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  1. AU="Jie Chen"
  2. AU="Ballarin, Barbara"
  3. AU="Thiel, Nadine"
  4. AU="Gerti Pishtari"
  5. AU="Alexander Hammers, ProfPhD"
  6. AU="Dessimoz, Christophe"
  7. AU="Planchuelo-Gómez, Álvaro"
  8. AU="McKay, Lindsay G A"
  9. AU="Laude, Marie-Charlotte"
  10. AU="Hale, Lillian V A"
  11. AU="Hassan Hartman"
  12. AU="Song, Mengwei"
  13. AU="Yimin Geng"
  14. AU="Wang, Chang-Sheng"
  15. AU="Doyle, Andrew D"
  16. AU="Redpath, Sophie H A"
  17. AU="Hopman, Maria Te"
  18. AU="Pomputius, William"
  19. AU="Agrawal, Sonali"
  20. AU="Martinez, Luis R"
  21. AU="Passoni, Lorena"
  22. AU="Slimani, Wafa"
  23. AU="Jin, J"
  24. AU="Xia, Hongmin"
  25. AU="Akdemir, İrem"
  26. AU=Ciccone Giovannino

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  1. Artikel ; Online: Research on Intelligentized Anti-UAV Command Control Scheme Technology

    Jie Chen

    E3S Web of Conferences, Vol 233, p

    2021  Band 04020

    Abstract: In view of this situation, our research project aims at accurately locating UAVs in detection mode, effectively damaging UAVs in defensive means, and constantly suppressing UAVs in key technologies. The optimal anti-UAV scheme is formulated. Combining ... ...

    Abstract In view of this situation, our research project aims at accurately locating UAVs in detection mode, effectively damaging UAVs in defensive means, and constantly suppressing UAVs in key technologies. The optimal anti-UAV scheme is formulated. Combining with the above anti-UAV program, together with the control of relevant monitoring ZTE and decision-making center, the anti-UAV prevention and control command system is set up in the camp. According to the characteristics of different types of UAVs, the system can formulate effective anti-UAV plan for deployment, and also can play a significant role in the defense of key protected areas.
    Schlagwörter Environmental sciences ; GE1-350
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag EDP Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Development and validation of an online dynamic prognostic nomogram for incidental gallbladder adenocarcinoma patients without distant metastasis after surgery

    Jie Chen / Yehong Han

    Frontiers in Medicine, Vol

    a population-based study

    2023  Band 10

    Abstract: BackgroundGallbladder cancer is the most common malignant tumor of the biliary system, most of which is adenocarcinoma. Our study explored developing and validating a nomogram to predict overall and cancer-specific survival probabilities internally and ... ...

    Abstract BackgroundGallbladder cancer is the most common malignant tumor of the biliary system, most of which is adenocarcinoma. Our study explored developing and validating a nomogram to predict overall and cancer-specific survival probabilities internally and externally for incidental gallbladder adenocarcinoma patients without distant metastasis after surgery.MethodsPatients screened and filtered in the Surveillance, Epidemiology, and End Results (SEER) database, whose years of diagnosis between 2010 and 2015 were collected as a derivation cohort, while those between 2016 and 2019 were a temporal validation cohort. Overall survival (OS) and cancer-specific survival (CSS) were chosen as the primary and secondary endpoints of the retrospective study cohort. Potential clinical variables were selected for a Cox regression model analysis by performing both-direction stepwise selection to confirm the final variables. The performance of final nomograms was evaluated by Harrell’s C statistic and Brier score, with a graphical receptor operating characteristic (ROC) curve and calibration curve.ResultsSeven variables of age, race, tumor size, histologic grade, T stage, regional lymph nodes removed, and positive regional lymph nodes were finally determined for the OS nomogram; sex had also been added to the CSS nomogram. Novel dynamic nomograms were established to predict the prognosis of incidental gallbladder adenocarcinoma patients without distant metastasis after surgery. The ROC curve demonstrated good accuracy in predicting 1-, 3-, and 5-year OS and CSS in both derivation and validation cohorts. Correspondingly, the calibration curve presented perfect reliability between the death or cancer-specific death probability and observed death or cancer-specific death proportion in both derivation and validation cohorts.ConclusionOur study established novel dynamic nomograms based on seven and eight clinical variables separately to predict OS and CSS of incidental gallbladder adenocarcinoma patients without distant metastasis after ...
    Schlagwörter incidental gallbladder adenocarcinoma ; dynamic nomogram ; overall survival ; cancer-specific survival ; SEER ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Trichoderma harzianum Cellulase Gene thph2 Affects Trichoderma Root Colonization and Induces Resistance to Southern Leaf Blight in Maize

    Bo Lang / Jie Chen

    Journal of Fungi, Vol 9, Iss 12, p

    2023  Band 1168

    Abstract: Trichoderma , widely distributed all over the world, is commonly found in soil and root ecosystems. It is a group comprising beneficial fungi that improve plant disease resistance and promote plant growth. Studies have shown that Trichoderma cellulases ... ...

    Abstract Trichoderma , widely distributed all over the world, is commonly found in soil and root ecosystems. It is a group comprising beneficial fungi that improve plant disease resistance and promote plant growth. Studies have shown that Trichoderma cellulases can also improve plant disease resistance. Based on previous studies, we reported that a C6 zinc finger protein (Thc6) regulates two cellulase genes, thph1 and thph2 , to induce ISR responses in plants. Therefore, in this study, we focused on the role of thph2 in the colonization of maize roots by T. harzianum and the induction of systemic resistance against southern leaf blight. The results showed that thph2 had a positive regulatory effect on the Trichoderma colonization of maize roots. After the root was treated with Trichoderma , the leaf defense genes AOS , LOX5 , HPL , and OPR1 were expressed to resist the attack of Cochliobolus heterostrophus . The pure Thph2 protein also resulted in a similar induction activity of the AOS , LOX5 , HPL , and OPR1 expression in maize roots, further demonstrating that thph2 can induce plant defense responses and that signal transduction occurs mainly through the JA signaling pathway.
    Schlagwörter Trichoderma ; cellulase ; thph2 ; colonization ; ISR ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: The prognostic analysis of different metastatic patterns in advanced liver cancer patients

    Jie Chen

    PLoS ONE, Vol 13, Iss 8, p e

    A population based analysis.

    2018  Band 0200909

    Abstract: BACKGROUND:The prognostic impact of different distant metastases pattern in liver cancer is unexplored still now. The aim of this study is to analyze the metastasis patterns and prognosis differences for patients with stage IV liver cancers. METHODS:A ... ...

    Abstract BACKGROUND:The prognostic impact of different distant metastases pattern in liver cancer is unexplored still now. The aim of this study is to analyze the metastasis patterns and prognosis differences for patients with stage IV liver cancers. METHODS:A SEER analysis was performed. Overall survival and cancer-specific survival were calculated by the Kaplan-Meier method. Multivariable Cox regression models were used to further analyze survival outcome and other prognostic factors. RESULTS:A total of 37526 eligible cases were retrieved in the Surveillance, Epidemiology, and End Results database. Among these patients, stage of IV liver cancer accounted for 14.80% (5555/37526) at initial diagnosis. Patients who suffered bone, brain or lung metastasis occupied 55.61% (3089/5555). Comparing with other two single metastases, the patients with brain metastasis exhibited worst overall survival whose mean of survival was 4.758 months. Multivariate analysis with Cox hazard regression model showed that metastatic site was an independent prognostic factor of overall survival and cancer-specific survival in patients with single metastasis (P<0.05). The results of univariate analysis showed that metastatic pattern was significantly correlated with overall survival (P = 0.038) and cancer-specific survival (P = 0.035) of patients with two sites. CONCLUSIONS:Lung was the most common site of single metastasis for liver cancers. Patients with bone metastasis had best survival outcome comparing with other two distant metastases. Patients with two metastatic sites, where one of them is the lung tends to have a slight trend to a worse outcome.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616 ; 610
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
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  5. Artikel ; Online: Graph deep learning locates magnesium ions in RNA

    Yuanzhe Zhou / Shi-Jie Chen

    QRB Discovery, Vol

    2022  Band 3

    Abstract: Magnesium ions (Mg2+) are vital for RNA structure and cellular functions. Present efforts in RNA structure determination and understanding of RNA functions are hampered by the inability to accurately locate Mg2+ ions in an RNA. Here we present a machine- ... ...

    Abstract Magnesium ions (Mg2+) are vital for RNA structure and cellular functions. Present efforts in RNA structure determination and understanding of RNA functions are hampered by the inability to accurately locate Mg2+ ions in an RNA. Here we present a machine-learning method, originally developed for computer visual recognition, to predict Mg2+ binding sites in RNA molecules. By incorporating geometrical and electrostatic features of RNA, we capture the key ingredients of Mg2+-RNA interactions, and from deep learning, predict the Mg2+ density distribution. Five-fold cross-validation on a dataset of 177 selected Mg2+-containing structures and comparisons with different methods validate the approach. This new approach predicts Mg2+ binding sites with notably higher accuracy and efficiency. More importantly, saliency analysis for eight different Mg2+ binding motifs indicates that the model can reveal critical coordinating atoms for Mg2+ ions and ion-RNA inner/outer-sphere coordination. Furthermore, implementation of the model uncovers new Mg2+ binding motifs. This new approach may be combined with X-ray crystallography structure determination to pinpoint the metal ion binding sites.
    Schlagwörter Magnesium ion ; RNA-ion interaction ; ion binding site/motif ; machine learning ; convolutional neural network ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Cambridge University Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: A bibliometric analysis on global eHealth

    Hua Tian / Jie Chen

    Digital Health, Vol

    2022  Band 8

    Abstract: Background The current coronavirus disease 2019 pandemic highlights the potential of eHealth. Drawing the knowledge map of eHealth research through data mining and visual analysis technology was helpful to systematically present the research status and ... ...

    Abstract Background The current coronavirus disease 2019 pandemic highlights the potential of eHealth. Drawing the knowledge map of eHealth research through data mining and visual analysis technology was helpful to systematically present the research status and future trends of global academic circles. Methods Based on the web of Science Core Collection (SCIE/SSCI) database, using bibliometric theory and visual analysis technology, this work analyzed the global eHealth research publications from 2000 to 2021, and introduced the interdisciplinary characteristics, hot topics and future trends in this field. Results A total of 10188 authors, 891 journals, 3586 institutions, 98 countries using 12 languages had conducted eHealth research in the world. The United States, the Netherlands, Australia and the United Kingdom were the main forces and international cooperation. However, the international co-operation between Eastern and Western countries was still relatively few. The frontier of global eHealth research mainly focused on #0eHealth innovation, #1physical activity, #2generalised anxiety disorder, #3lightweight authentication protocol, #4 eHealth information, #5technology readiness, #6 ehealth literacy scale, #7family carer, #8citance analysis, #9 guiding patient. Clusters #3 lightweight authentication protocol and #9 guiding patient were the latest clusters, indicating the research trend and direction of eHealth in the future. Conclusions Cooperation network framework at the regional, national and global levels and the cooperation of multidisciplinary teams with complementary backgrounds and expertise were needed to realize the in-depth popularization and application of eHealth knowledge. Interdisciplinary international cooperation should be the trend of eHealth research in the future.
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7
    Thema/Rubrik (Code) 001
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Health of Widowed Elderly and Related Factors in China

    Hua Tian / Jie Chen

    Journal of Men's Health, Vol 18, Iss 8, p

    2022  Band 163

    Abstract: Background: The widowed elderly are in poor health, but studies mainly focus on their mental health, physiological response, chronic disease, or death. The aim of this study was to investigate the health of the widowed elderly and related factors in ... ...

    Abstract Background: The widowed elderly are in poor health, but studies mainly focus on their mental health, physiological response, chronic disease, or death. The aim of this study was to investigate the health of the widowed elderly and related factors in China from the three dimensions of self-reported health, objective physical health and mental health. Methods: Data were obtained from the Chinese Longitudinal Health Longevity Survey (CLHLS-2018). 3320 participants aged 65 years and older were selected, included 1573 widowed elderly and 1747 non-widowed elderly. A simplified version of the center for epidemiological research depression scale (CES-D-10) was used to assess depressive symptoms. The differences of depression and chronic diseases between widows and widowers were tested by independent sample t-test. A fully aligned polygonal graphical indexing method and binary logistic regression analysis were used to explore health and related factors of the widowed elderly. Results: Of the 1573 widowed elderly 70.88% were female, 59.19% were aged 80–99, 48.00% and 36.75% were from rural and urban areas respectively, and 92.05% lived with their families. Depressive symptoms were found in 20.15% of widowers and 49.33% of widows, and 60.26% of widowers and 64.75% of widows had more than one chronic disease. Statistically significant differences were found between widowers and widows in the above two. Self-reported health and mental health were slightly better than that of non-widowed elderly, with the exception of objective physical health. The variables of life restriction, physical exercise, life satisfaction and depressive symptoms were significant factors that influenced the widowed elderly health. Conclusions: Strengthening the monitoring and management of negative emotions and physiological functions of the widowed elderly, improving their awareness of physical and mental health and then promoting communication were found to be effective intervention measures.
    Schlagwörter widowed elderly ; self-reported health ; objective physical health ; mental health ; china ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag MRE Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Migration law for random parameters rockfall in steeply dipping coal seams

    Ming Liu / Jie Chen / Yang Xiao / Wenyu Lv

    Frontiers in Earth Science, Vol

    2023  Band 11

    Abstract: The migration process of rockfall has certain complexity and randomness in steeply dipping coal seams (SDCS). The three-dimensional random migration of rockfall with random parameters cannot be accurately simulated. Taking the transport process of ... ...

    Abstract The migration process of rockfall has certain complexity and randomness in steeply dipping coal seams (SDCS). The three-dimensional random migration of rockfall with random parameters cannot be accurately simulated. Taking the transport process of arbitrarily shaped rockfall formed by roof leakage in steep seam working face as the research object, a method for generating rockfall with the random shape of irregular polyhedrons based on the ellipsoid equation is provided. And based on the geographic information system data, such as the contour line of the bottom floor of the working face, the 3D grid model of the bottom floor is established. The random transport process of rockfall in three-dimensional mining space was simulated using Monte Carlo random simulation technology combined with the energy tracking method (ETM) to compile the program, considering the randomness of collision recovery coefficient and friction coefficient between rockfall and working face floor. The influence of randomness of parameters on the migration velocity, angular velocity and energy of rockfall is analyzed. With the increase of the coefficient of variation of parameters, the influence of the randomness of the parameters on the transport characteristics of rockfall becomes greater. The impact of the collision recovery coefficient on the migration process of rockfall is much more significant than that of the friction coefficient. The offset ratio of rockfall increases with the increase of the variation coefficient. The method presented in this paper can be used to simulate the motion of rockfall more accurately, and a theoretical basis is provided for predicting and protecting rockfall hazards.
    Schlagwörter steeply dipping coal seam ; rockfall ; the energy tracking method ; migration ; random parameters ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag Frontiers Media S.A.
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Assessing the Water Budget Closure Accuracy of Satellite/Reanalysis-Based Hydrological Data Products over Mainland China

    Zengliang Luo / Han Yu / Huan Liu / Jie Chen

    Remote Sensing, Vol 15, Iss 21, p

    2023  Band 5230

    Abstract: A good water budget involving four variables, including precipitation ( P ), evapotranspiration ( ET ), streamflow ( R ), and terrestrial water storage change ( TWSC ), is reflected in two aspects: a high accuracy against observations for each budget ... ...

    Abstract A good water budget involving four variables, including precipitation ( P ), evapotranspiration ( ET ), streamflow ( R ), and terrestrial water storage change ( TWSC ), is reflected in two aspects: a high accuracy against observations for each budget component and the low water budget closure residual error (Δ Res ). Due to the lack of consideration of observations of budget components in existing water budget closure assessment methods ( BCMs ), when the Δ Res of budget components is low, their error against respective observations may still be high. In this study, we assess the water budget closure accuracy of satellite/reanalysis-based hydrological data products over mainland China based on six popular P products and multiple datasets of additional budget components ( ET , R , and TWSC ). The results indicated that the Δ Res changes between ±15 mm over mainland China. Satellite P products such as GPM IMERG showed better performance by comparing them with rain gauge-based observations. However, reanalysis P products such as GLDAS and FLDAS showed a better water budget closure since the selected datasets of additional budget components ( ET and R ) are also derived from reanalysis datasets. This indicates that these same data sources for budget components make it easier to close the water budget. The further development of satellite P products should consider the closure of the water budget with other water cycle variables.
    Schlagwörter precipitation products ; water budget closure ; hydrological cycle ; mainland China ; Science ; Q
    Thema/Rubrik (Code) 551
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag MDPI AG
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: A comparison of CMIP5 and CMIP6 climate model projections for hydrological impacts in China

    Yawen Lei / Jie Chen / Lihua Xiong

    Hydrology Research, Vol 54, Iss 3, Pp 330-

    2023  Band 347

    Abstract: Global climate model (GCM) outputs from Coupled Model Inter-comparison Project Phase 5 (CMIP5) were widely used to investigate climate change impacts last 10 years. It is important to know whether Coupled Model Inter-comparison Project Phase 6 (CMIP6) is ...

    Abstract Global climate model (GCM) outputs from Coupled Model Inter-comparison Project Phase 5 (CMIP5) were widely used to investigate climate change impacts last 10 years. It is important to know whether Coupled Model Inter-comparison Project Phase 6 (CMIP6) is more reliable than CMIP5. Number of studies compared GCMs from two CMIPs in simulating climate variables, but they are not in the field of hydrology for large quantities of watersheds. The objective of this study is to compare CMIP5 and CMIP6 climate model projections in projecting hydrological changes between future (2071–2100) and historical (1976–2005) periods and inter-model variability of hydrological impacts for the future period over 343 catchments in China's mainland. The results show that the GCMs in CMIP6 show more increase in daily mean temperature and mean annual precipitation. However, GCMs in CMIP6 and CMIP5 show similar increases in mean and peak streamflow. Moreover, GCMs in CMIP6 show less inter-model variability for streamflow in southern and northeastern China, but more in central China, which is consistent to that for precipitation after bias correction. Overall, this comparison provides the consistency of future change and uncertainty in predicted streamflow with climate simulations, which bring confidence for hydrological impact studies using CMIP6. HIGHLIGHTS GCMs in CMIP6 under SSP5-85 show more increase in temperature and precipitation than those in CMIP5 under RCP8.5 in China.; GCMs in CMIP6 and CMIP5 show similar increases in mean and peak streamflow.; GCMs in CMIP6 show less inter-model variability for mean and peak flow in southern and northeastern China, but more in central China.;
    Schlagwörter climate change ; cmip5 ; cmip6 ; gcm ; hydrological impacts ; variability ; River ; lake ; and water-supply engineering (General) ; TC401-506 ; Physical geography ; GB3-5030
    Thema/Rubrik (Code) 550
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag IWA Publishing
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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