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Article ; Online: TransCUNet: UNet cross fused transformer for medical image segmentation.

Jiang, Shen / Li, Jinjiang

2022 Volume 150, Page(s) 106207

Abstract: Accurate segmentation of medical images is crucial for clinical diagnosis and evaluation. However, medical images have complex shapes, the structures of different objects are very different, and most medical datasets are small in scale, making it ... ...

Abstract	Accurate segmentation of medical images is crucial for clinical diagnosis and evaluation. However, medical images have complex shapes, the structures of different objects are very different, and most medical datasets are small in scale, making it difficult to train effectively. These problems increase the difficulty of automatic segmentation. To further improve the segmentation performance of the model, we propose a multi-branch network model, called TransCUNet, for segmenting medical images of different modalities. The model contains three structures: cross residual fusion block (CRFB), pyramidal pooling module (PPM) and gated axial-attention, which achieve effective extraction of high-level and low-level features of images, while showing high robustness to different size segmentation objects and different scale datasets. In our experiments, we use four datasets to train, validate and test the models. The experimental results show that TransCUNet has better segmentation performance compared to the current mainstream segmentation methods, and the model has a smaller size and number of parameters, which has great potential for clinical applications.
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2022.106207
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transformer with progressive sampling for medical cellular image segmentation.

Jiang, Shen / Li, Jinjiang / Hua, Zhen

Mathematical biosciences and engineering : MBE

2023 Volume 19, Issue 12, Page(s) 12104–12126

Abstract: The convolutional neural network, as the backbone network for medical image segmentation, has shown good performance in the past years. However, its drawbacks cannot be ignored, namely, convolutional neural networks focus on local regions and are ... ...

Abstract	The convolutional neural network, as the backbone network for medical image segmentation, has shown good performance in the past years. However, its drawbacks cannot be ignored, namely, convolutional neural networks focus on local regions and are difficult to model global contextual information. For this reason, transformer, which is used for text processing, was introduced into the field of medical segmentation, and thanks to its expertise in modelling global relationships, the accuracy of medical segmentation was further improved. However, the transformer-based network structure requires a certain training set size to achieve satisfactory segmentation results, and most medical segmentation datasets are small in size. Therefore, in this paper we introduce a gated position-sensitive axial attention mechanism in the self-attention module, so that the transformer-based network structure can also be adapted to the case of small datasets. The common operation of the visual transformer introduced to visual processing when dealing with segmentation tasks is to divide the input image into equal patches of the same size and then perform visual processing on each patch, but this simple division may lead to the destruction of the structure of the original image, and there may be large unimportant regions in the divided grid, causing attention to stay on the uninteresting regions, affecting the segmentation performance. Therefore, in this paper, we add iterative sampling to update the sampling positions, so that the attention stays on the region to be segmented, reducing the interference of irrelevant regions and further improving the segmentation performance. In addition, we introduce the strip convolution module (SCM) and pyramid pooling module (PPM) to capture the global contextual information. The proposed network is evaluated on several datasets and shows some improvement in segmentation accuracy compared to networks of recent years.
MeSH term(s)	Computer Systems ; Electric Power Supplies ; Image Processing, Computer-Assisted ; Neural Networks, Computer ; Visual Perception
Language	English
Publishing date	2023-01-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1551-0018
ISSN (online)	1551-0018
ISSN	1551-0018
DOI	10.3934/mbe.2022563
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A retroperitoneal bronchogenic cyst clinically mimicking an adrenal mass

Bi-yue Hu / Hong Yu / Jiang Shen

Journal of International Medical Research, Vol

three case reports and a literature review

2022 Volume 50

Abstract: Bronchogenic cysts are a congenital primitive foregut-derived developmental malformation, generally occurring in the posterior mediastinum. Their development in the retroperitoneum is extremely rare. Imaging techniques, such as multidetector computed ... ...

Abstract	Bronchogenic cysts are a congenital primitive foregut-derived developmental malformation, generally occurring in the posterior mediastinum. Their development in the retroperitoneum is extremely rare. Imaging techniques, such as multidetector computed tomography (MDCT), are typically effective in the detection of these lesions. Here, we describe three cases of a retroperitoneal cyst presenting as a para-adrenal mass. Only one boy presented with abdominal pain, and the other two showed no clinical symptoms. Endocrinological evaluation of all three cases was performed, and no adrenal hormone secretion was detected. All three cases were misdiagnosed preoperatively. Each patient underwent surgery, and one symptomatic patient became asymptomatic after surgery. Pathologic examination confirmed all three masses as bronchogenic cysts. The three cases showed some similar MDCT imaging features, including a complete adrenal structure, a cystic or solid mass in the adrenal region, and no obvious enhancement. Therefore, bronchogenic cysts should be considered in the differential diagnosis of retroperitoneal masses, even though accurate preoperative diagnosis remains difficult. A contrast-enhanced MDCT scan may be useful for differentiating hyper-attenuated cysts from other soft tissue masses.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Preoperative moderate to severe anemia is associated with increased postoperative major adverse cardiac and cerebral events and pulmonary complications: a propensity score-matched analysis in hip fracture surgery patients over 80 years old.

Min, Li / Linyi, Yang / Chen, Li / Jiang, Shen / Chen, Chen

Perioperative medicine (London, England)

2023 Volume 12, Issue 1, Page(s) 56

Abstract: Background: Anemia is a common health problem in the elderly. Preoperative anemia is a risk factor for postoperative outcomes in the elderly for hip fracture. The objective of the study was to explore the relationship between preoperative moderate to ... ...

Abstract	Background: Anemia is a common health problem in the elderly. Preoperative anemia is a risk factor for postoperative outcomes in the elderly for hip fracture. The objective of the study was to explore the relationship between preoperative moderate to severe anemia and postoperative morbidity and mortality in hip fracture patients over 80 years old. Methods: We performed a retrospective cohort study exploring preoperative moderate to severe anemia and postoperative morbidity and mortality. Patients over 80 years old undergoing hip fracture surgery were included in the study. Data were collected for major adverse cardiac and cerebral events (MACCE), postoperative pulmonary complications (PPCs), in-hospital mortality, delirium, gastrointestinal complication, deep venous thrombus (DVT), acute renal failure, ICU admission, and perioperative transfusion > 2 units rate. Results: A total of 912 eligible patients were included for unmatched cohort analysis, and 512 patients were included for matched cohort analysis after propensity score matching. Baseline characteristics between the normal to mild anemia and moderate to severe anemia groups were significantly different. More patients in the moderate to severe cohort had a higher ASA classification grade III and female ratio. Patients in the moderate and severe anemia cohorts had more MACCE (unadjusted: odds ratio [OR] 1.968, 96% CI 1.090-3.555, P 0.023; adjusted: OR 1.929, 95% CI 1.014-3.668, P 0.045) and PPCs (unadjusted: OR 2.616, 95% CI 1.442-4.748, P 0.001; adjusted: OR 2.352, 95% CI 1.225-4.516, P 0.010) than patients with normal or mild anemia. However, the transfusion > 2 units rate was not significantly different between the two cohorts (unadjusted: OR 0.967, 95% CI 0.737-1.270, P 0.811; adjusted: OR 0.941, 95% CI 0.693-1.278, P 0.697). The in-hospital mortality, delirium rate, gastrointestinal complication, ICU admission, and DVT were similar. However, the in-hospital mortality was much higher (3.6%, 21/591 vs 1.6%, 5/321) in the moderate to severe anemia cohort. Furthermore, after propensity score-matched analysis, MACCE and PPCs were also significantly increased in the moderate to severe anemia cohort (OR 2.196 & 3.171, 95% CI 1.0794.470 & 1.563-6.436, P 0.027 & 0.001), which were in accordance with the unadjusted and adjusted results in the unmatched cohorts. Conclusions: Moderate to severe preoperative anemia (< 11 g/dl) is associated with increased postoperative major adverse cardiac and cerebral events and pulmonary complications. Additionally, in-hospital mortality was not significant but was higher in the preoperative moderate to severe anemia cohort. Preoperative assessment and correction of hemoglobin level to above 11 g/dl might reduce MACCE, PPCs, and in-hospital mortality in hip fracture patients over 80 years old.
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2683800-X
ISSN	2047-0525
ISSN	2047-0525
DOI	10.1186/s13741-023-00349-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Changes in Anterior Chamber Angle and Choroidal Thickness in Patients with Primary Angle-Closure Glaucoma after Phaco-Goniosynechialysis

Surong Luo / Guomei Yuan / Chenwei Zhao / Jiang Shen / Li Zhang / Man Luo / Wei Chen

Journal of Clinical Medicine, Vol 12, Iss 406, p

2023 Volume 406

Abstract: We aimed to observe changes in angle width and choroidal thickness (CT) before and after phacoemulsification intraocular lens implantation (PEI) combined with goniosynechialysis (GSL) in patients with primary angle-closure glaucoma (PACG) complicated by ... ...

Abstract	We aimed to observe changes in angle width and choroidal thickness (CT) before and after phacoemulsification intraocular lens implantation (PEI) combined with goniosynechialysis (GSL) in patients with primary angle-closure glaucoma (PACG) complicated by cataracts. This prospective cohort study included 60 patients with PACG complicated by cataracts from the Department of Ophthalmology of Shaoxing People’s Hospital, China. Patients underwent PEI combined with GSL (PEI-GSL group) or laser peripheral iridotomy (LPI) followed by PEI (PEI group). Intraocular pressure (IOP) and endothelial counts were significantly decreased in both groups after surgery, while best-corrected visual acuity and central anterior chamber depth were significantly increased. However, there were no significant differences between the two groups. The opening degrees of room corners at 12, 3, 6, and 9 o’clock were recorded as AA12, AA3, AA6, and AA9, respectively. Anterior chamber depth was significantly increased postoperatively compared to preoperatively in both groups, with no significant between-group differences (all p s > 0.05). At 1, 3, and 6 months postoperatively, the width at AA12, AA3, and AA9 points was higher in the PEI-GSL group than in the PEI group (all p s < 0.05). Significant between-group differences at AA6 were observed preoperatively ( p = 0.023) and at 1 ( p = 0.027) and 3 ( p = 0.033) months postoperatively but not at 6 months postoperatively ( p = 0.055). CT was smaller postoperatively than preoperatively (all p s < 0.001). The present study suggests that patients with PACG who underwent PEI with or without GSL had reduced IOP and CT after surgery.
Keywords	primary angle closure glaucoma ; goniosynechialysis ; anterior chamber angle width ; choroidal thickness ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: "Magnet" Based on Activated Silver Nanoparticles Adsorbed Bacteria to Predict Refractory Apical Periodontitis Via Surface-Enhanced Raman Scattering.

Liu, Xin / Jiang, Shen / Zhang, Ting / Xu, Ziming / Liu, Ling / Zhang, Zhe / Pan, Shuang / Li, Yang

ACS applied materials & interfaces

2024 Volume 16, Issue 7, Page(s) 8499–8508

Abstract: Refractory apical periodontitis (RAP) is an endodontic apical inflammatory disease caused ... ...

Abstract	Refractory apical periodontitis (RAP) is an endodontic apical inflammatory disease caused by
MeSH term(s)	Humans ; Silver ; Spectrum Analysis, Raman/methods ; Metal Nanoparticles ; Reproducibility of Results ; Periapical Periodontitis/diagnosis ; Periapical Periodontitis/microbiology ; Porphyromonas gingivalis ; Escherichia coli
Chemical Substances	Silver (3M4G523W1G)
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c16677
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rapid Detection of the Monkeypox Virus Genome and Antigen Proteins Based on Surface-Enhanced Raman Spectroscopy.

Zhang, Zhe / Jiang, Heng / Jiang, Shen / Dong, Tuo / Wang, Xiaotong / Wang, Yunpeng / Li, Yang

ACS applied materials & interfaces

2023 Volume 15, Issue 29, Page(s) 34419–34426

Abstract: The conventional detection methods cannot satisfy the need for early and rapid detection of monkeypox virus (MPXV) infection. This is due to complicated pretreatment, time consumption, and complex operation of the diagnostic tests. Based on surface- ... ...

Abstract	The conventional detection methods cannot satisfy the need for early and rapid detection of monkeypox virus (MPXV) infection. This is due to complicated pretreatment, time consumption, and complex operation of the diagnostic tests. Based on surface-enhanced Raman spectroscopy (SERS), this study attempted to capture the characteristic fingerprints of the MPXV genome and multiple antigenic proteins without the need to design specific probes. The minimum detection limit of this method is 100 copies/mL, with good reproducibility and signal-to-noise ratio. Therefore, the relationship between characteristic peak intensity and the protein and nucleic acid concentration can be used to construct a concentration-dependent spectral line with a good linear relationship. Additionally, principal component analysis (PCA) could identify the SERS spectra of four different MPXV proteins in serum. Therefore, this rapid detection method in the current outbreak of monkeypox control and the future response to possible new outbreaks has broad application prospects.
MeSH term(s)	Monkeypox virus/isolation & purification ; Principal Component Analysis ; Reproducibility of Results ; Signal-To-Noise Ratio ; Spectrum Analysis, Raman/methods ; Mpox (monkeypox)/diagnosis ; Rapid Diagnostic Tests/methods ; Rapid Diagnostic Tests/standards ; Antigens, Viral/blood ; Limit of Detection ; Genome, Viral/genetics
Chemical Substances	Antigens, Viral
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c04285
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Experiencing an art education program through immersive virtual reality or iPad: Examining the mediating effects of sense of presence and extraneous cognitive load on enjoyment, attention, and retention.

Tang, Qingyang / Wang, Yanyun / Liu, Hao / Liu, Qian / Jiang, Shen

Frontiers in psychology

2022 Volume 13, Page(s) 957037

Abstract: Sense of presence and extraneous cognitive load (ECL) are the two psychological effects widely employed to explain the cognitive outcomes caused by high-immersive media (e. g., virtual reality). This study identified the concepts of both technological ... ...

Abstract	Sense of presence and extraneous cognitive load (ECL) are the two psychological effects widely employed to explain the cognitive outcomes caused by high-immersive media (e. g., virtual reality). This study identified the concepts of both technological affordance (i.e., immersion) and the psychological effects of VR learning. It investigated the mechanism by which immersion leads to better or worse communication in the context of art education. We operationalized the concept of immersion into two levels: a high-immersive VR system (HTC VIVE Cosmos) and a low-immersive tablet system (iPad). Through a between-subject experiment, we found that higher immersion not only led to a greater sense of presence but also lowered extraneous cognitive load. Enjoyment and attention increased as a sense of presence rose but were not necessarily predicted by extraneous cognitive load. This study found that sense of presence was a more robust explanatory variable than ECL and that cognitive load could be lower in a high-immersive environment with content specifically designed for VR.
Language	English
Publishing date	2022-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.957037
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Article ; Online: Unveiling Anoikis-related genes: A breakthrough in the prognosis of bladder cancer.

Jiang, Shen / Yang, Xiping / Lin, Yang / Liu, Yunfei / Tran, Lisa Jia / Zhang, Jing / Qiu, Chengjun / Ye, Fangdie / Sun, Zhou

The journal of gene medicine

2024 Volume 26, Issue 1, Page(s) e3651

Abstract: Background: Bladder cancer (BLCA) is a prevalent malignancy worldwide. Anoikis remains a new form of cell death. It is necessary to explore Anoikis-related genes in the prognosis of BLCA.: Methods: We obtained RNA expression profiles from the The ... ...

Abstract	Background: Bladder cancer (BLCA) is a prevalent malignancy worldwide. Anoikis remains a new form of cell death. It is necessary to explore Anoikis-related genes in the prognosis of BLCA. Methods: We obtained RNA expression profiles from the The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases for dimensionality reduction analysis and isolated epithelial cells, T cells and fibroblasts for copy number variation analysis, pseudotime analysis and transcription factor analysis based on R package. We integrated machine-learning algorithms to develop the artificial intelligence-derived prognostic signature (AIDPS). Results: The performance of AIDPS with clinical indicators was stable and robust in predicting BLCA and showed better performance in every validation dataset compared to other models. Mendelian randomization analysis was conducted. Single nucleotide polymorphism (SNP) sites of rs3100578 (HK2) and rs66467677 (HSP90B1) exhibited significant correlation of bladder problem (not cancer) and bladder cancer, whereasSNP sites of rs3100578 (HK2) and rs947939 (BAD) had correlation between bladder stone and bladder cancer. The immune infiltration analysis of the TCGA-BLCA cohort was calculated via the ESTIMATE (i.e. Estimation of STromal and Immune cells in MAlignantTumours using Expression data) algorithm which contains stromal, immune and estimate scores. We also found significant differences in the IC Conclusions: In conclusion, these findings indicated Anoikis-related prognostic genes in BLCA and constructed an innovative machine-learning model of AIDPS with high prognostic value for BLCA.
MeSH term(s)	Humans ; Anoikis/genetics ; Artificial Intelligence ; DNA Copy Number Variations ; Urinary Bladder Neoplasms/genetics ; Algorithms
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1458024-x
ISSN	1521-2254 ; 1099-498X
ISSN (online)	1521-2254
ISSN	1099-498X
DOI	10.1002/jgm.3651
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Zs.A 5423: Show issues

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Article ; Online: The "time-response" effect of Wenyang Pingchuan Formula on miR-19a in asthmatic mice experiment.

Jiang, Shen-Hua / Piao, Xiang / Yu, Jian-Er / Feng, Qi-Mao

Allergologia et immunopathologia

2022 Volume 50, Issue 5, Page(s) 129–137

Abstract: Background: Wenyang Pingchuan Formula (WPCF) is an empirical formula for the treatment of acute childhood asthma. However, the "time-effect" relationship of this prescription is not clear. This paper explores the relationship between Janus activated ... ...

Abstract	Background: Wenyang Pingchuan Formula (WPCF) is an empirical formula for the treatment of acute childhood asthma. However, the "time-effect" relationship of this prescription is not clear. This paper explores the relationship between Janus activated kinase signal transducer and activator of transcriptions (JAK/STAT), nuclear factor-κB (NF-κB), and microRNA (miR-19a), and also preliminarily determines the best time-effect relationship of WPCF in reducing the airway inflammation in asthmatic mice. Method: 80 BALB/c mice were randomly divided into four groups: control (CON) group, model (MDL) group, dexamethasone (DEX) group, and WPCF group. MDL group was established through intraperitoneal injection of 10% ovalbumin (OVA) and Al(OH) Results: Significant down-regulation of IL-4 and IL-13 expression (P<0.05) and up-regulation of IFN-γ expression (P<0.05) in BALF have been observed for WPCF group compared with the MDL group. The significant down-regulation of miR-19a mRNA and STAT6, p-STAT6, p65, p-p65 proteins (P<0.05) and up-regulation of SOCS1 and Tnfaip3 proteins (P<0.05) in BALF was also observed for WPCF group compared to the MDL group. During the experiment, the weight of the mice in DEX group significantly decreased (P<0.05) compared with the other groups. Conclusions: WPCF could restore Th1/Th2 balance. The longer the intervention time, the more effective the treatment. The down-regulation of miR-19a mRNA by activating JAK/STAT and NF-κB signal pathways may be a possible mechanism by which WPCF alleviates airway inflammation.
MeSH term(s)	Animals ; Asthma/genetics ; Inflammation ; Interferon-gamma/metabolism ; Interleukin-13 ; Mice ; Mice, Inbred BALB C ; MicroRNAs/genetics ; MicroRNAs/metabolism ; NF-kappa B ; Ovalbumin ; RNA, Messenger/genetics
Chemical Substances	Interleukin-13 ; MicroRNAs ; NF-kappa B ; RNA, Messenger ; Interferon-gamma (82115-62-6) ; Ovalbumin (9006-59-1)
Language	English
Publishing date	2022-09-01
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.15586/aei.v50i5.531
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