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  1. Article: The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A.

    Stachelscheid, Johanna / Jiang, Qu / Herling, Marco

    Cancers

    2021  Volume 13, Issue 21

    Abstract: Incomplete biological concepts in lymphoid neoplasms still dictate to a large extent the limited availability of efficient targeted treatments, which entertains the mostly unsatisfactory clinical outcomes. Aberrant expression of the embryonal and ... ...

    Abstract Incomplete biological concepts in lymphoid neoplasms still dictate to a large extent the limited availability of efficient targeted treatments, which entertains the mostly unsatisfactory clinical outcomes. Aberrant expression of the embryonal and lymphatic TCL1 family of oncogenes, i.e., the paradigmatic
    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13215455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Complete plastome sequence of

    Tang, Jiang-Qu / Zhang, Xiao-Feng / Zhu, Zhi-Xin / Wang, Hua-Feng

    Mitochondrial DNA. Part B, Resources

    2021  Volume 6, Issue 3, Page(s) 929–930

    Abstract: Macaranga ... ...

    Abstract Macaranga tanarius
    Language English
    Publishing date 2021-03-16
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2021.1888332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Paraneoplastic pemphigus associated with chronic lymphocytic leukemia: A case report.

    Jiang, Qu / Zhang, Bin Hong

    Medicine

    2017  Volume 96, Issue 8, Page(s) e6184

    Abstract: Rationale: Paraneoplastic pemphigus (PNP) is an autoimmune syndrome associated with neoplasms. The treatment approach principally includes suppressing the immunity, but its therapeutic effect is not satisfying.: Patient concerns: We report a case of ... ...

    Abstract Rationale: Paraneoplastic pemphigus (PNP) is an autoimmune syndrome associated with neoplasms. The treatment approach principally includes suppressing the immunity, but its therapeutic effect is not satisfying.
    Patient concerns: We report a case of paraneoplastic pemphigus linked to chronic lymphocytic leukemia in a 63-year-old man.
    Diagnoses: At first, the patient was diagnosed with pityriasis rose caused by a viral infection. Biopsies for histology and immunofluorescence showed PNP, was treated with immunosuppressive and antiinfective therapy.
    Interventions: Immunosuppressive and antiinfective therapy were performed.
    Outcomes: The skin lesions of PNP were alleviated. However, the infections were aggravated and the disease progressed. The patient died of respiratory failure.
    Lessons: Treatment for PNP should be adapted to disease severity as early as possible. Antiinfection treatment should be timely and effective because infections are the most common complication that can lead to death.
    MeSH term(s) Diagnosis, Differential ; Fatal Outcome ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Male ; Middle Aged ; Paraneoplastic Syndromes/diagnosis ; Paraneoplastic Syndromes/drug therapy ; Paraneoplastic Syndromes/etiology ; Paraneoplastic Syndromes/pathology ; Pemphigus/diagnosis ; Pemphigus/drug therapy ; Pemphigus/etiology ; Pemphigus/pathology ; Respiratory Insufficiency/etiology
    Language English
    Publishing date 2017-01-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000006184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: On-chip integrated process-programmable sub-10 nm thick molecular devices switching between photomultiplication and memristive behaviour

    Tianming Li / Martin Hantusch / Jiang Qu / Vineeth Kumar Bandari / Martin Knupfer / Feng Zhu / Oliver G. Schmidt

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 10

    Abstract: Developing molecular electronics is challenged by integrating fragile organic molecules into modern micro/nanoelectronics based on inorganic semiconductors. Li et al. apply rolled-up nanotechnology to assemble on-chip molecular devices, which can be ... ...

    Abstract Developing molecular electronics is challenged by integrating fragile organic molecules into modern micro/nanoelectronics based on inorganic semiconductors. Li et al. apply rolled-up nanotechnology to assemble on-chip molecular devices, which can be switched between photodiodes and volatile memristors.
    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Identifying the geometric catalytic active sites of crystalline cobalt oxyhydroxides for oxygen evolution reaction.

    Wang, Sihong / Jiang, Qu / Ju, Shenghong / Hsu, Chia-Shuo / Chen, Hao Ming / Zhang, Di / Song, Fang

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6650

    Abstract: Unraveling the precise location and nature of active sites is of paramount significance for the understanding of the catalytic mechanism and the rational design of efficient electrocatalysts. Here, we use well-defined crystalline cobalt oxyhydroxides ... ...

    Abstract Unraveling the precise location and nature of active sites is of paramount significance for the understanding of the catalytic mechanism and the rational design of efficient electrocatalysts. Here, we use well-defined crystalline cobalt oxyhydroxides CoOOH nanorods and nanosheets as model catalysts to investigate the geometric catalytic active sites. The morphology-dependent analysis reveals a ~50 times higher specific activity of CoOOH nanorods than that of CoOOH nanosheets. Furthermore, we disclose a linear correlation of catalytic activities with their lateral surface areas, suggesting that the active sites are exclusively located at lateral facets rather than basal facets. Theoretical calculations show that the coordinatively unsaturated cobalt sites of lateral facets upshift the O 2p-band center closer to the Fermi level, thereby enhancing the covalency of Co-O bonds to yield the reactivity. This work elucidates the geometrical catalytic active sites and enlightens the design strategy of surface engineering for efficient OER catalysts.
    Language English
    Publishing date 2022-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-34380-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: The oncogenic role of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia

    Jiang, Qu Verfasser] / [Schweiger, Michal-Ruth [Gutachter] / Riemer, J. [Gutachter] / Odenthal, M. [Gutachter] / Gehring, N. [Gutachter]

    2022  

    Author's details Qu Jiang ; Gutachter: M.R. Schweiger, J. Riemer, M. Odenthal, N. Gehring
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: Active oxygen species mediate the iron-promoting electrocatalysis of oxygen evolution reaction on metal oxyhydroxides.

    Jiang, Qu / Wang, Sihong / Zhang, Chaoran / Sheng, Ziyang / Zhang, Haoyue / Feng, Ruohan / Ni, Yuanman / Tang, Xiaoan / Gu, Yichuan / Zhou, Xinhong / Lee, Seunghwa / Zhang, Di / Song, Fang

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6826

    Abstract: Iron is an extraordinary promoter to impose nickel/cobalt (hydr)oxides as the most active oxygen evolution reaction catalysts, whereas the synergistic effect is actively debated. Here, we unveil that active oxygen species mediate a strong electrochemical ...

    Abstract Iron is an extraordinary promoter to impose nickel/cobalt (hydr)oxides as the most active oxygen evolution reaction catalysts, whereas the synergistic effect is actively debated. Here, we unveil that active oxygen species mediate a strong electrochemical interaction between iron oxides (FeO
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42646-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The miR-141/200c-STAT4 Axis Contributes to Leukemogenesis by Enhancing Cell Proliferation in T-PLL.

    Otte, Moritz / Stachelscheid, Johanna / Glaß, Markus / Wahnschaffe, Linus / Jiang, Qu / Lone, Waseem / Ianevski, Aleksandr / Aittokallio, Tero / Iqbal, Javeed / Hallek, Michael / Hüttelmaier, Stefan / Schrader, Alexandra / Braun, Till / Herling, Marco

    Cancers

    2023  Volume 15, Issue 9

    Abstract: T-prolymphocytic leukemia (T-PLL) is a rare and mature T-cell malignancy with characteristic chemotherapy-refractory behavior and a poor prognosis. Molecular concepts of disease development have been restricted to protein-coding genes. Recent global ... ...

    Abstract T-prolymphocytic leukemia (T-PLL) is a rare and mature T-cell malignancy with characteristic chemotherapy-refractory behavior and a poor prognosis. Molecular concepts of disease development have been restricted to protein-coding genes. Recent global microRNA (miR) expression profiles revealed miR-141-3p and miR-200c-3p (miR-141/200c) as two of the highest differentially expressed miRs in T-PLL cells versus healthy donor-derived T cells. Furthermore, miR-141/200c expression separates T-PLL cases into two subgroups with high and low expression, respectively. Evaluating the potential pro-oncogenic function of miR-141/200c deregulation, we discovered accelerated proliferation and reduced stress-induced cell death induction upon stable miR-141/200c overexpression in mature T-cell leukemia/lymphoma lines. We further characterized a miR-141/200c-specific transcriptome involving the altered expression of genes associated with enhanced cell cycle transition, impaired DNA damage responses, and augmented survival signaling pathways. Among those genes, we identified
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15092527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effect of Transport Properties of Crystalline Transition Metal (Oxy)hydroxides on Oxygen Evolution Reaction.

    Zhang, Haoyue / Wu, Lingling / Ni, Yuanman / Feng, Jianghan / Jiang, Qu / Zhang, Chaoran / Ahmad, Ashfaq / Majeed, Abdul / Li, Yao / Guo, Cuiping / Zhang, Wang / Song, Fang

    ACS applied materials & interfaces

    2023  Volume 15, Issue 21, Page(s) 25575–25583

    Abstract: Electronic transport plays a pivotal role in the electrolysis of semiconducting electrocatalysts for oxygen evolution reaction (OER), while it is mostly underestimated and largely unexplored. Here, by investigating the electronic transport behavior of ... ...

    Abstract Electronic transport plays a pivotal role in the electrolysis of semiconducting electrocatalysts for oxygen evolution reaction (OER), while it is mostly underestimated and largely unexplored. Here, by investigating the electronic transport behavior of seven archetypical crystalline Co/Ni/Fe-based (oxy)hydroxides (unary, binary, and ternary) under OER potential, we study how and the extent to which it affects the apparent catalytic performances. The electronic transports of unary metal (oxy)hydroxides follow the order of Co > Ni > Fe, and their binary or ternary compounds can generally impose one order of magnitude higher electrical conductivity. By studying the dependence of catalytic performances on electrical conductivities, we further unveil that charge transportability not only determines the electronic accessibility of catalytic nanoparticles but also, to our surprise, regulates the reaction kinetics of the electronically accessible active sites. Remarkably, the regulation extent of reaction kinetics correlates with the electrical conductivities of electrocatalysts, suggesting that the electrocatalytic process is strongly coupled with electronic transport. The work presents an overview of electronic transports of crystalline (oxy)hydroxides under OER potentials and highlights their pivotal role in unfolding catalytic potential, holding both fundamental and technical implications for the screen and design of efficient electrocatalysts.
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c03270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Knockdown of the Meq gene in Marek's disease tumor cell line MSB1 might induce cell apoptosis and inhibit cell proliferation and invasion

    Chun-fang ZHAO / Xin LI / Bo HAN / Lu-jiang QU / Chang-jun LIU / SONG Jiuzhou / Ning YANG / Ling LIAN

    Journal of Integrative Agriculture, Vol 19, Iss 11, Pp 2767-

    2020  Volume 2774

    Abstract: Marek's disease (MD), a highly cell-associated and contagious disease of chickens caused by Marek's disease virus (MDV) can result in neural lesions, immunosuppression and neoplasia in chicken. The Meq gene is an important oncogene in the MDV genome, and ...

    Abstract Marek's disease (MD), a highly cell-associated and contagious disease of chickens caused by Marek's disease virus (MDV) can result in neural lesions, immunosuppression and neoplasia in chicken. The Meq gene is an important oncogene in the MDV genome, and it is expressed highly in MD tumor tissues and MD T-lymphoblastoid cell lines. An experiment was conducted to elucidate the role of Meq in MD tumor transformation. RNA interference technology was used to block its expression, and then analyzed the biological effects of Meq knockdown on the MD tumor cell line MSB1. A small interfering RNA with an interference efficiency of 70% (P<0.01) was transfected into MSB1 cells to knock down the expression of Meq gene. The cell proliferation, cycle and apoptosis were detected post-Meq knockdown. The results showed that MSB1 cell proliferation was downregulated remarkably at 48 h (P<0.01), 60 h (P<0.05) and 72 h (P<0.01) post-Meq knockdown. The cell cycle was unaffected (P>0.05). B-cell lymphoma 2 gene (BCL2) was anti-apoptotic and caspase-6 was the effector in the apoptosis pathway. The activity of caspase-6 was upregulated (P<0.05) significantly and BCL2 gene expression was downregulated (P<0.05) significantly post-Meq knockdown, suggesting cell apoptosis might be induced. MSB1 cell migration did not exhibit any obvious change (P>0.05) post-Meq knockdown, but the expression of two genes (matrix metalloproteinase 2 (MMP2) and MMP9) that are correlated closely to cell invasion was downregulated (P<0.05) remarkably post-Meq knockdown. The Meq knockdown might affect the main features of tumorous cells, including proliferation, apoptosis, and invasion, suggesting that the Meq gene might play a crucial role in interfering with lymphomatous cell transformation.
    Keywords Marek's disease ; Meq ; proliferation ; migration ; invasion ; Agriculture (General) ; S1-972
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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