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  1. Book ; Online ; E-Book: Biomedical photonic technologies

    Li, Buhong / Zhang, Zhenxi / Jiang, Shudong

    2023  

    Author's details edited by Shudong Jiang, Buhong Li, and Zhenxi Zhang
    Keywords Photonics ; Biomedical engineering
    Subject code 610.28
    Language English
    Size 1 online resource (305 pages)
    Publisher Wiley-VCH
    Publishing place Weinheim, Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-527-82355-7 ; 3-527-82353-0 ; 9783527346561 ; 978-3-527-82355-0 ; 978-3-527-82353-6 ; 3527346562
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Biomedical Photonic Technologies

    Zhang, Zhenxi / Jiang, Shudong / Li, Buhong

    2023  

    Author's details Zhenxi Zhang is Professor in the School of Life Science and Technology at Xi'an Jiaotong University, China. After his PhD from University of Science and Technology of China, he joined Xi'an Jiaotong University. His research interests include biomedical photonics imaging and spectral analysis techniques. He has published more than 200 scientific papers. He received two times the provincial and ministerial level scientific and technological progress awards and the Outstanding Teacher Award of Baogang Education Foundation. Jiang Shudong is Associate Professor in the Thayer School of Engineering at Dartmouth College, USA. She received her PhD in optoelectronics from Tokyo Institute of Technology, Japan. Her research interests include optical spectroscopy and imaging systems for biomedical applications. She has published more than 70 journal articles. Shudong Jiang is professor and doctoral tutor of the engineering college of Dartmouth College, USA. In 1992, she received a Ph.D. in optoe
    Keywords Analytical Chemistry ; Analytische Chemie ; Biomedizin ; Biomedizinische Technik ; Biotechnologie ; Chemie ; Chemistry ; Materials Characterization ; Materials Science ; Materialwissenschaften ; Optics & Photonics ; Optik ; Optik u. Photonik ; Physics ; Physik ; Werkstoffprüfung
    Language English
    Size 288 p.
    Edition 1
    Publisher Verlag Wiley VCH
    Document type Book
    Note PDA Manuell_21
    Format 175 x 251 x 20
    ISBN 9783527346561 ; 3527346562
    Database PDA

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  3. Article ; Online: Grafting of Maleic Anhydride onto Poly(vinylidene fluoride) Using Reactive Extrusion.

    Zhang, Cuichuan / Lu, Zhiqiang / Wu, Bin / Jiang, Shu-Dong / Qian, Jiasheng

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 5

    Abstract: Poly(vinylidene fluoride) was grafted with maleic anhydride through reactive extrusion by using diisopropyl benzene peroxide as an initiator and 9-vinyl anthracene as a stabilizer. Effects of various parameters on grafting degree were investigated ... ...

    Abstract Poly(vinylidene fluoride) was grafted with maleic anhydride through reactive extrusion by using diisopropyl benzene peroxide as an initiator and 9-vinyl anthracene as a stabilizer. Effects of various parameters on grafting degree were investigated including the amounts of monomer, initiator and stabilizer. The maximum extent of grafting achieved was 0.74%. The graft polymers were characterized using FTIR, water contact angle, thermal, mechanical and XRD studies. Improved hydrophilic and mechanical properties were observed for graft polymers.
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28052246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Monitoring optoporated process on mammalian cells by real-time measurement of membrane resealing time.

    Du, Xiaofan / Fu, Lei / Wang, Zhuqu / Zhang, Zhenxi / Jiang, Shudong / Wang, Jing / Yao, Cuiping

    Journal of biomedical optics

    2023  Volume 28, Issue 6, Page(s) 65006

    Abstract: Significance: Resealing time based loading efficiency of optoporation is the key parameter for drug or gene delivery. This work describes a comparatively simple optical approach to directly measure the cell membrane resealing time of the gold ... ...

    Abstract Significance: Resealing time based loading efficiency of optoporation is the key parameter for drug or gene delivery. This work describes a comparatively simple optical approach to directly measure the cell membrane resealing time of the gold nanoparticle mediated photoporation.
    Aim: To establish a membrane potential detection optical system, which can provide a direct measurement of resealing time of the optoporated cells.
    Approach: Voltage sensitive dye has been used to label the gold nanoparticle covered cell before laser activation and the resealing time was estimated from the voltage change due to the fluorescence light intensity change before and after laser activation. The approach has been validated by the simulated data based on diffusion model and Monte Carlo simulation and the experimental data obtained from a flow cytometry analysis.
    Results: The measured resealing time after perforation varied from 28.6 to 163.8 s on Hela cells when the irradiation fluence was increased, with a correlation coefficient (
    Conclusion: The method described here can be used to directly measure resealing time of optoporated cells for accurately estimating the loading efficiency on discovering the mechanism of optoporation.
    MeSH term(s) Animals ; Humans ; HeLa Cells ; Gold ; Metal Nanoparticles ; Cell Membrane ; Pharmaceutical Preparations/metabolism ; Mammals
    Chemical Substances Gold (7440-57-5) ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.28.6.065006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4699: Show issues Location:
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  5. Article: Performance assessment of MRI guided continuous wave near-infrared spectral tomography for breast imaging.

    Feng, Jinchao / Jiang, Shudong / Pogue, Brian W / Paulsen, Keith D

    Biomedical optics express

    2021  Volume 12, Issue 12, Page(s) 7657–7672

    Abstract: Integration of magnetic resonance imaging (MRI) and near-infrared spectral tomography (NIRST) has yielded promising diagnostic performance for breast imaging in the past. This study focused on whether MRI-guided NIRST can quantify hemoglobin ... ...

    Abstract Integration of magnetic resonance imaging (MRI) and near-infrared spectral tomography (NIRST) has yielded promising diagnostic performance for breast imaging in the past. This study focused on whether MRI-guided NIRST can quantify hemoglobin concentration using only continuous wave (CW) measurements. Patients were classified into four breast density groups based on their MRIs. Optical scattering properties were assigned based on average values obtained from these density groups, and MRI-guided NIRST images were reconstructed from calibrated CW data. Total hemoglobin (HbT) contrast between suspected lesions and surrounding normal tissue was used as an indicator of the malignancy. Results obtained from simulations and twenty-four patient cases indicate that the diagnostic power when using only CW data to differentiate malignant from benign abnormalities is similar to that obtained from combined frequency domain (FD) and CW data. These findings suggest that eliminating FD detection to reduce the cost and complexity of MRI-guided NIRST is possible.
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.444131
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  6. Article: Spatial and temporal patterns in dynamic-contrast enhanced intraoperative fluorescence imaging enable classification of bone perfusion in patients undergoing leg amputation.

    Han, Xinyue / Demidov, Valentin / Vaze, Vikrant S / Jiang, Shudong / Gitajn, Ida Leah / Elliott, Jonathan T

    Biomedical optics express

    2022  Volume 13, Issue 6, Page(s) 3171–3186

    Abstract: Dynamic contrast-enhanced fluorescence imaging (DCE-FI) classification of tissue viability in twelve adult patients undergoing below knee leg amputation is presented. During amputation and with the distal bone exposed, indocyanine green contrast-enhanced ...

    Abstract Dynamic contrast-enhanced fluorescence imaging (DCE-FI) classification of tissue viability in twelve adult patients undergoing below knee leg amputation is presented. During amputation and with the distal bone exposed, indocyanine green contrast-enhanced images were acquired sequentially during baseline, following transverse osteotomy and following periosteal stripping, offering a uniquely well-controlled fluorescence dataset. An unsupervised classification machine leveraging 21 different spatiotemporal features was trained and evaluated by cross-validation in 3.5 million regions-of-interest obtained from 9 patients, demonstrating accurate stratification into normal, suspicious, and compromised regions. The machine learning (ML) approach also outperformed the standard method of using fluorescence intensity only to evaluate tissue perfusion by a two-fold increase in accuracy. The generalizability of the machine was evaluated in image series acquired in an additional three patients, confirming the stability of the model and ability to sort future patient image-sets into viability categories.
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.459497
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  7. Article ; Online: Stable tissue-mimicking phantoms for longitudinal multimodality imaging studies that incorporate optical, CT, and MRI contrast.

    Zhao, Mengyang / Zhou, Mingwei / Cao, Xu / Feng, Jinchao / Pogue, Brian W / Paulsen, Keith D / Jiang, Shudong

    Journal of biomedical optics

    2023  Volume 28, Issue 4, Page(s) 46006

    Abstract: Significance: Tissue phantoms that mimic the optical and radiologic properties of human or animal tissue play an important role in the development, characterization, and evaluation of imaging systems. Phantoms that are easily produced and stable for ... ...

    Abstract Significance: Tissue phantoms that mimic the optical and radiologic properties of human or animal tissue play an important role in the development, characterization, and evaluation of imaging systems. Phantoms that are easily produced and stable for longitudinal studies are highly desirable.
    Aim: A new type of long-lasting phantom was developed with commercially available materials and was assessed for fabrication ease, stability, and optical property control. Magnetic resonance imaging (MRI) and x-ray computed tomography (CT) contrast properties were also evaluated.
    Approach: A systematic investigation of relationships between concentrations of skin-like pigments and composite optical properties was conducted to realize optical property phantoms in the red and near-infrared (NIR) wavelength range that also offered contrast for CT and MRI.
    Results: Phantom fabrication time was
    Conclusions: The phantoms described here mimic optical properties of soft tissue and are suitable for multimodality imaging studies involving CT or MRI without adding secondary contrast agents.
    MeSH term(s) Animals ; Humans ; Contrast Media ; Multimodal Imaging ; Tomography, Optical ; Tomography, X-Ray Computed ; Phantoms, Imaging ; Magnetic Resonance Imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.28.4.046006
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    Zs.A 4699: Show issues Location:
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  8. Article: A multiplex nanoparticle-assisted polymerase chain reaction assay for detecting three canine epidemic viruses using a dual priming oligonucleotide system

    Wang, Yong / Wang, Yuanhong / Chen, Zongyan / Liu, Guangqing / Jiang, Shudong / Li, Chuanfeng

    Journal of virological methods. 2021 Dec., v. 298

    2021  

    Abstract: A rapid and accurate diagnosis of mixed viral infections is important for providing timely therapeutic interventions. The aim of this study was to develop a highly sensitive and specific method for the simultaneous detection of canine distemper virus ( ... ...

    Abstract A rapid and accurate diagnosis of mixed viral infections is important for providing timely therapeutic interventions. The aim of this study was to develop a highly sensitive and specific method for the simultaneous detection of canine distemper virus (CDV), canine parvovirus (CPV) and canine coronavirus (CCV) in mixed infections by combining the high specificity of a dual priming oligonucleotide (DPO) primer system with the high sensitivity of a nanoparticle-assisted PCR (nanoPCR) assay. Under the optimised assay conditions, the multiplex DPO-nanoPCR assay developed using DPO primers was 100-fold more sensitive than the multiplex PCR assay using conventional primers. The detection limits of the multiplex DPO-nanoPCR assay for the recombinant plasmids containing the cloned CDV, CPV and CCV target sequences were 5.4 × 10², 6.5 × 10² and 1.6 × 10² copies in a 25 μL assay, respectively. No cross-reaction with other canine viruses was observed. This is the first reported use of a multiplex nanoPCR assay with the DPO primer system for the simultaneous detection of CDV, CPV and CCV in mixed infections. The high sensitivity and specificity of the assay indicated its potential for use in clinical diagnosis and field surveillance of animal epidemics.
    Keywords Canine coronavirus ; Canine morbillivirus ; Carnivore protoparvovirus 1 ; cross reaction ; dogs ; monitoring ; oligonucleotides ; plasmids ; polymerase chain reaction ; therapeutics
    Language English
    Dates of publication 2021-12
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2021.114290
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: A Comparison of Near-Infrared Diffuse Optical Imaging and 18F-FDG PET/CT for the Early Prediction of Breast Cancer Response to Neoadjuvant Chemotherapy.

    Jiang, Shudong / Pogue, Brian W

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2016  Volume 57, Issue 8, Page(s) 1166–1167

    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.116.174367
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    Zs.MO 328: Show issues

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  10. Article ; Online: Duplex SYBR Green I-based real-time PCR assay for the rapid detection of canine kobuvirus and canine astrovirus.

    Wang, Yong / Li, Yeqiu / Cui, Yongqiu / Jiang, Shudong / Liu, Hua / Wang, Jing / Li, Yongdong

    Journal of virological methods

    2021  Volume 290, Page(s) 114066

    Abstract: A duplex SYBR Green I-based real-time PCR assay was established for the simultaneous detection of canine kobuvirus (CaKoV) and canine astrovirus (CaAstV). This assay can easily distinguish the two viruses according to their different melting temperatures ...

    Abstract A duplex SYBR Green I-based real-time PCR assay was established for the simultaneous detection of canine kobuvirus (CaKoV) and canine astrovirus (CaAstV). This assay can easily distinguish the two viruses according to their different melting temperatures (Tm) of 80 °C for CaKoV and 86.5 °C for CaAstV; other canine enteroviruses used as controls showed no specific melting peaks. The detection limit of this assay was determined to be 10
    MeSH term(s) Animals ; Benzothiazoles ; Diamines ; Dogs ; Kobuvirus/genetics ; Organic Chemicals ; Quinolines ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results ; Sensitivity and Specificity
    Chemical Substances Benzothiazoles ; Diamines ; Organic Chemicals ; Quinolines ; SYBR Green I (163795-75-3)
    Language English
    Publishing date 2021-01-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2021.114066
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