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Article: MiR-1180-5p regulates apoptosis of Wilms' tumor by targeting

Jiang, Xiuyun / Li, Huaicheng

2018 Volume 11, Page(s) 823–831

Abstract: Introduction: Wilms' tumor (WT), the most common childhood tumor, occurs in sporadic or familial forms. Recent findings reported that abnormal expression in microRNA (miRNA) suggests an important role of miRNAs during WT progress. MiRNAs are endogenous ... ...

Abstract	Introduction: Wilms' tumor (WT), the most common childhood tumor, occurs in sporadic or familial forms. Recent findings reported that abnormal expression in microRNA (miRNA) suggests an important role of miRNAs during WT progress. MiRNAs are endogenous short-chain noncoding RNAs, which have been reported as key biomarkers for detecting tumor onset and progression. However, the functional role of miR-1180 in WT has remained unknown. Materials and methods: MTT and clonogenic survival assays were used to detect WT cell proliferation. Flow cytometry Annexin V-FITC was used to measure apoptosis. In addition, proteins expressions in the cells were determined by Western blotting. Results: In the present study, we demonstrated that miR-1180 is upregulated in WT when compared with adjacent tissues by quantitative reverse-transcription polymerase chain reaction. In addition, the inhibition of miR-1180 induced apoptosis in SK-NEP-1 cell line in vitro. Moreover, luciferase reporter assay showed that Conclusion: Our results indicate that miR-1180 might serve as a therapeutic target for future WT therapy.
Language	English
Publishing date	2018-02-16
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S148684
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Article ; Online: Ergodicity Breaking in Thermal Biological Electron Transfer? Cytochrome C Revisited II.

Futera, Zdenek / Jiang, Xiuyun / Blumberger, Jochen

The journal of physical chemistry. B

2020 Volume 124, Issue 16, Page(s) 3336–3342

Abstract: It was recently suggested that cytochrome c operates in an ergodicity-breaking regime characterized by unusually large energy gap thermal fluctuations and associated reorganization free energies for heme oxidation of up to 3.0 eV. The large fluctuations ... ...

Abstract	It was recently suggested that cytochrome c operates in an ergodicity-breaking regime characterized by unusually large energy gap thermal fluctuations and associated reorganization free energies for heme oxidation of up to 3.0 eV. The large fluctuations were reported to lower activation free energy for oxidation of the heme cofactor by almost a factor of 2 compared to the case where ergodicity is maintained. Our group has recently investigated this claim computationally at several levels of theory and found no evidence for such large energy gap fluctuations. Here we address the points of our earlier work that have raised criticism and we also extend our previous investigation by considering a simple linear polarizability model for cytochrome c oxidation. We find very consistent results among all our computational approaches, ranging from classical molecular dynamics, to the linear polarizability model to QM(PMM)/MM to full QM(DFT)/MM electrostatic emdedding. None of them support the notion of very large energy gap fluctuations or ergodicity breaking. The deviation between our simulations and the ones reported in [
MeSH term(s)	Cytochromes c/metabolism ; Electron Transport ; Electrons ; Molecular Dynamics Simulation ; Oxidation-Reduction
Chemical Substances	Cytochromes c (9007-43-6)
Language	English
Publishing date	2020-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.0c01414
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Article: Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With

Bao, Yanhong / Yao, Yu / Wang, Zi / Wu, Shuiyin / Jiang, Xiuyun / Ma, Hongxia

Frontiers in microbiology

2022 Volume 12, Page(s) 796922

Abstract: Mycobacterium ... ...

Abstract	Mycobacterium avium
Language	English
Publishing date	2022-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.796922
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Article ; Online: Analysis of long non-coding RNA expression profile of bovine monocyte-macrophage infected by Mycobacterium avium subsp. paratuberculosis.

Bao, Yanhong / Wu, Shuiyin / Yang, Tianze / Wang, Zi / Wang, Yiming / Jiang, Xiuyun / Ma, Hongxia

BMC genomics

2022 Volume 23, Issue 1, Page(s) 768

Abstract: Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis. As a potential zoonotic pathogen, MAP also seriously threatens human health and social security. At present, long non-coding RNA (lncRNA) has attracted wide ... ...

Abstract	Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis. As a potential zoonotic pathogen, MAP also seriously threatens human health and social security. At present, long non-coding RNA (lncRNA) has attracted wide attention as an useful biomarker in various diseases. Therefore, our study analyzed the lncRNA expression profiles and lncRNA-mRNA regulatory network of MAP infected bovine monocytes-macrophages and uninfected bovine cells by high-throughput sequencing. A total of 4641 differentially expressed lncRNAs genes were identified, including 3111 up-regulated genes and 1530 down-regulated genes. In addition, lncRNA-mRNA interaction analysis was performed to predict the target genes of lncRNA. Among them, after MAP infection, 86 lncRNAs targeted to mRNA, of which only 6 genes were significantly different. The results of Gene Ontology (GO) enrichment analysis showed that the differentially expressed genes significantly enriched in functional groups were related to immune regulation. Multiple signal pathways including NF-κB, NOD-like receptor, Cytokine-cytokine receptor, Toll-like receptor signaling pathway, Chemokine signaling pathway, and other important biochemical, metabolic and signal transduction pathways were enriched in Kyoto Encyclopedia of Genes and Genomes (KEGG). In this study, analysis of macrophage transcriptomes in response to MAP infection is expected to provide key information to deeply understand role of the pathogen in initiating an inappropriate and persistent infection in susceptible hosts and molecular mechanisms that might underlie the early phases of paratuberculosis.
MeSH term(s)	Animals ; Cattle ; Macrophages/metabolism ; Monocytes ; Mycobacterium avium subsp. paratuberculosis/physiology ; Paratuberculosis/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger/metabolism
Chemical Substances	RNA, Long Noncoding ; RNA, Messenger
Language	English
Publishing date	2022-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-022-08997-5
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Article ; Online: Organotypic Models for Functional Drug Testing of Human Cancers.

Huang, Yu Ling / Dickerson, Lindsay K / Kenerson, Heidi / Jiang, Xiuyun / Pillarisetty, Venu / Tian, Qiang / Hood, Leroy / Gujral, Taranjit S / Yeung, Raymond S

BME frontiers

2023 Volume 4, Page(s) 22

Abstract: In the era of personalized oncology, there have been accelerated efforts to develop clinically relevant platforms to test drug sensitivities of individual cancers. An ideal assay will serve as a diagnostic companion to inform the oncologist of the ... ...

Abstract	In the era of personalized oncology, there have been accelerated efforts to develop clinically relevant platforms to test drug sensitivities of individual cancers. An ideal assay will serve as a diagnostic companion to inform the oncologist of the various treatments that are sensitive and insensitive, thus improving outcome while minimizing unnecessary toxicities and costs. To date, no such platform exists for clinical use, but promising approaches are on the horizon that take advantage of improved techniques in creating human cancer models that encompass the entire tumor microenvironment, alongside technologies for assessing and analyzing tumor response. This review summarizes a number of current strategies that make use of intact human cancer tissues as organotypic cultures in drug sensitivity testing.
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2765-8031
ISSN (online)	2765-8031
DOI	10.34133/bmef.0022
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Article: Ergodicity-Breaking in Thermal Biological Electron Transfer? Cytochrome C Revisited

Jiang, Xiuyun / Futera, Zdenek / Blumberger, Jochen

Journal of physical chemistry. 2019 Aug. 13, v. 123, no. 35

2019

Abstract: It was recently suggested that certain redox proteins operate in an ergodicity-breaking regime to facilitate biological electron transfer (ET). A signature for this is a large variance reorganization free energy (several electronvolts) but a ... ...

Abstract	It was recently suggested that certain redox proteins operate in an ergodicity-breaking regime to facilitate biological electron transfer (ET). A signature for this is a large variance reorganization free energy (several electronvolts) but a significantly smaller Stokes reorganization free energy due to incomplete protein relaxation on the time scale of the ET event. Here we investigate whether this picture holds for oxidation of cytochrome c in aqueous solution, at various levels of theory including classical molecular dynamics with two additive and one electronically polarizable force field, and QM/MM calculations with the QM region treated by full electrostatic DFT embedding and by the perturbed matrix method. Sampling the protein and energy gap dynamics over more than 250 ns, we find no evidence for ergodicity-breaking effects. In particular, the inclusion of electronic polarizability of the heme group at QM/MM levels did not induce nonergodic effects, contrary to previous reports by Matyushov et al. The well-known problem of overestimation of reorganization free energies with additive force fields is cured when the protein and solvent are treated as electronically polarizable. Ergodicity-breaking effects may occur in other redox proteins, and our results suggest that long simulations, ideally on the ET time scale, with electronically polarizable force fields are required to obtain strong numerical evidence for them.
Keywords	Gibbs free energy ; aqueous solutions ; cytochrome c ; electron transfer ; energy ; heme ; molecular dynamics ; oxidation ; solvents ; variance
Language	English
Dates of publication	2019-0813
Size	p. 7588-7598.
Publishing place	American Chemical Society
Document type	Article
ISSN	1520-5207
DOI	10.1021/acs.jpcb.9b05253
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ergodicity-Breaking in Thermal Biological Electron Transfer? Cytochrome C Revisited.

Jiang, Xiuyun / Futera, Zdenek / Blumberger, Jochen

The journal of physical chemistry. B

2019 Volume 123, Issue 35, Page(s) 7588–7598

Abstract	It was recently suggested that certain redox proteins operate in an ergodicity-breaking regime to facilitate biological electron transfer (ET). A signature for this is a large variance reorganization free energy (several electronvolts) but a significantly smaller Stokes reorganization free energy due to incomplete protein relaxation on the time scale of the ET event. Here we investigate whether this picture holds for oxidation of cytochrome c in aqueous solution, at various levels of theory including classical molecular dynamics with two additive and one electronically polarizable force field, and QM/MM calculations with the QM region treated by full electrostatic DFT embedding and by the perturbed matrix method. Sampling the protein and energy gap dynamics over more than 250 ns, we find no evidence for ergodicity-breaking effects. In particular, the inclusion of electronic polarizability of the heme group at QM/MM levels did not induce nonergodic effects, contrary to previous reports by Matyushov et al. The well-known problem of overestimation of reorganization free energies with additive force fields is cured when the protein and solvent are treated as electronically polarizable. Ergodicity-breaking effects may occur in other redox proteins, and our results suggest that long simulations, ideally on the ET time scale, with electronically polarizable force fields are required to obtain strong numerical evidence for them.
MeSH term(s)	Cytochromes c/chemistry ; Cytochromes c/metabolism ; Density Functional Theory ; Electron Transport ; Molecular Dynamics Simulation ; Oxidation-Reduction ; Temperature
Chemical Substances	Cytochromes c (9007-43-6)
Language	English
Publishing date	2019-08-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.9b05253
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Article ; Online: Superoxide dismutases: marker in predicting reduced left ventricular ejection fraction in patients with type 2 diabetes and acute coronary syndrome.

Jiang, Xiu-Yun / Chen, Qing / Chen, Xiao-Yu / Sun, Qiu-Ying / Jing, Fei / Zhang, Hai-Qing / Xu, Jin / Li, Xiao-Hong / Guan, Qing-Bo

BMC cardiovascular disorders

2024 Volume 24, Issue 1, Page(s) 191

Abstract: Aim: To examine the prognostic value of superoxide dismutase (SOD) activity for monitoring reduced left ventricular ejection fraction(LVEF)in the patients with type 2 diabetes and acute coronary syndrome (ACS).: Methods: The population of this cross- ... ...

Abstract	Aim: To examine the prognostic value of superoxide dismutase (SOD) activity for monitoring reduced left ventricular ejection fraction(LVEF)in the patients with type 2 diabetes and acute coronary syndrome (ACS). Methods: The population of this cross-sectional study included 2377 inpatients with type 2 diabetes who had an ACS admitted to the Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2016 to January 2021. Results: Diabetic patients with ACS were divided into 2 subgroups based on LVEF. The mean SOD activity was significantly lower in patients with an LVEF ≤ 45% than in those with an LVEF > 45% (149.1 (146.4, 151.9) versus 161.9 (160.8, 163.0)). Using ROC statistic, a cut-off value of 148.8 U/ml indicated an LVEF ≤ 45% with a sensitivity of 51.6% and a specificity of 73.7%. SODs activity were found to be correlated with the levels of NT-proBNP, hs-cTnT, the inflammatory marker CRP and fibrinogen. Despite taking the lowest quartile as a reference (OR 0.368, 95% CI 0.493-0.825, P = 0.001) or examining 1 normalized unit increase (OR 0.651, 95% CI 0.482-0.880, P = 0.005), SOD activity was found to be a stronger predictor of reduced LVEF than CRP and fibrinogen, independent of confounding factors. Conclusions: Our cross-sectional study suggests that SOD activity might be a valuable and easily accessible tool for assessing and monitoring reduced LVEF in the diabetic patients with ACS.
MeSH term(s)	Humans ; Acute Coronary Syndrome/diagnosis ; Stroke Volume ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Biomarkers ; Cross-Sectional Studies ; Ventricular Function, Left ; Ventricular Dysfunction, Left/epidemiology ; Prognosis ; Superoxide Dismutase ; Fibrinogen
Chemical Substances	Biomarkers ; Superoxide Dismutase (EC 1.15.1.1) ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-024-03867-2
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Article ; Online: M.neoaurum infection increased the inhibitory function of Tregs and the death rate associated with Salmonella coinfection.

Wang, Chunfang / Sun, Rongkuan / Wang, Chunfeng / Qian, Aidong / Jiang, Xiuyun

Research in veterinary science

2020 Volume 132, Page(s) 108–115

Abstract: Mycobacterium neoaurum belongs to the nontuberculous mycobacteria (NTM) and is ubiquitously present in the environment. However, the changes in Treg percentages and suppressive properties in mice infected with M. neoaurum are still not elucidated. In ... ...

Abstract	Mycobacterium neoaurum belongs to the nontuberculous mycobacteria (NTM) and is ubiquitously present in the environment. However, the changes in Treg percentages and suppressive properties in mice infected with M. neoaurum are still not elucidated. In this study, mice were intraperitoneally injected with M. neoaurum. The change in the CD4
MeSH term(s)	Animals ; Coinfection/immunology ; Coinfection/microbiology ; Coinfection/mortality ; Coinfection/veterinary ; Female ; Mice ; Mice, Inbred C57BL ; Mycobacteriaceae/physiology ; Mycobacterium Infections/immunology ; Mycobacterium Infections/microbiology ; Mycobacterium Infections/mortality ; Mycobacterium Infections/veterinary ; Salmonella/physiology ; Salmonella Infections, Animal/immunology ; Salmonella Infections, Animal/microbiology ; Salmonella Infections, Animal/mortality ; Specific Pathogen-Free Organisms ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/microbiology
Language	English
Publishing date	2020-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2020.05.002
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Article ; Online: Phenotypic spectrum and mechanism analysis of Schaff Yang syndrome: A case report on new mutation of MAGEL2 gene.

Duan, Yanjie / Liu, Lu / Zhang, Xiujuan / Jiang, Xiuyun / Xu, Jin / Guan, Qingbo

Medicine

2021 Volume 100, Issue 24, Page(s) e26309

Abstract: Rationale: The Schaaf-Yang syndrome (SYS) is an autosomal dominant multi-system genetic disease caused by melanoma antigen L2 (MAGEL2) gene mutations imprinted by mothers and expressed by fathers on the 15q11-15q13 chromosomes in the critical region of ... ...

Abstract	Rationale: The Schaaf-Yang syndrome (SYS) is an autosomal dominant multi-system genetic disease caused by melanoma antigen L2 (MAGEL2) gene mutations imprinted by mothers and expressed by fathers on the 15q11-15q13 chromosomes in the critical region of Prader-Willi. MAGEL2 is a single exon gene and one of the protein-coding genes of the Prader-Willi domain. MAGEL2 is a matrilineal imprinted gene (i.e., the maternal chromosome is methylated). It is only expressed by unmethylated paternal alleles, and the individual is affected only when the variation occurs on the paternal allele. Patient concerns: We reported a patient with MAGEL2 gene new site mutation who had mild intellectual disability, social fear, small hands and feet, obesity issues, dyskinesia, growth retardation, language lag and sexual development disorder. Diagnosis: Whole-exome sequencing showed a heterozygous variation in the MAGEL2 gene, NM_019066.4:c.1687C > T (p.Q563X) and diagnosed as Schaaf-Yang syndrome. Interventions: Patient was advised to reduce weight, control blood lipids, blood glucose through appropriate strengthening of exercise and diet control in the future. At the same time, the family members were advised to provide mental training to the patient to strengthen the contact and communication with the outside world and improve the autistic symptoms. Because of the patient's bilateral cryptorchidism, it is recommended that the patient should be treated with bilateral cryptorchidism reduction fixation. Outcomes: After a follow-up of the patient for 2 months, the patient is still walking unsteadily and requires an auxiliary reference material to walk normally. There is no significant change in height compared to before, and the weight has dropped by about 2 kg in the past 2 months. The symptoms of autism have improved slightly. The patient is willing to communicate with outsiders; his intelligence has not improved significantly, and his academic performance in school is still at the middle and lower levels. Lessons: The pathogenesis of SYS is complex, involving multiple pathways such as Leptin-POMC, MAGEL2-USP7-TRIM27 complex and oxytocin. Our study has also found that certain fatal phenotypes such as respiratory distress have a high incidence at individual sites, and early detection and timely intervention may prolong the life span of patients. Therefore, for patients in whom SYS is highly suspected, gene detection should be carried out as soon as possible.
MeSH term(s)	Adolescent ; Chromosome Disorders/genetics ; Humans ; Male ; Mutation ; Phenotype ; Proteins/genetics ; Whole Exome Sequencing
Chemical Substances	MAGEL2 protein, human ; Proteins
Language	English
Publishing date	2021-07-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000026309
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