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Article ; Online: A high-efficiency discretized immersed boundary method for moving boundaries in incompressible flows

Dong Xu / Jianing Liu / Yunfeng Wu / Chunning Ji

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract The Immersed Boundary Method (IBM) has an advantage in simulating fluid–structure interaction, owning to its simplicity, intuitiveness, and ease of handling complex object boundaries. The interpolation function plays a vital role in IBM and it ... ...

Abstract	Abstract The Immersed Boundary Method (IBM) has an advantage in simulating fluid–structure interaction, owning to its simplicity, intuitiveness, and ease of handling complex object boundaries. The interpolation function plays a vital role in IBM and it is usually computationally intensive. For moving or deforming solids, the interpolation weights of all the immersed boundary points ought to be updated every time step, which takes quite a lot CPU time. Since the interpolation procedure within all uniform structured grids is highly repetitive and very similar, we propose a simple and generalized Discretized Immersed Boundary Method (DIBM), which significantly improves efficiency by discretizing the interpolation functions onto subgrid points within each control volume and reusing a predefined universal interpolation stencil. The accuracy and performance of DIBM are analyzed using both theoretical estimation and simulation tests. The results show speedup ratios of 30–40 or even higher using DIBM when compared with conventional IBM for typical moving boundary simulations like particle-laden flows, while the error is estimated to be under 1% and can be further decreased by using finer subgrid stencils. By balancing the performance and accuracy demands, DIBM provides an efficient alternative framework for handling moving boundaries in incompressible viscous flows.
Keywords	Medicine ; R ; Science ; Q
Subject code	518
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Economic Policy Uncertainty and Enterprise Financing Efficiency

Tingli Liu / Xiao Chen / Jianing Liu

Sustainability, Vol 15, Iss 8847, p

Evidence from China

2023 Volume 8847

Abstract: This study investigates the effect of economic policy uncertainty on financing efficiency in China’s high-tech manufacturing industry from static and dynamic perspectives. Using data envelopment analysis (DEA) and the Malmquist index, we measure ... ...

Abstract	This study investigates the effect of economic policy uncertainty on financing efficiency in China’s high-tech manufacturing industry from static and dynamic perspectives. Using data envelopment analysis (DEA) and the Malmquist index, we measure financing efficiency and its changes over time. The results show that China’s high-tech manufacturing firms exhibit low static financing efficiency, yet they exhibit relatively high dynamic efficiency. A significant positive relationship is found between economic policy uncertainty and both static and dynamic financing efficiency. The uncertainty motivates firms to improve their financing efficiency, mainly by enhancing technical and scale efficiency and by increasing comprehensive efficiency. Moreover, different financing channels, such as commercial credit, equity financing, bank credit, and internal financing, have varied effects on the relationship between economic policy uncertainty and static financing efficiency. This study demonstrates that high-tech manufacturing enterprises can respond to economic policy uncertainty by improving their financing efficiency.
Keywords	high-tech manufacturing industry ; economic policy uncertainty ; static-dynamic financing efficiency ; data envelopment analysis (DEA) ; Malmquist index ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	338
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ubiquitination in T-Cell Activation and Checkpoint Inhibition

Shubhangi Gavali / Jianing Liu / Xinyi Li / Magdalena Paolino

International Journal of Molecular Sciences, Vol 22, Iss 10800, p

New Avenues for Targeted Cancer Immunotherapy

2021 Volume 10800

Abstract: The advent of T-cell-based immunotherapy has remarkably transformed cancer patient treatment. Despite their success, the currently approved immunotherapeutic protocols still encounter limitations, cause toxicity, and give disparate patient outcomes. Thus, ...

Abstract	The advent of T-cell-based immunotherapy has remarkably transformed cancer patient treatment. Despite their success, the currently approved immunotherapeutic protocols still encounter limitations, cause toxicity, and give disparate patient outcomes. Thus, a deeper understanding of the molecular mechanisms of T-cell activation and inhibition is much needed to rationally expand targets and possibilities to improve immunotherapies. Protein ubiquitination downstream of immune signaling pathways is essential to fine-tune virtually all immune responses, in particular, the positive and negative regulation of T-cell activation. Numerous studies have demonstrated that deregulation of ubiquitin-dependent pathways can significantly alter T-cell activation and enhance antitumor responses. Consequently, researchers in academia and industry are actively developing technologies to selectively exploit ubiquitin-related enzymes for cancer therapeutics. In this review, we discuss the molecular and functional roles of ubiquitination in key T-cell activation and checkpoint inhibitory pathways to highlight the vast possibilities that targeting ubiquitination offers for advancing T-cell-based immunotherapies.
Keywords	ubiquitination ; T cells ; checkpoint inhibition ; cancer immunotherapy ; deubiquitinases ; E3 ligases ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Polyaniline-coated core-shell silica microspheres-based dispersive-solid phase extraction for detection of benzophenone-type UV filters in environmental water samples

Anping Wang / Lihuan Hu / Jianing Liu / Miaomiao Tian / Li Yang

Environmental Advances, Vol 3, Iss , Pp 100037- (2021)

2021

Abstract: Polyaniline-modified core-shell mesoporous silica (CSMS@PANI) nanocomposite microspheres are synthesized as adsorbent in dispersion-solid phase extraction (d-SPE) for enrichment and purification of benzophenone-type UV filters. The synthesized CSMS@PANI ... ...

Abstract	Polyaniline-modified core-shell mesoporous silica (CSMS@PANI) nanocomposite microspheres are synthesized as adsorbent in dispersion-solid phase extraction (d-SPE) for enrichment and purification of benzophenone-type UV filters. The synthesized CSMS@PANI nanocomposite microspheres exhibit large specific surface area (33.45 m2/g) and uniform fibrous shell (microsphere diameter of 1.3 μm, outer silica shell thickness of 120 nm, pore diameter of 12.04 nm), which can greatly improve the extraction efficiency of the samples. Combining CSMS@PANI based d-SPE with sheathless capillary electrophoresis-tandem mass spectrometry for detection, we can achieve sensitive determination of six benzophenone-type UV filters with the detection limit of 0.6 pg/mL-0.2 ng/mL and the enrichment factors of 470-660. The method is successfully applied for ultrasensitive detection of trace amount benzophenone-type UV filters in environment water samples. It is indicated that the method has the advantages of rapid and efficient enrichment, high sensitivity, and excellent repeatability. Our study extends the application of core-shell mesoporous silica materials and would be of value for pretreatment of trace-amount and complex real samples.
Keywords	Benzophenone-type ultraviolet filters ; Polyaniline ; Core-shell silica microspheres ; Dispersive-solid phase extraction ; Capillary electrophoresis-tandem mass spectrometry ; Environmental sciences ; GE1-350
Subject code	500
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Therapeutic drug combinations against COVID-19 obtained by employing a collaborative filtering method

Ruiyuan Yao / Fan Yang / Jianing Liu / Qiang Jiao / Hong Yu / Xiushan Nie / Hongkai Li / Xin Wang / Fuzhong Xue

Heliyon, Vol 9, Iss 3, Pp e14023- (2023)

2023

Abstract: The outbreak of coronavirus disease 2019 (COVID-19) has severely harmed human society and health. Because there is currently no specific drug for the treatment and prevention of COVID-19, we used a collaborative filtering algorithm to predict which ... ...

Abstract	The outbreak of coronavirus disease 2019 (COVID-19) has severely harmed human society and health. Because there is currently no specific drug for the treatment and prevention of COVID-19, we used a collaborative filtering algorithm to predict which traditional Chinese medicines (TCMs) would be effective in combination for the prevention and treatment of COVID-19. First, we performed drug screening based on the receptor structure prediction method, molecular docking using q-vina to measure the binding ability of TCMs, TCM formulas, and neo-coronavirus proteins, and then performed synergistic filtering based on Laplace matrix calculations to predict potentially effective TCM formulas. Combining the results of molecular docking and synergistic filtering, the new recommended formulas were analyzed by reviewing data platforms or tools such as PubMed, Herbnet, the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, the Guide to the Dispensing of Medicines for Clinical Evidence, and the Dictionary of Chinese Medicine Formulas, as well as medical experts' treatment consensus in terms of herbal efficacy, modern pharmacological studies, and clinical identification and typing of COVID-19 pneumonia, to determine the recommended solutions. We found that the therapeutic effect of a combination of six TCM formulas on the COVID-19 virus is the result of the overall effect of the formula rather than that of specific components of the formula. Based on this, we recommend a formula similar to that of Jinhua Qinggan Granules for the treatment of COVID-19 pneumonia. This study may provide new ideas and new methods for future clinical research. Classification: Biological Science.
Keywords	COVID-19 ; SARS-CoV-2 ; Traditional Chinese medicine ; Collaborative filtering ; Drug combination ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sperm ultrastructure of Pochazia shantungensis (Chou & Lu) and Ricania speculum (Walker) (Hemiptera, Ricaniidae) with phylogenetic implications

Zhen Jiang / Jianing Liu / Daozheng Qin

ZooKeys, Vol 880, Iss , Pp 43-

2019 Volume 59

Abstract: The sperm ultrastructure of two ricaniid species, Pochazia shantungensis (Chou & Lu) and Ricania speculum (Walker), was investigated using light and transmission electron microscopy. Both species have monoflagellate sperm, the shape and ultrastructure of ...

Abstract	The sperm ultrastructure of two ricaniid species, Pochazia shantungensis (Chou & Lu) and Ricania speculum (Walker), was investigated using light and transmission electron microscopy. Both species have monoflagellate sperm, the shape and ultrastructure of the mature spermatozoon of these two species are similar in morphology, and 128 spermatozoa are organized into sperm bundles with their heads embedded in a homogenous matrix forming the spermatodesmata. The individual sperm is filiform and includes the head, neck and flagellum. The head is needle-like, with a bilayer acrosome and an inferior elongated nucleus which is formed of homogeneously compact and electron-dense chromatin. The neck region is indistinct and is comprised of the centriole and centriole adjunct with a homogeneous dense substance. The long flagellum has the typical 9 + 9 + 2 axoneme microtubule pattern and two symmetrical mitochondrial derivatives with an orderly array of cristae flanking both sides, and a pair of well-developed fishhook-shaped accessory bodies. Current evidence shows that ricaniid species have D-shaped mitochondrial derivatives in cross-section and a serrated electron-dense region. The phylogenetic relationship of Fulgoroidea with other superfamilies in Auchenorrhyncha is briefly discussed.
Keywords	Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Follow-Up Study of Motor Skill Development and Its Determinants in Preschool Children from Middle-Income Family

Huan Wang / Yanjie Chen / Jianing Liu / Huanhuan Sun / Weizhen Gao

BioMed Research International, Vol

2020 Volume 2020

Abstract: We tracked the motor skill development of young children aged 3–6 years and investigated the influence of middle-income home environment on the development of motor skill. 268 children were selected from kindergartens in Beijing. The Test of Gross Motor ... ...

Abstract	We tracked the motor skill development of young children aged 3–6 years and investigated the influence of middle-income home environment on the development of motor skill. 268 children were selected from kindergartens in Beijing. The Test of Gross Motor Development (TGMD) tool was used to test the development of locomotor and object-control skills (LS and OS), and a survey of children’s behaviour and home environment was conducted. During the follow-up, the LS and OS of children aged 3–6 years continued to grow, with an annual growth rate of 20% and 30%. Five LS indicators and two OS indicators were significantly higher in the 3–4-year group than in the 4–5 and 5–6-year groups (p<0.01). The age-sex trend model showed that girls’ locomotor skill developed at a significantly higher rate than that of boys (β=6.3004 and 4.6782, p<0.001). Three-year-old boys performed significantly better than girls on object-control motor skill (p<0.05). Factors affecting the rate of children’s motor skill development in middle-income families included the frequency of playing with friends (β=0.133, p=0.032) and the frequency of bicycling, skateboarding, dancing, running, and jumping (β=0.041, p=0.042). Family income, parents’ education level, and family activity area did not significantly affect the growth rate of motor skills. For middle-income families, the improvement of material environment at home like more playing spaces and toys did not speed up the motor development, while more opportunities to play with friends and engage in a variety of sports activities could promote children’s motor skill development.
Keywords	Medicine ; R
Subject code	796
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Plasmonic ommatidia for lensless compound-eye vision

Leonard C. Kogos / Yunzhe Li / Jianing Liu / Yuyu Li / Lei Tian / Roberto Paiella

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 9

Abstract: The compound eyes of arthropods provide a visual advantage by seeing a wide range of angles all at once, but cameras that mimic them are usually curved and bulky. Here, the authors develop a flat, plasmonic image sensor array that enables high-quality ... ...

Abstract	The compound eyes of arthropods provide a visual advantage by seeing a wide range of angles all at once, but cameras that mimic them are usually curved and bulky. Here, the authors develop a flat, plasmonic image sensor array that enables high-quality wide-angle vision without lenses or curvature.
Keywords	Science ; Q
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Plasmonic ommatidia for lensless compound-eye vision

Leonard C. Kogos / Yunzhe Li / Jianing Liu / Yuyu Li / Lei Tian / Roberto Paiella

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 9

Abstract	The compound eyes of arthropods provide a visual advantage by seeing a wide range of angles all at once, but cameras that mimic them are usually curved and bulky. Here, the authors develop a flat, plasmonic image sensor array that enables high-quality wide-angle vision without lenses or curvature.
Keywords	Science ; Q
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Investigating the Associations among Drug Dependents’ Family Function and Exercise Attitudes

Jianing Liu / Daniel J. McDonough / Yingying Wang / Yu Zhou / Zan Gao / Chenglin Zhou

International Journal of Environmental Research and Public Health, Vol 17, Iss 8111, p

Marital Status Differences

2020 Volume 8111

Abstract: This paper examines: (1) The demographic characteristics of different marital statuses of drug dependents; (2) differences in exercise attitudes and family function by marital status; and (3) if family function factors correlated with exercise attitudes ... ...

Abstract	This paper examines: (1) The demographic characteristics of different marital statuses of drug dependents; (2) differences in exercise attitudes and family function by marital status; and (3) if family function factors correlated with exercise attitudes and if exercise attitude factors correlated with family function. Multivariate analyses of variance (MANOVAs) revealed significant differences in drug dependents’ exercise attitudes between married and single groups ( p < 0.05) and the married and “other” groups ( p < 0.01). Furthermore, we observed significant differences in drug dependents’ family function between married and single groups ( p < 0.01) and married and other groups ( p < 0.05). Regression analyses indicated that communication [F change (1,1791) = 137.819; p < 0.001] was a significant positive predictor for drug dependents’ exercise attitude, accounting for 7.1% of the observed variance. Moreover, 50% of the variance was explained by willingness [F change (1,1791) = 850.49, p < 0.001] and control [F change (1,1790) = 141.415, p < 0.001], which were two significant predictors of drug dependents’ family function. Findings of this study were: (1) Exercise attitude and family function of married drug dependents were better than single drug dependents and other marital status addicts; (2) communication was observed as a factor of family function that correlated with exercise attitude; and (3) willingness was related with family function.
Keywords	behavior control ; drug addiction ; drug dependence ; drug rehabilitation ; physical activity and exercise ; Medicine ; R
Subject code	796
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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