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  1. Article: [Influence of coronavirus disease 2019 on the nervous system of children].

    Jiang, Xin-Yi / Zhou, Wen-Hao

    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

    2021  Volume 23, Issue 5, Page(s) 530–535

    Abstract: Coronavirus disease 2019 (COVID-19) has become a worldwide pandemic and can occur at any age, including children. Children with COVID-19 can develop the clinical symptoms of multiple systems, among which symptoms of the nervous system have been reported ... ...

    Abstract Coronavirus disease 2019 (COVID-19) has become a worldwide pandemic and can occur at any age, including children. Children with COVID-19 can develop the clinical symptoms of multiple systems, among which symptoms of the nervous system have been reported increasingly, and thus it is particularly important to understand COVID-19-associated neurological damage in children. This article reviews the mechanisms and types of COVID-19-associated neurological damage in children.
    MeSH term(s) COVID-19 ; Child ; Humans ; Nervous System Diseases ; Pandemics ; SARS-CoV-2
    Language Chinese
    Publishing date 2021-05-14
    Publishing country China
    Document type Journal Article ; Review
    ISSN 1008-8830
    ISSN 1008-8830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Urine Self-Sampling Kit Combined with an Automated Preparation-Sampler Device for Convenient and Reliable Analysis of Arsenic Metabolites by HPLC-ICPMS.

    Zhang, Xiao / Jiang, Xin-Yi / Zhao, Lin / Chen, Shuai / Yu, Yong-Liang / Wang, Jian-Hua

    Analytical chemistry

    2024  Volume 96, Issue 4, Page(s) 1742–1749

    Abstract: Speciation analysis of arsenic in urine is essential for the studies of arsenic metabolism and biological effects, but the unstable arsenic species represented by ... ...

    Abstract Speciation analysis of arsenic in urine is essential for the studies of arsenic metabolism and biological effects, but the unstable arsenic species represented by MMA
    MeSH term(s) Arsenic/analysis ; Arsenicals/analysis ; Chromatography, High Pressure Liquid/methods ; Mass Spectrometry/methods ; Organometallic Compounds
    Chemical Substances Arsenic (N712M78A8G) ; monomethylarsonous acid ; Arsenicals ; Organometallic Compounds
    Language English
    Publishing date 2024-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c04881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dynamic Stomach Model-Capillary Electrophoresis-ICPMS for Evaluation of Release and Transformation Behaviors of Arsenic Species from Microplastics during Digestion.

    Zhang, Xiao / Jiang, Xin-Yi / Cai, Ji-Ying / Chen, Shuai / Yu, Yong-Liang / Wang, Jian-Hua

    Analytical chemistry

    2024  Volume 96, Issue 18, Page(s) 7155–7162

    Abstract: Microplastics (MPs) can act as carriers of environmental arsenic species into the stomach with food and release arsenic species during digestion, which threatens human health. Herein, an integrated dynamic stomach model (DSM)-capillary electrophoresis- ... ...

    Abstract Microplastics (MPs) can act as carriers of environmental arsenic species into the stomach with food and release arsenic species during digestion, which threatens human health. Herein, an integrated dynamic stomach model (DSM)-capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICPMS) is developed for online monitoring of the release and transformation behaviors of arsenic species loaded on MPs (As-MPs) in the simulated human stomach. The 3D-printed DSM with a soft stomach chamber enables the behaviors of gastric peristalsis, gastric and salivary fluid addition, pH adjustment, and gastric emptying (GE) to be controlled by a self-written program after oral ingestion of food with As-MPs. The gastric extract during digestion is introduced into the spiral channel to remove the large particulate impurity and online filtered to obtain the clarified arsenic-containing solution for subsequent speciation analysis of arsenic by CE-ICPMS. The digestion conditions and pretreatment processes of DSM are tracked and validated, and the release rates of As-MPs digested by DSM are compared with those digested by the static stomach model and DSM without GE. The release rate of inorganic arsenic on MPs is higher than that of organic arsenic throughout the gastric digestion process, and 8% of As(V) is reduced to As(III). The detection limits for As(III), DMA, MMA, and As(V) are 0.5-0.9 μg L
    MeSH term(s) Arsenic/analysis ; Humans ; Mass Spectrometry/methods ; Electrophoresis, Capillary/methods ; Microplastics/analysis ; Stomach/chemistry ; Digestion ; Models, Biological
    Chemical Substances Arsenic (N712M78A8G) ; Microplastics
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.4c00654
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  4. Article ; Online: Facile Lego-Spinner Pretreatment Device for Analysis of Arsenic Species in Dried Blood Spots by Ion Chromatography-Inductively Coupled Plasma-Mass Spectrometry

    Zhang, Xiao / Jiang, Xin-Yi / Chen, Shuai / Yu, Yong-Liang / Wang, Jian-hua

    Analytical Chemistry. 2023 Jan. 18, v. 95, no. 4 p.2375-2381

    2023  

    Abstract: Dried blood spot (DBS) detection has the advantages of small blood collection, convenience, and reliability, which provides a possibility for large-scale evaluation of arsenic exposure in human population. Herein, a facile Lego-spinner pretreatment ... ...

    Abstract Dried blood spot (DBS) detection has the advantages of small blood collection, convenience, and reliability, which provides a possibility for large-scale evaluation of arsenic exposure in human population. Herein, a facile Lego-spinner pretreatment device is rationally designed for speciation analysis of arsenic in DBSs by ion chromatography-inductively coupled plasma-mass spectrometry (IC-ICP-MS). In the mixing mode of the Lego-spinner, the magnetic stir bar in the centrifuge tube rotates under a magnetic field to assist the dispersive extraction of arsenic species in the DBS with reagents. In the centrifugation mode of the Lego-spinner, the arsenic extract is separated from the blood matrix for the subsequent IC-ICP-MS analysis. For the DBS prepared from 80 μL of whole blood, the whole pretreatment operation can be completed within 25 min. The detection limits of arsenobetaine, arsenite, dimethylarsenate, monomethylarsonate, and arsenate in the DBS are 0.09–0.15 μg L–¹, and precisions are <11%. The concentrations of these five arsenic species are highly correlated between whole blood and the DBS (r ² > 0.97), and Bland–Altman analysis indicates that the concentration difference of arsenic species between whole blood and the DBS is within ±20%. The DBS sampling approach can effectively preserve arsenic species for at least 30 days at 4 °C, and the contents of arsenic species in the DBS prepared from capillary blood are in a reasonable agreement with those of venous whole blood (gold standard). This Lego-spinner provides a handy and efficient tool for fast extraction of arsenic species in DBSs, facilitating the in-depth study of arsenic migration and transformation in the human body.
    Keywords analytical chemistry ; arsenates ; arsenic ; arsenites ; blood ; blood sampling ; centrifugation ; human population ; humans ; magnetic fields ; spectroscopy
    Language English
    Dates of publication 2023-0118
    Size p. 2375-2381.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c04368
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  5. Article ; Online: Facile Lego-Spinner Pretreatment Device for Analysis of Arsenic Species in Dried Blood Spots by Ion Chromatography-Inductively Coupled Plasma-Mass Spectrometry.

    Zhang, Xiao / Jiang, Xin-Yi / Chen, Shuai / Yu, Yong-Liang / Wang, Jian-Hua

    Analytical chemistry

    2023  Volume 95, Issue 4, Page(s) 2375–2381

    Abstract: Dried blood spot (DBS) detection has the advantages of small blood collection, convenience, and reliability, which provides a possibility for large-scale evaluation of arsenic exposure in human population. Herein, a facile Lego-spinner pretreatment ... ...

    Abstract Dried blood spot (DBS) detection has the advantages of small blood collection, convenience, and reliability, which provides a possibility for large-scale evaluation of arsenic exposure in human population. Herein, a facile Lego-spinner pretreatment device is rationally designed for speciation analysis of arsenic in DBSs by ion chromatography-inductively coupled plasma-mass spectrometry (IC-ICP-MS). In the mixing mode of the Lego-spinner, the magnetic stir bar in the centrifuge tube rotates under a magnetic field to assist the dispersive extraction of arsenic species in the DBS with reagents. In the centrifugation mode of the Lego-spinner, the arsenic extract is separated from the blood matrix for the subsequent IC-ICP-MS analysis. For the DBS prepared from 80 μL of whole blood, the whole pretreatment operation can be completed within 25 min. The detection limits of arsenobetaine, arsenite, dimethylarsenate, monomethylarsonate, and arsenate in the DBS are 0.09-0.15 μg L
    MeSH term(s) Humans ; Arsenic/analysis ; Mass Spectrometry/methods ; Reproducibility of Results ; Spectrum Analysis ; Chromatography, Ion Exchange/methods ; Dried Blood Spot Testing ; Chromatography, High Pressure Liquid/methods
    Chemical Substances Arsenic (N712M78A8G)
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c04368
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  6. Article ; Online: PPh

    Jiang, Xin-Yi / Yang, Cheng-Li / Li, Ning / Xiao, Hua-Qing / Yu, Jun-Xia / Dong, Zhi-Bing

    The Journal of organic chemistry

    2023  Volume 88, Issue 18, Page(s) 13272–13278

    Abstract: A simple and efficient method for the synthesis of unsymmetrical disulfides is reported. Using sodium sulfites and 2-mercaptobenzo heterocyclic compounds as starting materials, the unsymmetrical sulfur-sulfur bonds could be quickly constructed in the ... ...

    Abstract A simple and efficient method for the synthesis of unsymmetrical disulfides is reported. Using sodium sulfites and 2-mercaptobenzo heterocyclic compounds as starting materials, the unsymmetrical sulfur-sulfur bonds could be quickly constructed in the PPh
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c01575
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  7. Article: Synthesis of Unsymmetric Thiosulfonates Starting from N-Substituted O-Thiocarbamates: Easy Access to the S–SO₂ Bond

    Yang, Cheng-Li / Gao, Xue-Jie / Jiang, Xin-Yi / Shi, Zhen / Hao, Er-Jun / Dong, Zhi-Bing

    Journal of organic chemistry. 2022 Aug. 12, v. 87, no. 17

    2022  

    Abstract: Using phenyliodine diacetate as an oxidant and nickel acetate as a promoter, a wide range of unsymmetric thiosulfonates could be furnished easily in moderate to excellent yields starting from N-substituted O-thiocarbamates and sodium sulfinates. This ... ...

    Abstract Using phenyliodine diacetate as an oxidant and nickel acetate as a promoter, a wide range of unsymmetric thiosulfonates could be furnished easily in moderate to excellent yields starting from N-substituted O-thiocarbamates and sodium sulfinates. This protocol features mild conditions, short reaction times, and high atomic utilization, which can provide an alternative method for the synthesis of unsymmetric thiosulfonates. In addition, the reaction could be scaled up on a gram scale, showing potential application value in industry.
    Keywords acetates ; industry ; iodobenzenes ; nickel ; organic chemistry ; oxidants ; sodium
    Language English
    Dates of publication 2022-0812
    Size p. 11656-11668.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c01301
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  8. Article ; Online: Characterization of the TcCYPE2 Gene and Its Role in Regulating Trehalose Metabolism in Response to High CO2 Stress

    Zhou, Yan-Fei / Zhou, Min / Wang, Yuan-Yuan / Jiang, Xin-Yi / Zhang, Pei / Xu, Kang-Kang / Tang, Bin / Li, Can

    Agronomy. 2023 Aug. 28, v. 13, no. 9

    2023  

    Abstract: Cytochrome P450 monooxygenase (CYP) is one of the three detoxification metabolic enzymes in insects, and is involved in the metabolism and transformation of endogenous substances as well as the activation and degradation of exogenous compounds. This ... ...

    Abstract Cytochrome P450 monooxygenase (CYP) is one of the three detoxification metabolic enzymes in insects, and is involved in the metabolism and transformation of endogenous substances as well as the activation and degradation of exogenous compounds. This study aims to reveal the molecular mechanism of CYP9E2 in Tribolium castaneum in adapting to high-CO₂ stress. By predicting the sequence function of CYP9E2, analyzing the temporal and spatial expression profile of TcCYP9E2, and using RNAi to silence TcCYP9E2 combined with a high-CO₂ stress treatment, we measured the carbohydrate content, trehalase activity, and gene expression levels in trehalose metabolism of T. castaneum. A bioinformatics analysis showed that the predicted molecular weight of the protein encoded by TcCYP9E2 is 60.15, the theoretical isoelectric point is 8.63, there is no signal peptide, and the protein is hydrophilic. An evolutionary tree analysis showed that TcCYP9E2 belongs to the CYP6 family and belongs to the CYP3 group; and the spatiotemporal expression profile results showed that TcCYP9E2 was highly expressed in the larvae midgut 48 h after injection of dsCYP9E2, with survival rates decreasing with the increase in CO₂ concentration. Under the condition of 75% CO₂, the contents of glycogen, glucose, ATP, and membrane-bound trehalase decreased significantly after the injection of dsCYP9E2. The expression of TRE-1, TRE-2, and GP in trehalose metabolism and energy pathways was significantly downregulated.
    Keywords Tribolium castaneum ; agronomy ; bioinformatics ; carbohydrate content ; carbon dioxide ; cytochrome P-450 ; energy ; gene expression ; genes ; glucose ; glycogen ; hydrophilicity ; isoelectric point ; metabolism ; midgut ; molecular weight ; phylogeny ; signal peptide ; trehalase ; trehalose
    Language English
    Dates of publication 2023-0828
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy13092263
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  9. Article ; Online: Synthesis of Unsymmetric Thiosulfonates Starting from N-Substituted

    Yang, Cheng-Li / Gao, Xue-Jie / Jiang, Xin-Yi / Shi, Zhen / Hao, Er-Jun / Dong, Zhi-Bing

    The Journal of organic chemistry

    2022  Volume 87, Issue 17, Page(s) 11656–11668

    Abstract: Using phenyliodine diacetate as an oxidant and nickel acetate as a promoter, a wide range of unsymmetric thiosulfonates could be furnished easily in moderate to excellent yields starting from N- ... ...

    Abstract Using phenyliodine diacetate as an oxidant and nickel acetate as a promoter, a wide range of unsymmetric thiosulfonates could be furnished easily in moderate to excellent yields starting from N-substituted
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c01301
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  10. Article ; Online: Risk factors for postoperative myocardial injury-related cardiogenic shock in patients undergoing cardiac surgery.

    Cheng, Xiao-Feng / Wang, Kuo / Zhang, Hai-Tao / Zhang, He / Jiang, Xin-Yi / Lu, Li-Chong / Chen, Cheng / Cheng, Yong-Qing / Wang, Dong-Jin / Li, Kai

    Journal of cardiothoracic surgery

    2023  Volume 18, Issue 1, Page(s) 220

    Abstract: Background: Myocardial injury-related cardiogenic shock (MICS) is significantly associated with poor outcomes in patients after cardiac surgery. Herein, we aimed to investigate the risk factor for postoperative MICS.: Methods: We performed a case- ... ...

    Abstract Background: Myocardial injury-related cardiogenic shock (MICS) is significantly associated with poor outcomes in patients after cardiac surgery. Herein, we aimed to investigate the risk factor for postoperative MICS.
    Methods: We performed a case-control study on 792 patients undergoing cardiac surgery from 2016 to 2019, including 172 patients with postoperative MICS and 620 age- and sex-matched controls. MICS was defined as composite criteria: a cardiac index of < 2.2 L/m
    Results: A total of 4671 patients who underwent cardiac surgery in our hospital between 2016 and 2019 were included; of these, 172 (3.68%) had MICS and the remaining 4499 did not. For investigating the risk factors, we selected 620 age- and sex-matched controls. In the univariate analysis, MICS was significantly associated with death (P < 0.05), extracorporeal membrane oxygenation (P < 0.05), continuous renal replacement therapy (P < 0.01), and ventricular arrhythmias (P < 0.05). Multivariable logistic regression analysis revealed that diabetes mellitus (OR:8.11, 95% CI: 3.52-18.66, P < 0.05) and a cardiopulmonary bypass (CPB) time of > 2 h (OR: 3.16, 95% CI: 1.94-5.15, P < 0.05) were associated with postoperative MICS. Moreover, long-time administration of preoperative calcium channel blocker (CCB) was associated with a less incidence of MICS (OR: 0.11, 95% CI: 0.05-0.27, P < 0.05).
    Conclusions: Postoperative MICS is significantly associated with poor outcomes. Diabetes mellitus and long CPB time are associated with MICS. Preoperative CCB administration is associated with less incidence of MICS.
    MeSH term(s) Humans ; Shock, Cardiogenic/etiology ; Case-Control Studies ; Retrospective Studies ; Cardiac Surgical Procedures/adverse effects ; Risk Factors
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2227224-0
    ISSN 1749-8090 ; 1749-8090
    ISSN (online) 1749-8090
    ISSN 1749-8090
    DOI 10.1186/s13019-023-02312-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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