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  1. Article ; Online: Enhancing the Performance of Global Optimization of Platinum Cluster Structures by Transfer Learning in a Deep Neural Network.

    Yang, Qi / Jiang, Gui-Duo / He, Sheng-Gui

    Journal of chemical theory and computation

    2023  Volume 19, Issue 6, Page(s) 1922–1930

    Abstract: The global optimization of metal cluster structures is an important research field. The traditional deep neural network (T-DNN) global optimization method is a good way to find out the global minimum (GM) of metal cluster structures, but a large number ... ...

    Abstract The global optimization of metal cluster structures is an important research field. The traditional deep neural network (T-DNN) global optimization method is a good way to find out the global minimum (GM) of metal cluster structures, but a large number of samples are required. We developed a new global optimization method which is the combination of the DNN and transfer learning (DNN-TL). The DNN-TL method transfers the DNN parameters of the small-sized cluster to the DNN of the large-sized cluster to greatly reduce the number of samples. For the global optimization of Pt
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.2c00923
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  2. Article ; Online: Risk factors for severe COVID-19 infection and the impact of COVID-19 infection on disease progression among patients with AAV.

    Wang, Chen / Li, Zhi-Ying / Jiang, Gui-Ping / Zhao, Ming-Hui / Chen, Min

    Clinical and experimental medicine

    2024  Volume 24, Issue 1, Page(s) 88

    Abstract: To identify risk factors for COVID-19 infection and investigate the impact of COVID-19 infection on chronic kidney disease (CKD) progression and vasculitis flare in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). ... ...

    Abstract To identify risk factors for COVID-19 infection and investigate the impact of COVID-19 infection on chronic kidney disease (CKD) progression and vasculitis flare in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This cohort study retrospectively analyzed the prevalence and severity of COVID-19 infection in 276 patients with AAV who were followed up. Logistic regression was employed to estimate the risk of COVID-19 infection as well as CKD progression and vasculitis flare upon COVID-19 infection. During the 6-month observation period, 213 (77.2%) of 276 patients were diagnosed with COVID-19 infection. Of these 213 patients, 49 (23.0%) had a COVID-19-related inpatient admission, including 17 patients who died of COVID-19 infection. AAV patients with severe COVID-19 infection were more likely to be male (OR 1.921 [95% CI 1.020-3.619], P = 0.043), suffered from worse kidney function (serum creatinine [Scr], OR 1.901 [95% CI 1.345-2.687], P < 0.001), had higher C-reactive protein (CRP) (OR 1.054 [95% CI 1.010-1.101], P = 0.017) and less likely to have evidence of initial vaccination (OR 0.469 [95% CI 0.231-0.951], P = 0.036), and Scr and COVID-19 vaccination were proven to be significantly associated with severe COVID-19 infection even after multivariable adjustment. Severe COVID-19 infection was significantly associated with subsequent CKD progression (OR 7.929 [95% CI 2.030-30.961], P = 0.003) and vasculitis flare (OR 11.842 [95% CI 1.048-133.835], P = 0.046) among patients with AAV. AAV patients who were male, and with worse kidney function were more susceptible to severe COVID-19 infection, which subsequently increased the risk of CKD progression and vasculitis flare.
    MeSH term(s) Humans ; COVID-19/complications ; COVID-19/epidemiology ; Male ; Female ; Middle Aged ; Disease Progression ; Risk Factors ; Retrospective Studies ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Renal Insufficiency, Chronic/etiology ; Aged ; SARS-CoV-2 ; Severity of Illness Index ; Adult
    Language English
    Publishing date 2024-04-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-024-01351-x
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    Zs.A 5481: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Phosphorus enrichment masked the negative effects of ocean acidification on picophytoplankton and photosynthetic performance in the oligotrophic Indian Ocean

    Yuqiu Wei / Yuying Zhao / Jiang Gui / Jun Sun

    Ecological Indicators, Vol 125, Iss , Pp 107459- (2021)

    2021  

    Abstract: Dynamics of picophytoplankton and photosynthesis will be inevitably impacted by changing marine environment, such as ocean acidification and nutrient supply, but related studies are very scarce. Here we cultured the picophytoplankton-dominated surface ... ...

    Abstract Dynamics of picophytoplankton and photosynthesis will be inevitably impacted by changing marine environment, such as ocean acidification and nutrient supply, but related studies are very scarce. Here we cultured the picophytoplankton-dominated surface water of the oligotrophic Eastern Indian Ocean (EIO; R/V Shiyan-3, 20 March to 18 May 2019) at two levels of pCO2 (400 and 1000 ppm) and phosphate (0.05 and 1.50 µM) to investigate the interactive effects of elevated pCO2 and phosphate (P) on the dynamics of picophytoplankton and photosynthetic properties. High pCO2 and P levels interactively increased the abundances of Synechococcus, Prochlorococcus and picoeukaryotes by 33%, 18%, and 21%, respectively, of which high P level had a major promoting effect. Conversely, rising pCO2 alone decreased their abundances by 9%, 32%, and 46%, respectively. For the photophysiological responses in relation to the combination of high pCO2 and P levels, there was an increase in the maximum (Fv/Fm) and effective (Fq'/Fm') photochemical efficiency, the electron transfer rates (ETRRCII) and the charge separation rates (JVPSII, an indicator of primary production), but a decrease in the non-photochemical quenching (NPQNSV). Elevated pCO2 alone facilitated the NPQNSV process significantly, ultimately leading to reduced light use efficiency (e.g., Fv/Fm, Fq'/Fm' and ETRRCII) and primary production (JVPSII). There was a strong coupling of picophytoplankton and JVPSII, suggesting the EIO primary productivity was potentially controlled by picophytoplankton. Overall, our results indicate that the negative effects caused by ocean acidification may be masked or outweighted by the role that P availability plays in regulating growth and metabolism in this oligotrophic ecosystem.
    Keywords Picophytoplankton ; Photosynthesis ; Ocean acidification ; Nutrient supply ; Eastern Indian Ocean ; Ecology ; QH540-549.5
    Subject code 551
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Strategy Analysis of Promoting Pollution Control of SMEs

    Zhang Yanying / Jiang Gui / Yu Ziwei

    E3S Web of Conferences, Vol 237, p

    2021  Volume 01025

    Abstract: The pollution problem of SMEs is an important problem to be solved in the process of China’s economic development. Based on the game theory, this paper takes the government and SMEs as the two sides of the game, constructing the game theory model of ... ...

    Abstract The pollution problem of SMEs is an important problem to be solved in the process of China’s economic development. Based on the game theory, this paper takes the government and SMEs as the two sides of the game, constructing the game theory model of pollution control of SMEs, putting forward the strategies to promote the pollution control of SMEs according to the analysis results of the model.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Superior Reactivity of Molybdenum-Sulfur Cluster Anions Mo

    Jiang, Gui-Duo / Yang, Qi / Wei, Gong-Ping / Li, Zi-Yu / He, Sheng-Gui

    Inorganic chemistry

    2023  Volume 62, Issue 29, Page(s) 11318–11324

    Abstract: Inspired by the fact that Mo is a key element in biological nitrogenase, a series of gas-phase ... ...

    Abstract Inspired by the fact that Mo is a key element in biological nitrogenase, a series of gas-phase Mo
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c00644
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  6. Article: Effects of medical insurance system on the hospitalization cost of acute myocardial infarction patients.

    Chu, Ying-Hong / Jiang, Gui-Hua / Zhang, Hong / Luan, Xiao-Rong

    Cost effectiveness and resource allocation : C/E

    2022  Volume 20, Issue 1, Page(s) 8

    Abstract: Background: Acute myocardial infarction is still a burden on Chinese patients. Whether different medical insurance system have any influence on the hospitalization cost and therapeutic effect of acute myocardial infarction patient needs further ... ...

    Abstract Background: Acute myocardial infarction is still a burden on Chinese patients. Whether different medical insurance system have any influence on the hospitalization cost and therapeutic effect of acute myocardial infarction patient needs further investigation.
    Method: In this study, 600 patients were stratified by health insurance status to investigate the cost effectiveness.
    Result: Compared with free medical care, patients with other health insurance status have a significantly lower age (P ˂ 0.05-0.001), the youngest of which is new rural cooperative medical system. The hospital expense, nursing fee, length of stay, daily hospitalization cost, daily drug cost, daily nursing cost and percent of nursing cost of different health insurance status were statistically significant. ANCOVA analyses controlling for age showed that the differences of hospital expenses, nursing fee, length of stay and daily hospitalization cost were still statistically significant. Further studies found that health insurance status was the leading factors influencing length of stay (β = - 0.305, P = 0.0000001), nursing costs (β = - 0.319, P = 0.004), daily hospitalization costs (β = 0.296, P = 0.0001) and occurrence of clinical events (β = - 0.186, OR = 0.830, 95% CI 0.694-0.993, P = 0.041).
    Conclusions: The hospitalization cost, length of stay, nursing work and therapeutic effect of acute myocardial infarction patients are affected by different health insurance status and age.
    Language English
    Publishing date 2022-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2119372-1
    ISSN 1478-7547
    ISSN 1478-7547
    DOI 10.1186/s12962-022-00343-6
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  7. Article ; Online: [Synthetic phenolic compounds perturb lipid metabolism and induce obesogenic effects].

    Liu, Hui-Nan / Sun, Zhen-Dong / Liu, Qian / Zhou, Qun-Fang / Jiang, Gui-Bin

    Se pu = Chinese journal of chromatography

    2023  Volume 42, Issue 2, Page(s) 131–141

    Abstract: Given continuous development in society and the economy, obesity has become a global epidemic, arousing great concern. In addition to genetic and dietary factors, exposure to environmental chemicals is associated with the occurrence and development of ... ...

    Abstract Given continuous development in society and the economy, obesity has become a global epidemic, arousing great concern. In addition to genetic and dietary factors, exposure to environmental chemicals is associated with the occurrence and development of obesity. Current research has indicated that some chemicals with endocrine-disrupting effects can affect lipid metabolism
    MeSH term(s) Humans ; Lipid Metabolism ; Environmental Exposure ; Obesity/etiology ; Obesity/genetics ; Adipogenesis ; Endocrine Disruptors/pharmacology ; Benzhydryl Compounds ; Lipids
    Chemical Substances Endocrine Disruptors ; Benzhydryl Compounds ; Lipids
    Language Chinese
    Publishing date 2023-12-12
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 1872-2059
    ISSN (online) 1872-2059
    DOI 10.3724/SP.J.1123.2023.12018
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  8. Article ; Online: Adaptive-mixture-categorization (AMC)-based g-computation and its application to trace element mixtures and bladder cancer risk

    Siting Li / Margaret R. Karagas / Brian P. Jackson / Michael N. Passarelli / Jiang Gui

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 9

    Abstract: Abstract Several new statistical methods have been developed to identify the overall impact of an exposure mixture on health outcomes. Weighted quantile sum (WQS) regression assigns the joint mixture effect weights to indicate the overall association of ... ...

    Abstract Abstract Several new statistical methods have been developed to identify the overall impact of an exposure mixture on health outcomes. Weighted quantile sum (WQS) regression assigns the joint mixture effect weights to indicate the overall association of multiple exposures, and quantile-based g-computation is a generalized version of WQS without the restriction of directional homogeneity. This paper proposes an adaptive-mixture-categorization (AMC)-based g-computation approach that combines g-computation with an optimal exposure categorization search using the F statistic. AMC-based g-computation reduces variance within each category and retains the variance between categories to build more powerful predictors. In a simulation study, the performance of association analysis was improved using categorizing by AMC compared with quantiles. We applied this method to assess the association between a mixture of 12 trace element concentrations measured from toenails and the risk of non-muscle invasive bladder cancer. Our findings suggested that medium-level (116.7–145.5 μg/g) vs. low-level (39.5–116.2 μg/g) of toenail zinc had a statistically significant positive association with bladder cancer risk.
    Keywords Medicine ; R ; Science ; Q
    Subject code 310
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Atmospheric and room temperature plasma mutagenesis and astaxanthin production from sugarcane bagasse hydrolysate by Phaffia rhodozyma mutant Y1

    Zhuang, Yuan / Jiang, Gui-Li / Zhu, Ming-Jun

    Process biochemistry. 2020 Apr., v. 91

    2020  

    Abstract: In this study, atmospheric and room temperature plasma and ultraviolet mutagenesis was studied for astaxanthin overproducing mutant. Phaffia rhodozyma mutant Y1 was obtained from the selection plate with 120 μmol/L diphenylamine as selection agent, and ... ...

    Abstract In this study, atmospheric and room temperature plasma and ultraviolet mutagenesis was studied for astaxanthin overproducing mutant. Phaffia rhodozyma mutant Y1 was obtained from the selection plate with 120 μmol/L diphenylamine as selection agent, and its carotenoid concentration and content were 54.38 mg/L and 5.38 mg/g, which were 19.02 % and 21.20 % higher than that of the original strain, respectively. Sugarcane bagasse hydrolysate was used for astaxanthin production by mutant Y1 at 22 °C and 220 rpm for 96 h, and the biomass and carotenoid concentration reached 12.65 g/L and 88.57 mg/L, respectively. Ultrasonication and cellulase were used to break cell wall and the parameters were optimized, achieving an astaxanthin extraction rate of 96.01 %. The present work provided a novel combined mutagenesis method for astaxanthin overproducing mutant and a green cell wall disruption process for astaxanthin extraction, which would play a solid foundation on the development of natural astaxanthin.
    Keywords ambient temperature ; aromatic amines ; astaxanthin ; biomass ; cell walls ; diphenylamine ; endo-1,4-beta-glucanase ; hydrolysates ; mutagenesis ; mutants ; sugarcane bagasse ; ultrasonic treatment
    Language English
    Dates of publication 2020-04
    Size p. 330-338.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1359-5113
    DOI 10.1016/j.procbio.2020.01.003
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Dual Iron Sites in Activation of N

    Jiang, Gui-Duo / Li, Zi-Yu / Mou, Li-Hui / He, Sheng-Gui

    The journal of physical chemistry letters

    2021  Volume 12, Issue 38, Page(s) 9269–9274

    Abstract: Inspired by the fact that the active centers of natural nitrogenases are polynuclear iron-sulfur clusters, the reactivity of isolated iron-sulfur clusters toward ... ...

    Abstract Inspired by the fact that the active centers of natural nitrogenases are polynuclear iron-sulfur clusters, the reactivity of isolated iron-sulfur clusters toward N
    Language English
    Publishing date 2021-09-17
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.1c02683
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