its inhalation or dermal exposure may lead to very serious clinical outcomes in non-target animals. In line to its exposure and toxicity related damage, FPN has been investigated in many invertebrates, however, its exposure-related noxiousness is less reported in higher animals.
    Objective: To assess the FPN-induced effects to agro-workers in the field, in the present study, we used physiological human surrogates, adult rhesus monkeys as models.
    Method: We exposed well habituated, chair restraint adult rhesus monkeys with a field spray concentration of FPN (0.3 mg/1 mL distilled water) through an inhalation route in the closed system. Animals were divided into control and treatment groups, each containing three animals. Inflammatory and hematological effects were determined by evaluating the kidney and liver biomarker enzymes; serum creatinine and alanine transaminase (ALT), aspartate transaminase (AST) levels respectively.
    Results: Our findings reveal that FPN treated monkeys show significantly increased levels of ALT (p = 0.000461), AST (p = 0.0681) and creatinine (p = 0.00656) as compared to the control group. Furthermore, significant differences of red blood cells (RBCs) (p = 0.0139) and white blood cells (WBCs) (p = 0.00642) were also observed in the treated and control group monkeys which reflect strong toxic effects on the blood cells.
    Conclusion: Our findings demonstrate that FPN exposure is very toxic to higher animals and causes severe damage to the liver and kidneys along with other clinical problems. The study highlights the effect and impact of passive inhalation of insecticides in intentionally carefree agro-workers and raises the concern of public awareness toward pesticides use.
    Language English
    Publishing date 2023-12-29
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S386145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Efficacy evaluation and metabolomics analysis of raw and salt-processed Achyranthes bidentata Radix in zebrafish larvae for osteoporosis treatment.

    Jiang, Enci / Yang, Ying / Pan, Meiling / Tao, Yi

    Journal of pharmaceutical and biomedical analysis

    2023  Volume 237, Page(s) 115774

    Abstract: Osteoporosis, characterized by reduced bone density and the deterioration of bone tissue, poses a significant health challenge. The mechanisms underlying the protective effects of both raw and salt-processed Achyranthes bidentata Radix in osteoporosis ... ...

    Abstract Osteoporosis, characterized by reduced bone density and the deterioration of bone tissue, poses a significant health challenge. The mechanisms underlying the protective effects of both raw and salt-processed Achyranthes bidentata Radix in osteoporosis remains unclear. This study endeavors to unravel and analyze the therapeutic mechanisms of these two forms of Achyranthes bidentata Radix in osteoporotic zebrafish larvae, utilizing GC/MS-based metabolomics. Zebrafish larvae were categorized into five groups: blank control, model, positive control, and groups treated with raw and salt-processed Achyranthes bidentata Radix. Following drug administration, notable enhancements were observed in both mineralized bone area and cumulative optical density. Various data mining techniques were employed, encompassing principal component analysis, orthogonal projections to latent structures discriminant analysis, and metabolic pathway analysis. These analyses unveiled 26 differential endogenous metabolites with significant biological implications in the zebrafish osteoporosis model. Among these metabolites, 12 (including acetamide, L-lactic acid, threonine, glycerol, rhamnose, azelaic acid, palmitic acid, inositol, stearic acid, hexadecane, sucrose, and glyceryl monostearate) were validated using standard compounds, exhibiting strong linear correlation coefficients (R
    MeSH term(s) Animals ; Zebrafish ; Achyranthes ; Sodium Chloride/chemistry ; Osteoporosis/drug therapy ; Osteoporosis/metabolism ; Plant Extracts/chemistry
    Chemical Substances Sodium Chloride (451W47IQ8X) ; Plant Extracts
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2023.115774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Refractory cytomegalovirus infections in Chinese patients receiving allogeneic hematopoietic cell transplantation: a review of the literature.

    Yang, Donglin / Yao, Yuanyuan / Sun, Yi / Jiang, Erlie

    Frontiers in immunology

    2023  Volume 14, Page(s) 1287456

    Abstract: In the absence of prophylactic therapy, cytomegalovirus (CMV) viremia is a common complication following allogeneic hematopoietic cell transplantation (allo-HCT) and represents a significant cause of morbidity and mortality. Approximately 25% of allo-HCT ...

    Abstract In the absence of prophylactic therapy, cytomegalovirus (CMV) viremia is a common complication following allogeneic hematopoietic cell transplantation (allo-HCT) and represents a significant cause of morbidity and mortality. Approximately 25% of allo-HCT happen in China, where the development and refinement of the 'Beijing protocol' has enabled frequent and increasing use of haploidentical donors. However, refractory CMV infection (an increase by >1 log
    MeSH term(s) Humans ; China ; Cytomegalovirus Infections/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Viremia
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1287456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 3D Co-culture of Cancer-Associated Fibroblast with Oral Cancer Organoids.

    Zhao, H / Jiang, E / Shang, Z

    Journal of dental research

    2020  Volume 100, Issue 2, Page(s) 201–208

    Abstract: Limits of the available model have, in the long term, challenged the studies of cancer-associated fibroblasts (CAFs) and their interplay with cancer stem cells, one of the key driving forces of patients with oral squamous cell carcinoma (OSCC). In the ... ...

    Abstract Limits of the available model have, in the long term, challenged the studies of cancer-associated fibroblasts (CAFs) and their interplay with cancer stem cells, one of the key driving forces of patients with oral squamous cell carcinoma (OSCC). In the present study, the 3-dimensional organoid model was employed to investigate whether co-culture with paralleled CAFs promotes stem-like properties of OSCC. Experimentally, tumor organoids and paralleled CAFs were generated from patients with OSCC. Then, the CD44
    MeSH term(s) Cancer-Associated Fibroblasts ; Carcinoma, Squamous Cell ; Cell Line, Tumor ; Coculture Techniques ; Fibroblasts ; Head and Neck Neoplasms ; Humans ; Mouth Neoplasms ; Organoids
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/0022034520956614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Recent Advances in the Application of Podophyllotoxin Derivatives to Fight Against Multidrug-Resistant Cancer Cells.

    Guo, Qiuyan / Jiang, Enshe

    Current topics in medicinal chemistry

    2021  Volume 21, Issue 19, Page(s) 1712–1724

    Abstract: Podophyllotoxins, including epipodophyllotoxin derivatives, can act on a diverse array of drug targets in cancer cells and thus possess potent activity against various forms of cancer cell lines, including drug-resistant forms. Moreover, several ... ...

    Abstract Podophyllotoxins, including epipodophyllotoxin derivatives, can act on a diverse array of drug targets in cancer cells and thus possess potent activity against various forms of cancer cell lines, including drug-resistant forms. Moreover, several podophyllotoxin derivatives represented by etoposide and teniposide, have already been approved for cancer therapy, demonstrating podophyllotoxin moiety as a useful pharmacophore for the discovery of novel anticancer agents. This review reports the recent advances in the exploitation of podophyllotoxin derivatives to fight against multidrug-resistant cancer cells. The mechanism of action and structure-activity relationship (SAR) studies are also highlighted.
    MeSH term(s) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Podophyllotoxin/analogs & derivatives ; Podophyllotoxin/chemistry ; Podophyllotoxin/pharmacology
    Chemical Substances Antineoplastic Agents ; Podophyllotoxin (L36H50F353)
    Language English
    Publishing date 2021-01-13
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1568026621666210113163327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Differences in the origins of kinetochore-positive and kinetochore-negative micronuclei: A live cell imaging study.

    Jiang, Erkang

    Mutation research

    2016  Volume 787, Page(s) 7–14

    Abstract: Micronuclei (MNi) are extensively used to evaluate genotoxicity and chromosomal instability. Classification of kinetochore-negative (K-MNi) and kinetochore-positive micronuclei (K+MNi) improves the specificity and sensitivity of the micronucleus (MN) ... ...

    Abstract Micronuclei (MNi) are extensively used to evaluate genotoxicity and chromosomal instability. Classification of kinetochore-negative (K-MNi) and kinetochore-positive micronuclei (K+MNi) improves the specificity and sensitivity of the micronucleus (MN) test; however, the fundamental differences in the origins of K-MNi and K+MNi have not been addressed due to the limitations of traditional methods. In the current study, HeLa CENP B-GFP H2B-mCherry cells were constructed in which histone 2B (H2B) and centromere protein B (CENP B) were expressed as fusion proteins to monomeric Cherry (mCherry) and EGFP, respectively. MNi were identified using H2B-mCherry; K+MN contained CENP B-GFP, while K-MN did not. Long-term live cell imaging was conducted to examine MN formation in the dual-color fluorescent HeLa cells. The results suggested that K-MNi were derived from kinetochore-negative displaced chromosomes (K-DCs), kinetochore-negative lagging chromosomes (K-LCs) and fragments of broken chromosome bridges (CBs) during late mitotic stages. The results also indicated that K+MNi are derived from kinetochore-positive displaced chromosomes (K+DCs), kinetochore-positive lagging chromosomes (K+LCs), and fragments of broken CBs. Different aberrant chromosomes emerged during mitosis at different frequencies and developed into K-MNi and/or K+MNi in the daughter cells at different rates. K+LCs formed K+MNi at a higher frequency than K+DCs, and K-LCs formed K-MNi at a higher rate than K-DCs; however, broken CBs transformed into K-MNi and/or K+MNi. In summary, these results show that K-MNi and K+MNi have different origins in HeLa cells and that each mechanism of MN formation contributes differently to the overall number of K-MNi and K+MNi.
    MeSH term(s) Anaphase ; Cell Nucleus/metabolism ; Cell Nucleus/ultrastructure ; Centromere Protein B/metabolism ; DNA Damage ; HeLa Cells ; Humans ; Kinetochores/physiology ; Micronucleus Tests ; Telophase
    Chemical Substances Centromere Protein B
    Language English
    Publishing date 2016-05
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 206607-5
    ISSN 1873-135X ; 1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
    ISSN (online) 1873-135X
    ISSN 1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
    DOI 10.1016/j.mrfmmm.2016.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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