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  1. Article ; Online: Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes.

    Xie, Wenzhi / Jiang, Jinyu / Shu, Dunji / Zhang, Yanjun / Yang, Sheng / Zhang, Kai

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 10

    Abstract: Biothiols such as cysteine, homocysteine, and glutathione play significant roles in important biological activities, and their abnormal concentrations have been found to be closely associated with certain diseases, making their detection a critical task. ...

    Abstract Biothiols such as cysteine, homocysteine, and glutathione play significant roles in important biological activities, and their abnormal concentrations have been found to be closely associated with certain diseases, making their detection a critical task. To this end, fluorescent probes have become increasingly popular due to their numerous advantages, including easy handling, desirable spatiotemporal resolution, high sensitivity, fast response, and favorable biocompatibility. As a result, intensive research has been conducted to create fluorescent probes for the detection and imaging of biothiols. This brief review summarizes recent advances in the field of biothiol-responsive fluorescent probes, with an emphasis on rational probe design, including the reaction mechanism, discriminating detection, reversible detection, and specific detection. Furthermore, the challenges and prospects of fluorescence probes for biothiols are also outlined.
    MeSH term(s) Fluorescent Dyes ; Cysteine ; Glutathione ; Homocysteine ; Spectrometry, Fluorescence/methods
    Chemical Substances Fluorescent Dyes ; Cysteine (K848JZ4886) ; Glutathione (GAN16C9B8O) ; Homocysteine (0LVT1QZ0BA)
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28104252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article: Changes of inflammatory factors in patients after resection of lung adenocarcinoma with propofol and etomidate.

    Zheng, Xianjun / Wei, Lai / Kong, Gaoyin / Jiang, Jinyu

    American journal of translational research

    2021  Volume 13, Issue 12, Page(s) 14081–14088

    Abstract: Objective: This research was designed to investigate the changes of inflammatory factors in patients after resection of lung adenocarcinoma with propofol versus etomidate.: Methods: A total of 104 patients who underwent resection of lung ... ...

    Abstract Objective: This research was designed to investigate the changes of inflammatory factors in patients after resection of lung adenocarcinoma with propofol versus etomidate.
    Methods: A total of 104 patients who underwent resection of lung adenocarcinoma in our hospital were divided into a propofol group (group A, n=50) and an etomidate group (group B, n=54). The levels of CRP and IL-6 at different time points and the changes of blood gas indexes at 10 min before and after operation were observed in both groups. Their pain score and quality of life score were compared. Besides, we observed the wake-up time, tracheal extubation time and the incidence of adverse reactions.
    Results: The anesthesia recovery and tracheal extubation time in group B were shorter than those in group A (
    Conclusion: Etomidate has better anesthetic effect than propofol in lung adenocarcinoma resection, leading to better stabilization of the vital signs of patients and it also has higher safety.
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Unveiling the Critical Role of Ion Coordination Configuration of Ether Electrolytes for High Voltage Lithium Metal Batteries.

    Chen, Shunqiang / Fan, JiaJia / Cui, Zhuangzhuang / Tan, Lijiang / Ruan, Digen / Zhao, Xin / Jiang, Jinyu / Jiao, Shuhong / Ren, Xiaodi

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 23, Page(s) e202219310

    Abstract: Albeit ethers are favorable electrolyte solvents for lithium (Li) metal anode, their inferior oxidation stability (<4.0 V vs. Li/ ... ...

    Abstract Albeit ethers are favorable electrolyte solvents for lithium (Li) metal anode, their inferior oxidation stability (<4.0 V vs. Li/Li
    Language English
    Publishing date 2023-04-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202219310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular anchoring of free solvents for high-voltage and high-safety lithium metal batteries.

    Cui, Zhuangzhuang / Jia, Zhuangzhuang / Ruan, Digen / Nian, Qingshun / Fan, Jiajia / Chen, Shunqiang / He, Zixu / Wang, Dazhuang / Jiang, Jinyu / Ma, Jun / Ou, Xing / Jiao, Shuhong / Wang, Qingsong / Ren, Xiaodi

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2033

    Abstract: Constraining the electrochemical reactivity of free solvent molecules is pivotal for developing high-voltage lithium metal batteries, especially for ether solvents with high Li metal compatibility but low oxidation stability ( <4.0 V vs ... ...

    Abstract Constraining the electrochemical reactivity of free solvent molecules is pivotal for developing high-voltage lithium metal batteries, especially for ether solvents with high Li metal compatibility but low oxidation stability ( <4.0 V vs Li
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46186-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Strongly Solvating Ether Electrolytes for High-Voltage Lithium Metal Batteries.

    Chen, Shunqiang / Zhu, Weiduo / Tan, Lijiang / Ruan, Digen / Fan, JiaJia / Chen, Yunhua / Meng, Xianhui / Nian, Qingshun / Zhao, Xin / Jiang, Jinyu / Wang, Zihong / Jiao, Shuhong / Wu, Xiaojun / Ren, Xiaodi

    ACS applied materials & interfaces

    2023  Volume 15, Issue 10, Page(s) 13155–13164

    Abstract: Ethers are promising electrolytes for lithium (Li) metal batteries (LMBs) because of their unique stability with Li metal. Although intensive research on designing anion-enriched electrolyte solvation structures has greatly improved their electrochemical ...

    Abstract Ethers are promising electrolytes for lithium (Li) metal batteries (LMBs) because of their unique stability with Li metal. Although intensive research on designing anion-enriched electrolyte solvation structures has greatly improved their electrochemical stabilities, ether electrolytes are approaching an anodic bottleneck. Herein, we reveal the strong correlation between electrolyte solvation structure and oxidation stability. In contrast to previous designs of weakly solvating solvents for enhanced anion reactivities, the triglyme (G3)-based electrolyte with the largest Li
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c00165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Chromosome-scale Cerasus humilis genome assembly reveals gene family evolution and possible genomic basis of calcium accumulation in fruits

    Zhao, Yang / Fu, Guangjun / Jiang, Jinyu / Li, Yingchao / Liu, Xiaojuan / Li, Jian / Sun, Jingyu / Wang, Qi / Liu, Donglin / Luo, Zhumei / Ding, Shuxia / Bi, Quanxin / Shi, Changchun / Wang, Libing

    Scientia horticulturae. 2022 June 01, v. 299

    2022  

    Abstract: Chinese dwarf cherry (Cerasus humilis), which is well known as “calcium fruit” for its high calcium content, is widely utilized in North China for its ecological and economical value. Understanding the evolutionary history and genetic basis underlying ... ...

    Abstract Chinese dwarf cherry (Cerasus humilis), which is well known as “calcium fruit” for its high calcium content, is widely utilized in North China for its ecological and economical value. Understanding the evolutionary history and genetic basis underlying the calcium accumulation in this fruit is a fundamental goal in comparative genomics. In this study, we obtained a full phased chromosome-scale C. humilis genome for the cultivar “zhisha” using PacBio circular consensus sequencing reads and Phase genomics Proximo Hi-C technologies. The final assembled genome lengths were 235.41 and 237.35 Mb for primary assembly (p0) and alternate haplotig (p1), respectively, with an N50 contig length of 3.23 Mb. The genome contained 26,800 protein-coding genes, while 41.33% of the genome length consisted of TEs. Phylogenetic analysis revealed that C. humilis displayed a close relationship with Prunus and phylogenetically diverged from its common ancestor ∼23.2 million years ago (MYA). Functional enrichment of expanded gene families in C. humilis genome highlighted genes involved in signal transduction, antiporter activity, polygalacturonase activity, auxin efflux transmembrane transporter activity, and auxin efflux, which is related to calcium transport and distribution. Phylogenetic analysis coupled with tissue-specific expression patterns indicated that PSGs WAK2 and CBL10, may also be responsible for the high Ca²⁺accumulation ability in C. humilis. These results glean tremendous insight into the fundamental genetic basis of the high calcium content in C. humilis fruit. In addition, the reference C. humilis genome we present in this study will be valuable resources for molecular breeding and genetic research of this fruit species.
    Keywords Prunus ; ancestry ; antiporters ; auxins ; calcium ; cherries ; cultivars ; fruits ; genes ; genome assembly ; genomics ; phylogeny ; polygalacturonase ; signal transduction ; China
    Language English
    Dates of publication 2022-0601
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 185557-8
    ISSN 0304-4238
    ISSN 0304-4238
    DOI 10.1016/j.scienta.2022.111012
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2810: Show issues

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  7. Article: [Transfection of hBcl-2 gene protects the liver against ischemia/reperfusion injury in rats during liver transplantation].

    Liu, Ji-tong / Liu, Jing-shi / Jiang, Jin-yu / Zhou, Li-xue / Liang, Gang / Li, Yan-chun

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2010  Volume 30, Issue 12, Page(s) 2679–2682

    Abstract: Objective: To study the effect of hBcl-2 gene transfer on rat liver against ischemia-reperfusion injury, and explore the feasibility of this approach to reduce ischemia-reperfusion injury in liver transplantation.: Methods: We constructed the ... ...

    Abstract Objective: To study the effect of hBcl-2 gene transfer on rat liver against ischemia-reperfusion injury, and explore the feasibility of this approach to reduce ischemia-reperfusion injury in liver transplantation.
    Methods: We constructed the replication-deficient recombinant adenoviruses Adv-EGFP and Adv-Bcl-2 and transfected them into 293 cells and packaged into adenovirus particles for amplification and purification. The empty plasmid vector virus was constructed similarly. Male SD rats were randomized into Adv-Bcl-2-transfected group, Adv-EGFP-transfected group, ischemia-reperfusion group, and sham-operated group, and liver allograft transplantation model was established by sleeve method. In the transfected groups, the recombinant viruses were administered by perfusion through the portal vein, and the ischemia-reperfusion and sham-operated groups received no treatment. Real-time quantitative PCR and Western blotting were used to detect the mRNA and protein expressions of bcl-2 in the liver tissue of each group, and at 0, 60 and 180 min after reperfusion, serum AST, LDH, and MDA levels were measured. Histological changes of the liver cells were evaluated by HE staining.
    Results: Bcl-2 mRNA and protein expressions in Adv-Bcl-2-transfected group, as compared with those in Adv-EGFP-transfected group and control group, were significantly increased (P<0.01); the serum levels of AST, LDH and MDA in Adv-Bcl-2-transfected group were significantly lower than those of Adv-EGFP-transfected group and ischemia-reperfusion group (P<0.05 or 0.01). Compared with the sham-operated group, Adv-Bcl-2 treatment group showed lessened edema and vacuolar degeneration of the liver cells without patches or spots of necrosis. In ischemia-reperfusion and Adv-EGFP group, HE staining revealed hepatic lobular destruction and extensive liver cell swelling, enlargement, vacuolar degeneration, edema and occasional focal necrosis.
    Conclusion: Adv-Bcl-2 transfection can induce the expression of bcl-2 gene to reduce ischemia-reperfusion injury of the liver graft in rats.
    MeSH term(s) Animals ; Genes, bcl-2 ; Liver/blood supply ; Liver Transplantation ; Male ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; Transfection
    Language Chinese
    Publishing date 2010-12
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6344: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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