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Article: A case of maculopathy from rush poppers.

Guo, Si-Tong / Jiang, Li-Bin

2022 Volume 15, Issue 4, Page(s) 674–676

Language	English
Publishing date	2022-04-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2022.04.25
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Article: Rhizoma Dioscoreae Nipponicae Relieves Asthma by Inducing the Ferroptosis of Eosinophils and Inhibiting the p38 MAPK Signaling Pathway.

Jiang, Libin / Xu, Liying / Liu, Huazuo / Chen, Hanwen / Wang, Weiyi

Critical reviews in immunology

2024 Volume 44, Issue 2, Page(s) 77–87

Abstract: Rhizoma Dioscoreae Nipponicae (RDN) is a traditional Chinese medicine that widely applied in the treatment of human diseases. This study aims to explore the therapeutic potential of RDN in asthma and the underlying mechanisms. A mouse model of asthma was ...

Abstract	Rhizoma Dioscoreae Nipponicae (RDN) is a traditional Chinese medicine that widely applied in the treatment of human diseases. This study aims to explore the therapeutic potential of RDN in asthma and the underlying mechanisms. A mouse model of asthma was established by the stimulation of ovalbumin (OVA). HE staining was performed to detect the pathological injuries of tracheal tissues. The protein expression of collagen I, FN1, α-SMA (airway remodeling markers), and p-p38 (a marker of the p38 MAPK pathway) were detected by Western blot. Eosinophils were then isolated from the model mice. Cell viability and ROS level were measured by CCK-8 and Flow cytometry, respectively. The mRNA expression of GPX4 and ACSL4 (ferroptosis markers) in eosinophils were measured by qRT-PCR. RDN significantly reduced the numbers of total cells and eosnophils in bronchoalveolar lavage fluid (BALF), inhibited inflammatory cell infiltration, and down-regulated remodeling markers (Collagen I, FN1, and α-SMA) in OVA-induced mice. The p38 MAPK pathway was blocked by the intervention of RDN in the model mice, and its blocking weakens the poor manifestations of OVA-induced asthma. In addition, RDN induced the ferroptosis of eosnophils both in vitro and in vivo. Blocking of the p38 MAPK pathway also enhanced the ferroptosis of eosnophils in vitro, evidenced by the decreased cell viability and GPX4 expression, and increased ROS level and ACSL4 expression. RDN induced the ferroptosis of eosinophils through inhibiting the p38 MAPK pathway, contributing to the remission of asthma.
MeSH term(s)	Animals ; Humans ; Mice ; Asthma/metabolism ; Collagen/metabolism ; Disease Models, Animal ; Eosinophils/metabolism ; Ferroptosis ; Lung/pathology ; Ovalbumin/adverse effects ; p38 Mitogen-Activated Protein Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction
Chemical Substances	Collagen (9007-34-5) ; Ovalbumin (9006-59-1) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Reactive Oxygen Species
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1353116-5
ISSN	1040-8401
ISSN	1040-8401
DOI	10.1615/CritRevImmunol.2023050922
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Zs.A 1699: Show issues

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Article ; Online: Bilateral retrobulbar optic neuritis combined with optic perineuritis associated with atezolizumab treatment for small cell lung carcinoma.

Zhang, Jing / Wang, Lian / Zhang, Luyin / Liu, Hongjuan / Yang, Bentao / Jiang, Libin

European journal of ophthalmology

2024 Volume 34, Issue 3, Page(s) NP29–NP33

Abstract: Introduction: Ocular immune-related adverse events (OirAEs) associated with novel cancer therapies of immune checkpoint inhibitors (ICIs) are emerging. Retrobulbar optic neuritis (ON) combined with optic perineuritis (OPN), associated with atezolizumab, ...

Abstract	Introduction: Ocular immune-related adverse events (OirAEs) associated with novel cancer therapies of immune checkpoint inhibitors (ICIs) are emerging. Retrobulbar optic neuritis (ON) combined with optic perineuritis (OPN), associated with atezolizumab, has been rarely reported and has a unique clinical manifestation. Case description: A 67-year-old woman was diagnosed with small-cell lung cancer. As maintenance therapy, atezolizumab was administered continuously for 10 cycles for approximately 14 months. One week after the administration of the tenth dose of atezolizumab, the patient experienced a bilateral, successive painless visual decline. The fundus and the retinal nerve fiber layer revealed no abnormalities, but the ganglion cell of the macula disappeared loss. The concentric shrinking of the peripheral visual field of the left eye was noticed. Orbital MRI revealed bilateral optic nerve thickening and peripheral optic nerve sheath enhancement ("tram-track" and "doughnut" signs). Serology, cerebrospinal fluid results, and image examination ruled out common causes of vision decline, and the condition was identified as bilateral retrobulbar ON combined with OPN as a probable atezolizumab-related immune adverse event. Thereafter, atezolizumab was discontinued, and intravenous methylprednisolone pulse (IVMP) (160 mg/day for 5 days) plus intravenous immunoglobulin (20 g/day for 3 days) was administered. The patient's visual function considerably improved after three weeks. Conclusions: Retrobulbar ON and OPN associated with atezolizumab are rare side effects that are easily overlooked. Immune-related ON has unique features and requires early identification. The primary treatment for optic nerve irAEs is corticosteroids, but this is not standardized and should be used with caution.
MeSH term(s)	Humans ; Female ; Optic Neuritis/drug therapy ; Optic Neuritis/chemically induced ; Optic Neuritis/diagnosis ; Aged ; Small Cell Lung Carcinoma/drug therapy ; Lung Neoplasms/drug therapy ; Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Magnetic Resonance Imaging ; Visual Acuity ; Optic Nerve/pathology ; Tomography, Optical Coherence ; Visual Fields/physiology ; Methylprednisolone/therapeutic use ; Methylprednisolone/administration & dosage
Chemical Substances	atezolizumab (52CMI0WC3Y) ; Antibodies, Monoclonal, Humanized ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721231222659
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Zs.A 3342: Show issues

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Article ; Online: Visual function loss in fungal sphenoid sinusitis: clinical characteristics and outcomes.

Chen, Fei / Shao, Yonghui / Huang, Qian / Chen, Yue / Yang, Bentao / Jiang, Libin

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8649

Abstract: Potentially fatal fungal sphenoid sinusitis (FSS) causes visual damage. However, few studies have reported on its visual impairment and prognosis. Five hundred and eleven FSS patients with ocular complications treated at Beijing Tongren Hospital were ... ...

Abstract	Potentially fatal fungal sphenoid sinusitis (FSS) causes visual damage. However, few studies have reported on its visual impairment and prognosis. Five hundred and eleven FSS patients with ocular complications treated at Beijing Tongren Hospital were recruited and clinical features and visual outcomes were determined. Thirty-two of the 511 patients (6%) had visual impairment, with 13 and 19 patients having invasive and noninvasive FSS, respectively. Eighteen patients (56.25%) had diabetes and 2 patient (6.25%) had long-term systemic use of antibiotics (n = 1) and corticosteroids (n = 1). All patients had visual impairment, which was more severe in invasive FSS than in noninvasive FSS. Bony wall defects and sclerosis were observed in 19 patients (59.38%), and 11 patients (34.38%) had microcalcification in their sphenoid sinusitis on computed tomography (CT). After a 5-year follow-up, three patients (9.38%) died. Patients with noninvasive FSS had a higher improvement rate in visual acuity than their counterparts. In the multivariate analysis, sphenoid sinus wall sclerosis on CT was associated with better visual prognosis. FSS can cause vision loss with persistent headaches, particularly in those with diabetes. CT showed the sphenoid sinus wall sclerosis, indicating a better visual prognosis in FSS with visual impairment.
MeSH term(s)	Humans ; Sphenoid Sinusitis/complications ; Sphenoid Sinusitis/diagnostic imaging ; Sclerosis ; Sinusitis/complications ; Sinusitis/diagnostic imaging ; Sinusitis/microbiology ; Mycoses/complications ; Vision Disorders/complications ; Vision, Low/complications ; Retrospective Studies ; Diabetes Mellitus
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59107-2
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Article ; Online: Bilateral optic atrophy in Wilson disease: A case report and literature review.

Chen, Fei / Chen, Chunli / Zhang, Yang / Jiang, Libin / Huang, Zhiqin / Chen, Fred K

Clinics and research in hepatology and gastroenterology

2024 Volume 48, Issue 3, Page(s) 102299

Abstract: Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. The clinical manifestations of WD are complex and variable, with Kayser-Fleischer ring (K-F ring) and the sunflower cataract being the most common ocular findings. Visual ... ...

Abstract	Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. The clinical manifestations of WD are complex and variable, with Kayser-Fleischer ring (K-F ring) and the sunflower cataract being the most common ocular findings. Visual impairment is rare in patients with WD. We report the case of a 17-year-old female with bilateral optic atrophy associated with WD and summarize the clinical features of previously reported cases of optic neuropathy in WD, Clinicians should be aware that WD is a rare cause of optic neuropathy and that optic neuropathy in patients with WD may need to be recognized and screened.
MeSH term(s)	Female ; Humans ; Adolescent ; Hepatolenticular Degeneration/complications ; Hepatolenticular Degeneration/diagnosis ; Copper ; Optic Nerve Diseases/complications ; Optic Atrophy/complications
Chemical Substances	Copper (789U1901C5)
Language	English
Publishing date	2024-02-15
Publishing country	France
Document type	Review ; Case Reports
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2024.102299
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Article: Cryptococcal antigen testing of lung tissue homogenate improves pulmonary cryptococcosis diagnosis: Two case reports.

Wang, Wei-Yi / Zheng, Yu-Lu / Jiang, Li-Bin

World journal of clinical cases

2022 Volume 10, Issue 12, Page(s) 3893–3898

Abstract: Background: Pulmonary cryptococcosis (PC) is an opportunistic infectious disease of the respiratory system. Lung tissue biopsies, culture of respiratory samples (: Case summary: We report two female patients who underwent computed tomography-guided ... ...

Abstract	Background: Pulmonary cryptococcosis (PC) is an opportunistic infectious disease of the respiratory system. Lung tissue biopsies, culture of respiratory samples ( Case summary: We report two female patients who underwent computed tomography-guided percutaneous needle pulmonary biopsy of a lung nodule for a confirmed diagnosis. In both patients, the CrAg test on the lung biopsy tissue homogenate was positive, while the serum CrAg test was negative. Combined with the lung tissue pathology, we made the diagnosis of PC. Antifungal therapy was effective in both patients. Conclusion: Given the findings of our cases and the literature review, lung tissue homogenate CrAg testing can be helpful in improving the diagnosis of PC.
Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i12.3893
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Article ; Online: Intralobular pulmonary sequestration in the middle lobe supplied by a right internal mammary artery: a case report.

Gao, Rundi / Jiang, Libin / Ren, Zhe / Zhou, Linshui

BMC pulmonary medicine

2022 Volume 22, Issue 1, Page(s) 286

Abstract: Background: Pulmonary sequestration (PS) is a rare congenital malformation that is more common in the left lower lobe, and the thoracic aorta is the most common arterial supply.: Case presentation: We describe a case of a 67-year-old man with a chief ...

Abstract	Background: Pulmonary sequestration (PS) is a rare congenital malformation that is more common in the left lower lobe, and the thoracic aorta is the most common arterial supply. Case presentation: We describe a case of a 67-year-old man with a chief complaint of intermittent cough and hemoptysis who had been diagnosed by multidetector computed tomography angiography with right middle lobe intralobular pulmonary sequestration supplied by a right internal mammary artery. Finally, he underwent middle pulmonary lobectomy with normal postoperative recovery. Discussion: This is a rare intralobular pulmonary sequestration case for a feeding artery from the right internal mammary. Multidetector computed tomography angiography should be performed for diagnosis and preoperative evaluation once pulmonary sequestration is suspected.
MeSH term(s)	Aged ; Angiography/adverse effects ; Bronchopulmonary Sequestration/diagnostic imaging ; Bronchopulmonary Sequestration/surgery ; Hemoptysis/etiology ; Humans ; Lung/blood supply ; Lung/diagnostic imaging ; Male ; Mammary Arteries/diagnostic imaging ; Pulmonary Artery/abnormalities
Language	English
Publishing date	2022-07-26
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-022-02083-y
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Article: Oncocytic Carcinoma of the Cranio-Orbital Area: A Case Report.

Yang, Peng / Jiang, Libin / Liu, Honggang / Zhang, Jialiang / Kang, Jun

Frontiers in surgery

2022 Volume 9, Page(s) 897319

Abstract: Oncocytic carcinoma is a malignant tumor characterized by a proliferation of epithelial cells with abundant eosinophilic granular cytoplasm. In this article, we report on the first case of a 61-year-old male patient presenting with oncocytic carcinoma ... ...

Abstract	Oncocytic carcinoma is a malignant tumor characterized by a proliferation of epithelial cells with abundant eosinophilic granular cytoplasm. In this article, we report on the first case of a 61-year-old male patient presenting with oncocytic carcinoma involving the cranio-orbital area. An oncocytic carcinoma in the patient, who reported a sudden decrease in vision in his right eye, was removed through a frontal orbital approach craniotomy. The patient's postoperative development was rapid, and he was admitted to the neurosurgery department for a combined operation after ophthalmological screening. Pathological analysis revealed the tumour cells were large, round or polygonal, and the cytoplasm was finely granular and appeared to be more pleomorphic than the eosinophilic adenoma. Oncocytic carcinoma in the cranio-orbital area is extremely rare. The most effective treatment is early resection to be performed jointly by ophthalmology and neurosurgery, and long-term follow-up and adjuvant chemoradiotherapy are beneficial.
Language	English
Publishing date	2022-07-01
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.897319
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Article: A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Rhizoma Dioscoreae Nipponicae in the Treatment of Asthma.

Wang, Weiyi / Xu, Liying / Zhou, Lingming / Wan, Shanhong / Jiang, Libin

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 4749613

Abstract: Background: In this study, network pharmacological methods were used to analyze the targets of Rhizoma Dioscoreae Nipponicae (RDN) and investigate the potential underlying mechanism of RDN in the treatment of asthma.: Methods: Asthma-related targets ... ...

Abstract	Background: In this study, network pharmacological methods were used to analyze the targets of Rhizoma Dioscoreae Nipponicae (RDN) and investigate the potential underlying mechanism of RDN in the treatment of asthma. Methods: Asthma-related targets were obtained from the GeneCards and DisGeNET databases. The bioactive components of RDN were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database, and the targets of these compounds were predicted using the BATMAN-TCM database. The network of RDN component targets was constructed using Cytoscape. A protein-protein interaction (PPI) network was constructed in Cytoscape to determine the potential targets of RDN for the treatment of asthma. The hub genes of RDN in the treatment of asthma were screened using network topological parameters. Gene ontology (GO) and the KEGG pathways were analyzed. Molecular docking and in vivo experiments were performed to validate the network pharmacology results. Results: A total of four bioactive components and 55 targets were identified. The results of the enrichment analysis suggested that the treatment of asthma with RDN involved signaling pathways, such as those related to systemic lupus erythematosus, alcoholism, viral carcinogenesis, the cell cycle, prostate cancer, transcriptional misregulation in cancer, hepatitis B, thyroid hormone signaling, and PI3K-AKT signaling, as well as other signaling pathways. Molecular docking showed that the active components of RDN could stably bind to the predicted target. In vivo experiments showed that RDN could regulate the expression of target genes and inhibit the activation of the PI3K-AKT signaling pathway. Conclusion: To a certain extent, this study reveals the potential bioactive components and molecular mechanisms of RDN in the treatment of asthma and provides new insights for the development of new drugs for asthma.
Language	English
Publishing date	2022-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/4749613
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Zs.A 5995: Show issues

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Article ; Online: Dioscorea nipponica Makino Relieves Ovalbumin-Induced Asthma in Mice through Regulating RKIP-Mediated Raf-1/MEK/MAPK/ERK Signaling Pathway.

Wang, Weiyi / Xu, Liying / Zhou, Lingming / Wan, Shanhong / Jiang, Libin

publication RETRACTED

BioMed research international

2022 Volume 2022, Page(s) 8077058

Abstract: Purpose: Dioscorea nipponica Makino (DNM) is a traditional herb with multiple medicinal functions. This study is aimed at exploring the therapeutic effects of DNM on asthma and the underlying mechanisms involving RKIP-mediated MAPK signaling pathway.: ...

Abstract	Purpose: Dioscorea nipponica Makino (DNM) is a traditional herb with multiple medicinal functions. This study is aimed at exploring the therapeutic effects of DNM on asthma and the underlying mechanisms involving RKIP-mediated MAPK signaling pathway. Methods: An ovalbumin-induced asthma model was established in mice, which was further administrated with DNM and/or locostatin (RKIP inhibitor). ELISA was performed to detect the serum titers of OVA-IgE and OVA-IgG1, bronchoalveolar lavage fluid (BALF) levels of inflammation-related biomarkers, and tissue levels of oxidative stress-related biomarkers. The expression of RKIP was measured by quantitative real-time PCR, Western blot, immunohistochemistry, and immunofluorescence. HE staining was used to observe the pathological morphology of lung tissues. The protein expression of MAPK pathway-related proteins was detected by Western blot. Results: Compared with the controls, the model mice exhibited significantly higher serum titers of OVA-IgE and OVA-IgG1, BALF levels of IL-6, IL-8, IL-13, TGF- Conclusion: DNM relieves asthma via blocking the Raf-1/MEK/MAPK/ERK pathway that mediated by RKIP upregulation.
MeSH term(s)	Animals ; Asthma/chemically induced ; Asthma/drug therapy ; Asthma/metabolism ; Bronchoalveolar Lavage Fluid ; Cytokines/metabolism ; Dioscorea/chemistry ; Disease Models, Animal ; Immunoglobulin E/metabolism ; Immunoglobulin G/metabolism ; MAP Kinase Signaling System/drug effects ; Mice ; Mice, Inbred BALB C ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Ovalbumin ; Phosphatidylethanolamine Binding Protein/metabolism ; Plant Extracts/pharmacology ; Proto-Oncogene Proteins c-raf/metabolism
Chemical Substances	Cytokines ; Immunoglobulin G ; Phosphatidylethanolamine Binding Protein ; Plant Extracts ; Raf kinase inhibitory protein, mouse ; Immunoglobulin E (37341-29-0) ; Ovalbumin (9006-59-1) ; Proto-Oncogene Proteins c-raf (EC 2.7.11.1) ; Raf1 protein, mouse (EC 2.7.11.1) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
Language	English
Publishing date	2022-06-15
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/8077058
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