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Article ; Online: Evolution of SARS-CoV-2 Viral Mutations in Individuals with Prolonged Infections.

Jiang-Qin, Luna / Weitemier, Kevin / Fan, Guang / Qin, Xuan

Annals of clinical and laboratory science

2024 Volume 53, Issue 6, Page(s) 931–937

Abstract: Objective: The world has been faced with the repeat rise of SARS-CoV-2 variants since late 2020, including Alpha, Beta, Gamma, Delta, and the latest simultaneous emergence of far-flung spawn of Omicron sub-lineages in different parts of the globe. This ... ...

Abstract	Objective: The world has been faced with the repeat rise of SARS-CoV-2 variants since late 2020, including Alpha, Beta, Gamma, Delta, and the latest simultaneous emergence of far-flung spawn of Omicron sub-lineages in different parts of the globe. This has brought us the challenge of determining what factor(s) have been the selective force behind these immune evasive and therapy resistant mutations. It is very possible that such variants evolved in limited host individuals with prolonged infections, or from a localized community of patients. Methods: This study surveys the GISAID time capsule of mutations found in viral genomes from patients with prolonged same lineage viral infections. We analyzed 288 SARS-CoV-2 genomes representing 113 patients who had same lineage viral genomes in two or more samples stored in GISAID. Results: Of these, thirty-five (30.9%) of the 113 patients developed mutations during their infections. Samples from patients whose viral genomes showed nucleotide changes(s) (n=35) versus those that showed no change (n=78) had a statistically significant difference ( Conclusion: This suggests the duration of infection is a contributing factor that gives rise to mutations, but not the sole factor, and individual host conditions may play a critical role in driving viral evolution.
MeSH term(s)	Humans ; COVID-19/genetics ; SARS-CoV-2/genetics ; Mutation/genetics ; Biotin
Chemical Substances	Biotin (6SO6U10H04)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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Zs.A 942: Show issues

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Article ; Online: Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 or positive allosteric modulation of the protein affects the motivation to chronically self-administer nicotine.

Sharp, Burt M / Jiang, Qin / Kim, Panjun / Chen, Hao

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2562

Abstract: Large scale human genome wide association studies (GWAS) have identified a growing pool of genes associated with cigarette smoking. One of the most prominent, phosphodiesterase-4B (PDE4B), has been associated with multiple smoking phenotypes. Although ... ...

Abstract	Large scale human genome wide association studies (GWAS) have identified a growing pool of genes associated with cigarette smoking. One of the most prominent, phosphodiesterase-4B (PDE4B), has been associated with multiple smoking phenotypes. Although PDE4B modulates the half-life of neuronal cAMP, its precise role in smoking behaviors is unknown. To address this knowledge gap, we used a reverse translational approach. We inactivated PDE4B in bilateral medial nucleus accumbens shell (NAcs) neurons by injecting AAV containing a specific gRNA in female transgenic Cas9+ Long Evans rats. These rats then were given 23-h chronic access to nicotine intravenous self-administration (IVSA) under a schedule of increasing fixed ratios (FR). With the increased effort required at FR7, nicotine SA (i.e. active presses and drug infusions) declined significantly in controls, whereas it was maintained in the mutagenized group. A progressive ratio (PR) study also showed significantly greater cumulative nicotine infusions in the PDE4B-edited group. Hence, we hypothesized that enhanced PDE4B protein activity would reduce nicotine IVSA. A positive allosteric modulator, 2-(3-(4-chloro-3-fluorophenyl)-5-ethyl-1H-1,2,4-triazol-1-yl)-N-(3,5-dichlorobenzyl)acetamide (MR-L2), was microinfused into NAcs bilaterally at FR3 or FR5; in both cohorts, MR-L2 acutely reduced nicotine IVSA. In summary, these studies show that the activity of PDE4B regulates the capacity of NAcs to maintain nicotine IVSA in face of the cost of increasing work. This finding and the results of the PR study indicate that PDE4B affects the motivation to obtain nicotine. These reverse translational studies in rats provide insight into the motivational effects of NAcs PDE4B that advance our understanding of the smoking behaviors mapped in human GWAS.
MeSH term(s)	Humans ; Rats ; Female ; Animals ; Nicotine ; Nucleus Accumbens/metabolism ; CRISPR-Cas Systems ; Motivation ; Cyclic Nucleotide Phosphodiesterases, Type 4/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Genome-Wide Association Study ; Rats, Long-Evans ; RNA, Guide, CRISPR-Cas Systems ; Self Administration/methods
Chemical Substances	Nicotine (6M3C89ZY6R) ; Cyclic Nucleotide Phosphodiesterases, Type 4 (EC 3.1.4.17) ; RNA, Guide, CRISPR-Cas Systems
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53037-9
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Article ; Online: Predictive value of stromal tumor-infiltrating lymphocytes in patients with breast cancer treated with neoadjuvant chemotherapy: A meta-analysis.

Xia, Guangfa / Zhang, Ziran / Jiang, Qin / Wang, Huan / Wang, Jie

Medicine

2024 Volume 103, Issue 6, Page(s) e36810

Abstract: Background: The predictive value of tumor-infiltrating lymphocytes (TILs) in response to neoadjuvant chemotherapy (NAC) for breast cancer (BC) has received increasing attention. Here, a meta-analysis was conducted to evaluate the correlation between the ...

Abstract	Background: The predictive value of tumor-infiltrating lymphocytes (TILs) in response to neoadjuvant chemotherapy (NAC) for breast cancer (BC) has received increasing attention. Here, a meta-analysis was conducted to evaluate the correlation between the expression of stromal TILs and pathological complete response (pCR) after NAC in BC patients. Methods: The PubMed, Embase, Cochrane Library, and Web of Science databases were searched online by using a combination of keywords and free words to screen literature on the expression of stromal TILs and pCR after NAC in patients with BC. The data were extracted and evaluated for quality. Relative risk (RR) was used to evaluate the relationship between the expression of stromal TILs before NAC and pCR in BC patients. Meta-analysis was performed with Review Manager 5.3 and STATA 14.0 software. Results: Eleven studies involving 6039 BC patients were included in the meta-analysis. The results showed a generally high expression of stromal TILs in BC patients, and the pCR rate after NAC in BC patients with a high expression of stromal TILs was significantly higher than that in BC patients with a low expression of stromal TILs [RR = 1.83, 95% confidence interval (CI): 1.69-1.97]. Subgroup analysis based on the molecular subtypes of BC showed that the pCR rate was significantly higher in patients with a high expression of stromal TILs in hormone receptor (HR)-positive BC [RR = 3.23, 95% CI: 2.43-4.30], human epidermal growth factor receptor 2 (HER-2)-positive BC [RR = 1.41, 95% CI: 1.25-1.60], and triple-negative BC [RR = 1.70, 95% CI: 1.53-1.90] than in those with a low expression of stromal TILs. Subgroup analysis based on expression threshold showed that the pCR rate was higher in patients with a high expression of stromal TILs than in patients with a low expression of stromal TILs at different expression thresholds (10% [RR = 1.99, 95% CI: 1.55-2.55], 20%/30% [RR = 1.57, 95% CI: 1.37-1.81], 50%/60% [RR = 1.91, 95% CI: 1.73-2.11]. Conclusion: TILs can be used as a predictor of pCR after NAC in patients with BC, and the appropriate high expression threshold of stromal TILs should be selected as the predictive value according to the molecular subtype of BC.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Neoadjuvant Therapy/methods ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Triple Negative Breast Neoplasms/pathology ; Lymphocytes/metabolism ; Prognosis
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036810
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Article ; Online: The cognitive neural mechanism of trait anxiety influences mind wandering: An ERP study.

Jiang, Qin / Lin, Wenxia / Pan, Yu / Li, Dongfang / Wang, Qi

Neuroscience letters

2024 Volume 822, Page(s) 137648

Abstract: Converging evidence from behavioral and neuroscience studies demonstrated that our attention to the external world is influenced by emotion, especially anxiety. However, little is known about how trait anxiety influences neural and behavioral responses ... ...

Abstract	Converging evidence from behavioral and neuroscience studies demonstrated that our attention to the external world is influenced by emotion, especially anxiety. However, little is known about how trait anxiety influences neural and behavioral responses during mind wandering. The present study aimed to examine the neural and cognitive time courses of how trait anxiety affects mind wandering. Event-related potentials (ERPs) were recorded from 20 individuals with high trait anxiety and 20 with low trait anxiety when they performed the Sustained Attention to Response Task (SART) in which they were asked to respond to frequent ''nontargets'' (digits 0-6, 8-9) but withhold responses to infrequent ''targets'' (the digit 7). We compared the behavioral performance and electroencephalographic waves between the high and low trait anxiety groups during states of "mind wandering" (fail to withhold a response to the target number) and being "on-task" (correctly withhold a response to the target number). Results showed that a larger late positive component (LPC, 400-950 ms) was elicited when participants were "on task" than when they were mind wandering. Additionally, a larger late slow waveform (LSW, 950-1050 ms) was elicited in the high trait anxiety group than in the low trait anxiety group. Moreover, there was a positive correlation between self-reported trait anxiety scores and the LSW amplitudes during mind wandering. It was proposed that the effect of trait anxiety on the cognitive neural mechanism underlying attentional processing was primarily reflected in a later process involving the redistribution of cognitive resources.
MeSH term(s)	Humans ; Evoked Potentials ; Electroencephalography ; Anxiety Disorders ; Cognition/physiology ; Anxiety
Language	English
Publishing date	2024-01-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2024.137648
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Zs.A 1166: Show issues

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Article ; Online: Non-Coding RNAs: Novel Regulators of Macrophage Homeostasis in Ocular Vascular Diseases.

Zhang, Qiuyang / Liu, Qing / Feng, Siguo / Li, Xiumiao / Jiang, Qin

Biomolecules

2024 Volume 14, Issue 3

Abstract: Ocular neovascularization can impair vision and threaten patients' quality of life. However, the underlying mechanism is far from transparent. In all mammals, macrophages are a population of cells playing pivotal roles in the innate immune system and the ...

Abstract	Ocular neovascularization can impair vision and threaten patients' quality of life. However, the underlying mechanism is far from transparent. In all mammals, macrophages are a population of cells playing pivotal roles in the innate immune system and the first line of defense against pathogens. Therefore, it has been speculated that the disfunction of macrophage homeostasis is involved in the development of ocular vascular diseases. Moreover, various studies have found that non-coding RNAs (ncRNAs) regulate macrophage homeostasis. This study reviewed past studies of the regulatory roles of ncRNAs in macrophage homeostasis in ocular vascular diseases.
MeSH term(s)	Animals ; Humans ; Quality of Life ; RNA, Untranslated/genetics ; Vascular Diseases/genetics ; Macrophages ; Homeostasis/genetics ; RNA, Long Noncoding ; Mammals
Chemical Substances	RNA, Untranslated ; RNA, Long Noncoding
Language	English
Publishing date	2024-03-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14030328
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Article ; Online: Significance of Aneuploidy in Predicting Prognosis and Treatment Response of Uveal Melanoma.

Zhang, Xiaoqian / Jin, Ling / Zhou, Chenchen / Liu, Jinghua / Jiang, Qin

Current medicinal chemistry

2024

Abstract: Aims: This study aimed to improve personalized treatment strategies and predict survival outcomes for patients with uveal melanoma (UM).: Background: Copy number aberrations (CNAs) have been considered as a main feature of metastatic UM.: Objective! ...

Abstract	Aims: This study aimed to improve personalized treatment strategies and predict survival outcomes for patients with uveal melanoma (UM). Background: Copy number aberrations (CNAs) have been considered as a main feature of metastatic UM. Objective: This study was designed to explore the feasibility of using copy number variation (CNV) in UM classification, prognosis stratification and treatment response. Methods: The CNV data in the TCGA-UVM cohort were used to classify the samples. The differentially expressed genes (DEGs) between subtypes were screened by the "Limma" package. The module and hub genes related to aneuploidy score were identified by performing weighted gene co-expression network analysis (WGCNA) on the DEGs. Univariate Cox and least absolute shrinkage and selection operator (LASSO) regression analysis were employed to train the hub genes for developing a prognosis model for UM. Finally, the expression levels of the screened prognostic key genes were verified in UM cells, and the cell migration and invasion abilities were detected using real-time quantitative PCR (qRT-PCR) and transwell assay. Results: The UM samples were divided into 3 CNV subtypes, which differed significantly in overall survival (OS) and disease-specific survival (DSS). C1 had the shortest OS and DSS and the highest level of immune infiltration. A total of 2036 DEGs were obtained from the three subtypes. Eighty hub genes with the closest correlation with aneuploidy scores were selected by WGCNA. Univariate Cox and LASSO regression-based analyses finally determined eight genes as the key prognostic genes, including HES6, RNASEH2C, NQO1, NUDT14, TTYH3, GJC1, FKBP10, and MRPL24. A prognostic model was developed using the eight genes, demonstrating a strong prediction power. Differences in the response to immunotherapy among patients in different risk groups were significant. We found that high-risk patients were more sensitive to two drugs (Palbociclib_ 1054 and Ribociclib_1632), while low-risk patients were more sensitive to AZD1208_1449, ERK_2440_1713, Mirin_1048, and Selumetinib_1736. Conclusion: UM in this study was divided into three CNV subtypes, and a model based on eight aneuploidy score-related genes was established to evaluate the prognosis and drug treatment efficacy of UM patients. The current results may have the potential to help the clinical decision-making process for UM management.
Language	English
Publishing date	2024-03-19
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0109298673286788240123044411
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Zs.A 4432: Show issues

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Article ; Online: The Efficacy of Traditional Chinese Herbal Medicine Across Multiple Cardiovascular Diseases: An Umbrella Review of Systematic Reviews of Randomized Controlled Trials.

Li, Xi / Yu, Tao / Jiang, Qin / Tan, Jin / Liu, Ke

Journal of cardiovascular pharmacology

2024 Volume 83, Issue 4, Page(s) 340–352

Abstract: Abstract: Traditional Chinese herbal medicine (CHM) has been extensively used in cardiovascular disease (CVD) in modern clinical practice, alone or in combination with conventional treatment. However, its efficacy has not been assessed extensively. From ...

Abstract	Abstract: Traditional Chinese herbal medicine (CHM) has been extensively used in cardiovascular disease (CVD) in modern clinical practice, alone or in combination with conventional treatment. However, its efficacy has not been assessed extensively. From inception until August 2023, we systematically searched 5 public literature databases to conduct the umbrella review. The inclusion criterion is systematic reviews of randomized controlled trials investigating the effect of CHM in the contemporary management of CVDs. The quality of the included systematic reviews, the certainty of the evidence, and the potential risk of bias were assessed. Five hundred and thirty-nine systematic reviews, including 346 studies in Chinese and 193 in English, were selected before the quantitative synthesis. The methodological quality was generally moderate, with a median value of 11. The favorable efficacy of CHM was primarily presented on 5 main conditions: coronary artery disease, hypertension, heart failure, restenosis, and angina pectoris. CHM, with or without conventional treatment, showed a consistent beneficial effect in various CVDs. Nevertheless, the magnitude of the effect requires further investigation as the lack of relevant research and the complexity of the clinical practice of CHM.
MeSH term(s)	Humans ; Drugs, Chinese Herbal/adverse effects ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/drug therapy ; Randomized Controlled Trials as Topic ; Systematic Reviews as Topic ; Angina Pectoris ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001535
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Zs.A 1471: Show issues

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Article: An integrated analysis revealing the angiogenic function of TP53I11 in tumor microenvironment.

Bai, Wen / Ren, Jun-Song / Li, Ke-Ran / Jiang, Qin

Heliyon

2024 Volume 10, Issue 8, Page(s) e29504

Abstract: Despite growing evidence suggesting an important contribution of Tumor Protein P53 Inducible Protein 11 (TP53I11) in cancer progression, the role of TP53I11 remains unclear. Our first pan-cancer analysis of TP53I11 showed some tumor tissues displayed ... ...

Abstract	Despite growing evidence suggesting an important contribution of Tumor Protein P53 Inducible Protein 11 (TP53I11) in cancer progression, the role of TP53I11 remains unclear. Our first pan-cancer analysis of TP53I11 showed some tumor tissues displayed reduced TP53I11 expression compared to normal tissues, while others exhibited high TP53I11 expression. Meanwhile, TP53I11 expression carries a particular pan-cancer risk, as high TP53I11 expression levels are detrimental to survival for BRCA, KIRP, MESO, and UVM, but to beneficial survival for KIRC. We demonstrated that TP53I11 expression negatively correlates with DNA methylation in most cancers, and the S14 residue of TP53I11 is phosphorylated in several cancer types. Additionally, TP53I11 was found to be associated with endothelial cells in pan-cancer, and functional enrichment analysis provided strong evidence for its role in tumor angiogenesis. In vitro angiogenesis assays confirmed that TP53I11 can promote angiogenic function of human umbilical vein endothelial cells (HUVECs) in vitro. Mechanistic investigations reveal that TP53I11 is transcriptionally up-regulated by HIF2A under hypoxia.
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e29504
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Article ; Online: Effect of Grape Seed Procyanidins Combined with Allicin on Lipid Levels in Hyperlipidemic Rats.

Sun, Liu-Qing / Zhu, Chao-Feng / He, Jiang-Qin

Studies in health technology and informatics

2023 Volume 308, Page(s) 130–136

Abstract: Objectives: To study the effects of grape seed proanthocyanidins (GSP) combined with allicin on serum lipids level and vascular damage in a rat model of hyperlipidemia.: Materials and methods: SD rats(male, 170-220 gn= 40) were randomized into five ... ...

Abstract	Objectives: To study the effects of grape seed proanthocyanidins (GSP) combined with allicin on serum lipids level and vascular damage in a rat model of hyperlipidemia. Materials and methods: SD rats(male, 170-220 gn= 40) were randomized into five groups (n = 8/group): modelhigh fat and cholesterol diet; controlnormal diet; model+low-dose (GSP+allicin )(GSP 45mg/kg, allicin 30mg/kg, orally); model+high-dose (GSP+allicin) (GSP180mg/kg, allicin 90mg/kg, orally) and positive control (model+simvastatin (4 mg/kg)). Normal control group was fed conventionally, and remaining four groups were fed high cholesterol and fat food to replicate the high fat model. After 9 weeks, the normal control group continued to receive regular feeding, while the other groups continued to receive high-fat feeding. At the same time, model and normal control groups were given equal volume of physiological saline by gavage, and the other treatment groups began to receive corresponding drugs by gavage once a day. After 4 weeks, serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) as well as high-density lipoprotein cholesterol (HDL-C) in rats were determined. And the body weight of rat, total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and malondialdehyde (MDA)in serum were identified. The level of endothelin-1(ET-1) was quantitative analysis by ELISA assay. Results: In comparison to normal controls, the model group displayed a marked rise in body weight, an increment in serum concentrations of LDL-C, TG and TC, as well as a decline in HDL (P<0.01), demonstrating successful model replication; All doses of GSP in combination with allicin resulted in a reduction in TG, LDL-C, and TC and an enhancement in HDL-C in contrast to the model control (all P<0.05). High-dose (GSP+allicin ) decreased MDA, and increased T-AOC and SOD activity(all P<0.01). All doses of GSP combined with allicin decreased ET-1 (all P<0.05). In addition, the protective effect of GSP combined with allicin was dose-dependent. Conclusions: Studies have shown that GSP combined with allicin can significantly improve blood lipids in hyperlipidemic rats, and this mechanism may be related to antioxidants and reduced endothelial damage.
MeSH term(s)	Rats ; Male ; Animals ; Vitis ; Rats, Sprague-Dawley ; Proanthocyanidins/pharmacology ; Proanthocyanidins/therapeutic use ; Cholesterol, LDL/therapeutic use ; Lipids ; Hyperlipidemias/drug therapy ; Triglycerides/therapeutic use ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Cholesterol/therapeutic use ; Superoxide Dismutase/therapeutic use ; Cholesterol, HDL/therapeutic use ; Body Weight ; Seeds
Chemical Substances	allicin (3C39BY17Y6) ; Proanthocyanidins ; Cholesterol, LDL ; Lipids ; Triglycerides ; Antioxidants ; Cholesterol (97C5T2UQ7J) ; Superoxide Dismutase (EC 1.15.1.1) ; Cholesterol, HDL
Language	English
Publishing date	2023-11-26
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI230833
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Article ; Online: Recent progress in metal-organic framework-based sonosensitizers for sonodynamic tumor therapy.

Jiang, Qin / Gao, Xinran / Zhang, Wen / Chen, Zhigang

Biomaterials science

2023 Volume 11, Issue 13, Page(s) 4452–4470

Abstract: In recent years, sonodynamic therapy (SDT) has emerged as a promising approach in biomedicine, due to its low toxicity, non-invasiveness, and deep tissue penetration for effective treatment of deep tumors. SDT utilizes ultrasound to irradiate ... ...

Abstract	In recent years, sonodynamic therapy (SDT) has emerged as a promising approach in biomedicine, due to its low toxicity, non-invasiveness, and deep tissue penetration for effective treatment of deep tumors. SDT utilizes ultrasound to irradiate sonosensitizers accumulated in tumors to generate reactive oxygen species (ROS), which can kill tumors by inducing apoptosis or necrosis in tumor cells. Developing safe and efficient sonosensitizers is a top priority in SDT. Recently reported sonosensitizers can be divided into three basic categories: organic, inorganic, and organic-inorganic hybrid sonosensitizers. Among these, metal-organic frameworks (MOFs) are a promising class of hybrid sonosensitizers due to their advantages of the linker-to-metal charge transfer mechanism for rapid ROS generation and the porous structure to eliminate self-quenching to increase the ROS generation efficiency. Moreover, MOF-based sonosensitizers can be combined with other therapies due to their large specific surface area, high porosity, and easy modification, which can increase the therapeutic efficacy through various synergistic effects. This review focuses on the latest progress in MOF-based sonosensitizers, strategies to improve the therapeutic effect, and the use of MOF-based sonosensitizers as multifunctional platforms for combination therapies emphasizing on increased therapeutic efficacy. Additionally, the challenges of MOF-based sonosensitizers from a clinical perspective are discussed.
MeSH term(s)	Humans ; Metal-Organic Frameworks ; Reactive Oxygen Species ; Combined Modality Therapy ; Apoptosis ; Necrosis ; Neoplasms/therapy ; Cell Line, Tumor
Chemical Substances	Metal-Organic Frameworks ; Reactive Oxygen Species
Language	English
Publishing date	2023-06-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d3bm00556a
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