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  1. Article ; Online: Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin.

    Jiang, Wei I / De Belly, Henry / Wang, Bingying / Wong, Andrew / Kim, Minseo / Oh, Fiona / DeGeorge, Jason / Huang, Xinya / Guang, Shouhong / Weiner, Orion D / Ma, Dengke K

    Science advances

    2024  Volume 10, Issue 4, Page(s) eadj3880

    Abstract: Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here, we show that early-life thermal stress strongly up- ... ...

    Abstract Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here, we show that early-life thermal stress strongly up-regulates
    MeSH term(s) Adult ; Humans ; Animals ; Longevity ; Thrombospondin 1 ; Adverse Childhood Experiences ; Caenorhabditis elegans ; Resilience, Psychological ; Tetraspanins/genetics ; Transcription Factors ; Caenorhabditis elegans Proteins/genetics ; Histone Acetyltransferases
    Chemical Substances Thrombospondin 1 ; Tetraspanins ; CBP-1 protein, C elegans (EC 2.3.1.48) ; Transcription Factors ; Caenorhabditis elegans Proteins ; Histone Acetyltransferases (EC 2.3.1.48)
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adj3880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Suppressing mortality and curbing cellular damage by targeting VHL.

    Jiang, Wei I / Cao, Yiming / Xue, Yue / Ji, Yichun / Winer, Benjamin Y / Zhang, Mengqi / Singhal, Neel S / Pierce, Jonathan T / Chen, Song / Ma, Dengke K

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Mortality rate increases with age and can accelerate upon extrinsic or intrinsic damage to individuals. Identifying factors and mechanisms that curb population mortality rate has wide-ranging implications. Here, we show that targeting the VHL-1 (Von ... ...

    Abstract Mortality rate increases with age and can accelerate upon extrinsic or intrinsic damage to individuals. Identifying factors and mechanisms that curb population mortality rate has wide-ranging implications. Here, we show that targeting the VHL-1 (Von Hippel-Lindau) protein suppresses
    Language English
    Publishing date 2024-03-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.28.582664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin.

    Jiang, Wei I / De Belly, Henry / Wang, Bingying / Wong, Andrew / Kim, Minseo / Oh, Fiona / DeGeorge, Jason / Huang, Xinya / Guang, Shouhong / Weiner, Orion D / Ma, Dengke K

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here we show that early-life thermal stress strongly up- ... ...

    Abstract Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here we show that early-life thermal stress strongly up-regulates
    Language English
    Publishing date 2023-12-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.25.550452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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