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  1. AU="Jiang, Haiyue"
  2. AU="Kuznetsov, N S"
  3. AU=Rimmer Abi AU=Rimmer Abi
  4. AU="Zhou, Qinyao"
  5. AU="Taniguchi, Ryou"
  6. AU="Krauss, Thomas F"
  7. AU="Papoulidis, Ioannis"
  8. AU="Migaud, Henri"
  9. AU="Kelion, Andrew"
  10. AU="Harry Jabs"
  11. AU="Patel, Yatindra"
  12. AU="Aziza Jamal-Allial"
  13. AU="Montiel, Olga Martha"
  14. AU="Pérez Latorre, Leire"
  15. AU=Vardhan Seshu
  16. AU="OJ Baker"
  17. AU="Dalton, R C"
  18. AU="Mrozikiewicz-Rakowska, Beata"
  19. AU="Penkert, Judith"
  20. AU="Mak, Susanna"
  21. AU="Karkoszka, Henryk"
  22. AU="Burton, Jeffrey H"
  23. AU="Frederique Pitel"
  24. AU="Pierce, Aimee"
  25. AU="Luque-Ballesteros, Laura"
  26. AU="Dondi, Francesco"
  27. AU="McLachlan, Alex"
  28. AU="Krizova, Ludmila"
  29. AU="Balog, Attila"
  30. AU="Faerber, Karin"
  31. AU="Prettner, Klaus"
  32. AU="Ambrožová, I."
  33. AU="William, Doreen"
  34. AU="Gutiérrez-Sánchez, A M"
  35. AU="Bohan, Dana"
  36. AU="Spracklen, D."
  37. AU="Lobo, Brian C"
  38. AU=Zhuang Jianjian AU=Zhuang Jianjian
  39. AU=Pathanki Adithya M
  40. AU="Armando Vilchis-Ordoñez"
  41. AU="Zhongfu Lu"
  42. AU="Lo, Hong-Yip"
  43. AU="Ziman Xiong"
  44. AU="Oakes, Allison H"
  45. AU="Ma, Shaotong"
  46. AU="Zang, Lili"
  47. AU="Adams Brian D"
  48. AU="Maria Papaioannou"
  49. AU="Kollia, Georgia"
  50. AU="Auxiette, Catherine"
  51. AU="Guzmán, Luis"
  52. AU="Alipour, Elnaz"
  53. AU="Queiroz, Dayanna Joyce Marques"
  54. AU="Ramamurthy, Santosh"
  55. AU="Xueying Huang"
  56. AU="Cromwell, Howard C"
  57. AU="Spence, John C H"
  58. AU="Chapinal, Libertad"
  59. AU=Rohaim Mohammed A AU=Rohaim Mohammed A
  60. AU=Hempel Cornelius

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  1. Artikel ; Online: Relocation of polyotia tissue to reconstruct the tragus and fill the preauricular depression.

    Deng, Yiwen / Jiang, Haiyue / Pan, Bo / Li, Chuan

    International journal of pediatric otorhinolaryngology

    2024  Band 180, Seite(n) 111937

    Abstract: Objectives: The present article introduces a lingual composite tissue flap based on the tragus-like structure for correcting polyotia deformity, with the aim of providing a surgical technique that involves relocating polyotia tissue to reconstruct the ... ...

    Abstract Objectives: The present article introduces a lingual composite tissue flap based on the tragus-like structure for correcting polyotia deformity, with the aim of providing a surgical technique that involves relocating polyotia tissue to reconstruct the tragus and fill the preauricular depression.
    Methods: The study included a total of 21 patients with polyotia who underwent lingual composite tissue flap reconstruction between January 2020 to December 2022. Patients were retrospectively assessed through a comprehensive review of their medical records and photographic data. Tragus morphology was evaluated based on the measurements of tragus length and width. The Aesthetic Outcomes Scale (AOS), modified Vancouver Scar Scale (mVSS), and Visual Analogue Scale (VAS) were employed for the assessment of surgical outcomes.
    Results: The follow-up period for all patients ranged from 6 to 15 months. The length and width of the normal tragus were not significantly different from those of the reconstructed tragus. The mean preoperative AOS score was 2.73 ± 0.51, while the mean postoperative AOS score increased to 7.61 ± 0.65. The mVSS yielded an average score of 1.80 ± 1.43, indicating inconspicuous scarring post polyotia surgery. The preoperative VAS satisfaction score was recorded as 1.57 ± 0.67, while the postoperative VAS score significantly increased to 8.33 ± 0.91. The flaps all successfully survived post-operation without any occurrences of flap hematoma, necrosis, infection, or wound dehiscence.
    Conclusion: The reconstruction of the tragus should be given careful consideration when addressing polyotia. The utilization of a lingual composite tissue flap for correction can achieve excellent aesthetic results for the tragus, with high patient satisfaction and minimal complications.
    Mesh-Begriff(e) Humans ; Female ; Male ; Retrospective Studies ; Plastic Surgery Procedures/methods ; Surgical Flaps/transplantation ; Child ; Esthetics ; Adolescent ; Treatment Outcome ; Child, Preschool ; Ear Auricle/surgery ; Ear Auricle/abnormalities
    Sprache Englisch
    Erscheinungsdatum 2024-04-03
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2024.111937
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  2. Artikel ; Online: New Method Using Local Affected Cartilage and Flap for the Cleft in Question Mark Ear.

    Wang, Tiange / Yu, Xiaobo / Jiang, Haiyue / Pan, Bo

    Aesthetic plastic surgery

    2024  

    Abstract: Background: As a rare auricular deformity, despite numerous surgical procedures for correcting moderate-to-severe question mark ears described in past studies, there remains a need to explore a more cost-effective approach. The optimal utilization of ... ...

    Abstract Background: As a rare auricular deformity, despite numerous surgical procedures for correcting moderate-to-severe question mark ears described in past studies, there remains a need to explore a more cost-effective approach. The optimal utilization of ear cartilage and surrounding skin while achieving superior outcomes continues to pose a significant challenge.
    Methods: From 2018 to 2023, twenty-four patients with unilateral question mark ear were enrolled in this study. Seven of them were severe type deformities (absence of lower part of auricle), and seventeen were moderate (only cleft between helix and lobule). All patients were treated with new method using local cartilage and flap without damage in unaffected area.
    Results: All patients were satisfied with significant improvement of question mark ear and the overall symmetrical appearance. The surgical scar was not obvious. No complications were observed. The follow-up period revealed that the corrective procedure kept producing the symmetrical and cosmetic results.
    Conclusion: Our new method enables optimal utilization of deformed tissue and surrounding skin, rendering this method effective and reliable for correcting moderate-to-severe question mark ears.
    Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Sprache Englisch
    Erscheinungsdatum 2024-04-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-024-04030-0
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  3. Artikel ; Online: Retrospective study on unilateral polyotia combined with microtia utilizing the technique of preserving residual ear tissue.

    Deng, Yiwen / Jiang, Haiyue / Pan, Bo / Yu, Xiaobo

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2024  Band 92, Seite(n) 237–243

    Abstract: Background: The presence of polyotia in individuals with microtia is a rare deformity. Due to the intricate structure of the auricle, uncertain etiology, and challenging corrective techniques, it has always been a focal point in the field of plastic ... ...

    Abstract Background: The presence of polyotia in individuals with microtia is a rare deformity. Due to the intricate structure of the auricle, uncertain etiology, and challenging corrective techniques, it has always been a focal point in the field of plastic surgery. The present study presents a technique for correcting the combination of polyotia and microtia by utilizing residual ear tissue as graft material.
    Methods: The retrospective study included 23 patients with polyotia and microtia from 2018 to 2022. The residual ear tissue was used to rectify auricular deformities in all patients. The patients were instructed to evaluate the satisfaction of the auricle shape using a visual analog scale (VAS) both before and 6 months after the surgical procedure. The esthetic outcomes of auricle subunits were simultaneously assessed by a senior physician pre- and postoperatively.
    Results: The mean duration of follow-up in this study was 8.73 months. The preoperative VAS satisfaction score was recorded as 2.26 ± 0.86, while the post-operative VAS score significantly increased to 7.86 ± 0.86. The preoperative auricle esthetic outcomes score was recorded as 9.95 ± 1.74, while the post-operative score significantly increased to 24.04 ± 2.16. The follow-up period did not present any cases of flap necrosis, hematoma, infection, or wound dehiscence.
    Conclusion: The study demonstrates that comprehensive utilization of residual auricular tissue can lead to optimal outcomes in correcting polyotia with concha-type microtia. The utilization of residual ear tissue can be maximized to streamline the operation, minimize bodily harm, and enhance patient satisfaction.
    Mesh-Begriff(e) Humans ; Congenital Microtia/surgery ; Male ; Retrospective Studies ; Female ; Plastic Surgery Procedures/methods ; Child ; Adolescent ; Ear Auricle/surgery ; Ear Auricle/abnormalities ; Patient Satisfaction ; Esthetics ; Young Adult ; Adult ; Ear, External/surgery ; Ear, External/abnormalities
    Sprache Englisch
    Erscheinungsdatum 2024-03-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2024.03.008
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  4. Artikel ; Online: The impact of national health insurance on the cost of auricular reconstruction with skin expansion for microtia in China: A single-center retrospective study based on 1290 surgeries.

    Wang, Tiange / Zhi, Jiajun / Pan, Bo / Jiang, Haiyue

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2024  Band 94, Seite(n) 62–71

    Abstract: Background: Congenital microtia presents challenges that encompass physical disabilities and psychosocial distress. It is reported that people with low income have a higher possibility of giving birth to babies with congenital malformations. At the end ... ...

    Abstract Background: Congenital microtia presents challenges that encompass physical disabilities and psychosocial distress. It is reported that people with low income have a higher possibility of giving birth to babies with congenital malformations. At the end of June 2023, auricular reconstruction was partially incorporated into national health insurance in our hospital.
    Methods: Briefly, 1290 surgeries, including stage-I and stage-II auricular reconstruction with tissue expansion were performed in 2023, involving 779 patients. Patient data, including age, sex, length of stay, residence, and costs, were retrieved from the electronic medical record system. The final cost before and after health insurance coverage, as well as the medical insurance reimbursement ratio in each province and municipality were statistically analyzed.
    Results: Following insurance coverage, a significant increase in the number of surgeries was observed (514 [39.84%] vs. 776 [60.16%], χ
    Conclusion: The health insurance coverage for microtia treatment significantly alleviated financial burdens on the patients' family and increased the number of auricular reconstruction surgeries. These findings underscore the critical role of insurance coverage in enhancing healthcare accessibility and affordability for patients with congenital microtia.
    Sprache Englisch
    Erscheinungsdatum 2024-05-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2024.04.067
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  5. Artikel ; Online: Beneficial effects of Aucubin on restoration of rabbits with cartilage defect.

    Zhao, Gaofeng / Jiang, Haiyue

    Cell and tissue banking

    2022  Band 23, Heft 4, Seite(n) 887–897

    Abstract: Osteochondral grafts are suitable materials for repair of articular cartilage defect and plastic and reconstructive surgery. In our study, osteochondral allografts from rabbits were preserved in vitro for 28 days, and chondrocyte death, degradation of ... ...

    Abstract Osteochondral grafts are suitable materials for repair of articular cartilage defect and plastic and reconstructive surgery. In our study, osteochondral allografts from rabbits were preserved in vitro for 28 days, and chondrocyte death, degradation of collagen and proteoglycan, morphological alterations, and inflammatory reaction were observed in the grafts. Supplementing of Aucubin with 10 or 20 μM in the preservation solution inhibited chondrocyte death, matrix degradation, pathological alterations and inflammation in allografts preserved in vitro, compared with that preserved in standard preservation solution. In addition, after transplantation of 20 μM Aucubin-treated allografts, the osteochondral repair and regeneration of rabbits with knee joint defect were accelerated. In conclusion, Aucubin was beneficial for maintaining chondrocyte viability and normal morphology, and inhibiting inflammatory occurrence in rabbit osteochondral grafts preserved in vitro, and facilitated osteochondral repair and regeneration of rabbits with knee defect. These findings might provide novel insights for preservation of grafts for clinical articular cartilage repair and plastic surgery.
    Mesh-Begriff(e) Animals ; Rabbits ; Cartilage, Articular/surgery ; Chondrocytes/transplantation ; Iridoid Glucosides/metabolism ; Knee Joint/surgery
    Chemische Substanzen aucubin (2G52GS8UML) ; Iridoid Glucosides
    Sprache Englisch
    Erscheinungsdatum 2022-04-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2170897-6
    ISSN 1573-6814 ; 1389-9333
    ISSN (online) 1573-6814
    ISSN 1389-9333
    DOI 10.1007/s10561-022-10004-w
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  6. Artikel ; Online: Photo-induced universal modification of small-diameter decellularized blood vessels with a hemocompatible peptide improves in vivo patency.

    Zhang, Wei / Fukazawa, Kyoko / Mahara, Atsushi / Jiang, Haiyue / Yamaoka, Tetsuji

    Acta biomaterialia

    2024  Band 176, Seite(n) 116–127

    Abstract: Decellularized vessels (DVs) have the potential to serve as available grafts for small-diameter vascular (<6 mm) reconstruction. However, the absence of functional endothelia makes them likely to trigger platelet aggregation and thrombosis. Luminal ... ...

    Abstract Decellularized vessels (DVs) have the potential to serve as available grafts for small-diameter vascular (<6 mm) reconstruction. However, the absence of functional endothelia makes them likely to trigger platelet aggregation and thrombosis. Luminal surface modification is an efficient approach to prevent thrombosis and promote endothelialization. Previously, we identified a hemocompatible peptide, HGGVRLY, that showed endothelial affinity and antiplatelet ability. By conjugating HGGVRLY with a phenylazide group, we generated a photoreactive peptide that can be modified onto multiple materials, including non-denatured extracellular matrices. To preserve the natural collagen of DVs as much as possible, we used a lower ultrahydrostatic pressure than that previously reported to prepare decellularized grafts. The photoreactive HGGVRLY peptide could be modified onto DV grafts via UV exposure for only 2 min. Modified DVs showed improved endothelial affinity and antiplatelet ability in vitro. When rat abdominal aortas were replaced with DVs, modified DVs with more natural collagen demonstrated the highest patent rate after 10 weeks. Moreover, the photoreactive peptide remained on the lumen surface of DVs over two months after implantation. Therefore, the photoreactive peptide could be efficiently and sustainably modified onto DVs with more natural collagens, resulting in improved hemocompatibility. STATEMENT OF SIGNIFICANCE: We employed a relatively lower ultrahydrostatic pressure to prepare decellularized vessels (DVs) with less denatured collagens to provide a more favorable environment for cell migration and proliferation. The hemocompatibility of DV luminal surface can be enhanced by peptide modification, but undenatured collagens are difficult to modify. We innovatively introduce a phenylazide group into the hemocompatible peptide HGGVRLY, which we previously identified to possess endothelial affinity and antiplatelet ability, to generate a photoreactive peptide. The photoreactive peptide can be efficiently and stably modified onto DVs with more natural collagens. DV grafts modified with photoreactive peptide exhibit enhanced in vivo patency. Furthermore, the sustainability of photoreactive peptide modification on DV grafts within bloodstream is evident after two months of transplantation.
    Mesh-Begriff(e) Rats ; Animals ; Blood Vessel Prosthesis ; Peptides/pharmacology ; Thrombosis/prevention & control ; Thrombosis/metabolism ; Collagen/pharmacology ; Azides
    Chemische Substanzen phenylazide (622-37-7) ; Peptides ; Collagen (9007-34-5) ; Azides
    Sprache Englisch
    Erscheinungsdatum 2024-01-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2024.01.012
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  7. Artikel ; Online: The Effects of Radial Cartilage Incision on the Growth of Rabbit Ear.

    Guo, Fengfeng / Liu, Wenshuai / Yu, Xiaobo / Lin, Lin / Jiang, Haiyue

    Aesthetic plastic surgery

    2024  Band 48, Heft 9, Seite(n) 1679–1687

    Abstract: Objectives: Recently, radial cartilage incision (first-stage) at an early age combined with free auricular composite tissue grafting (second-stage) can effectively correct the concha-type microtia with the moderate or severe folded cartilage in the ... ...

    Abstract Objectives: Recently, radial cartilage incision (first-stage) at an early age combined with free auricular composite tissue grafting (second-stage) can effectively correct the concha-type microtia with the moderate or severe folded cartilage in the middle and upper third auricle, but radial cartilage incision's effects on the growth of the ear remain to be determined. The authors aimed to evaluate the effects of radial cartilage incision in young rabbits model.
    Methods: Ten New Zealand white rabbits were included in our experiment. Two ears of each rabbit were divided randomly into two groups. The experimental group was operated with radial cartilage incision, and no intervention was given to the control group. The ear width, length, and perimeter were noted every two weeks. Auricular surface area was noted at 4 and 22 weeks old. The repeated measures ANOVA was used to describe ears' growth trend. A paired-sample's t test is conducted to test whether there are significant differences among the variables through the SPSS25.0 software.
    Results: The growth tendencies of the ear length, width, and perimeter were observed and analyzed. The growth curves of the experimental ears were similar to that of the control. There was no significant difference in the increased ratio of surface area among the two groups. The cartilage of the experimental ears showed no change in biomechanical properties compared to that of control group.
    Conclusion: This study shows that radial cartilage incision at an early age does not influence the growth of rabbit ear length, width, perimeter, and surface area and also does not change the biomechanical properties of the cartilage.
    Level of evidence i: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .
    Mesh-Begriff(e) Animals ; Rabbits ; Ear Cartilage/surgery ; Random Allocation ; Ear, External/surgery ; Congenital Microtia/surgery ; Plastic Surgery Procedures/methods ; Female ; Disease Models, Animal
    Sprache Englisch
    Erscheinungsdatum 2024-02-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-023-03833-x
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  8. Artikel ; Online: Peelable Microneedle Patches Deliver Fibroblast Growth Factors to Repair Skin Photoaging Damage.

    Yang, Guojun / Hu, Shiqi / Jiang, Haiyue / Cheng, Ke

    Nanotheranostics

    2023  Band 7, Heft 4, Seite(n) 380–392

    Abstract: Rationale: ...

    Abstract Rationale:
    Mesh-Begriff(e) Mice ; Animals ; Skin Aging ; Fibroblast Growth Factor 2/pharmacology ; Drug Delivery Systems/methods ; Fibroblast Growth Factors ; Inflammation
    Chemische Substanzen Fibroblast Growth Factor 2 (103107-01-3) ; Fibroblast Growth Factors (62031-54-3)
    Sprache Englisch
    Erscheinungsdatum 2023-06-19
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ISSN 2206-7418
    ISSN (online) 2206-7418
    DOI 10.7150/ntno.79187
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Subtractive thinking: A novel combined application of antihelix reconstruction and outer helix reconstruction to treat mild cases of type I to II conchal microtia.

    Gu, Luosha / Sun, Pengfei / Pan, Bo / Jiang, Haiyue

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2023  Band 84, Seite(n) 462–468

    Abstract: Background: The management of mild cases of type Ⅰ to Ⅱ conchal microtia involves grafting cartilage to the affected ear to increase the cartilaginous area and transfer more skin to cover the larger cartilage. Herein, we performed a novel combined ... ...

    Abstract Background: The management of mild cases of type Ⅰ to Ⅱ conchal microtia involves grafting cartilage to the affected ear to increase the cartilaginous area and transfer more skin to cover the larger cartilage. Herein, we performed a novel combined surgical procedure based on "subtractive thinking" that included antihelix reconstruction and outer helix reconstruction that was successful in patients with mild type I to II conchal microtia.
    Methods: From January 2018 to September 2022, 65 patients with mild, unilateral, type I to II conchal microtia were enrolled in this study. All patients were treated with a novel method at the Plastic Surgery Hospital of Peking Union Medical College. The perimeters, widths, and lengths of the healthy and affected ears were measured both preoperatively and postoperatively. Patients' levels of satisfaction were determined based on postoperative results.
    Results: The mean postoperative follow-up duration was 14.9 ± 2.65 months. All patients experienced no complications. Analysis revealed that our surgical method could effectively treat mild type I to II concha microtia irrespective of the auricular perimeter, width, and length (p < 0.0001). Furthermore, the patient satisfaction rate was 100%.
    Conclusion: The combined surgical procedure, which includes antihelix and outer helix reconstructions, is a viable method of reconstructing type I to II auricular concha microtia.
    Mesh-Begriff(e) Humans ; Congenital Microtia/surgery ; Ear Auricle/surgery ; Plastic Surgery Procedures ; Surgical Flaps/surgery ; Surgery, Plastic/methods
    Sprache Englisch
    Erscheinungsdatum 2023-06-10
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2023.06.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Genetically engineered chondrocytes overexpressing elastin improve cell retention and chondrogenesis in a three-dimensional GelMA culture system.

    Zhang, Wei / Lu, Wei / Sun, Kexin / Jiang, Haiyue

    Biotechnology and bioengineering

    2023  Band 120, Heft 5, Seite(n) 1423–1436

    Abstract: Elastic cartilage possesses many elastic fibers and has a high degree of elasticity. However, insufficient elastic fiber production remains unsolved in elastic cartilage tissue engineering. Exogenous elastin is difficult to degrade and violates cell ... ...

    Abstract Elastic cartilage possesses many elastic fibers and has a high degree of elasticity. However, insufficient elastic fiber production remains unsolved in elastic cartilage tissue engineering. Exogenous elastin is difficult to degrade and violates cell proliferation and migration during cartilage regeneration. Moreover, exogenous elastic fibers are difficult to assemble with endogenous extracellular matrix components. We produced genetically engineered chondrocytes overexpressing elastin to boost endogenous elastic fiber production. After identifying that genetic manipulation hardly impacted the cell viability and chondrogenesis of chondrocytes, we co-cultured genetically engineered chondrocytes with untreated chondrocytes in a three-dimensional gelatin methacryloyl (GelMA) system. In vitro study showed that the co-culture system produced more elastic fibers and increased cell retention, resulting in strengthened mechanics than the control system with untreated chondrocytes. Moreover, in vivo implantation revealed that the co-culture GelMA system greatly resisted host tissue invasion by promoting elastic fiber production and cartilage tissue regeneration compared with the control system. In summary, our study indicated that genetically engineered chondrocytes overexpressing elastin are efficient and safe for promoting elastic fiber production and cartilage regeneration in elastic cartilage tissue engineering.
    Mesh-Begriff(e) Chondrocytes ; Elastin/genetics ; Elastin/metabolism ; Chondrogenesis/genetics ; Cartilage ; Tissue Engineering/methods ; Cells, Cultured
    Chemische Substanzen gelatin methacryloyl ; Elastin (9007-58-3)
    Sprache Englisch
    Erscheinungsdatum 2023-01-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.28330
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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