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Artikel ; Online: Intranasal oxytocin as a treatment for anxiety and autism: From subclinical to clinical applications.

Yin, Hailian / Jiang, Meiyun / Han, Tao / Xu, Xiaolei

2024 Band 176, Seite(n) 171211

Abstract: Animal and human studies have demonstrated that intranasal oxytocin (OT) can penetrate the brain and induce cognitive, emotional, and behavioral changes, particularly in social functioning. Consequently, numerous investigations have explored the ... ...

Abstract	Animal and human studies have demonstrated that intranasal oxytocin (OT) can penetrate the brain and induce cognitive, emotional, and behavioral changes, particularly in social functioning. Consequently, numerous investigations have explored the potential of OT as a treatment for anxiety and autism, conditions characterized by social deficits. Although both subclinical and clinical studies provide converging evidence of the therapeutic effects of OT in reducing anxiety levels and improving social symptoms in autism, results are not always consistent. Additionally, the pharmacological mechanism of OT requires further elucidation for its effective clinical application. Therefore, this review aims to examine the contentious findings concerning the effects of OT on anxiety and autism, offer interpretations of the inconsistent results from the perspectives of individual differences and varying approaches to OT administration, and shed light on the underlying mechanisms of OT. Ultimately, standardization of dosage, frequency of administration, formulation characteristics, and nasal spray devices is proposed as essential for future human studies and clinical applications of OT treatment.
Mesh-Begriff(e)	Oxytocin/administration & dosage ; Oxytocin/therapeutic use ; Oxytocin/pharmacology ; Humans ; Administration, Intranasal ; Anxiety/drug therapy ; Autistic Disorder/drug therapy ; Animals
Chemische Substanzen	Oxytocin (50-56-6)
Sprache	Englisch
Erscheinungsdatum	2024-04-03
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	769028-9
ISSN	1873-5169 ; 0196-9781
ISSN (online)	1873-5169
ISSN	0196-9781
DOI	10.1016/j.peptides.2024.171211
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Construction of arabinogalactans/selenium nanoparticles composites for enhancement of the antitumor activity

Tang, Shuo / Wang, Ting / Jiang, Meiyun / Huang, Caoxing / Lai, Chenhuan / Fan, Yimin / Yong, Qiang

International journal of biological macromolecules. 2019 May 01, v. 128

2019

Abstract: Selenium nanoparticles (SeNPs) were synthesized using arabinogalactans (LAG) as a formation scaffolding and particle stabilizer to investigate their anti-tumor properties. The formation, morphology, size, and in vitro biological activity of LAG-SeNPs ... ...

Abstract	Selenium nanoparticles (SeNPs) were synthesized using arabinogalactans (LAG) as a formation scaffolding and particle stabilizer to investigate their anti-tumor properties. The formation, morphology, size, and in vitro biological activity of LAG-SeNPs were characterized by UV–vis, FT-IR, scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS) and cell toxicity assays. SEM and TEM of LAG-SeNPs visualized the individual spherical nanoparticles, while the spectroscopic characterization revealed the modes of interaction which lead to the stable particle properties of the LAG-SeNPs. Cell toxicity assays indicated that the products had significant inhibitory effect on A549, HepG-2 and MCF-7 cells with a dose-dependent effect. The toxicity mechanisms of LAG-SeNPs were further investigated, and assay results revealed that LAG-SeNPs mainly induced cancer cellular apoptosis to promote atrophy and inhibit cell proliferation. The sum of these findings demonstrates the positive effects that a biomass-derived polysaccharide exert upon non-metal/metalloid-based nanoparticles and the ensuing material's viability as treatment against human cancers.
Schlagwörter	Fourier transform infrared spectroscopy ; antineoplastic activity ; apoptosis ; arabinogalactans ; atrophy ; cell proliferation ; cytotoxicity ; dose response ; humans ; light scattering ; nanoparticles ; neoplasms ; scanning electron microscopy ; selenium ; spectral analysis ; stabilizers ; transmission electron microscopy ; ultraviolet-visible spectroscopy ; viability
Sprache	Englisch
Erscheinungsverlauf	2019-0501
Umfang	p. 444-451.
Erscheinungsort	Elsevier B.V.
Dokumenttyp	Artikel
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2019.01.152
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Construction of arabinogalactans/selenium nanoparticles composites for enhancement of the antitumor activity.

Tang, Shuo / Wang, Ting / Jiang, Meiyun / Huang, Caoxing / Lai, Chenhuan / Fan, Yimin / Yong, Qiang

International journal of biological macromolecules

2019 Band 128, Seite(n) 444–451

Abstract	Selenium nanoparticles (SeNPs) were synthesized using arabinogalactans (LAG) as a formation scaffolding and particle stabilizer to investigate their anti-tumor properties. The formation, morphology, size, and in vitro biological activity of LAG-SeNPs were characterized by UV-vis, FT-IR, scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS) and cell toxicity assays. SEM and TEM of LAG-SeNPs visualized the individual spherical nanoparticles, while the spectroscopic characterization revealed the modes of interaction which lead to the stable particle properties of the LAG-SeNPs. Cell toxicity assays indicated that the products had significant inhibitory effect on A549, HepG-2 and MCF-7 cells with a dose-dependent effect. The toxicity mechanisms of LAG-SeNPs were further investigated, and assay results revealed that LAG-SeNPs mainly induced cancer cellular apoptosis to promote atrophy and inhibit cell proliferation. The sum of these findings demonstrates the positive effects that a biomass-derived polysaccharide exert upon non-metal/metalloid-based nanoparticles and the ensuing material's viability as treatment against human cancers.
Mesh-Begriff(e)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Galactans/chemistry ; Humans ; Nanocomposites/chemistry ; Nanoparticles/chemistry ; Particle Size ; Selenium/chemistry
Chemische Substanzen	Antineoplastic Agents ; Galactans ; Selenium (H6241UJ22B) ; arabinogalactan (SL4SX1O487)
Sprache	Englisch
Erscheinungsdatum	2019-01-28
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2019.01.152
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The role of tetraspanins pan-cancer.

Huang, Runzhi / Sun, Hanlin / Lin, Ruoyi / Zhang, Jie / Yin, Huabin / Xian, Shuyuan / Li, Man / Wang, Siqiao / Li, Zhenyu / Qiao, Yannan / Jiang, Meiyun / Yan, Penghui / Meng, Tong / Huang, Zongqiang

iScience

2022 Band 25, Heft 8, Seite(n) 104777

Abstract: Tetraspanins (TSPANs) are a class of four-transmembrane segmented proteins. The precise functions of TSPANs and their roles in pan-cancer are unclear. In this work, we analyzed TSPAN1, TSPAN10, TSPAN11, TSPAN12, TSPAN13, TSPAN14, TSPAN15, TSPAN16, ... ...

Abstract	Tetraspanins (TSPANs) are a class of four-transmembrane segmented proteins. The precise functions of TSPANs and their roles in pan-cancer are unclear. In this work, we analyzed TSPAN1, TSPAN10, TSPAN11, TSPAN12, TSPAN13, TSPAN14, TSPAN15, TSPAN16, TSPAN17, TSPAN18, TSPAN18-AS1, TSPAN19, TSPAN2, TSPAN3, TSPAN31, TSPAN32, TSPAN33, TSPAN4, TSPAN5, TSPAN6, TSPAN7, TSPAN8, TSPAN9, TSPAN9-IT1 (24 TSPAN family genes) in relation to tumor characteristics from 11,057 TCGA samples across 33 cancer types. On 24 TSPAN family genes, multidimensional studies were conducted, including gene differential expression, immunological subtype analysis, clinical analysis, stemness indices analysis, drug sensitivity analysis, alteration analysis, and multi-omics validation (including ATAC-seq validation, single-cell sequencing validation, and other external validation). Genes were differentially expressed in 33 cancers, and several of them showed high consistency in terms of tumor characteristics. In particular, the potential roles of TSPAN15 and TSPAN1 in cancer deserve further attention.
Sprache	Englisch
Erscheinungsdatum	2022-07-19
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2022.104777
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Characterization of arabinogalactans from Larix principis-rupprechtii and their effects on NO production by macrophages.

Tang, Shuo / Jiang, Meiyun / Huang, Caoxing / Lai, Chenhuan / Fan, Yimin / Yong, Qiang

Carbohydrate polymers

2018 Band 200, Seite(n) 408–415

Abstract: Arabinogalactans are a source of dietary fiber with health benefits. In this work, two arabinogalactans assigned as AGW and AGS were isolated from Larix principis-rupprechtii, and characterized by gel permeation chromatography (GPC), monosaccharide ... ...

Abstract	Arabinogalactans are a source of dietary fiber with health benefits. In this work, two arabinogalactans assigned as AGW and AGS were isolated from Larix principis-rupprechtii, and characterized by gel permeation chromatography (GPC), monosaccharide analysis, methylation analysis and NMR spectroscopy analysis. The average molecular weights of AGW and AGS were 1.53 × 10
Mesh-Begriff(e)	Animals ; Carbohydrate Sequence ; Galactans/chemistry ; Galactans/pharmacology ; Larix/chemistry ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Molecular Weight ; Monosaccharides/analysis ; Nitric Oxide/biosynthesis ; RAW 264.7 Cells
Chemische Substanzen	Galactans ; Monosaccharides ; Nitric Oxide (31C4KY9ESH) ; arabinogalactan (SL4SX1O487)
Sprache	Englisch
Erscheinungsdatum	2018-08-09
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2018.08.027
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Comparison of analgesic and anxiolytic effects of nitrous oxide in burn wound treatment: A single-blind prospective randomized controlled trial.

Li, Lin / Pan, Qiong / Xu, Le / Lin, Renqin / Dai, Jiaxi / Chen, Xinyan / Jiang, Meiyun / Chen, Zhaohong

Medicine

2019 Band 98, Heft 51, Seite(n) e18188

Abstract: Aim: We compared the effects of 50% N2O and N2O titration in burn management to alleviate pain and anxiety associated with burn dressing.: Methods: In this single-blind prospective randomized controlled trial, 70 stable adult burn patients were ... ...

Abstract	Aim: We compared the effects of 50% N2O and N2O titration in burn management to alleviate pain and anxiety associated with burn dressing. Methods: In this single-blind prospective randomized controlled trial, 70 stable adult burn patients were randomized to 2 groups during May 2015 to January 2016. The experimental group was titrated with N2O ranging from 30% to the ideal sedation concentration before dressing change until the end. The control group was treated with 50% N2O 2 minutes before dressing change until the end. Pain, anxiety, vital signs, and the highest concentrations of N2O inhaled were recorded at 1 minute before N2O inhalation (T0), dismantling of outer (T1), inner dressings (T2), debridement (T3), drug-smearing (T4), bandaging (T5), and 10 minutes after completion of the procedure (T6). Results: The pain and anxiety scores in the experimental group performed significantly less than the control group during T2-T6. The systolic blood pressure in T2 and the heart rate at T2 and T3 varied significantly between the 2 groups. The highest N2O concentrations of the experimental group were mainly 60% to 70% at T2 (87.9%), T3 (87.9%), and T4 (81.8%). Conclusion: N2O titration significantly reduced pain and anxiety in burn patients, with minimal side effects.
Mesh-Begriff(e)	Administration, Inhalation ; Adolescent ; Adult ; Aged ; Analgesics, Non-Narcotic/administration & dosage ; Analgesics, Non-Narcotic/therapeutic use ; Anti-Anxiety Agents/administration & dosage ; Anti-Anxiety Agents/therapeutic use ; Anxiety/prevention & control ; Burns/therapy ; Female ; Humans ; Male ; Middle Aged ; Nitrous Oxide/administration & dosage ; Nitrous Oxide/therapeutic use ; Pain Management ; Single-Blind Method ; Young Adult
Chemische Substanzen	Analgesics, Non-Narcotic ; Anti-Anxiety Agents ; Nitrous Oxide (K50XQU1029)
Sprache	Englisch
Erscheinungsdatum	2019-12-20
Erscheinungsland	United States
Dokumenttyp	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000018188
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Epidemiological investigation of hospitalized children with burn injuries in a hospital of Fuzhou].

Li, Lin / Lin, Renqin / Xu, Le / Pan, Qiong / Dai, Jiaxi / Jiang, Meiyun / Chen, Zhaohong

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns

2016 Band 32, Heft 6, Seite(n) 351–355

Abstract: Objective: To analyze the epidemiological characteristics of hospitalized children with burn injuries in Fujian Medical University Union Hospital, so as to provide evidence to complete an adequate, timely, and effective prevention and treatment system ... ...

Abstract	Objective: To analyze the epidemiological characteristics of hospitalized children with burn injuries in Fujian Medical University Union Hospital, so as to provide evidence to complete an adequate, timely, and effective prevention and treatment system of children with burn injuries. Methods: Medical records of children with burn injuries, aged 14 and under, hospitalized in the Department of Burns from July 2012 to June 2015 were collected. Data of gender and age, location and cause of injury, time of injury, state of injury, admission time after injury, first aid, length of hospital stay, and treatment and so on were recorded. They were divided into 4 age brackets: less than or equal to 1 year old, more than 1 year old and less than or equal to 3 years old, more than 3 years old and less than or equal to 7 years old, more than 7 years old and less than or equal to 14 years old, then gender and cause of injury of children in the 4 age brackets were analyzed. Admission months of the children were divided into spring (March to May), summer (June to August), autumn (September to November) and winter (December to February of the following year), and then the cause of injury of children in each season was analyzed. Severities of male and female children, length of hospital stay of children with different causes of injury were analyzed. Data were processed with chi-square test, Wilcoxon rank-sum test. Results: Out of 2 608 inpatients with burn injuries, 1 407 children with burn injuries, aged 14 and under, accounting for 53.9%, were admitted in the recent 3 years. The ratio of male to female was 1.6 ∶1.0. Children more than 1 year old and less than or equal to 3 years old ranked the largest number (68.3%, 961/1 407) in the 4 age brackets. There was statistically significant difference in constituent ratios of gender of children among the 4 age brackets (χ(2)=11.00, P=0.012). One thousand three hundred and seventy-two children were burned indoors (97.5%), while 35 children were burned outdoors (2.5%). Scalding with hot fluids was the most common cause of burn (95.0%, 1 337/1 407). There was statistically significant difference in constituent ratios of injury cause of children among the 4 age brackets (χ(2)=107.23, P<0.01). There was statistically significant difference in constituent ratios of injury cause of children more than 7 years old and less than or equal to 14 years old compared with those of the other 3 age brackets (with χ(2) values from 12.88 to 119.85, P values below 0.01). Most burn accidents occurred between 17: 00-20: 59 (33.5%, 472/1 407). Burns were more likely to happen in April to October. July (10.4%, 146/1 407) and August (10.5%, 148/1 407) were the crest-time. Most of the children were burned in summer (35.3%, 496/1 407). There was statistically significant difference in the injury cause of children among each season (χ(2)=14.61, P=0.024). The burn degrees of male and female children were mainly mild or moderate, and there was no statistically significant difference in the severity (Z=-0.39, P>0.05). The trunk was the most involved anatomic site (61.1%, 859/1 407). Most of children were admitted to hospital within 2 hours post burn (79.7%, 1 121/1 407). Majority of children were taken off clothes as first aid on spot or did not receive any treatment. Most of the children were discharged within 2 weeks after admission (80.0%, 1 126/1 407). There was statistically significant difference in length of hospital stay of children with causes of hot liquid scald, flame burn, electric burn, high temperature solid burn, chemical burn (χ(2) =17.33, P=0.002). Most of the children were treated with non-surgical methods, and the majority of the children got better condition or totally recovered and then discharged. Conclusions: The majority of hospitalized children with burn injuries in our unit are young boys in preschool period, who were burnt by hot fluid at the time of dinner and bathing at home during summer. So we should make more effort on popularization of prevention about burn.
Mesh-Begriff(e)	Adolescent ; Burns/classification ; Burns/epidemiology ; Burns, Chemical ; Burns, Electric ; Child ; Child, Hospitalized/statistics & numerical data ; Child, Preschool ; Female ; Hospitalization ; Humans ; Infant ; Inpatients ; Length of Stay ; Male
Sprache	Chinesisch
Erscheinungsdatum	2016-06
Erscheinungsland	China
Dokumenttyp	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2229222-6
ISSN	1009-2587
ISSN	1009-2587
DOI	10.3760/cma.j.issn.1009-2587.2016.06.010
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The effect of a rehabilitation nursing intervention model on improving the comprehensive health status of patients with hand burns.

Li, Lin / Dai, Jia-Xi / Xu, Le / Huang, Zhen-Xia / Pan, Qiong / Zhang, Xi / Jiang, Mei-Yun / Chen, Zhao-Hong

Burns : journal of the International Society for Burn Injuries

2017 Band 43, Heft 4, Seite(n) 877–885

Abstract: Aims and objectives: To observe the effect of a rehabilitation intervention on the comprehensive health status of patients with hand burns.: Background: Most studies of hand-burn patients have focused on functional recovery. There have been no ... ...

Abstract	Aims and objectives: To observe the effect of a rehabilitation intervention on the comprehensive health status of patients with hand burns. Background: Most studies of hand-burn patients have focused on functional recovery. There have been no studies involving a biological-psychological-social rehabilitation model of hand-burn patients. Design: A randomized controlled design was used. Methods: Patients with hand burns were recruited to the study, and sixty patients participated. Participants were separated into two groups: (1) The rehabilitation intervention model group (n=30) completed the rehabilitation intervention model, which included the following measures: enhanced social support, intensive health education, comprehensive psychological intervention, and graded exercise. (2) The control group (n=30) completed routine treatment. Intervention lasted 5 weeks. Analysis of variance (ANOVA) and Student's t test were conducted. Results: The rehabilitation intervention group had significantly better scores than the control group for comprehensive health, physical function, psychological function, social function, and general health. The differences between the index scores of the two groups were statistically significant. Conclusions: The rehabilitation intervention improved the comprehensive health status of patients with hand burns and has favorable clinical application. Relevance to clinical practice: The comprehensive rehabilitation intervention model used here provides scientific guidance for medical staff aiming to improve the integrated health status of hand-burn patients and accelerate their recovery. What does this paper contribute to the wider global clinical community?
Sprache	Englisch
Erscheinungsdatum	2017-06
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2016.11.003
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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