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  1. Book: Sphingolipid metabolism and metabolic disease

    Jiang, Xian-Cheng

    (Advances in experimental medicine and biology ; 1372)

    2022  

    Author's details Xian-Cheng Jiang editor
    Series title Advances in experimental medicine and biology ; 1372
    Collection
    Keywords Sphingolipids/Metabolism ; Metabolism/Disorders
    Subject code 572.57
    Language English
    Size viii, 213 Seiten, Illustrationen, 26 cm
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book
    HBZ-ID HT021374482
    ISBN 978-981-19-0393-9 ; 9789811903946 ; 981-19-0393-X ; 9811903948
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1372- not available for loan Lesesaal EG

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  2. Book: Lipid transfer in lipoprotein metabolism and cardiovascular disease

    Jiang, Xian-Cheng

    (Advances in experimental medicine and biology ; 1276)

    2020  

    Author's details Xian-Cheng Jiang editor
    Series title Advances in experimental medicine and biology ; 1276
    Collection
    Language English
    Size viii, 234 Seiten, Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book
    HBZ-ID HT020549797
    ISBN 978-981-15-6081-1 ; 9789811560828 ; 981-15-6081-1 ; 981156082X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1276- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Evidence for no genetic causal association between skin response to sun exposure and systemic lupus erythematosus: A Mendelian randomization study in Europeans and East Asians.

    Yang, Fengjuan / Li, Jiaqi / Jiang, Xian

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2024  

    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 413: Show issues

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  4. Article ; Online: Clinical characteristics of rosacea in perimenopausal women.

    Yang, Fengjuan / Wang, Lian / Jiang, Xian

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

    2024  Volume 30, Issue 1, Page(s) e13542

    MeSH term(s) Female ; Humans ; Perimenopause ; Rosacea/diagnosis
    Language English
    Publishing date 2024-01-14
    Publishing country England
    Document type Letter
    ZDB-ID 1229160-2
    ISSN 1600-0846 ; 0909-752X ; 1397-1344
    ISSN (online) 1600-0846
    ISSN 0909-752X ; 1397-1344
    DOI 10.1111/srt.13542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4278: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A Case of Drug Reaction With Eosinophilia and Systemic Symptoms Caused by Mitotane: A Cytotoxic Drug Treating Adrenocortical Carcinoma.

    Qi, Jinxin / Zhang, Qian / Jiang, Xian

    Dermatitis : contact, atopic, occupational, drug

    2024  

    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1089/derm.2023.0325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3680: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Causal relationship between gut microbiota and rosacea: a two-sample Mendelian randomization study.

    Li, Jiaqi / Yang, Fengjuan / Liu, Yuling / Jiang, Xian

    Frontiers in medicine

    2024  Volume 11, Page(s) 1322685

    Abstract: Background: Rosacea, a chronic inflammatory skin condition affecting millions worldwide, is influenced by complex interactions between genetic and environmental factors. Although gut microbiota's role in skin health is well-acknowledged, definitive ... ...

    Abstract Background: Rosacea, a chronic inflammatory skin condition affecting millions worldwide, is influenced by complex interactions between genetic and environmental factors. Although gut microbiota's role in skin health is well-acknowledged, definitive causal links between gut microbiota and rosacea remain under-explored.
    Methods: Using a two-sample Mendelian randomization (MR) design, this study examined potential causal relationships between gut microbiota and rosacea. Data was sourced from the largest Genome-Wide Association Study (GWAS) for gut microbiota and the FinnGen biobank for rosacea. A total of 2078 single nucleotide polymorphisms (SNPs) associated with gut microbiota were identified and analyzed using a suite of MR techniques to discern causal effects.
    Results: The study identified a protective role against rosacea for two bacterial genera: phylum Actinobacteria and genus Butyrivibrio. Furthermore, 14 gut microbiota taxa were discovered to exert significant causal effects on variant categories of rosacea. While none of these results met the strict False Discovery Rate correction threshold, they retained nominal significance. MR outcomes showed no pleiotropy, with homogeneity observed across selected SNPs. Directionality tests pointed toward a robust causative path from gut microbiota to rosacea.
    Conclusion: This study provides compelling evidence of the gut microbiota's nominal causal influence on rosacea, shedding light on the gut-skin axis's intricacies and offering potential avenues for therapeutic interventions in rosacea management. Further research is warranted to validate these findings and explore their clinical implications.
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1322685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Photodynamic Effect of Vascular-targeted Polyphenol Nanoparticles on Endothelial Cells.

    Yang, Lihua / Liu, Danni / Liu, Lian / Jiang, Xian

    Photodiagnosis and photodynamic therapy

    2024  , Page(s) 104096

    Abstract: Background: Port wine stains (PWS) are vascular malformations, and photodynamic therapy (PDT) is a promising treatment. Emerging drug delivery method employs nanoparticles (NPs) to enhance drug permeability and retention in diseased blood vessels and ... ...

    Abstract Background: Port wine stains (PWS) are vascular malformations, and photodynamic therapy (PDT) is a promising treatment. Emerging drug delivery method employs nanoparticles (NPs) to enhance drug permeability and retention in diseased blood vessels and improving drug bioavailability. (-) -epigallocatechin-3-gallate glycine (EGCG) has anti-angiogenetic effects and boosts photodynamic therapy. Chlorin e6 (Ce6) is capable of efficiently producing singlet oxygen, rendering it a very promising photosensitizer for utilization in nanomedicine.
    Material and methods: EGCG-Ce6-NPs were synthesized and characterized using various techniques. The photodynamic effects of EGCG-Ce6-NPs on endothelial cells were evaluated. The compatibility and toxicity of the nanoparticle was tested using the CCK-8 assay. The intracellular uptake of the nanoparticle was observed using an inverted fluorescence microscope, and the intracellular fluorescence intensity was detected using flow cytometry. The ROS generation and apoptosis induced by EGCG-Ce6-NPs was observed using confocal laser scanning microscope and flow cytometry respectively.
    Results: EGCG-Ce6-NPs exhibited stability, spherical shape of uniform size while reducing the particle diameter, low polydisperse profile and retaining the ability to effectively generate singlet oxygen. These characteristics suggest promising potential for enhancing drug permeability and retention. Additionally, EGCG-Ce6-NPs demonstrated good compatibility with endothelial cells and enhanced intracellular uptake of Chlorin e6. Furthermore, EGCG-Ce6-NPs increased activation efficiency, induced significant toxicity, more reactive oxygen species, and higher rate of late apoptosis after laser irradiation.
    Conclusion: This in vitro study showed the potentials EGCG-Ce6-NPs for the destruction of endothelial cells in vasculature.
    Language English
    Publishing date 2024-04-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2024.104096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Impact of Phospholipid Transfer Protein in Lipid Metabolism and Cardiovascular Diseases.

    Jiang, Xian-Cheng

    Advances in experimental medicine and biology

    2020  Volume 1276, Page(s) 1–13

    Abstract: PLTP plays an important role in lipoprotein metabolism and cardiovascular disease development in humans; however, the mechanisms are still not completely understood. In mouse models, PLTP deficiency reduces cardiovascular disease, while its ... ...

    Abstract PLTP plays an important role in lipoprotein metabolism and cardiovascular disease development in humans; however, the mechanisms are still not completely understood. In mouse models, PLTP deficiency reduces cardiovascular disease, while its overexpression induces it. Therefore, we used mouse models to investigate the involved mechanisms. In this chapter, the recent main progresses in the field of PLTP research are summarized, and our focus is on the relationship between PLTP and lipoprotein metabolism, as well as PLTP and cardiovascular diseases.
    MeSH term(s) Animals ; Cardiovascular Diseases ; Disease Models, Animal ; Humans ; Lipid Metabolism ; Mice ; Phospholipid Transfer Proteins
    Chemical Substances Phospholipid Transfer Proteins
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-15-6082-8_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Contrasting Responses of the Microbial Community Structure and Functional Traits to Soil pH in Purple Soils].

    Wang, Zhi-Hui / Jiang, Xian-Jun

    Huan jing ke xue= Huanjing kexue

    2022  Volume 43, Issue 7, Page(s) 3876–3883

    Abstract: To clarify the effect of pH on the structure and functional traits of soil microbial communities in purple soils, three purple upland soils developed from the same parent material that differed in pH were selected as the research objects, and metagenomic ...

    Abstract To clarify the effect of pH on the structure and functional traits of soil microbial communities in purple soils, three purple upland soils developed from the same parent material that differed in pH were selected as the research objects, and metagenomic shotgun sequencing was used to investigate the structure and functional traits of the microbial communities among different pH soils. The shotgun sequencing identified a total of 89 phyla, 222 classes, 527 orders, 1009 families, 2769 genera, and 14354 species in these soils. Regardless of the phylogenetic classification level, the microbial community structures of these three purple soils with different pHs were significantly different. RDA results corroborated the highly significant difference in the microbial community structures among the three purple soils with different pHs, and the soil properties tested here all had significant correlations with soil microbial community structure, in which the soil pH had the greatest effect (
    MeSH term(s) Humans ; Microbiota ; Nitrogen ; Phylogeny ; Soil/chemistry ; Soil Microbiology
    Chemical Substances Soil ; Nitrogen (N762921K75)
    Language Chinese
    Publishing date 2022-06-01
    Publishing country China
    Document type Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.202111055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Sphingomyelin Synthase Family and Phospholipase Cs.

    Jiang, Xian-Cheng / Chiang, Yeun-Po

    Advances in experimental medicine and biology

    2022  Volume 1372, Page(s) 77–86

    Abstract: The sphingomyelin synthase (SMS) gene family has three members: SMS1 and SMS2 have SM synthase activity, while SMS-related protein (SMSr) has no SM synthase activity but has ceramide phosphorylethanolamine (CPE) synthase activity in vitro. Recently, we ... ...

    Abstract The sphingomyelin synthase (SMS) gene family has three members: SMS1 and SMS2 have SM synthase activity, while SMS-related protein (SMSr) has no SM synthase activity but has ceramide phosphorylethanolamine (CPE) synthase activity in vitro. Recently, we found that SMS family members are a group of phospholipase Cs (PLC). SMS1 and SMS2 are two phosphatidylcholine (PC)-PLCs and SMSr is a phosphatidylethanolamine (PE)-PLC. SMS family members not only influence SM levels but also influence the levels of diacylglycerol (DAG), PC, PE, and glycosphingolipids, thus influencing cell functions. In this chapter, we will discuss the recent progress in the research field of SMS family and will focus on its impact on metabolic diseases.
    MeSH term(s) Phosphatidylcholines/metabolism ; Phospholipases ; Sphingomyelins/genetics ; Sphingomyelins/metabolism ; Transferases (Other Substituted Phosphate Groups)/genetics ; Transferases (Other Substituted Phosphate Groups)/metabolism ; Type C Phospholipases/metabolism
    Chemical Substances Phosphatidylcholines ; Sphingomyelins ; Transferases (Other Substituted Phosphate Groups) (EC 2.7.8.-) ; phosphatidylcholine-ceramide phosphocholine transferase (EC 2.7.8.-) ; Phospholipases (EC 3.1.-) ; Type C Phospholipases (EC 3.1.4.-)
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-19-0394-6_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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