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Article ; Online: Patching Retinal Breaks with Chitosan for Retinal Detachment in Rabbits.

Wei, Qingquan / Jiang, Yanyun

2023 Volume 35, Issue 176, Page(s) 293–299

Abstract: Background: Rhegmatogenous retinal detachment (RRD) is caused by one or more full-thickness retinal breaks. The current RRD treatments have several drawbacks. Chitosan is one of the most commonly used natural polymers for wound healing and has been ... ...

Abstract	Background: Rhegmatogenous retinal detachment (RRD) is caused by one or more full-thickness retinal breaks. The current RRD treatments have several drawbacks. Chitosan is one of the most commonly used natural polymers for wound healing and has been demonstrated to be biodegradable, biocompatible, non-toxic, bioadhesive, and bioactive. This study aimed to determine the reliability and effectiveness of chitosan for sealing retinal breaks in rabbits. Methods: Eighteen blue purple rabbits were randomly divided into three groups: chitosan (n = 6), RRD (n = 6), and control (n = 6). The RRD model was established using vitrectomy, making retinal holes, and subretinal fluid injection in the RRD and chitosan groups. One week after the establishment of the model, chitosan was applied within the range of the holes in the chitosan group, and the vitreous body was filled with perfusion fluid. Except the chitosan treatment, the RRD group underwent the same procedure. Intraocular pressure (IOP) measurement, fundus photography, B-mode ultrasound, optical coherence tomography (OCT), histology, and enzyme linked immunosorbent assay (ELISA) were performed. Results: Retinas of all eyes in the RRD group were detached, whereas those of all eyes in the chitosan group remained attached. The concentrations of epidermal growth factor (EGF), fibroblast growth factor (FGF)-2, transforming growth factor β (TGF-β), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), and IL-8 in the vitreous fluid of the RRD group were significantly higher than those of the control group ( Conclusions: Chitosan may be a reliable method for sealing retinal breaks. Moreover, chitosan can maintain high levels of growth factors and reduce inflammatory factors in the vitreous, which may reduce and delay the death of retinal cells and help restore visual function after retinal repositioning.
MeSH term(s)	Animals ; Rabbits ; Retinal Detachment/therapy ; Retinal Detachment/etiology ; Retinal Detachment/pathology ; Retinal Perforations/complications ; Retinal Perforations/surgery ; Vascular Endothelial Growth Factor A ; Chitosan/therapeutic use ; Epidermal Growth Factor ; Interleukin-6 ; Interleukin-8 ; Reproducibility of Results ; Transforming Growth Factor beta ; Retrospective Studies
Chemical Substances	Vascular Endothelial Growth Factor A ; Chitosan (9012-76-4) ; Epidermal Growth Factor (62229-50-9) ; Interleukin-6 ; Interleukin-8 ; Transforming Growth Factor beta
Language	English
Publishing date	2023-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2415544-5
ISSN	1944-7930 ; 1944-7930
ISSN (online)	1944-7930
ISSN	1944-7930
DOI	10.24976/Discov.Med.202335176.30
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Topical histone deacetylase 1 inhibitor Entinostat ameliorates psoriasiform dermatitis through suppression of IL-17A response.

Jiang, Yanyun / Lu, Siyao / Lai, Yuhsien / Wang, Liangchun

Journal of dermatological science

2023 Volume 110, Issue 3, Page(s) 89–98

Abstract: Background: Biologics against IL-17A, IL-23 and TNF-α achieve a great success in treating psoriasis. However, the majority of patients still have some residual lesions left and require combination therapy to reach complete clearance. Topical medicine is ...

Abstract	Background: Biologics against IL-17A, IL-23 and TNF-α achieve a great success in treating psoriasis. However, the majority of patients still have some residual lesions left and require combination therapy to reach complete clearance. Topical medicine is an optional choice but only has limited categories. Besides, drug resistance is very often. Thus, topical medicine targeting new signaling pathway is still in an urgent need in the biologics era. Objective: To investigate the role of topical Entinostat, a selective inhibitor of histone deacetylases 1 (HDAC1) that has been tested in clinic trials to treat solid tumors and hematological malignancies, in psoriasis therapy. Methods: Efficacious Entinostat were tested in a mouse imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) model. An in vitro model consisting of human CD4 + T cell, murine T cells and NHEKs were used to screen Entinostat for inhibition of cutaneous inflammatory genes. Results: Topical application of Entinostat significantly improved psoriasiform inflammation in imiquimod-induced mice model with great reduction of IL-17A+ γδT cell infiltration in skin. Entinostat is powerful agent in inhibition of Th17 cell generation and the expression of psoriasis-related inflammatory mediators by primary keratinocytes upon CD4 Conclusion: Our findings suggest Entinostat is a promising topical medicine for psoriasis treatment.
MeSH term(s)	Humans ; Animals ; Mice ; Imiquimod/therapeutic use ; Interleukin-17/metabolism ; Histone Deacetylase 1 ; Skin/pathology ; Psoriasis/chemically induced ; Psoriasis/drug therapy ; Psoriasis/pathology ; Eczema ; Disease Models, Animal ; Mice, Inbred BALB C
Chemical Substances	Imiquimod (P1QW714R7M) ; entinostat (1ZNY4FKK9H) ; Interleukin-17 ; Histone Deacetylase 1 (EC 3.5.1.98)
Language	English
Publishing date	2023-05-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1024446-3
ISSN	1873-569X ; 0923-1811
ISSN (online)	1873-569X
ISSN	0923-1811
DOI	10.1016/j.jdermsci.2023.05.001
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Article ; Online: Correction: Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification.

Luo, Liying / Guan, Zhiyuan / Jin, Xiao / Guan, Zhiqiang / Jiang, Yanyun

Molecular medicine (Cambridge, Mass.)

2023 Volume 29, Issue 1, Page(s) 56

Language	English
Publishing date	2023-04-21
Publishing country	England
Document type	Published Erratum
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-023-00654-1
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Article ; Online: Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification.

Luo, Liying / Guan, Zhiyuan / Jin, Xiao / Guan, Zhiqiang / Jiang, Yanyun

Molecular medicine (Cambridge, Mass.)

2023 Volume 29, Issue 1, Page(s) 36

Abstract: Background: Osteoporosis (OP) is a major and growing public health problem characterized by decreased bone mineral density and destroyed bone microarchitecture. Previous studies found that Lycium Chinense Mill (LC) has a potent role in inhibiting bone ... ...

Abstract	Background: Osteoporosis (OP) is a major and growing public health problem characterized by decreased bone mineral density and destroyed bone microarchitecture. Previous studies found that Lycium Chinense Mill (LC) has a potent role in inhibiting bone loss. Kukoamine A (KuA), a bioactive compound extract from LC was responsible for the anti-osteoporosis effect. This study aimed to investigate the anti-osteoporosis effect of KuA isolated from LC in treating OP and its potential molecular mechanism. Method: In this study, network pharmacology and molecular docking were investigated firstly to find the active ingredients of LC such as KuA, and the target genes of OP by the TCMSP platform. The LC-OP-potential Target gene network was constructed by the STRING database and network maps were built by Cytoscape software. And then, the anti-osteoporotic effect of KuA in OVX-induced osteoporosis mice and MC3T3-E1 cell lines were investigated and the potential molecular mechanism including inflammation level, cell apoptosis, and oxidative stress was analyzed by dual-energy X-ray absorptiometry (DXA), micro-CT, ELISA, RT-PCR, and Western Blotting. Result: A total of 22 active compounds were screened, and we found KuA was identified as the highest active ingredient. Glycogen Phosphorylase (PYGM) was the target gene associated with a maximum number of active ingredients of LC and regulated KuA. In vivo, KuA treatment significantly increased the bone mineral density and improve bone microarchitecture for example increased BV/TV, Tb.N and Tb.Th but reduced Tb.Sp in tibia and lumber 4. Furthermore, KuA increased mRNA expression of osteoblastic differentiation-related genes in OVX mice and protects against OVX-induced cell apoptosis, oxidative stress level and inflammation level. In vitro, KuA significantly improves osteogenic differentiation and mineralization in cells experiment. In addition, KuA also attenuated inflammation levels, cell apoptosis, and oxidative stress level. Conclusion: The results suggest that KuA could protect against the development of OP in osteoblast cells and ovariectomized OP model mice and these found to provide a better understanding of the pharmacological activities of KuA again bone loss.
MeSH term(s)	Mice ; Animals ; Network Pharmacology ; Osteogenesis/genetics ; Molecular Docking Simulation ; Osteoporosis/drug therapy
Chemical Substances	kukoamine A
Language	English
Publishing date	2023-03-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-023-00625-6
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Article: Relationship Between Risk Factors and Macular Thickness in Patients with Early Diabetic Retinopathy.

Wei, Qingquan / Qiu, Wei / Liu, Qing / Jiang, Yanyun

International journal of general medicine

2022 Volume 15, Page(s) 6021–6029

Abstract: Purpose: The purpose of this study was to explore the changes in macular thickness (MT) in normal people, patients without obvious diabetic retinopathy (NDR) and patients with nonproliferative diabetic retinopathy (NPDR) and to study the possible risk ... ...

Abstract	Purpose: The purpose of this study was to explore the changes in macular thickness (MT) in normal people, patients without obvious diabetic retinopathy (NDR) and patients with nonproliferative diabetic retinopathy (NPDR) and to study the possible risk factors for early diabetic retinopathy (DR). Methods: Thirty-one healthy individuals, 40 people with no sign of DR and 60 people with mild NPDR were included in this cross-sectional study. All patients underwent a complete ophthalmological examination. Optical coherence tomography (OCT) was used to measure the MT of each participant. The potential relationship between MT and systemic risk factors for DR, including diabetes duration, body mass index (BMI), hemoglobin A1c (HbA1c), serum lipids, and blood pressure, was analyzed. Results: The MT of the right and left eyes in the central and inner ring regions of the NPDR group and NDR group were significantly different from that in the control group. The MTs of the right and left eyes in the central region and inner ring region were also significantly different between the NPDR group and NDR group, but the MTs of the right and left eyes in the outer ring region were not significantly different among the three groups. Diabetic duration, total cholesterol (TC), triglycerides (TGs), systolic pressure, and diastolic pressure were positively correlated with the MT of the right and left eyes in the central region. Conclusion: MT increases, especially in the central region and inner ring, may be the first structural retinal change in diabetic patients and is related to the duration of diabetes, TC, TG, systolic pressure and diastolic pressure.
Language	English
Publishing date	2022-07-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S366348
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Article: Preservice mathematics teachers' perceptions of mathematical problem solving and its teaching: A case from China.

Jiang, Peijie / Zhang, Yong / Jiang, Yanyun / Xiong, Bin

Frontiers in psychology

2022 Volume 13, Page(s) 998586

Abstract: Preservice mathematics teachers' accurate understanding of mathematical problem solving and its teaching is key to the performance of their professional quality. This study aims to investigate preservice mathematics teachers' understanding of problem ... ...

Abstract	Preservice mathematics teachers' accurate understanding of mathematical problem solving and its teaching is key to the performance of their professional quality. This study aims to investigate preservice mathematics teachers' understanding of problem solving and its teaching and compares it with the understanding of in-service mathematics teachers. After surveying 326 in-service mathematics teachers, this study constructs a reliable and valid tool for the cognition of mathematical problem solving and its teaching and conducts a questionnaire survey on 26 preservice mathematics teachers. Survey results reveal that preservice mathematics teachers have a good understanding of mathematical problem solving and its teaching and are more confident in the transfer value of problem solving ability. By contrast, in-service teachers are more optimistic that problem solving requires exploration, continuous thinking, and the participation of metacognition. This article concludes that preservice mathematics teachers should focus more on the initiative and creativity of students and put students at the center of education. In addition, teacher educators should provide more teaching practice opportunities for preservice teachers. The findings also show that in-service teachers' understanding of problem solving and its teaching is inferior to that of preservice teachers on some indicators, implying the importance of post-service training for in-service teachers.
Language	English
Publishing date	2022-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.998586
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Article: Evaluation of Foldable Capsular Vitreous Body Implantation Surgery.

Luo, Liying / Wei, Qingquan / Liu, Qing / Wang, Li / Jiang, Yanyun

International journal of general medicine

2022 Volume 15, Page(s) 7077–7087

Abstract: Background: Foldable capsular vitreous body (FCVB), a novel artificial vitreous substitute product, has been used clinically in recent years. The aim of this study was to evaluate the outcomes and complications of FCVB implantation surgery during the ... ...

Abstract	Background: Foldable capsular vitreous body (FCVB), a novel artificial vitreous substitute product, has been used clinically in recent years. The aim of this study was to evaluate the outcomes and complications of FCVB implantation surgery during the postoperative period. Methods: We performed a prospective, nonrandomized study from November 2021 to March 2022. Eight patients with severe retinal detachment that could not be easily reattached were included in this study. Before and after surgery, visual acuity (VA), intraocular pressure (IOP), slit-lamp microscopy, optical coherence tomography (OCT), B-scan and CT were performed. Results: After the operation, the FCVB was well distributed in the vitreous cavity and supported the retina according to the B-scan and CT images. During the follow-up period, no vitreous hemorrhage or retinal detachment was found in any of the patients. On the first postoperative day, the average IOP increased from 9.6 ± 7.7 mmHg preoperatively to 13.8 ± 14.3 mmHg. Although the IOP of two patients fell outside the normal range, IOP was finally held steady after the fifth postoperative day in all cases. In addition, three patients (37.5%) experienced eye ache, and after taking a Saridon tablet, the pain was greatly alleviated. Moreover, no adverse events, such as silicone oil (SO) spillage and emulsification or serious complications, were observed. Conclusion: The current vitreous substitute FCVB is effective and safe for treating complicated retinal detachments in ophthalmic applications. Further multiple-center clinical designs should focus on indications and complications of FCVB during long-term follow-up periods.
Language	English
Publishing date	2022-09-06
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S380609
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Article: A semi-supervised learning approach with consistency regularization for tumor histopathological images analysis.

Jiang, Yanyun / Sui, Xiaodan / Ding, Yanhui / Xiao, Wei / Zheng, Yuanjie / Zhang, Yongxin

Frontiers in oncology

2023 Volume 12, Page(s) 1044026

Abstract: Introduction: Manual inspection of histopathological images is important in clinical cancer diagnosis. Pathologists implement pathological diagnosis and prognostic evaluation through the microscopic examination of histopathological slices. This entire ... ...

Abstract	Introduction: Manual inspection of histopathological images is important in clinical cancer diagnosis. Pathologists implement pathological diagnosis and prognostic evaluation through the microscopic examination of histopathological slices. This entire process is time-consuming, laborious, and challenging for pathologists. The modern use of whole-slide imaging, which scans histopathology slides to digital slices, and analysis using computer-aided diagnosis is an essential problem. Methods: To solve the problem of difficult labeling of histopathological data, and improve the flexibility of histopathological analysis in clinical applications, we herein propose a semi-supervised learning algorithm coupled with consistency regularization strategy, called"Semi- supervised Histopathology Analysis Network"(Semi-His-Net), for automated normal-versus-tumor and subtype classifications. Specifically, when inputted disturbing versions of the same image, the model should predict similar outputs. Based on this, the model itself can assign artificial labels to unlabeled data for subsequent model training, thereby effectively reducing the labeled data required for training. Results: Our Semi-His-Net is able to classify patches from breast cancer histopathological images into normal tissue and three other different tumor subtypes, achieving an accuracy was 90%. The average AUC of cross-classification between tumors reached 0.893. Discussion: To overcome the limitations of visual inspection by pathologists for histopathology images, such as long time and low repeatability, we have developed a deep learning-based framework (Semi-His-Net) for automatic classification subdivision of the subtypes contained in the whole pathological images. This learning-based framework has great potential to improve the efficiency and repeatability of histopathological image diagnosis.
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.1044026
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Article ; Online: Metabolomic study of eyeball rupture and patients with cataracts in aqueous humor.

Wei, Qingquan / Luo, Liyin / Qiu, Wei / Gong, Yingying / Jiang, Yanyun

Experimental and therapeutic medicine

2022 Volume 24, Issue 5, Page(s) 657

Abstract: The purpose of the present study was to identify metabolic biomarkers and study the metabolic changes in relation to cataracts and eyeball rupture in human aqueous humor. This case-control study included 3 patients with traumatic ocular rupture treated ... ...

Abstract	The purpose of the present study was to identify metabolic biomarkers and study the metabolic changes in relation to cataracts and eyeball rupture in human aqueous humor. This case-control study included 3 patients with traumatic ocular rupture treated by surgery as the control group, 10 patients with severe cataracts as the severe cataracts group and 10 patients with mild cataracts as the mild cataracts group. The present study used liquid chromatography-mass spectrometry to analyze the metabolomics of aqueous humor samples. Databases including the Kyoto Encyclopedia of Genes and Genomes and MetaboAnalyst were used to find potential pathways for metabolites. Aqueous humor metabolic spectrum can competently distinguish patients with different degrees of cataracts from the control group. A total of 34 metabolites were identified as potential biomarkers that could distinguish patients with different degrees of cataracts; 36 metabolites were identified as potential biomarkers that could distinguish patients with severe cataracts from the control group; 34 metabolites were identified as potential biomarkers that could distinguish patients with mild cataracts from controls. In pathway analysis, glycerolphospholipid metabolism was highly affected, which meant that these metabolic markers serve an important role in the regulation of this pathway. The present study identified valuable metabolic biomarkers and pathways, which is helpful for an improved understanding of the pathogenesis of cataracts. This discovery has transformation value for the development of new treatment methods for cataracts.
Language	English
Publishing date	2022-09-07
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2022.11593
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Article: A comparative study of high school mathematics teachers' audible teaching language: A student satisfaction perspective.

Jiang, Peijie / Zhang, Xiangjun / Ruan, Xiaomeng / Feng, Zirong / Xiong, Bin / Jiang, Yanyun

Frontiers in psychology

2023 Volume 14, Page(s) 1108740

Abstract: Teachers' audible teaching language is essential for organizing classroom instruction. This study used a questionnaire to compare expert, skilled, and novice high school mathematics teachers' audible teaching language from the perspective of student ... ...

Abstract	Teachers' audible teaching language is essential for organizing classroom instruction. This study used a questionnaire to compare expert, skilled, and novice high school mathematics teachers' audible teaching language from the perspective of student satisfaction. The sample was selected using a purposive sampling technique, and the participants were students from a key high school in Changsha, China. A research framework and research instrument with good reliability and validity were constructed for this study. The data were analyzed using SPSS 22.0 and AMOS 22.0. The results showed 263 valid questionnaires, good measurement model fit, and high reliability and validity of the questionnaire. It was found that: (1) students were highly satisfied with the audible teaching language of high school mathematics teachers; (2) student satisfaction with the audible teaching language of skilled, expert, and novice mathematics teachers declined in order, but there was no significant difference overall; (3) students were more satisfied with expert mathematics teachers than with novice teachers in terms of the tone and adaptability of the audible teaching language. The researchers discussed the study's results, suggested how pre-service and post-service mathematics teachers can improve the quality of their audible teaching language, and pointed out the value and limitations of the study.
Language	English
Publishing date	2023-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1108740
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