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Article ; Online: Identify the Clinicopathological Characteristics of Lung Carcinoma Patients Being False Negative in Folate Receptor Based Circulating Tumor Cell Detection.

Jiang, Siming / Wang, Hao / Zhu, Junjie / Xu, Xinnan / Chen, Linsong / Wang, Bo / Zhou, Bin / Zhu, Yuming / Zhang, Zhemin / Ma, Benting / Du, Bin / Yang, Yang

Small methods

2023 Volume 7, Issue 9, Page(s) e2300055

Abstract: In lung cancer diagnosis, folate receptor (FR)-based circulating tumor cell (CTC) has shown its ability to distinguish malignancy from benign disease to some extent. However, there are still some patients that cannot be identified by FR-based CTC ... ...

Abstract	In lung cancer diagnosis, folate receptor (FR)-based circulating tumor cell (CTC) has shown its ability to distinguish malignancy from benign disease to some extent. However, there are still some patients that cannot be identified by FR-based CTC detection. And studies comparing the characteristics between true positive (TP) and false negative (FN) patients are few. Thus, the study comprehensively analyzes the clinicopathological characteristics of FN and TP patients in the current study. According to inclusion and exclusion criteria, 3420 patients are enrolled. Combining the pathological diagnosis with CTC results, patients are divided into FN and TP groups, and clinicopathological characteristics are compared between two groups. Compared with TP patients, FN patients have smaller tumor, early T stage, early pathological stage, and without lymph node metastasis. Epidermal growth factor receptor (EGFR) mutation status is different between FN and TP group. And this result is also demonstrated in lung adenocarcinoma subgroup but not in lung squamous cell carcinoma subgroup. Tumor size, T stage, pathological stage, lymph node metastasis, and EGFR mutation status may influence the accuracy of FR-based CTC detection in lung cancer. However, further prospective studies are needed to confirm the findings.
MeSH term(s)	Humans ; Lymphatic Metastasis/diagnosis ; Neoplastic Cells, Circulating/metabolism ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Adenocarcinoma of Lung/diagnosis ; Adenocarcinoma of Lung/genetics ; Lung/metabolism ; Lung/pathology ; ErbB Receptors/genetics ; Folic Acid
Chemical Substances	ErbB Receptors (EC 2.7.10.1) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2023-06-17
Publishing country	Germany
Document type	Journal Article
ISSN	2366-9608
ISSN (online)	2366-9608
DOI	10.1002/smtd.202300055
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Article: Efficacy evaluation of surgery combined with chemotherapy for stage IIIA small cell lung cancer patients: a retrospective analysis.

Bian, Dongliang / Jiang, Siming / Xiong, Yicheng / Qi, Mengfan / Wu, Jiawei / Addeo, Alfredo / Yamauchi, Yoshikane / Manapov, Farkhad / Dempke, Wolfram C M / Vannucci, Jacopo / Di Federico, Alessandro / Xu, Xiaoxiong / Chen, Linsong

Translational lung cancer research

2022 Volume 11, Issue 8, Page(s) 1631–1642

Abstract: Background: The efficacy of surgery in combination of chemotherapy for stage IIIA small cell lung cancer (IIIA-SCLC) is controversial. The aim of the present study was to analyze the efficacy of surgery combined with chemotherapy, especially in the ... ...

Abstract	Background: The efficacy of surgery in combination of chemotherapy for stage IIIA small cell lung cancer (IIIA-SCLC) is controversial. The aim of the present study was to analyze the efficacy of surgery combined with chemotherapy, especially in the setting of neoadjuvant chemotherapy (NAC) followed by surgery for IIIA-SCLC. Methods: Between 2004 and 2015, we reviewed 2,199 chemotherapy-treated stage IIIA (N1/2) SCLC cases in the Surveillance, Epidemiology, and End Results (SEER) database, and 32 NAC + intentional radical resection-treated, centrally-located IIIA-SCLC cases at Shanghai Pulmonary Hospital (SPH). Outcomes were compared between surgically and non-surgically treated patients from the SEER database after propensity score matching (PSM), and comparing lobectomy/bi-lobectomy and pneumonectomy patients from SPH. Prognostic factors were evaluated by Kaplan-Meier method and the Cox proportional hazards regression model. Results: There was significantly higher overall survival (OS) in surgically treated IIIA-SCLC patients (OS, 44.8 Conclusions: For stage IIIA SCLC patients, complete resection combined with chemotherapy might improve the prognosis than patients without surgery. Post-NAC lobectomy was not found to be superior to sub-lobectomy, while pneumonectomy was considered suitable for central-type IIIA-SCLC patients after NAC treatment.
Language	English
Publishing date	2022-09-01
Publishing country	China
Document type	Journal Article
ZDB-ID	2754335-3
ISSN	2226-4477 ; 2218-6751
ISSN (online)	2226-4477
ISSN	2218-6751
DOI	10.21037/tlcr-22-545
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Article ; Online: Extended Sleeve Lobectomy is an Alternative for Centrally Located Lung Cancer With Superior Short- and Long-term Outcomes.

Wang, Xing / Jiang, Siming / You, Xiaofang / Aramini, Beatrice / Shabaturov, Leonid / Jiang, Gening / Zhu, Yuming / Fan, Jiang

Clinical lung cancer

2020 Volume 22, Issue 4, Page(s) e621–e628

Abstract: Introduction: Extended sleeve lobectomy (ESL) is a feasible alternative to pneumonectomy; however, the survival benefit is unclear, and preoperative selection of potential candidates for ESL remains a problem.: Matierals and methods: ESL was ... ...

Abstract	Introduction: Extended sleeve lobectomy (ESL) is a feasible alternative to pneumonectomy; however, the survival benefit is unclear, and preoperative selection of potential candidates for ESL remains a problem. Matierals and methods: ESL was performed on selected candidates with double sleeve lobectomy for more than 1 lobe (eg, left upper lobe and S6 segment resection). Three-dimensional (3-D) reconstruction was routinely validated. Patients were candidates for ESL if the predicted distal stump length was > 6 mm and the pulmonary vein of the remaining segments was not invaded. Results: Of the 1809 patients with centrally located lung cancer for surgical resection, 86 patients with tumors invading more than 1 lobe were enrolled in the study. After evaluation by 3-D reconstruction, 22 (95.7%) of 23 selected candidates underwent ESL, and 63 patients were deemed unsuitable for ESL and underwent pneumonectomy (43 cases) or thoracic exploration (20 cases). Surgical outcomes between the ESL and pneumonectomy groups were similar in terms of complications, blood loss and surgical duration, but the 6-minute walking distance was significantly improved in the ESL group (371 ± 111 m vs. 191 ± 55 m, respectively; P < .001). The mean forced expiratory volume in 1 second was 1.6 ± 0.3 L at the 1-year follow up examination in the ESL group. In the survival analysis, no difference was observed between the ESL and pneumonectomy groups in terms of 3-year overall survival (85% vs. 89%, respectively; P = .626) and 3-year disease-free survival (75% vs. 76%, respectively; P = .625). Conclusions: ESL is a feasible and superior surgical procedure in terms of its short-term and long-term outcomes, and we suggest 3-D reconstruction to identify candidates for ESL.
MeSH term(s)	Adult ; Aged ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; Disease-Free Survival ; Female ; Follow-Up Studies ; Forced Expiratory Volume ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Pneumonectomy/methods ; Postoperative Complications/epidemiology ; Retrospective Studies ; Survival Rate ; Treatment Outcome ; Walk Test
Language	English
Publishing date	2020-12-17
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2020.12.002
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Zs.A 5893: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Uniportal video-assisted thoracic surgery-the experiences of Shanghai Pulmonary Hospital.

Wang, Haifeng / Zhou, Xiao / Xie, Dong / Jiang, Siming / Ding, Hongdou / Gonzalez, Diego / Jiang, Gening

Journal of visualized surgery

2016 Volume 2, Page(s) 56

Abstract: Uniportal video-assisted thoracic surgery (VATS) is getting recognized in thoracic surgery, especially in China. Although surgeons from some part of the world are still skeptic, those in China have witnessed its breathtaking growth, along with the ... ...

Abstract	Uniportal video-assisted thoracic surgery (VATS) is getting recognized in thoracic surgery, especially in China. Although surgeons from some part of the world are still skeptic, those in China have witnessed its breathtaking growth, along with the development of the specialty of thoracic surgery. By introducing the history and experiences of one specialty hospital-Shanghai Pulmonary Hospital (SPH), we show the feasibility and safety of uniportal VATS, and illustrate the technical details of this procedure with the example of right middle lobectomy (RML).
Keywords	covid19
Language	English
Publishing date	2016-03-16
Publishing country	China
Document type	Journal Article
ISSN	2221-2965
ISSN	2221-2965
DOI	10.21037/jovs.2016.03.06
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Article ; Online: Brain metabolic correlates of fatigue in Parkinson's disease: a PET study.

Zhang, Li / Li, Tiannv / Yuan, Yongsheng / Tong, Qing / Jiang, Siming / Wang, Min / Wang, Jianwei / Ding, Jian / Xu, Qinrong / Zhang, Kezhong

The International journal of neuroscience

2018 Volume 128, Issue 4, Page(s) 330–336

Abstract: Purpose: The neural bases of fatigue in Parkinson's disease (PD) remain uncertain. We aimed to assess the brain metabolic correlates of fatigue in patients with PD.: Patients and methods: Twenty-seven PD patients without clinically relevant ... ...

Abstract	Purpose: The neural bases of fatigue in Parkinson's disease (PD) remain uncertain. We aimed to assess the brain metabolic correlates of fatigue in patients with PD. Patients and methods: Twenty-seven PD patients without clinically relevant depression (17-item Hamilton Depression Rating Scale (HAMD) score ≥ 14), apathy (Apathy Scale (AS) score ≥ 14) and excessive daytime somnolence (Epworth Sleepiness Scale (ESS) score ≥ 10) were evaluated with Fatigue Severity Scale (FSS). Each patient had an F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scan. Motor symptoms were measured with the Unified Parkinson's Disease Rating Scale motor part. Levodopa equivalent daily dose for each patient was also calculated. The PET images were analyzed using statistical parametric mapping software. We introduced the age, educational level, HAMD scores, AS scores and ESS scores as covariates. Results: High FSS scores were associated with brain hypermetabolism in areas including the right middle temporal gyrus (Brodmann area (BA) 37) and left middle occipital gyrus (BA 19). Increased FSS scores correlated with hypometabolism in regions such as the right precuneus (BA 23), left inferior frontal gyrus (BA 45) and left superior frontal gyrus (orbital part, BA 11). Conclusion: This study demonstrates that brain areas including frontal, temporal and parietal regions indicative of emotion, motivation and cognitive functions are involved in fatigue in PD patients.
MeSH term(s)	Aged ; Aged, 80 and over ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/metabolism ; Fatigue/etiology ; Fatigue/pathology ; Female ; Fluorodeoxyglucose F18/metabolism ; Humans ; Male ; Middle Aged ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Positron-Emission Tomography ; Psychiatric Status Rating Scales ; Severity of Illness Index ; Statistics as Topic
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2018-04
Publishing country	England
Document type	Journal Article
ZDB-ID	3061-2
ISSN	1563-5279 ; 1543-5245 ; 0020-7454
ISSN (online)	1563-5279 ; 1543-5245
ISSN	0020-7454
DOI	10.1080/00207454.2017.1381093
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Zs.A 657: Show issues

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Article ; Online: Decreased interhemispheric homotopic connectivity in Parkinson's disease patients with freezing of gait: A resting state fMRI study.

Li, Junyi / Yuan, Yongsheng / Wang, Min / Zhang, Jiejin / Zhang, Li / Jiang, Siming / Wang, Xixi / Ding, Jian / Zhang, Kezhong

Parkinsonism & related disorders

2018 Volume 52, Page(s) 30–36

Abstract: Introduction: Freezing of gait is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of freezing of gait in PD remain uncertain. Existing studies on PD patients with freezing of gait (PD-FOG+) have reported damage of ...

Abstract	Introduction: Freezing of gait is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of freezing of gait in PD remain uncertain. Existing studies on PD patients with freezing of gait (PD-FOG+) have reported damage of the corpus callosum, the largest commissural bundle of the brain. Thus, in this study we explored homotopic connectivity to investigate FOG-related interehemispheric alterations METHODS: A total of 21 PD-FOG + patients, 33 PD patients without freezing of gait (PD-FOG-), and 24 matched healthy controls were recruited. All PD patients were evaluated via the FOG questionnaire (FOGQ) and all subjects had a resting state functional magnetic resonance imaging (rs-fMRI) scan. The pattern of the homotopic connectivity was measured with the voxel-mirrored homotopic connectivity (VMHC) approach. Result: The PD-FOG + patients showed decreased VMHC values in the inferior parietal lobe (IPL) compared to both PD-FOG-patients and healthy controls. In PD-FOG + patients, the mean VMHC values in the IPL were negatively correlated with the FOGQ scores. Receiver operating characteristic curves analyses revealed that the VMHC in the IPL had discriminatory function distinguishing PD-FOG + patients from PD-FOG-patients or healthy controls. Conclusion: Decreased VMHC values of PD-FOG + patients relative to PD-FOG- and healthy controls in IPL maybe a unique feature for PD-FOG+ and it may have the ability to separate PD-FOG + patients from PD-FOG- and healthy controls.
MeSH term(s)	Aged ; Analysis of Variance ; Brain Mapping ; Corpus Callosum/diagnostic imaging ; Female ; Gait Disorders, Neurologic/complications ; Gait Disorders, Neurologic/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways/diagnostic imaging ; Oxygen/blood ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Rest ; Severity of Illness Index
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2018-03-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2018.03.015
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Article ; Online: Alterations in regional homogeneity of resting-state brain activity in fatigue of Parkinson's disease.

Li, Junyi / Yuan, Yongsheng / Wang, Min / Zhang, Jiejin / Zhang, Li / Jiang, Siming / Ding, Jian / Zhang, Kezhong

Journal of neural transmission (Vienna, Austria : 1996)

2017 Volume 124, Issue 10, Page(s) 1187–1195

Abstract: Fatigue is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of fatigue in PD remain uncertain. In this cross-sectional study, our aim was to study the change of the local brain function in PD patients with fatigue. ... ...

Abstract	Fatigue is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of fatigue in PD remain uncertain. In this cross-sectional study, our aim was to study the change of the local brain function in PD patients with fatigue. Among 49 patients with PD, 17 of them had fatigue and the remaining 32 patients without fatigue, and 25 age- and gender-matched healthy controls were enrolled. All subjects were evaluated with Fatigue Severity Scale (FSS) and had a resting-state functional magnetic resonance imaging (rs-fMRI) scan. The fMRI images were analyzed using regional homogeneity (ReHo) to study the change of the local brain function. ReHo analysis controlling for gray matter volume, age, gender, and education showed decreased ReHo in the left anterior cingulate cortex (ACC) and the right superior frontal gyrus (dorsolateral part), and increased ReHo in the left postcentral gyrus and the right inferior frontal gyrus (orbital and triangular part), compared PD-F with PD-NF; In PD patients, the regional activity in the left ACC and the right superior frontal gyrus (dorsolateral part) was negatively correlated with the FSS scores, while that in the left postcentral gyrus, the right inferior frontal gyrus (orbital and triangular part) was positively correlated with the FSS scores. This study demonstrates that brain areas including frontal, postcentral and ACC regions indicative of sensory, motor, and cognitive systems are involved in fatigue in PD patients.
MeSH term(s)	Aged ; Brain/diagnostic imaging ; Case-Control Studies ; Cross-Sectional Studies ; Fatigue/diagnostic imaging ; Fatigue/etiology ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Mental Status and Dementia Tests ; Middle Aged ; Oxygen/blood ; Parkinson Disease/complications ; Rest ; Severity of Illness Index ; Statistics as Topic ; Statistics, Nonparametric
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2017-10
Publishing country	Austria
Document type	Journal Article
ZDB-ID	184163-4
ISSN	1435-1463 ; 0300-9564
ISSN (online)	1435-1463
ISSN	0300-9564
DOI	10.1007/s00702-017-1748-1
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Article ; Online: Cerebral metabolic change in Parkinson's disease patients with anxiety: A FDG-PET study.

Wang, Xixi / Zhang, Jiejin / Yuan, Yongsheng / Li, Tiannv / Zhang, Li / Ding, Jian / Jiang, Siming / Li, Junyi / Zhu, Lin / Zhang, Kezhong

Neuroscience letters

2017 Volume 653, Page(s) 202–207

Abstract: Object: To detect the cerebral metabolic bases of Parkinson's disease (PD) patients with anxiety.: Methods: Totally 28 idiopathic PD patients without depression (17-item Hamilton Depression Rating Scale, HAMD score <14) were enrolled in our study. ... ...

Abstract	Object: To detect the cerebral metabolic bases of Parkinson's disease (PD) patients with anxiety. Methods: Totally 28 idiopathic PD patients without depression (17-item Hamilton Depression Rating Scale, HAMD score <14) were enrolled in our study. All subjects were classified into PD with anxiety (PD-A) (n=13) and PD without anxiety (PD-NA) (n=15) by cutoff score of 11 according to Hamilton Anxiety Rating Scale (HAMA). Besides, age- and gender- matched healthy controls (HCs) (n=15) were selected. A resting-state F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scan was applied to estimate cerebral metabolic activity. All statistical analyses were performed using IBM SPSS Statistics V20.0.0 software, while statistical parametric mapping software (SPM) was used to analyze the FDG-PET images. Results: PD-A showed decreased glucose metabolism in the bilateral orbitofrontal cortex (OFC, BA10 and BA11) when compared with PD-NA. Significant decrease of cerebral glucose metabolism in the bilateral OFC, bilateral supplementary motor area (SMA, BA6), bilateral dorsal anterior cingulate cortex (dACC, BA32), right dorsolateral prefrontal cortex (dlPFC, BA9), right ventrolateral prefrontal cortex (vlPFC, BA44), right putamen and left caudatum was detected in PD-A compared with HCs. There was significant reduced glucose metabolism of the bilateral SMA in PD-NA when compared with HCs (uncorrected p<0.005). Conclusion: The anxiety of PD was associated with the metabolic reductions of PFC and striatal areas. OFC, part of PFC, could be taken as a characteristic feature for anxiety in PD. This metabolic pattern suggested that deficits of prefrontostriatal pathways might affect anxiety mood in PD.
Language	English
Publishing date	2017-07-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2017.05.062
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Article ; Online: Lung cancers associated with cystic airspaces: CT features and pathologic correlation.

Shen, Yingran / Xu, Xinnan / Zhang, Yunfei / Li, Weitong / Dai, Jie / Jiang, Siming / Wu, Tong / Cai, Haomin / Sihoe, Alan / Shi, Jingyun / Jiang, Gening

Lung cancer (Amsterdam, Netherlands)

2019 Volume 135, Page(s) 110–115

Abstract: Objective: Lung cancer associated with cystic airspaces (LCCA) is a rare entity. The diagnosis and treatment is often delayed due to lack of comprehension of this disease. We aimed to elucidate LCCA's clinicopathological characteristics and investigate ... ...

Abstract	Objective: Lung cancer associated with cystic airspaces (LCCA) is a rare entity. The diagnosis and treatment is often delayed due to lack of comprehension of this disease. We aimed to elucidate LCCA's clinicopathological characteristics and investigate imaging features correlated with pathological invasiveness. Method: The preoperative computed tomographic (CT) scans of 10,835 patients diagnosed with NSCLC between January 2015 and December 2016 were reviewed by two thoracic radiologists for association with a cystic airspace. A clinicopathological and radiological feature analysis was done. Result: A total number of 123 LCCA patients were identified and four morphologic patterns were recognized: I, thin-walled type (n = 23, 18.7%); II, thick-walled type (n = 34, 27.6%); III, a cystic airspace with a mural nodule (CWN) type (n = 43, 35.0%); and IV, mixed type (n = 23, 18.7%). A solid component in the cyst wall predicted histological invasiveness in all four types of LCCA. The proportion of moderately/poorly (M/P)-differentiated subtype in type III (85.0%) was higher than in other three patterns (which were 50.0%, 50.0%, and 69.6%, respectively). Multivariate analysis revealed that type III pattern (odds ratio [OR], 6.5; 95% confidence interval [CI], 1.1-36.4; P = 0.035), part-solid/solid component in wall (part-solid: OR, 27.2; 95% CI, 5.6-3131.6; P < 0.001; solid: OR 614.6; 95% CI, 36.4-10,368.6; P < 0.001), and irregular inner surface of cyst (OR 7.0; 95% CI 1.9-26.2; P = 0.004) were independent risk factors for the M/P-differentiated subtype. EGFR mutations were the predominant genetic alterations in each type of LCCAs, but no significant difference was found among them. Conclusions: In LCCA, morphological patterns and wall components were two important predictors for determining pathological invasiveness.
MeSH term(s)	Aged ; Biomarkers ; Biopsy ; Cysts/diagnostic imaging ; Cysts/pathology ; Female ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Odds Ratio ; Tomography, X-Ray Computed
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-05-12
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2019.05.012
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Article ; Online: Relationship between the plasma levels of neurodegenerative proteins and motor subtypes of Parkinson's disease.

Ding, Jian / Zhang, Jiejin / Wang, Xixi / Zhang, Li / Jiang, Siming / Yuan, Yongsheng / Li, Junyi / Zhu, Lin / Zhang, Kezhong

Journal of neural transmission (Vienna, Austria : 1996)

2016 Volume 124, Issue 3, Page(s) 353–360

Abstract: The aim of our study is to examine the plasma levels of the four kinds of neurodegenerative proteins in plasma: α-syn, T-tau, P- ... ...

Abstract	The aim of our study is to examine the plasma levels of the four kinds of neurodegenerative proteins in plasma: α-syn, T-tau, P-tau
MeSH term(s)	Aged ; Amyloid beta-Peptides/blood ; Biomarkers/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Gait ; Humans ; Linear Models ; Male ; Middle Aged ; Motor Activity ; Parkinson Disease/blood ; Parkinson Disease/classification ; Peptide Fragments/blood ; Phosphorylation ; Postural Balance ; Severity of Illness Index ; Tremor/blood ; Tremor/classification ; alpha-Synuclein/blood ; tau Proteins/blood
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; MAPT protein, human ; Peptide Fragments ; SNCA protein, human ; alpha-Synuclein ; amyloid beta-protein (1-42) ; tau Proteins
Language	English
Publishing date	2016-11-22
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184163-4
ISSN	1435-1463 ; 0300-9564
ISSN (online)	1435-1463
ISSN	0300-9564
DOI	10.1007/s00702-016-1650-2
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