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  1. Article ; Online: The search for authentic microbiome-disease relationships.

    Jiao, Na / Zhu, Lixin / Zhu, Ruixin

    Nature medicine

    2024  

    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-024-02920-z
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    Zs.A 4212: Show issues Location:
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  2. Article: Evidence challenging the causal role of gut microbiota in inflammatory bowel diseases.

    Jiao, Na / Ke, Xiao / Zhu, Lixin / Zhu, Ruixin

    Gastroenterology report

    2023  Volume 11, Page(s) goad064

    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2710871-5
    ISSN 2052-0034
    ISSN 2052-0034
    DOI 10.1093/gastro/goad064
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  3. Article ; Online: Multi-kingdom microbial signatures in excess body weight colorectal cancer based on global metagenomic analysis.

    Zhu, Xinyue / Xu, Pingping / Zhu, Ruixin / Gao, Wenxing / Yin, Wenjing / Lan, Ping / Zhu, Lixin / Jiao, Na

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 24

    Abstract: Excess body weight (EBW) increases the risk of colorectal cancer (CRC) and is linked to lower colonoscopy compliance. Here, we extensively analyzed 981 metagenome samples from multiple cohorts to pinpoint the specific microbial signatures and their ... ...

    Abstract Excess body weight (EBW) increases the risk of colorectal cancer (CRC) and is linked to lower colonoscopy compliance. Here, we extensively analyzed 981 metagenome samples from multiple cohorts to pinpoint the specific microbial signatures and their potential capability distinguishing EBW patients with CRC. The gut microbiome displayed considerable variations between EBW and lean CRC. We identify 44 and 37 distinct multi-kingdom microbial species differentiating CRC and controls in EBW and lean populations, respectively. Unique bacterial-fungal associations are also observed between EBW-CRC and lean-CRC. Our analysis revealed specific microbial functions in EBW-CRC, including D-Arginine and D-ornithine metabolism, and lipopolysaccharide biosynthesis. The best-performing classifier for EBW-CRC, comprising 12 bacterial and three fungal species, achieved an AUROC of 0.90, which was robustly validated across three independent cohorts (AUROC = 0.96, 0.94, and 0.80). Pathogenic microbial species, Anaerobutyricum hallii, Clostridioides difficile and Fusobacterium nucleatum, are EBW-CRC specific signatures. This work unearths the specific multi-kingdom microbial signatures for EBW-CRC and lean CRC, which may contribute to precision diagnosis and treatment of CRC.
    MeSH term(s) Humans ; Metagenome ; Arginine ; Gastrointestinal Microbiome/genetics ; Weight Gain ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics
    Chemical Substances Arginine (94ZLA3W45F)
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05714-0
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  4. Article: Engineering fluorescent protein chromophores with an internal reference for high-fidelity ratiometric G4 imaging in living cells.

    Han, Jiao-Na / Zhong, Caijun / Ge, Mingmin / Kuang, Shi / Nie, Zhou

    Chemical science

    2023  Volume 14, Issue 17, Page(s) 4538–4548

    Abstract: G-quadruplexes (G4s) are significant nucleic acid secondary structures formed by guanine-rich sequences. Many single-emission G4 fluorescent probes that are lit up by inhibiting intramolecular rotation have been reported. However, they are non- ... ...

    Abstract G-quadruplexes (G4s) are significant nucleic acid secondary structures formed by guanine-rich sequences. Many single-emission G4 fluorescent probes that are lit up by inhibiting intramolecular rotation have been reported. However, they are non-fluorescent unless structurally rigidified, making them sensitive to other intracellular crowding and confinement environments in the cell, like viscosity. Ratiometric measurements provide built-in self-calibration for signal correction, enabling more sensitive and reliable detection. Herein, we structurally modulate green fluorescent protein (GFP)-like chromophores by integrating the imidazolidinone scaffold of the GFP chromophore and coumarin 6H, obtaining a G4 responsive dual-emission chromophore, called NHCouI. The red emission signal of NHCouI can specifically respond to parallel G4s, while its green emission signal is inert and acts as an internal reference signal. NHCouI-G4 complexes feature high fluorescence quantum yield and excellent anti-photobleaching properties. NHCouI can self-calibrate the signal and avoid viscosity disturbances within the range of major subcellular organelles during G4 imaging in living cells. It is also applied to reflect the difference between apoptosis and ferroptosis
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc00022b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Integrated Transcriptomics and Metabolomics Reveal Changes in Cell Homeostasis and Energy Metabolism in

    Wang, Qing-Hua / Wu, Ren-Xie / Ji, Jiao-Na / Zhang, Jing / Niu, Su-Fang / Tang, Bao-Gui / Miao, Ben-Ben / Liang, Zhen-Bang

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Trachinotus ... ...

    Abstract Trachinotus ovatus
    MeSH term(s) Animals ; Energy Metabolism ; Hypoxia/genetics ; Gene Expression Profiling ; Fishes ; Homeostasis ; Amino Acids ; Fatty Acids
    Chemical Substances Amino Acids ; Fatty Acids
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021054
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  6. Article ; Online: Superconductivity in Ca-intercalated bilayer graphene: C

    Tan, Jin-Han / Wang, Hao / Chen, Ying-Jie / Jiao, Na / Zheng, Meng-Meng / Lu, Hong-Yan / Zhang, Ping

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 15, Page(s) 11429–11435

    Abstract: The deposition and intercalation of metal atoms can induce superconductivity in monolayer and bilayer graphenes. For example, it has been experimentally proved that Li-deposited graphene is a superconductor with critical ... ...

    Abstract The deposition and intercalation of metal atoms can induce superconductivity in monolayer and bilayer graphenes. For example, it has been experimentally proved that Li-deposited graphene is a superconductor with critical temperature
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp06245g
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  7. Article: RNA m6A dynamic modification mediated by nucleus-localized FTO is involved in follicular reserve.

    Zhang, Jiao-Na / Wang, Rui-Ting / Klinger, Francesca-Gioia / Cheng, Shun-Feng / Shen, Wei / Sun, Xiao-Feng

    Zoological research

    2024  Volume 45, Issue 2, Page(s) 415–428

    Abstract: In eukaryotic organisms, the most common internal modification of messenger RNA (mRNA) is N6-methyladenosine (m6A). This modification can be dynamically and reversibly controlled by specific enzymes known as m6A writers and erasers. The fat-mass and ... ...

    Abstract In eukaryotic organisms, the most common internal modification of messenger RNA (mRNA) is N6-methyladenosine (m6A). This modification can be dynamically and reversibly controlled by specific enzymes known as m6A writers and erasers. The fat-mass and obesity-associated protein (FTO) catalyzes RNA demethylation and plays a critical role in various physiological and pathological processes. Our research identified dynamic alterations in both m6A and FTO during the assembly of primordial follicles, with an inverse relationship observed for m6A levels and nuclear-localized FTO expression. Application of
    MeSH term(s) Animals ; RNA/metabolism ; RNA, Messenger/genetics ; Biomarkers ; Alternative Splicing ; Adenine/analogs & derivatives
    Chemical Substances 6-methyladenine (W7IBY2BGAX) ; RNA (63231-63-0) ; RNA, Messenger ; Biomarkers ; Adenine (JAC85A2161)
    Language English
    Publishing date 2024-03-14
    Publishing country China
    Document type Journal Article
    ISSN 2095-8137
    ISSN 2095-8137
    DOI 10.24272/j.issn.2095-8137.2023.236
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  8. Article ; Online: Association of VEGFA polymorphisms with chronic obstructive pulmonary disease in Chinese Han and Mongolian populations.

    Gao, Xiaoyu / Wang, Xin / Jiao, Na / Chen, Jiyuan / Sun, Dejun

    Experimental physiology

    2021  Volume 106, Issue 8, Page(s) 1839–1848

    Abstract: New findings: What is the central question of this study? Vascular endothelial growth factor A (VEGFA) is an important growth factor involved in changes in the bronchial microvascular and airway inflammation in chronic obstructive pulmonary disease ( ... ...

    Abstract New findings: What is the central question of this study? Vascular endothelial growth factor A (VEGFA) is an important growth factor involved in changes in the bronchial microvascular and airway inflammation in chronic obstructive pulmonary disease (COPD) progression. What is the association of single nucleotide polymorphisms (SNPs) in VEGFA with the risk of COPD in the Chinese Han and Mongolian populations? What is the main finding and its importance? The effect of five SNPs in the VEGFA gene was analysed and compared between the Chinese Han and Mongolian populations. A contribution of risk alleles rs833068, rs833070 and rs3024997 to COPD was detected in the Chinese Mongolian population only. The study provided data from different populations to validate the role of VEGFA polymorphisms in COPD and provided reliable SNPs to predict the risk of COPD.
    Abstract: We attempted to define the associations between single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor A (VEGFA) gene and chronic obstructive pulmonary disease (COPD) in Chinese Han and Mongolian cohorts. Five SNPs were genotyped in cohorts of 684 COPD patients (350 Mongolian and 334 Han) and 784 healthy controls (350 Mongolian and 434 Han) using SNPscan multiplex PCR. SNP frequencies, genetic models and haplotypes were analysed using the chi-square test. The associations of SNPs with COPD and linkage disequilibrium were analysed using logistic regression and HaploView, respectively. We found that only rs833068G>A, rs833070T>C and rs3024997G>A were significantly associated with the risk of COPD in the Mongolian population (rs833068: P < 0.001, rs833070: P < 0.001, rs3024997: P = 0.002). In the analysis of genotype distributions, the A/A and G/A genotypes in rs833068 (A/A: odds ratio (OR) = 0.313, P < 0.001; G/A: OR = 0.724, P < 0.001) and rs3024997 (A/A: OR = 0.513, P = 0.008; G/A: OR = 0.671, P = 0.008) and the C/C and T/C genotypes in rs833070 (C/C: OR = 0.435, P = 0.007; T/C: OR = 0.593, P = 0.007) were associated with protection against COPD in the Mongolian population. The haplotype frequencies of GCCAT and GTCGC were significantly different between the patients and controls (GCCAT: P = 0.001; GTCGC: P < 0.001) in the Mongolian population. Our findings indicate that five SNPs in the VEGFA gene play divergent roles in the Han and Mongolian populations. rs833068A, rs833070C and rs3024997A were observed to be associated with the risk of COPD in the Mongolian population.
    MeSH term(s) Case-Control Studies ; China ; Gene Frequency/genetics ; Genetic Association Studies ; Genetic Predisposition to Disease/genetics ; Genotype ; Haplotypes/genetics ; Humans ; Polymorphism, Single Nucleotide/genetics ; Pulmonary Disease, Chronic Obstructive/genetics ; Vascular Endothelial Growth Factor A/genetics
    Chemical Substances VEGFA protein, human ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP089523
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    Uc I Zs.102: Show issues Location:
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  9. Article ; Online: Advances in G-quadruplexes-based fluorescent imaging.

    Han, Jiao-Na / Ge, Mingmin / Chen, Pengfei / Kuang, Shi / Nie, Zhou

    Biopolymers

    2022  , Page(s) e23528

    Abstract: G-quadruplexes (G4s), the noncanonical nucleic acid secondary structure, form within guanine-rich DNA or RNA sequences. G4s formation can affect chromatin architecture and gene regulation and has been associated with various cellular functions, including ...

    Abstract G-quadruplexes (G4s), the noncanonical nucleic acid secondary structure, form within guanine-rich DNA or RNA sequences. G4s formation can affect chromatin architecture and gene regulation and has been associated with various cellular functions, including DNA replication, transcription, and genome maintenance. Visualizing and detecting G4s precisely in such processes is essential to increasing our understanding of G4s biology. Considerable attention has focused on the G4s targeting molecular imaging studies. Besides, fluorescent light-up aptamers (FLAPs, also referred to as fluorogenic aptamers) have gained momentum, which commonly have a G4 scaffolding for imaging intracellular RNAs and metabolites. In this review, we first introduce several representative fluorescent imaging approaches for tracking G4s in cells and in vivo. We also discuss the potential of G4-containing FLAPs in bioimaging and summarize current developments in this field from the standpoint of fluorescent molecules. Finally, we discuss the present challenges and future potential of G4 imaging and G4-containing FLAPs development.
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1123-x
    ISSN 1097-0282 ; 0006-3525
    ISSN (online) 1097-0282
    ISSN 0006-3525
    DOI 10.1002/bip.23528
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  10. Article ; Online: Efficient Charge Transfer and Effective Active Sites in Lead-Free Halide Double Perovskite S-Scheme Heterojunctions for Photocatalytic H

    Lv, Huijun / Yin, Hongfei / Jiao, Na / Yuan, Chunyu / Weng, Suting / Zhou, Kailing / Dang, Yangyang / Wang, Xuefeng / Lu, Zhen / Zhang, Yongzheng

    Small methods

    2023  Volume 7, Issue 3, Page(s) e2201365

    Abstract: The practical application of lead-free double perovskite ... ...

    Abstract The practical application of lead-free double perovskite Cs
    Language English
    Publishing date 2023-01-15
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202201365
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