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  1. AU="Jiang-Qi Liu"
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  1. Article ; Online: Author Correction

    Bo Yang / Lin-Jing Li / Ling-Zhi Xu / Jiang-Qi Liu / Huan-Ping Zhang / Xiao-Rui Geng / Zhi-Gang Liu / Ping-Chang Yang

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    Histone acetyltransferease p300 modulates TIM4 expression in dendritic cells

    2021  Volume 2

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Intestinal Epithelial Cell-Derived CD83 Contributes to Regulatory T-Cell Generation and Inhibition of Food Allergy

    Yong Yu / Qiao-Ruo Jin / Yang Mi / Jiang-Qi Liu / Zhi-Qiang Liu / Shuai Wang / Zhi-Gang Liu / Ping-Chang Yang / Peng-Yuan Zheng

    Journal of Innate Immunity, Pp 1-

    2021  Volume 11

    Abstract: The mechanism of generation of antigen-specific regulatory T cells (Treg) is not fully understood yet. This study aimed to investigate the role of intestinal epithelial cell (IEC)-derived CD83 in the Treg generation in the intestine. In this study, the ... ...

    Abstract The mechanism of generation of antigen-specific regulatory T cells (Treg) is not fully understood yet. This study aimed to investigate the role of intestinal epithelial cell (IEC)-derived CD83 in the Treg generation in the intestine. In this study, the role of CD83 in the generation of Tregs was assessed in a cell-culture model and a food allergy (FA) mouse model. We found that mouse IECs expressed CD83; its levels were markedly lower in sensitized mice. Mice with CD83-deficient IECs failed to induce Tregs in the intestine. CD83 promoted the transforming growth factor-β-inducible early gene 1 (TIEG1) expression in CD4+ T cells. Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex mediated the effects of CD83 on the expression of TIEG1. Activation of the CD83/TLR4/MD-2/TIEG1 promoted the Treg generation. Concomitant administration of CD83 and specific antigens, but not either one alone, efficiently inhibited experimental FA via inducing the Treg generation in the intestine. In Conclusion, IEC expresses CD83 that is low in sensitized mice. Concomitant administration of CD83 and specific antigens efficiently inhibits FA in a murine model via inducing Tregs in the intestine. The data suggest that CD83 has translation potential in the treatment of FA.
    Keywords food allergy ; intestine ; epithelial cell ; t lymphocyte ; immunotherapy ; Medicine ; R ; Internal medicine ; RC31-1245
    Subject code 570
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Karger Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Inhibition of livin overcomes radioresistance in nasopharyngeal carcinoma cells.

    Fei Ma / Xia Gu / Jiang-Qi Liu / Li-Hua Mo / Gui Yang / Xiao-Rui Geng / Zhi-Qiang Liu / Zhi-Gang Liu / Ping-Chang Yang

    PLoS ONE, Vol 15, Iss 3, p e

    2020  Volume 0229272

    Abstract: BACKGROUND AND AIMS:Radiotherapy is one of the major remedies for the treatment of cancer, including nasopharyngeal carcinoma (NPC). Radioresistance occurs very often in target cells that is a large drawback in cancer treated with radiotherapy. Livin ... ...

    Abstract BACKGROUND AND AIMS:Radiotherapy is one of the major remedies for the treatment of cancer, including nasopharyngeal carcinoma (NPC). Radioresistance occurs very often in target cells that is a large drawback in cancer treated with radiotherapy. Livin involves the over-growth of cancer cells. This study aims to investigate the role of livin in the radioresistance formation in NPC cells. METHODS:NPC cell lines were exposed to small doses of irradiation to establish a cell model of radioresistance, in which the role of livin in the development of radioresistance was evaluated. RESULTS:The expression of livin was observed in NPC cells, which was significantly increased after exposing to small doses of irradiation. A negative correlation was detected between livin and Fas expression in NPC cells. Livin formed a complex with heat shock factor-1 (HSF1, the transcription factor of Fas) in NPC cells after irradiation, which sped up ubiquitination of HSF1. Livin was involved in suppressing Fas expression in NPC cells with radioresistance. Exposure to livin inhibitors prevented radioresistance development and overcame the established radioresistance in NPC cells. CONCLUSIONS:Livin expression in NPC cells plays a critical role in the development of radioresistance. Depletion of livin increases the sensitiveness of NPC cells to irradiation. Target therapy against livin may have the translational potential for the treatment of NPC.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Retraction Note

    Jiang-Qi Liu / Xing-Yong Li / Hai-Qiong Yu / Gui Yang / Zhi-Qiang Liu / Xiao-Rui Geng / Shuai Wang / Li-Hua Mo / Lu Zeng / Miao Zhao / Yun-Ting Fu / Hong-Zhi Sun / Zhi-Gang Liu / Ping-Chang Yang

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    Tumor-specific Th2 responses inhibit growth of CT26 colon-cancer cells in mice via converting intratumor regulatory T cells to Th9 cells

    2021  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: The 3-methyl-4-nitrophenol (PNMC) compromises airway epithelial barrier function

    An, Yun-Fang / Xiao-Rui Geng / Li-Hua Mo / Jiang-Qi Liu / Li-Teng Yang / Xiao-Wen Zhang / Zhi-Gang Liu / Chang-Qing Zhao / Ping-Chang Yang

    Toxicology. 2018 Feb. 15, v. 395

    2018  

    Abstract: It is recognized that the air pollution is associated with the pathogenesis of airway diseases. This study aims to elucidate the role of the 3-methyl-4-nitrophenol (PNMC), one of the components of diesel-exhaust particles, in compromising the airway ... ...

    Abstract It is recognized that the air pollution is associated with the pathogenesis of airway diseases. This study aims to elucidate the role of the 3-methyl-4-nitrophenol (PNMC), one of the components of diesel-exhaust particles, in compromising the airway epithelial barrier integrity.A549 cells, an airway epithelial cell line, were cultured to monolayers to be used as an in vitro epithelial barrier model. BALB/c mice were treated with nasal drops containing PNMC to test the effects of PNMC on alternating the airway epithelial barrier functions.Exposure of mice to PNMC induced nasal epithelial cell apoptosis and increased the permeability of the nasal epithelial barrier. PNMC increased casp8 and casp3 activities in nasal epithelial cells. Exposure to PNMC up regulated Fas and FasL expression in airway epithelial cells. Inhibition of caspase abolished the PNMC-induced airway epithelial barrier dysfunction.Exposure of airway mucosa to PNMC induces epithelial cell apoptosis and compromises the epithelial barrier function, which can be prevented by the inhibition of caspases.
    Keywords air pollution ; apoptosis ; caspases ; cell lines ; enzyme inhibition ; epithelial cells ; mice ; models ; mucosa ; nitrophenols ; nose ; pathogenesis ; permeability
    Language English
    Dates of publication 2018-0215
    Size p. 9-14.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 184557-3
    ISSN 1879-3185 ; 0300-483X
    ISSN (online) 1879-3185
    ISSN 0300-483X
    DOI 10.1016/j.tox.2018.01.001
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Ampulla dilation with different sized balloons to remove common bile duct stones

    Neng-Ping Li / Jiang-Qi Liu / Zhi-Qiang Zhou / Tao-Ying Ji / Xiao-Yan Cai / Qing-Yun Zhu

    World Journal of Gastroenterology, Vol 19, Iss 6, Pp 903-

    2013  Volume 908

    Abstract: AIM: To assess the outcomes of ampulla dilation with different sized balloons to remove common bile duct (CBD) stones. METHODS: Patients (n = 208) were divided into five groups based on the largest CBD stone size of ... 14 mm. ... ...

    Abstract AIM: To assess the outcomes of ampulla dilation with different sized balloons to remove common bile duct (CBD) stones. METHODS: Patients (n = 208) were divided into five groups based on the largest CBD stone size of < 5, 6-8, 8-12, 12-14, and > 14 mm. Patients underwent limited endoscopic sphincterotomy (EST) alone or limited EST followed by endoscopic papillary balloon dilation with 8, 10, 12 and 14 mm balloons, such that the size of each balloon did not exceed the size of the CBD. Short- and long-term outcomes, such as post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, perforation, bleeding, and pneumobilia were compared among the five groups. RESULTS: The overall rate of successful stone removal in all groups was 100%, and all patients were cured. Eight (3.85%) patients had post-ERCP pancreatitis, none had perforations, and 6 (2.9%) had bleeding requiring transfusion. There were no significant differences in early complication rates among the five groups. We observed significant correlations between increased balloon size and the short- and long-term rates of post-ERCP pneumobilia. Post-ERCP pancreatitis and bleeding correlated significantly with age, with post-ERCP pancreatitis occurring more frequently in patients aged < 60 years, and bleeding occurring more frequently in patients aged > 70 years. We observed a significant correlation between patient age and the diameter of the largest CBD stone, with stones > 12 mm occurring more frequently in patients > 60 years old. CONCLUSION: Choosing a balloon size based on the largest stone diameter is safe and effective for removing CBD stones. Balloon size should not exceed 15 mm.
    Keywords Endoscopic papillary balloon dilation ; Endoscopic sphincterotomy ; Common bile duct stone ; Endoscopic retrograde cholangiopancreatography ; Pancreatitis ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Baishideng Publishing Group Co., Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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