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  1. Article ; Online: Advances in Immunogenic Cell Death for Cancer Immunotherapy.

    Ding, Dan / Jiang, Xiqun

    Small methods

    2023  Volume 7, Issue 5, Page(s) e2300354

    MeSH term(s) Humans ; Immunogenic Cell Death ; Neoplasms/therapy ; Cell Death ; Immunotherapy/adverse effects
    Language English
    Publishing date 2023-05-16
    Publishing country Germany
    Document type Editorial
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202300354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In Situ Engineering Cancer Mask to Immobilize Tumor Cells and Block Metastasis.

    Zhang, Xiaoke / Li, Cheng / Zhu, Dan / Mao, Hui / Jiang, Xiqun

    Advanced healthcare materials

    2024  , Page(s) e2400742

    Abstract: This work reports a new concept of cancer mask in situ to alter the specific biological functions of cancer cells. Metastatic cancer cells are highly invasive in part due to the presence of the glycan matrix in the cell membrane. Using a rational ... ...

    Abstract This work reports a new concept of cancer mask in situ to alter the specific biological functions of cancer cells. Metastatic cancer cells are highly invasive in part due to the presence of the glycan matrix in the cell membrane. Using a rational designed bio-orthogonal reaction, the cancer cell surface is reconstructed in situ by incorporating endogenous polysialic acids in the glycan matrix on the cell membrane to form a mesh-like network, called cancer mask. The network of the glycan matrix can not only immobilize cancer cells but also effectively block the stimulation of metastasis promoters to tumor cells and inhibit the formation of epithelial to mesenchymal transition (EMT), causing metastatic cancer cells incarceration. The results demonstrate a new strategy to control and even eliminate the cancer metastasis that is a major cause of treatment failure and poor patient outcome.
    Language English
    Publishing date 2024-04-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202400742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
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  3. Article ; Online: Dynamic monitoring of the fibrosis disease by a collagen targeting near infrared probe.

    Zhang, Xiaoke / Yang, Qianwen / Zhou, Sensen / Li, Cheng / Jiang, Xiqun

    Biomaterials science

    2024  Volume 12, Issue 7, Page(s) 1924–1931

    Abstract: The deposition of the extracellular matrix, especially collagen, and the elevated expression levels of reactive oxygen species, including ... ...

    Abstract The deposition of the extracellular matrix, especially collagen, and the elevated expression levels of reactive oxygen species, including H
    MeSH term(s) Humans ; Hydrogen Peroxide ; Fibrosis ; Collagen/metabolism ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/pathology ; Neoplasms
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Collagen (9007-34-5)
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d3bm01926h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Development of organic photosensitizers for antimicrobial photodynamic therapy.

    Zhou, Wenya / Jiang, Xiqun / Zhen, Xu

    Biomaterials science

    2023  Volume 11, Issue 15, Page(s) 5108–5128

    Abstract: Bacterial infection poses a significant threat to human health, and the emergence of antibiotic-resistant strains has exacerbated the situation. Antimicrobial photodynamic therapy (aPDT) has emerged as a promising antibiotic-free treatment option that ... ...

    Abstract Bacterial infection poses a significant threat to human health, and the emergence of antibiotic-resistant strains has exacerbated the situation. Antimicrobial photodynamic therapy (aPDT) has emerged as a promising antibiotic-free treatment option that employs reactive oxygen species (ROS) to cause oxidative damage to bacteria and surrounding biomolecules for treating microbial infections. This review summarizes the recent progress in the development of organic photosensitizers, including porphyrins, chlorophyll, phenothiazines, xanthenes and aggregation-induced emission photosensitizers, for aPDT. A detailed description of innovative therapeutic strategies that rely on the infection microenvironment or the unique structural properties of bacteria to amplify the therapeutic effects is provided. Moreover, the combination of aPDT with other therapy strategies such as antimicrobial peptide therapy, photothermal therapy (PTT) or gas therapy, is described. Finally, the current challenges and perspectives of organic photosensitizers for clinical antibacterial applications are discussed.
    MeSH term(s) Humans ; Photosensitizing Agents/chemistry ; Photochemotherapy ; Bacterial Infections/drug therapy ; Bacteria ; Anti-Bacterial Agents/chemistry
    Chemical Substances Photosensitizing Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d3bm00730h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Advanced Biomaterials with Intrinsic Immunomodulation Effects for Cancer Immunotherapy.

    Chen, Weizhi / Li, Cheng / Jiang, Xiqun

    Small methods

    2023  Volume 7, Issue 5, Page(s) e2201404

    Abstract: In recent years, tumor immunotherapy has achieved significant success in tumor treatment based on immune checkpoint blockers and chimeric antigen receptor T-cell therapy. However, about 70-80% of patients with solid tumors do not respond to immunotherapy ...

    Abstract In recent years, tumor immunotherapy has achieved significant success in tumor treatment based on immune checkpoint blockers and chimeric antigen receptor T-cell therapy. However, about 70-80% of patients with solid tumors do not respond to immunotherapy due to immune evasion. Recent studies found that some biomaterials have intrinsic immunoregulatory effects, except serve as carriers for immunoregulatory drugs. Moreover, these biomaterials have additional advantages such as easy functionalization, modification, and customization. In this review, the recent advances of these immunoregulatory biomaterials in cancer immunotherapy and their interaction with cancer cells, immune cells, and the immunosuppressive tumor microenvironment are summarized. Finally, the opportunities and challenges of immunoregulatory biomaterials used in the clinic and the prospect of their future in cancer immunotherapy are discussed.
    MeSH term(s) Humans ; Biocompatible Materials/therapeutic use ; Immunotherapy/methods ; Immunomodulation ; Neoplasms/therapy ; Immunotherapy, Adoptive ; Tumor Microenvironment
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2023-02-21
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202201404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement.

    Ge, Lei / Tang, Yikai / Wang, Chongzhi / Chen, Jian / Mao, Hui / Jiang, Xiqun

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 153

    Abstract: While performing oxygen-related tumour treatments such as chemotherapy and photodynamic therapy, real-time monitoring hypoxia of tumour is of great value and significance. Here, we design a theranostic combination for light-activated ratiometric hypoxia ... ...

    Abstract While performing oxygen-related tumour treatments such as chemotherapy and photodynamic therapy, real-time monitoring hypoxia of tumour is of great value and significance. Here, we design a theranostic combination for light-activated ratiometric hypoxia imaging, hypoxia modulating and prodrug activation. This combination consisted of an oxygen-sensitive near-infrared-emitting ratiometric phosphorescence probe and a hypoxia-activated prodrug-loaded covalent organic framework. In this combination, the probe plays two roles, including quantitative monitoring of oxygen concentration by ratiometric imaging and consuming the oxygen of tumour under light excitation by photodynamic therapy. Meanwhile, the enhanced hypoxia microenvironment of tumour can raise the cytotoxicity of prodrug loaded in covalent organic framework, resulting in boosting antitumour therapeutic effects in vivo. This theranostic combination can precisely provide therapeutic regime and screen hypoxia-activated prodrugs based on real-time tumour hypoxia level, offering a strategy to develop hypoxia mediated tumour theranostics with hypoxia targeted prodrugs.
    MeSH term(s) Humans ; Precision Medicine ; Oxygen ; Metal-Organic Frameworks/therapeutic use ; Photochemotherapy ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Hypoxia/drug therapy ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; Theranostic Nanomedicine ; Cell Line, Tumor ; Photosensitizing Agents/therapeutic use ; Tumor Microenvironment
    Chemical Substances Oxygen (S88TT14065) ; Metal-Organic Frameworks ; Prodrugs ; Photosensitizing Agents
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44429-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Semiphysical Design Concept for Developing Miniaturized Microrobots

    Zhang, Tiange / Liu, Xiaoshuai / Qin, Haifeng / Lin, Yufeng / Li, Baojun / Jiang, Xiqun / Zheng, Xianchuang

    Nano letters

    2024  

    Abstract: The miniaturization of biomedical microrobots is crucial for ... ...

    Abstract The miniaturization of biomedical microrobots is crucial for their
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.4c00025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Development of mesoporous silica-based nanoprobes for optical bioimaging applications

    Sun, Bo / Zhen, Xu / Jiang, Xiqun

    Biomaterials science. 2021 May 18, v. 9, no. 10

    2021  

    Abstract: A mesoporous silica nanoparticle (MSN)-based nanoplatform has attracted growing attention in the biomedical field due to the unique characteristics of MSNs including a high surface area, tunable pore sizes, colloidal stability, ease of functionalization, ...

    Abstract A mesoporous silica nanoparticle (MSN)-based nanoplatform has attracted growing attention in the biomedical field due to the unique characteristics of MSNs including a high surface area, tunable pore sizes, colloidal stability, ease of functionalization, and desirable biocompatibility. Typically, MSNs are designed as nanocarriers for the incorporation of a variety of contrast agents for bioimaging, which can address the intrinsic drawbacks of contrast agents, including poor solubility in water, rapid photobleaching, and low stability. This review summarizes the recent advances in the field of MSN-based nanoprobes for fluorescence imaging and photoacoustic (PA) imaging applications. The approaches for the incorporation of contrast agents into MSN-based nanoplatforms including encapsulating contrast agents within MSNs, covalently conjugating contrast agents on the surface or pores of MSNs, physically absorbing contrast agents in the pores of MSNs, and doping contrast agents in the framework of MSNs are introduced. MSN-based nanoprobes for fluorescence imaging and PA imaging are discussed. The enhanced fluorescence imaging and PA imaging performances of MSN-based nanoprobes relative to the bare contrast agents are introduced and the underlying mechanisms are discussed in detail. Finally, current challenges and perspectives of MSN-based nanoprobes in the bioimaging field are discussed.
    Keywords biocompatibility ; biocompatible materials ; bioimaging ; chemical bonding ; fluorescence ; nanocarriers ; photobleaching ; porous media ; silica ; solubility ; surface area
    Language English
    Dates of publication 2021-0518
    Size p. 3603-3620.
    Publishing place The Royal Society of Chemistry
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d1bm00204j
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Enhancing the tumor penetration of multiarm polymers by collagenase modification.

    Yu, Bo / Wang, Weijie / Zhang, Yongmin / Sun, Ying / Li, Cheng / Liu, Qian / Zhen, Xu / Jiang, Xiqun / Wu, Wei

    Biomaterials science

    2024  Volume 12, Issue 9, Page(s) 2302–2311

    Abstract: Tumor penetration is a critical determinant of the therapy efficacy of nanomedicines. However, the dense extracellular matrix (ECM) in tumors significantly hampers the deep penetration of nanomedicines, resulting in large drug-untouchable areas and ... ...

    Abstract Tumor penetration is a critical determinant of the therapy efficacy of nanomedicines. However, the dense extracellular matrix (ECM) in tumors significantly hampers the deep penetration of nanomedicines, resulting in large drug-untouchable areas and unsatisfactory therapy efficacy. Herein, we synthesized a third-generation PAMAM-cored multiarm copolymer and modified the polymer with collagenase to enhance its tumor penetration. Each arm of the copolymer was a diblock copolymer of poly(glutamic acid)-
    MeSH term(s) Collagenases/metabolism ; Animals ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Doxorubicin/administration & dosage ; Mice ; Polymers/chemistry ; Polymers/metabolism ; Humans ; Cell Line, Tumor ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/administration & dosage ; Polyglutamic Acid/chemistry ; Drug Carriers/chemistry
    Chemical Substances Collagenases (EC 3.4.24.-) ; Doxorubicin (80168379AG) ; Polymers ; Antineoplastic Agents ; Polyglutamic Acid (25513-46-6) ; Drug Carriers
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d3bm02123h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Polymer-based activatable optical probes for tumor fluorescence and photoacoustic imaging.

    Zhen, Xu / Jiang, Xiqun

    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

    2019  Volume 12, Issue 2, Page(s) e1593

    Abstract: Optical imaging including fluorescence imaging and photoacoustic imaging have been widely employed in early and accurate diagnosis of cancer. Compared to the "always on" optical probes, the molecular probes that could emit their signal in response to the ...

    Abstract Optical imaging including fluorescence imaging and photoacoustic imaging have been widely employed in early and accurate diagnosis of cancer. Compared to the "always on" optical probes, the molecular probes that could emit their signal in response to the tumor microenvironment exhibit the low background noise and high signal-to-background ratio, allowing sensitive and accurate cancer diagnosis. Polymer-based activatable optical probes display the advantages of improved water solubility, good photostability, extended blood circulation time, and easy functionalization, which enable them to accumulate in tumor for early and accurate diagnosis. This review focuses on recent advances in the development of polymer-based activatable optical probes for tumor fluorescence and PA imaging. The designs of polymer-based optical probes are first discussed. Then the applications for tumor fluorescence and PA imaging using pH, hypoxia, reactive oxygen and nitrogen species, and enzymes responsive polymer-based optical probes are discussed in details. At last, the present challenges and perspectives of polymer-based activatable optical probes to further advance them into the clinical application are also suggested. This article is categorized under: Diagnostic Tools > In vivo Nanodiagnostics and Imaging Diagnostic Tools > Biosensing.
    MeSH term(s) Fluorescent Dyes ; Humans ; Nanomedicine ; Nanostructures ; Neoplasms/diagnostic imaging ; Optical Imaging ; Photoacoustic Techniques ; Polymers
    Chemical Substances Fluorescent Dyes ; Polymers
    Language English
    Publishing date 2019-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2502698-7
    ISSN 1939-0041 ; 1939-5116
    ISSN (online) 1939-0041
    ISSN 1939-5116
    DOI 10.1002/wnan.1593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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