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  1. Article ; Online: Prevalence and coprevalence of modifiable risk factors for upper digestive tract cancer among residents aged 40–69 years in Yangzhong city, China

    Ru Chen / Xi Wang / Xiang Feng / Qin Zhou / Zhao-Lai Hua / Ai-Wu Shi / Tong-Qiu Song / Dong-Fu Qian / Gui-Qi Wang / Wen-Qiang Wei / Jin-Yi Zhou / Jie-Jun Wang / Gang Shao

    BMJ Open, Vol 11, Iss

    a cross-sectional study

    2021  Volume 4

    Abstract: Objectives To describe the prevalence of modifiable risk factors for upper digestive tract cancer (UDTC) and its coprevalence, and investigate relevant influencing factors of modifiable UDTC risk factors coprevalence among residents aged 40–69 years in ... ...

    Abstract Objectives To describe the prevalence of modifiable risk factors for upper digestive tract cancer (UDTC) and its coprevalence, and investigate relevant influencing factors of modifiable UDTC risk factors coprevalence among residents aged 40–69 years in Yangzhong city, China.Design Cross-sectional study.Participants A total of 21 175 participants aged 40–69 years were enrolled in the study. 1962 subjects were excluded due to missing age, marital status or some other selected information. Eventually, 19 213 participants were available for the present analysis.Main outcomes measures Prevalence and coprevalence of eight modifiable UDTC risk factors (overweight or obesity, current smoking, excessive alcohol consumption, insufficient vegetables intake, insufficient fruit intake and the consumption of pickled, fried and hot food) were analysed.Results The prevalence of overweight/obesity, current smoking, excessive alcohol consumption, insufficient vegetables intake, insufficient fruit intake and the consumption of pickled, fried and hot food in this study was 45.3%, 24.1%, 16.2%, 66.1%, 94.5%, 68.1%, 36.0% and 88.4%, respectively. Nearly all (99.9%) participants showed one or more UDTC risk factors, 98.6% of the participants showed at least two risk factors, 92.2% of the participants had at least three risk factors and 69.7% of the participants had four or more risk factors. Multivariate logistic regression analysis revealed that men, younger age, single, higher education, higher annual family income and smaller household size were more likely to present modifiable UDTC risk factors coprevalence.Conclusions The prevalence and coprevalence of modifiable UDTC risk factors are high among participants in Yangzhong city. Extra attention must be paid to these groups who are susceptible to risk factors coprevalence during screening progress. Relative departments also need to make significant public health programmes that aim to decrease modifiable UDTC risk factors coprevalence among residents aged 40–69 years from high-risk ...
    Keywords Medicine ; R
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Reduced protein expression of metastasis-related genes (nm23, KISS1, KAI1 and p53) in lymph node and liver metastases of gastric cancer.

    Guan-Zhen, Yu / Ying, Chen / Can-Rong, Ni / Guo-Dong, Wang / Jian-Xin, Qian / Jie-Jun, Wang

    International journal of experimental pathology

    2007  Volume 88, Issue 3, Page(s) 175–183

    Abstract: Purpose: Metastasis remains an incurable common complication in patients with gastric cancer. A variety of theories have been proposed to explain the inefficiency of the metastatic process. To compare protein expression of metastasis-related genes (nm23, ...

    Abstract Purpose: Metastasis remains an incurable common complication in patients with gastric cancer. A variety of theories have been proposed to explain the inefficiency of the metastatic process. To compare protein expression of metastasis-related genes (nm23, KISS1, KAI1 and p53) between primary tumours and metastatic tumours may be useful in illustrating these theories.
    Methods: Metastasis-related tissue microarrays (including normal tissues, primary tumours, nodal metastases and liver metastases) were constructed. The protein expression of nm23, KISS1, KAI1 and p53 in lymph node and liver metastases from advanced gastric cancer specimens was mainly examined by immunohistochemical staining in relation to primary tumours.
    Results: Immunohistochemical staining showed reduced protein expression of nm23, KISS1 and KAI1 in lymph node and liver metastases compared with primary tumours. Results for p53 were to the contrary.
    Conclusions: Our investigations revealed a tendency of reduced protein expression of metastasis suppressor genes nm23, KISS1 and KAI1 in gastric cancer with the progress of metastasis. This means that the progression theory is an important determinant of metastatic efficiency.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Female ; Gene Expression ; Gene Expression Profiling ; Genetic Markers ; Humans ; Immunohistochemistry ; Kangai-1 Protein/analysis ; Kangai-1 Protein/genetics ; Kisspeptins ; Liver Neoplasms/metabolism ; Liver Neoplasms/secondary ; Lymphatic Metastasis ; Male ; Middle Aged ; NM23 Nucleoside Diphosphate Kinases ; Nucleoside-Diphosphate Kinase/analysis ; Nucleoside-Diphosphate Kinase/genetics ; Oligonucleotide Array Sequence Analysis ; Staining and Labeling ; Stomach Neoplasms/metabolism ; Tumor Suppressor Protein p53/analysis ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Proteins/analysis ; Tumor Suppressor Proteins/genetics
    Chemical Substances Biomarkers, Tumor ; Genetic Markers ; KISS1 protein, human ; Kangai-1 Protein ; Kisspeptins ; NM23 Nucleoside Diphosphate Kinases ; Tumor Suppressor Protein p53 ; Tumor Suppressor Proteins ; NME1 protein, human (EC 2.7.4.6) ; Nucleoside-Diphosphate Kinase (EC 2.7.4.6)
    Language English
    Publishing date 2007-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1016006-1
    ISSN 1365-2613 ; 0959-9673 ; 0958-4625 ; 0007-1021
    ISSN (online) 1365-2613
    ISSN 0959-9673 ; 0958-4625 ; 0007-1021
    DOI 10.1111/j.1365-2613.2006.00510.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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