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Article ; Online: Coaxial electrospun Ag-NPs-loaded endograft membrane with long-term antibacterial function treating mycotic aortic aneurysm

Qingxi Hu / Zhenwei Huang / Haiguang Zhang / Pengcheng Ma / Rui Feng / Jiaxuan Feng

Materials Today Bio, Vol 25, Iss , Pp 100940- (2024)

2024

Abstract: The use of endovascular stent-graft has become an important option in the treatment of aortic pathologies. However, the currently used endograft membranes have limited ability to prevent bacterial colonization. This makes them unsuitable for the ... ...

Abstract	The use of endovascular stent-graft has become an important option in the treatment of aortic pathologies. However, the currently used endograft membranes have limited ability to prevent bacterial colonization. This makes them unsuitable for the treatment of mycotic aneurysms, as the infection is prone to progress after endograft implantation. Moreover, even in non-mycotic aortic pathologies, endograft infections can occur in the short or long term, especially for patients with diabetes mellitus or in immune insufficiency conditions. So, this study aimed to develop a kind of Ag-NPs-loaded endograft membrane by coaxial electrospinning technique, and a series of physical and chemical properties and biological properties of the Ag-NPs-loaded membrane were characterized. Animal experiments conducted in pigs confirmed that the Ag-NPs-loaded membrane was basically non-toxic, exhibited good biocompatibility, and effectively prevented bacterial growth in a mycotic aortic aneurysm model. In conclusion, the Ag-NPs-loaded membrane exhibited good biocompatibility, good anti-infection function and slow-release of Ag-NPs for long-term bacteriostasis. Thus, the Ag-NPs-loaded membrane might hold potential for preventing infection progression and treating mycotic aortic aneurysms in an endovascular way.
Keywords	Endograft ; Aortic aneurysm ; Coaxial electrospinning ; Ag-NPs ; Bacteriostasis ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2024-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differences in the Vertical Distribution of Aerosols, Nitrogen Dioxide, and Formaldehyde between Islands and Inland Areas

Jinping Ou / Qihou Hu / Chengzhi Xing / Yizhi Zhu / Jiaxuan Feng / Xinqi Wang / Xiangguang Ji / Hua Lin / Hao Yin / Cheng Liu

Remote Sensing, Vol 15, Iss 23, p

A Case Study in the Yangtze River Delta of China

2023 Volume 5475

Abstract: Due to the difference of industrialization degree and meteorological conditions, there are obvious differences in the composition of air pollution between islands and inland areas. With Zhoushan (ZS) and Nanjing (NJ) representing islands and inland ... ...

Abstract	Due to the difference of industrialization degree and meteorological conditions, there are obvious differences in the composition of air pollution between islands and inland areas. With Zhoushan (ZS) and Nanjing (NJ) representing islands and inland cities in the Yangtze River Delta, the differences in vertical distribution of atmospheric components were investigated. A combination of multi-axial differential optical absorption spectroscopy (MAX-DOAS), weather research and forecasting (WRF), and potential source contribution function (PSCF) models were used to obtain vertical distribution data for aerosols, nitrogen dioxide (NO 2 ) and formaldehyde (HCHO), meteorological factors, and pollution sources in summer 2019. The findings indicate that, except for the aerosol extinction coefficient (AE), the atmospheric composition at the ZS site was not significantly stratified. However, the AE, NO 2 , and HCHO at NJ all displayed a decreasing trend with altitude. Here is the interesting finding that the ZS site has a higher AE value than the NJ site, while NJ displays higher NO 2 and HCHO columns than the ZS site. This discrepancy was primarily attributable to Zhoushan City’s extremely low traffic emissions when compared to inland cities. In addition, HCHO in the YRD region was significantly affected by human activities. Analysis of potential pollution sources found that regional transport contributed to differences in atmospheric composition at different altitudes in different regions. Aerosols, NO 2 , and HCHO in Nanjing were significantly affected by transport in inland areas. Aerosols in Zhoushan were easily affected by transport in the Yellow Sea and East China Sea, and NO 2 and HCHO were significantly affected by transport contributions from surrounding areas in inland areas. The study strongly suggests that land and sea breezes play an important role in the vertical distribution of aerosols over island regions.
Keywords	aerosol ; formaldehyde ; vertical profile ; transport ; potential source ; Science ; Q
Subject code	333
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of the Vertical Distribution and Driving Factors of Aerosol and Ozone Precursors in Huaniao Island, China, Based on Ground-Based MAX-DOAS

Jinping Ou / Qihou Hu / Chengzhi Xing / Yizhi Zhu / Jiaxuan Feng / Xiangguang Ji / Mingzhu Zhang / Xinqi Wang / Liyuan Li / Ting Liu / Bowen Chang / Qihua Li / Hao Yin / Cheng Liu

Remote Sensing, Vol 15, Iss 21, p

2023 Volume 5103

Abstract: Urban air pollution has become a regional environmental problem. In order to explore whether island areas were affected by the urban development of surrounding areas, in this paper, we systematically study the vertical distribution characteristics of ... ...

Abstract	Urban air pollution has become a regional environmental problem. In order to explore whether island areas were affected by the urban development of surrounding areas, in this paper, we systematically study the vertical distribution characteristics of atmospheric components, meteorological drivers, potential pollution sources, and the population health risks of fine particulate matter in island cities in China. The vertical profiles of three atmospheric pollutants (aerosols, NO 2 , and HCHO) in the lower troposphere of Huaniao Island in the East China Sea (ECS) were obtained using ground-based multi-axial differential optical absorption spectroscopy (MAX-DOAS). The results show that the aerosol extinction coefficients, NO 2 , and HCHO were primarily distributed at altitudes below 1 km, and the atmospheric pollutants in Zhoushan were obviously affected by high-altitude transfer. The main meteorological driving factors of aerosols, NO 2 , and HCHO were different at different altitudes. The key factor contributing to the high column concentrations of NO 2 and HCHO in the upper air (greater than 400 m) was the transport of pollutants brought about by changes in wind speed. By exploring the main potential sources of atmospheric pollutants, it was found that the main sources of aerosols, NO 2 , and HCHO are coastal cities in the Yangtze River Delta, including southeast Zhejiang Province, southeast Fujian Province, Shanghai, ECS, and the Yellow Sea. Compared with aerosols and HCHO, local primary emissions are an important source of NO 2 , which are mainly related to industrial activities in Zhoushan Port. In addition, using the expose-response function model, the number of attributable cases of PM 2.5 air pollution in Zhoushan City in 2019 accounted for 6.58% of the total population. This study enriches our understanding of the vertical distribution characteristics of atmospheric composition and health risk assessment on Chinese islands.
Keywords	vertical profile ; MAX-DOAS ; meteorological effect ; regional transport ; health risk ; Science ; Q
Subject code	910
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nanopore long-read RNA sequencing reveals functional alternative splicing variants in human vascular smooth muscle cells

Hao Wu / Yicheng Lu / Zhenzhen Duan / Jingni Wu / Minghui Lin / Yangjun Wu / Siyang Han / Tongqi Li / Yuqi Fan / Xiaoyuan Hu / Hongyan Xiao / Jiaxuan Feng / Zhiqian Lu / Deping Kong / Shengli Li

Communications Biology, Vol 6, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract Vascular smooth muscle cells (VSMCs) are the major contributor to vascular repair and remodeling, which showed high level of phenotypic plasticity. Abnormalities in VSMC plasticity can lead to multiple cardiovascular diseases, wherein ... ...

Abstract	Abstract Vascular smooth muscle cells (VSMCs) are the major contributor to vascular repair and remodeling, which showed high level of phenotypic plasticity. Abnormalities in VSMC plasticity can lead to multiple cardiovascular diseases, wherein alternative splicing plays important roles. However, alternative splicing variants in VSMC plasticity are not fully understood. Here we systematically characterized the long-read transcriptome and their dysregulation in human aortic smooth muscle cells (HASMCs) by employing the Oxford Nanopore Technologies long-read RNA sequencing in HASMCs that are separately treated with platelet-derived growth factor, transforming growth factor, and hsa-miR-221-3P transfection. Our analysis reveals frequent alternative splicing events and thousands of unannotated transcripts generated from alternative splicing. HASMCs treated with different factors exhibit distinct transcriptional reprogramming modulated by alternative splicing. We also found that unannotated transcripts produce different open reading frames compared to the annotated transcripts. Finally, we experimentally validated the unannotated transcript derived from gene CISD1, namely CISD1-u, which plays a role in the phenotypic switch of HASMCs. Our study characterizes the phenotypic modulation of HASMCs from an insight of long-read transcriptome, which would promote the understanding and the manipulation of HASMC plasticity in cardiovascular diseases.
Keywords	Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy of “Pinggan Formula” in Controlling Acute Type B Aortic Dissection Perioperative Blood Pressure

Hao Zhang / Danying Zhang / Yudong Sun / Ye Lu / Jiaxuan Feng / Lei Zhang / Chao Song / Zaiping Jing / Chaoqin Yu / Qingsheng Lu

Evidence-Based Complementary and Alternative Medicine, Vol

A Randomized Controlled Clinical Trial

2019 Volume 2019

Abstract: Objective. To explore a new treatment that can proceed from the whole, control blood pressure smoothly and coordinate the treatment of multiple factors causing blood pressure fluctuations. Method. We conducted a single-center, double-blinded, and ... ...

Abstract	Objective. To explore a new treatment that can proceed from the whole, control blood pressure smoothly and coordinate the treatment of multiple factors causing blood pressure fluctuations. Method. We conducted a single-center, double-blinded, and randomized controlled clinical trial. 48 patients with acute Type B aortic dissection were randomly assigned into two groups: the experimental group, who received pinggan formula treatment, and the control group, who received placebo treatment. The drug was taken orally after meals three times a day. Only when the patients’ blood pressure fluctuated, conventional antihypertensive drugs were given to maintain the blood pressure within the target range and the dosage was recorded to convert the DDD value. Meanwhile, the international standardized score was used to evaluate the defecation, sleep, pain, anxiety, and depression of patients in the two groups during the hospitalization. Result. Univariate analysis was conducted on variables that might affect the assessment results, and it was found that grouping factors had a significant impact on the outcome variables, that is, after the intervention, the mean value of DDDs used in the perioperative period in the control group was 2.19 (0.38, 4.00). (P=0.0219), defecation score (2.13 (1.59, 2.67); P<0.0001), sleep score (0.95 (0.40, 1.50); P=0.0014), pain score (1.77 (0.61, 2.93); P=0.0045), depression score (4.04 (2.95, 5.12); and P<0.0001) were significantly higher than that of the experimental group, and the difference was statistically significant. Conclusion. Pinggan formula has a clear therapeutic regulation effect on the overall hemodynamics of acute Stanford type B aortic dissection during the perioperative period and can be recommended as an auxiliary drug for conventional antihypertensive drugs at the current stage.
Keywords	Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vascular e-Learning in the MENA Region during the COVID-19 Pandemic

Nikolaos Patelis / Sean Matheiken / Theodosios Bisdas / Zaiping Jing / Jiaxuan Feng / Matthias Trenner / Paulo Eduardo Ocke Reis / Stephane Elkouri / Alexandre Lecis / Dirk Le Roux / Mihai Ionac / Marton Berczeli / Vincent Jongkind / Kak Khee Yeung / Athanasios Katsargyris / Efthymios Avgerinos / Dimitrios Moris / Andrew Choong / Jun Jie Ng /

Ivan Cvjetko / George A. Antoniou / Phillipe Ghibu / Alexei Svetlikov / Harm P. Ebben / Hubert Stepak / Sviatoslav Kostiv / Stefano Ancetti / Niki Tadayon / Liliana Fidalgo-Domingos / Eduardo Sebastian Sarutte Rosello / Arda Isik / Kyriaki Kakavia / Sotirios Georgopoulos

Dubai Medical Journal, Pp 1-

2023 Volume 4

Abstract: Introduction: With the steady rise in interest in e-learning and the sudden boost provoked by the COVID-19 pandemic, it becomes necessary to explore the e-learning experience within the medical community in the MENA region. Methods: An online survey was ... ...

Abstract	Introduction: With the steady rise in interest in e-learning and the sudden boost provoked by the COVID-19 pandemic, it becomes necessary to explore the e-learning experience within the medical community in the MENA region. Methods: An online survey was conducted during the early phase of the COVID-19 pandemic (June 15 – October 15, 2020). Results: Seventy-eight vascular surgeons and trainees from 16 countries participated. 88% of the participants were male. 55% attended more than 4 activities. More than half of the activities did not lead to any official certification. Topic was the primary determinant for attending an activity. National societies and social media played a major role in disseminating activity-related information. Lack of time, increased workload, differences in time zone, and technical issues were the main obstacles cited. 84.7% of the participants had a positive impression. Conclusion: As the COVID-19 pandemic boosted e-learning activities in vascular surgery, a shift was observed in the learning mode and new leadership skills were called upon. Novel ways of quality control are required.
Keywords	vascular e-learning ; mena region ; covid-19 pandemic ; modes of learning ; Medicine ; R
Subject code	370
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Karger Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Efficient conversion of chitosan into 5-hydroxymethylfurfural via hydrothermal synthesis in ionic liquids aqueous solution

Li, Mingguang / Bowen Cheng / Hongjun Zang / Jiaxuan Feng / Nianqin Yu / Qing Yan / Xiaolong Shi

Polymer degradation and stability. 2015 Nov., v. 121

2015

Abstract: A new process for the efficient conversion of chitosan into 5-hydroxymethylfurfural (5-HMF) has been developed. Chitosan was hydrolyzed in the presence of acidic ionic liquids (ILs), with N-methyl imidazolium hydrogen sulfate ([MIM]HSO4) giving the best ... ...

Abstract	A new process for the efficient conversion of chitosan into 5-hydroxymethylfurfural (5-HMF) has been developed. Chitosan was hydrolyzed in the presence of acidic ionic liquids (ILs), with N-methyl imidazolium hydrogen sulfate ([MIM]HSO4) giving the best results. The effects of reaction time, temperature and quantity of water and IL were investigated in detail. The optimal reaction conditions were found to be 4wt % IL ([MIM]HSO4) aqueous solution under hydrothermal condition, 180 °C and a reaction time of 5 h. A yield of 29.5 mol% 5-HMF was obtained from 100 mg chitosan. Furthermore, chitosan with different molecular weight could be directly converted into 5-HMF in good yields under these conditions. More importantly, [MIM]HSO4 could be recovered by simple post-processing and exhibited constant activity over 5 cycles.
Keywords	aqueous solutions ; chitosan ; hydrogen ; hydroxymethylfurfural ; ionic liquids ; molecular weight ; sulfates ; temperature
Language	English
Dates of publication	2015-11
Size	p. 331-339.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1502217-1
ISSN	0141-3910
ISSN	0141-3910
DOI	10.1016/j.polymdegradstab.2015.09.009
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Thoracic aortic computed tomography angiography in swine: establishment of a baseline for endovascular evaluation of the ascending aorta.

Tao, Li / Xianhao, Bao / Yuxi, Zhao / Ziwen, Li / Ziyi, Xu / Zhaoxiang, Zeng / Mingwei, Wu / Yiming, Li / Ding, Xu / Jiaxuan, Feng / Rui, Feng / Jian, Zhou / Zaiping, Jing

Interactive cardiovascular and thoracic surgery

2020 Volume 31, Issue 2, Page(s) 248–253

Abstract: Objectives: Our goal was to establish a baseline of computed tomography (CT) angiographic data for the porcine ascending thoracic aorta for endovascular evaluation of animal experiments and device development.: Methods: Thoracic aortic CT angiography ...

Abstract	Objectives: Our goal was to establish a baseline of computed tomography (CT) angiographic data for the porcine ascending thoracic aorta for endovascular evaluation of animal experiments and device development. Methods: Thoracic aortic CT angiography was conducted on 49 pigs with an average body weight of 60-65 kg. The CT angiographic scans were done on an imaging reconstruction workstation to obtain the specific aortic geometric data, including the diameters of the planes, the heights among the planes and the clock positions of target arteries. Results: Fourteen important planes were defined in the study for endograft customizing reference. The diameters of the planes were measured, and the heights among the planes were recorded. For endograft fenestrations, the right coronary artery ostium clock position was 100.11 ± 7.29°, and the brachiocephalic trunk ostium clock position was 74.72 ± 6.45°. The best projection angle of the tangent position of the left coronary artery was the right anterior oblique 17 ± 7° position. A pig with a rare congenital giant dilated aorta was found among the candidate experimental animals. Conclusions: For experimental porcine models, CT angiography has proved to be a suitable imaging technique. The established baseline angiography of the swine can provide reference values for future animal experiments and device development.
MeSH term(s)	Animals ; Aorta/diagnostic imaging ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Computed Tomography Angiography/methods ; Disease Models, Animal ; Endovascular Procedures/methods ; Female ; Male ; Stents ; Swine
Language	English
Publishing date	2020-06-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivaa077
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Article ; Online: Dataset of the vascular e-Learning during the COVID-19 pandemic (EL-COVID) survey

Nikolaos Patelis / Theodosios Bisdas / Zaiping Jing / Jiaxuan Feng / Matthias Trenner / Nyityasmono Tri Nugroho / Paulo Eduardo Ocke Reis / Stephane Elkouri / Alexandre Lecis / Lamisse Karam / Dirk Le Roux / Mihai Ionac / Marton Berczeli / Vincent Jongkind / Kak Khee Yeung / Athanasios Katsargyris / Efthymios Avgerinos / Demetrios Moris / Andrew Choong /

Data in Brief, Vol 38, Iss , Pp 107442- (2021)

2021

Abstract: This dataset supports the findings of the vascular e-Learning during the COVID-19 pandemic survey (the EL-COVID survey). The General Data Protection Regulation (GDPR) of the European Union was taken into consideration in all steps of data handling. The ... ...

Abstract	This dataset supports the findings of the vascular e-Learning during the COVID-19 pandemic survey (the EL-COVID survey). The General Data Protection Regulation (GDPR) of the European Union was taken into consideration in all steps of data handling. The survey was approved by the institutional ethics committee of the Primary Investigator and an online English survey consisting of 18 questions was developed ad-hoc. A bilingual English-Mandarin version of the questionnaire was developed according to the instructions of the Chinese Medical Association in order to be used in mainland People's Republic of China. Differences between the two questionnaires were minor and did affect the process of data collection. Both questionnaires were hosted online.The EL-COVID survey was advertised through major social media. All national and regional contributors contacted their respective colleagues through direct messaging on social media or by email. Eight national societies or groups supported the dissemination of the EL-COVID survey.The data provided demographics information of the EL-COVID participants and an insight on the level of difficulty in accessing or citing previously attended online activities and whether participants were keen on citing these activities in their Curricula Vitae. A categorization of additional comments made by the participants are also based on the data.The survey responses were filtered, anonymized and submitted to descriptive analysis of percentage.
Keywords	e-learning ; Training ; Education ; Distance learning ; Vascular surgery ; Surgery ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
Subject code	028
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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