Artikel ; Online: Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation.
2023 Band 77, Heft 4, Seite(n) 677–687
Abstract: Type I and III interferons (IFNs) both serve as pivotal components of the host antiviral innate immune system. Although they exert similar antiviral effects, type I IFNs can also activate neutrophil inflammation, a function not born by type III IFNs. ... ...
| Abstract | Type I and III interferons (IFNs) both serve as pivotal components of the host antiviral innate immune system. Although they exert similar antiviral effects, type I IFNs can also activate neutrophil inflammation, a function not born by type III IFNs. Baicalin, the main bioactive component of Scutellariae radix, has been shown to exert therapeutic effects on viral diseases due to its anti-viral, anti-inflammatory and immunomulatory activities. There is uncertainty, however, on the association between the antiviral effects of baicalin and the modulation of anti-viral IFNs production and the immunological effects of type I IFNs. Here, a Poly (I:C)-stimulated A549 cell line was established to mimic a viral infection model. Our results demonstrated that baicalin could elevate the expression of type I and III IFNs and their receptors in Poly (I:C)-stimulated A549 cells. Moreover, the potential regulation effects of baicalin for type I IFN-induced neutrophil inflammation was further explored. Results showed that baicalin diminished the production of the pro-inflammatory cytokines (IL-1β, IL-6, IL-17 and TNF-α), ROS, and neutrophil extracellular traps and suppressed chemotaxis. Collectively, all these data indicated that baicalin had a dual role on IFNs production and effects: (1) Baicalin was able to elevate the expression of type I and III IFNs and their receptors, (2) and it alleviated type I IFN-mediated neutrophil inflammatory response. This meant that baicalin has the potential to act as an eximious immunomodulator, exerting antiviral effects and reducing inflammation. |
|---|---|
| Mesh-Begriff(e) | Humans ; Antiviral Agents/pharmacology ; Neutrophils/metabolism ; Interferon Type I/metabolism ; Inflammation/drug therapy |
| Chemische Substanzen | Antiviral Agents ; baicalin (347Q89U4M5) ; Interferon Type I |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-07-25 |
| Erscheinungsland | Japan |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2227540-X |
| ISSN | 1861-0293 ; 1340-3443 |
| ISSN (online) | 1861-0293 |
| ISSN | 1340-3443 |
| DOI | 10.1007/s11418-023-01702-0 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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