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  1. Article ; Online: Intrathermocline eddies observed in the northwestern subtropical Pacific Ocean

    Shangzhan Cai / Jiang Huang / Weibo Wang / Chunsheng Jing / Jindian Xu / Kai Li / Fangfang Kuang

    Frontiers in Marine Science, Vol

    2024  Volume 11

    Abstract: Two anticyclonic intrathermocline eddies (ITEs) were detected by an underwater glider in the northwestern subtropical Pacific Ocean during August-October 2019. They both exhibited a lens-shaped vertical structure within the thermocline with their cores ... ...

    Abstract Two anticyclonic intrathermocline eddies (ITEs) were detected by an underwater glider in the northwestern subtropical Pacific Ocean during August-October 2019. They both exhibited a lens-shaped vertical structure within the thermocline with their cores located at ~170 m. The North Pacific Subtropical Mode Water (STMW) was found within the cores of these two ITEs. The lens-shaped structure of ITE1 observed by the glider was very clear since the glider seemed to have moved into its core during the observation. Further analysis reveals that ITE1 displayed no signals at the sea surface and lasted for about 20 days (26 August-14 September 2019). ITE1 was locally formed and the water inside it was a mixture of local water and the water in the northern adjacent area. The low-salinity water at 0-50 m from the northern adjacent area extended southwestward and mixed with the local water. As a result, the local salinity-forced restratification caused a potential vorticity (PV) decrease in the subsurface and finally resulted in the generation of ITE1. The baroclinic instability at 50-170 m may be the main energy source for ITE1 generation. On the other hand, the lens-shaped structure of ITE2 observed by the glider was less prominent since the glider did not move into its core. Further analysis reveals that the lens-shaped structure of ITE2 was also very clear near its core and ITE2 displayed clear signals at the surface as an anticyclonic eddy (AE2). AE2/ITE2 was remotely generated within the main formation region of STMW and then moved southwestward. The low PV STMW was trapped in AE2 and a lens-shaped structure developed in the subsurface. Subduction of the STMW caused the generation of ITE2.
    Keywords intrathermocline eddies ; lens-shaped structure ; STMW ; potential vorticity ; stratification ; northwestern subtropical Pacific Ocean ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Subject code 551
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Microstructure and properties analysis of Ni60-based/WC composite coatings prepared by laser cladding.

    Jiang, Huang / Zhikai, Zhu / Wenqing, Shi / Yang, Zhao / Tianwen, Jiao / Kaiyue, Li

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24494

    Abstract: In this study, Ni60-WCx coatings (x = 0, 2, 4, 6 %) on 316L stainless steel (316Lss) were prepared via laser cladding technology. We examined all specimens s for microstructure, phase composition, microhardness and electrochemistry using several ... ...

    Abstract In this study, Ni60-WCx coatings (x = 0, 2, 4, 6 %) on 316L stainless steel (316Lss) were prepared via laser cladding technology. We examined all specimens s for microstructure, phase composition, microhardness and electrochemistry using several characterization techniques. It shows that the microstructure of the Ni-based coatings can be changed with WC powder. When the WC ratio is 2 %, crystalline crystals and cellular crystals can be found in the coating. As the WC ratio increases, more cellular crystals and fewer spiny crystals appear in the coating. When the WC ratio changes to 6 %, only cellular crystals can be found in the coating. The microhardness resultsshow that the Ni-based overcoat with added WC has a better microhardness compared to the pure Ni coating, and its average value of the coating area reaches a maximum value of 822.8 HV at a WC ratio of 2 %. That is due to the addition of WC which can cause regime transition. In addition, the Ni-based coating has better corrosion properties due to its different microstructure. When the WC ratio is 2 %, the specimen possesses the maximum Ecorr and smaller icorr with the best corrosion resistance.
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Paternal genetic structure analysis of the modern Han populations based on Y-SNP and Y-STR.

    Xin, Zhu / Xin, Jin / Jun, Liu / Lan, Yang / Li-Xin, Zou / Cai-Xia, Li / Jiang, Huang / Li, Jiang

    Yi chuan = Hereditas

    2024  Volume 46, Issue 2, Page(s) 149–167

    Abstract: The Han populations represent the largest ethnic group in China. Previous studies have primarily focused on investigating their genetic origins, migration and integration, as well as paternal genetic relationships within specific regional Han populations. ...

    Abstract The Han populations represent the largest ethnic group in China. Previous studies have primarily focused on investigating their genetic origins, migration and integration, as well as paternal genetic relationships within specific regional Han populations. However, a comprehensive analysis of the global paternal genetic structure of Han populations is lacking. In this study, we performed Y-chromosome sequencing on 362 unrelated male samples from Chinese Han individuals collected from Qinghai, Sichuan and Liaoning provinces. We then integrated relevant data from reported studies. Our final dataset comprised 1830 samples from 16 Han populations across 15 provinces in China, encompassing information on 89 Y-SNPs and 16 Y-STRs. Statistical analyses were conducted to assess Y-STR haplotype diversity (HD) and Y-SNP haplogroup frequencies. Additionally, we employed principal component analysis (PCA), phylogenetic tree and haplotype network to explore genetic differentiation within Han populations and the genetic relationships between Han populations and ethnic minorities surrounding them. Our results demonstrated that the O-M175 haplogroup represents the predominant paternal lineage in Han populations, with frequencies ranging from 60.53% (Qinghai Han) to 92.7% (Guangdong Han). Moreover, the subclades downstream of O-M175 showed distinct regional variations in their distribution patterns. The O2-M122 haplogroup was prevalent in all Han populations and demonstrated a gradual decline in frequency from north to south. Conversely, the distribution frequency of the O1b-M268 haplogroup decreased from south to north, particularly showed significant presence among Han populations in the Lingnan region. Haplogroup O1a-M119 distributed more frequently in the central Han populations. Our findings revealed that Chinese Han populations can be categorized into three subgroups: northern, central, and southern. Notably, there were significant differences among Han in Qinghai and other regions. Regarding the genetic relationships between Han populations and surrounding ethnic minorities, we observed a closer genetic affinity between different Han populations, but northern Han demonstrated a stronger relationship with the Hui ethnic group, while southern Han exhibited a closer connection with the Gelao and Li ethnic groups. In summary, this study presented a systematic analysis of haplogroup distribution, genetic substructure of Han populations and genetic relationships between Han populations and surrounding ethnic minorities based on 89 Y-SNPs and 16 Y-STRs systematically. Our research supplemented valuable insights into population genetics and forensic genetics, and provided data support for the forensic application of Y chromosome. The integration of Y-SNP haplogroups with Y-STR haplotypes offers enhanced understanding of the genetic substructure within Han populations, which holds significance for both population genetics research and forensic science applications.
    MeSH term(s) Humans ; Polymorphism, Single Nucleotide ; Phylogeny ; Microsatellite Repeats ; Genetics, Population ; Ethnicity/genetics ; Haplotypes ; Chromosomes, Human, Y/genetics ; China
    Language English
    Publishing date 2024-02-10
    Publishing country China
    Document type Journal Article
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.16288/j.yczz.23-260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Insight into forensic efficiency and genetic structure of the Guizhou Dong group via a 64-plex panel

    Wen Wan / Zheng Ren / Hongling Zhang / Qiyan Wang / Ting Wang / Yunteng Yang / Jiangtao You / Kun He / Jiang Huang / Xiaoye Jin

    Frontiers in Ecology and Evolution, Vol

    2023  Volume 10

    Abstract: Insertion/deletion polymorphisms (InDels) show great application values in forensic research because they own superiorities of short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs). Whereas, InDels commonly display low genetic ... ...

    Abstract Insertion/deletion polymorphisms (InDels) show great application values in forensic research because they own superiorities of short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs). Whereas, InDels commonly display low genetic diversities in comparison to STRs. Therefore, they may provide limited genetic information in forensic kinship testing. Here, we evaluated forensic application efficiency of a novel multiplex amplification system including two STRs, 59 InDels, and three sex-determination loci in the Guizhou Dong group. In addition, we explored the genetic background of the Guizhou Dong group in comparison to other reported populations based on 59 InDels. We found that 59 InDels displayed relatively high genetic diversities in the Guizhou Dong group. Moreover, the cumulative forensic efficiency of two STRs and 59 InDels could meet the requirement of individual identification and paternity testing in the Guizhou Dong group. For these 59 InDels, we observed that some loci exhibited relatively high genetic differentiations among different continental populations, especially for African and Non-African populations, which could be viewed as candidate ancestry informative markers in the future. Genetic structure results indicated that the Dong group had close genetic relationships with East Asian and some Southern Chinese Han populations. To sum up, we stated that the 64-plex panel could be performed for forensic application of the Guizhou Dong group.
    Keywords InDels ; Dong ; STR ; forensic application ; population genetic background ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Subject code 590
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Luteolin Ameliorates Methamphetamine-Induced Podocyte Pathology by Inhibiting Tau Phosphorylation in Mice

    Jiuyang Ding / Yuanhe Wang / Zhuo Wang / Shanshan Hu / Zhu Li / Cuiyun Le / Jian Huang / Xiang Xu / Jiang Huang / Pingming Qiu

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Volume 2022

    Abstract: Methamphetamine (METH) can cause kidney dysfunction. Luteolin is a flavonoid compound that can alleviate kidney dysfunction. We aimed to observe the renal-protective effect of luteolin on METH-induced nephropathies and to clarify the potential mechanism ... ...

    Abstract Methamphetamine (METH) can cause kidney dysfunction. Luteolin is a flavonoid compound that can alleviate kidney dysfunction. We aimed to observe the renal-protective effect of luteolin on METH-induced nephropathies and to clarify the potential mechanism of action. The mice were treated with METH (1.0–20.0 mg/kg/d bodyweight) for 14 consecutive days. Morphological studies, renal function, and podocyte specific proteins were analyzed in the chronic METH model in vivo. Cultured podocytes were used to support the protective effects of luteolin on METH-induced podocyte injury. We observed increased levels of p-Tau and p-GSK3β and elevated glomerular pathology, renal dysfunction, renal fibrosis, foot process effacement, macrophage infiltration, and podocyte specific protein loss. Inhibition of GSK3β activation protected METH-induced kidney injury. Furthermore, luteolin could obliterate glomerular pathologies, inhibit podocyte protein loss, and stop p-Tau level increase. Luteolin could also abolish the METH-induced podocyte injury by inactivating GSK3β-p-Tau in cultured podocytes. These results indicate that luteolin might ameliorate methamphetamine-induced podocyte pathology through GSK3β-p-Tau axis.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 616
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Physiological Ovarian Aging Is Associated with Altered Expression of Post-Translational Modifications in Mice

    Minli Wei / Jia Li / Huili Yan / Tao Luo / Jiang Huang / Yangyang Yuan / Liaoliao Hu / Liping Zheng

    International Journal of Molecular Sciences, Vol 23, Iss 2, p

    2022  Volume 2

    Abstract: Post-translational modifications (PTMs) have been confirmed to be involved in multiple female reproductive events, but their role in physiological ovarian aging is far from elucidated. In this study, mice aged 3, 12 or 17 months (3M, 12M, 17M) were ... ...

    Abstract Post-translational modifications (PTMs) have been confirmed to be involved in multiple female reproductive events, but their role in physiological ovarian aging is far from elucidated. In this study, mice aged 3, 12 or 17 months (3M, 12M, 17M) were selected as physiological ovarian aging models. The expression of female reproductive function-related genes, the global profiles of PTMs, and the level of histone modifications and related regulatory enzymes were examined during physiological ovarian aging in the mice by quantitative real-time PCR and western blot, respectively. The results showed that the global protein expression of Kbhb (lysineβ-hydroxybutyryllysine), Khib (lysine 2-hydroxyisobutyryllysine), Kglu (lysineglutaryllysine), Kmal (lysinemalonyllysine), Ksucc (lysinesuccinyllysine), Kcr (lysinecrotonyllysine), Kbu (lysinebutyryllysine), Kpr (lysinepropionyllysine), SUMO1 (SUMO1 modification), ub (ubiquitination), P-Typ (phosphorylation), and 3-nitro-Tyr (nitro-tyrosine) increased significantly as mice aged. Moreover, the modification level of Kme2 (lysinedi-methyllysine) and Kac (lysineacetyllysine) was the highest in the 3M mice and the lowest in 12M mice. In addition, only trimethylation of histone lysine was up-regulated progressively and significantly with increasing age ( p < 0.001), H4 ubiquitination was obviously higher in the 12M and 17M mice than 3M ( p < 0.001), whereas the modification of Kpr (lysinepropionylation) and O-GlcNA in 17M was significantly decreased compared with the level in 3M mice ( p < 0.05, p < 0.01). Furthermore, the expression levels of the TIP60, P300, PRDM9, KMT5B, and KMT5C genes encoding PTM regulators were up-regulated in 17M compared to 3M female mice ( p < 0.05). These findings indicate that altered related regulatory enzymes and PTMs are associated with physiological ovarian aging in mice, which is expected to provide useful insights for the delay of ovarian aging and the diagnosis and treatment of female infertility.
    Keywords physiological ovarian aging ; histone modifications ; female reproductive functions ; post-translational modifications ; mice ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Histopathology, immunoenzyme activity and transcriptome analysis of immune response in silver pomfret infected by cryptokaryon (Cryptorchidism irritant)

    Wang, Guanlin / Hu, Jiabao / Zhang, Man / Zhang, Youyi / Li, Yaya / Jiang, Huang / Wang, Xiangbing / Zhu, Jiajie / Xu, Shanliang / Wang, Yajun / Yan, Xiaojun

    Fish and Shellfish Immunology. 2023 Apr. 11, p.108731-

    2023  , Page(s) 108731–

    Abstract: Cryptorchidism irritant (CI) infection is a major problem in the culturing process of silver pomfret (Pampus argenteus), which can result in rapid and massive death. However, there is limited information available on the immune response of silver pomfret ...

    Abstract Cryptorchidism irritant (CI) infection is a major problem in the culturing process of silver pomfret (Pampus argenteus), which can result in rapid and massive death. However, there is limited information available on the immune response of silver pomfret infected by CI. To address this gap, we sampled naturally infected fish and observed milky white translucent oval CI trophozoites on the gills, body surface, and fin rays. Histological analysis showed that CI infection led to vacuolation of epithelial cells and a decrease in blood cells in the gills. We also performed transcriptome profiling of the gill, kidney complex, and spleen, generating 399,616,194 clean reads that assembled into 101,228 unigenes, which were annotated based on public databases. We detected 14,369 differentially expressed genes, and selected several key immune-related genes for further validation using RT-qPCR. The Graft-versus-host pathway and Allograft rejection pathway were enriched in the gills, leading to inflammation and ulceration. CI infection activated the immune system, increasing levels of interleukin-1 beta and MHC class II antigen, and also activated innate and acquired immune genes in silver pomfret. Furthermore, we measured the activities of five immune-related enzymes (SOD, AKP, CAT, CSH and ACP), which all increased to varying degrees after CI infection. Our findings enhance our understanding of the immune response of fish to parasitic infection and may contribute to the development of strategies to prevent high mortality in CI-stimulated fish in aquaculture.
    Keywords Pampus argenteus ; antigens ; aquaculture ; blood ; cryptorchidism ; death ; epithelium ; fish ; gene expression regulation ; graft rejection ; histology ; histopathology ; inflammation ; interleukin-1beta ; kidneys ; mortality ; parasitoses ; shellfish ; spleen ; transcriptome ; transcriptomics ; trophozoites ; unigenes ; Cryptorchidism irritant ; Silver pomfret ; Immunity ; Peroxide ; Dyspnoea
    Language English
    Dates of publication 2023-0411
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2023.108731
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Forensic efficiency evaluation of a novel multiplex panel of InDels and STRs in the Guizhou Han population and its phylogenetic relationships with other reference populations

    Yanhua Zheng / Ting Wang / Kun He / Yunteng Yang / Jiangtao You / Xiaolan Huang / Hongling Zhang / Zheng Ren / Qiyan Wang / Jiang Huang / Xiaoye Jin

    Annals of Human Biology, Vol 50, Iss 1, Pp 42-

    2023  Volume 47

    Abstract: Background Insertion/deletion polymorphism (InDel), as the third genetic marker, has been given a lot of attention by forensic geneticists since it has the advantages of extensive distributions in the human genome, small amplicon, and low mutation rate. ... ...

    Abstract Background Insertion/deletion polymorphism (InDel), as the third genetic marker, has been given a lot of attention by forensic geneticists since it has the advantages of extensive distributions in the human genome, small amplicon, and low mutation rate. However, the extant InDel panels were only viewed as supplemental tools for kinship analyses. In addition, these panels were not conductive to mixture deconvolution because InDels in these panels mainly displayed two alleles. Aims The purpose of this study is to investigate genetic distributions of a novel panel of InDels and STRs in the Guizhou Han population; assess the forensic application value of the panel; and conduct population genetic analyses of the Guizhou Han and other reference populations based on the overlapping loci. Subjects and methods The bloodstain samples of 209 Guizhou Han were gathered and genotyped by the novel panel. Allelic frequencies and forensic parameters of two miniSTRs and 59 InDels in the panel were estimated. In addition, we assessed phylogenetic relationships among the Guizhou Han and other reference populations by principal component analysis, DA genetic distance, and neighbor-joining tree. Results A total of 139 alleles of 61 loci could be observed in the Guizhou Han population. Polymorphic information content values of 59 InDels were greater than 0.3 in the Guizhou Han population. The cumulative power of discrimination and probability of exclusion of two miniSTRs and 59 InDels in the Guizhou Han population were 0.999999999999999999999999997984 and 0.9999986, respectively. Principal component analysis of 14 populations showed that the Guizhou Han population located closer to Hunan Han and Southern Han Chinese (CHS) populations. Similar results were also discerned from DA genetic distances and the neighbor-joining tree. Conclusion To sum up, the novel panel could be employed for forensic personal identification and paternity testing in the Guizhou Han population as a promising independent tool. Besides, the principal component ...
    Keywords indel ; str ; guizhou han ; principal component analysis ; population genetic analysis ; Biology (General) ; QH301-705.5 ; Human anatomy ; QM1-695 ; Physiology ; QP1-981
    Subject code 590
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low‐density lipoprotein‐induced injury of cardiac microvascular endothelial cells

    Ke Hu / Min‐Jiang Huang / Sha Ling / Yu‐Xian Li / Xiang‐Yu Cao / Yue‐Fu Chen / Jian‐Ming Lei / Wen‐Zhe Fu / Bi‐Feng Tan

    Kaohsiung Journal of Medical Sciences, Vol 39, Iss 8, Pp 758-

    2023  Volume 768

    Abstract: Abstract Long noncoding RNAs (LncRNAs) are essential to regulate the pathogenesis of coronary artery disease (CAD). This study was conducted to analyze the functionality of long noncoding RNA cancer susceptibility candidate 11 (lncRNA CASC11) in oxidized ...

    Abstract Abstract Long noncoding RNAs (LncRNAs) are essential to regulate the pathogenesis of coronary artery disease (CAD). This study was conducted to analyze the functionality of long noncoding RNA cancer susceptibility candidate 11 (lncRNA CASC11) in oxidized low‐density lipoprotein (ox‐LDL)‐induced injury of cardiac microvascular endothelial cells (CMECs). CMECs were treated with ox‐LDL to induce the CAD cell model. The cellular expression levels of CASC11 and histone deacetylase 4 (HDAC4) were determined by real‐time quantitative polymerase chain reaction or Western blot assay. Cell absorbance, apoptosis, angiogenesis, and inflammation were evaluated by cell counting kit‐8, flow cytometry, tube formation, and enzyme‐linked immunosorbent assays. The subcellular localization of CASC11 was examined by the nuclear/cytoplasmic fractionation assay. The binding of human antigen R (HuR) to CASC11 and HDAC4 was analyzed by RNA immunoprecipitation. HDAC4 stability was determined after actinomycin D treatment. CASC11 was found to be decreased in the CAD cell model. CASC11 upregulation increased cell viability and angiogenesis and reduced apoptosis and inflammation. CASC11 bound to HuR and improved HDAC4 expression. HDAC4 downregulation counteracted the protective role of CASC11 overexpression in CMECs. In summary, CASC11 alleviated ox‐LDL‐induced injury of CMECs by binding to HuR and stabilizing HDAC4.
    Keywords cell injury ; coronary artery disease ; HDAC4 ; LncRNA CASC11 ; microvascular endothelial cells ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Comprehensive analyses of genetic diversities and population structure of the Guizhou Dong group based on 44 Y-markers

    Hongling Zhang / Xiaolan Huang / Xiaoye Jin / Zheng Ren / Qiyan Wang / Meiqing Yang / Ronglan Xu / Xiang Yuan / Daiquan Yang / Hongyan Liu / Wanyi Shen / Huiying Zhang / Yangjie Que / Jiang Huang

    PeerJ, Vol 11, p e

    2023  Volume 16183

    Abstract: Background The non-recombining region of the human Y chromosome (NRY) is a strictly paternally inherited genetic marker and the best material to trace the paternal lineages of populations. Y chromosomal short tandem repeat (Y-STR) is characterized by ... ...

    Abstract Background The non-recombining region of the human Y chromosome (NRY) is a strictly paternally inherited genetic marker and the best material to trace the paternal lineages of populations. Y chromosomal short tandem repeat (Y-STR) is characterized by high polymorphism and paternal inheritance pattern, so it has been widely used in forensic medicine and population genetic research. This study aims to understand the genetic distribution of Y-STRs in the Guizhou Dong population, provide reference data for forensic application, and explore the phylogenetic relationships between the Guizhou Dong population and other comparison populations. Methods Based on the allele profile of 44 Y-markers in the Guizhou Dong group, we estimate their allele frequencies and haplotype frequencies. In addition, we also compare the forensic application efficiency of different Y-STR sets in the Guizhou Dong group. Finally, genetic relationships among Guizhou Dong and other reference populations are dissected by the multi-dimensional scaling and the phylogenetic tree. Results A total of 393 alleles are observed in 312 Guizhou Dong individuals for these Y-markers, with allele frequencies ranging from 0.0032 to 0.9679. The haplotype diversity and discriminatory capacity for these Y-markers in the Guizhou Dong population are 0.99984 and 0.97440, respectively. The population genetic analyses of the Guizhou Dong group and other reference populations show that the Guizhou Dong group has the closest genetic relationship with the Hunan Dong population, and followed by the Guizhou Tujia population. Conclusions In conclusion, these 44 Y-markers can be used as an effective tool for male differentiation in the Guizhou Dong group. The haplotype data in this study not only enrich the Y-STR data of different ethnic groups in China, but also have important significance for population genetics and forensic research.
    Keywords Guizhou Dong ; Forensic features ; Population genetics ; STR ; Y-chromosome ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 590
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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