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Article ; Online: Curcumin attenuates cadmium-induced atherosclerosis by regulating trimethylamine-N-oxide synthesis and macrophage polarization through remodeling the gut microbiota

Jiexin Zhang / Caiwen Ou / Minsheng Chen

Ecotoxicology and Environmental Safety, Vol 244, Iss , Pp 114057- (2022)

2022

Abstract: Background: Studies have shown that cadmium (Cd) exposure primarily occurs through diet, and Cd ingestion is a risk factor for atherosclerosis (AS). However, the underlying mechanism remains unclear. As a target organ, the gastrointestinal tract may play ...

Abstract	Background: Studies have shown that cadmium (Cd) exposure primarily occurs through diet, and Cd ingestion is a risk factor for atherosclerosis (AS). However, the underlying mechanism remains unclear. As a target organ, the gastrointestinal tract may play a key role in Cd-induced AS. Additionally, as curcumin is insoluble in water but stable in the stomach of acidic pH, it may play regulative roles in the gut. Objectives: We assess the effect of Cd exposure on gut flora, trimethylamine-N-oxide (TMAO) metabolism and macrophage polarization, further investigate whether curcumin protects against Cd-induced AS by remodeling gut microbiota. Methods and results: The results of 16 S rRNA sequencing show that Cd exposure causes diversity reduction and compositional alteration of the microbial community, resulting in the increasing TMAO synthesis, the imbalance of lipid metabolism, and the M1-type macrophage polarization in the mouse model (ApoE-/-) of AS. As a result, the plaque area is increased with Cd exposure, shown by oil red O staining. TMAO synthesis is positively correlated with the concentration of blood Cd, and the dynamics of specific bacteria in this process were revealed at the phylum to genus levels. Moreover, the effects of intestinal flora and TMAO on Cd-induced AS are further confirmed via microbial transplantation from a mouse model not exposed to Cd, as the transplantation decreases plaque area. Finally, the gavage with curcumin reverses the Cd-induced pathological progression via gut flora restoration. Conclusions: We first demonstrate that Cd exposure worsens the progression of AS via intestinal flora imbalance and increased TMAO synthesis. Curcumin was verified as a potential novel intervention for preventing Cd-induced AS via remodeling gut microbiota. This study elucidates a new approach for treating AS in regions with significant Cd exposure.
Keywords	Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: microRNA, a Subtle Indicator of Human Cytomegalovirus against Host Immune Cells

Mengyao Yu / Yuexinzi Jin / Shichang Zhang / Jian Xu / Jiexin Zhang

Vaccines, Vol 10, Iss 144, p

2022 Volume 144

Abstract: Human cytomegalovirus (HCMV) is a double-stranded DNA virus that belongs to the β-herpesvirus family and infects 40–90% of the adult population worldwide. HCMV infection is usually asymptomatic in healthy individuals but causes serious problems in ... ...

Abstract	Human cytomegalovirus (HCMV) is a double-stranded DNA virus that belongs to the β-herpesvirus family and infects 40–90% of the adult population worldwide. HCMV infection is usually asymptomatic in healthy individuals but causes serious problems in immunocompromised people. We restricted this narrative review (PubMed, January 2022) to demonstrate the interaction and molecular mechanisms between the virus and host immune cells with a focus on HCMV-encoded miRNAs. We found a series of HCMV-encoded miRNAs (e.g., miR-UL112 and miR-UL148D) are explicitly involved in the regulation of viral DNA replication, immune evasion, as well as host cell fate. MiRNA-targeted therapies have been explored for the treatment of atherosclerosis, cardiovascular disease, cancer, diabetes, and hepatitis C virus infection. It is feasible to develop an alternative vaccine to restart peripheral immunity or to inhibit HCMV activity, which may contribute to the antiviral intervention for serious HCMV-related diseases.
Keywords	HCMV ; microRNA ; innate immunity ; adaptive immunity ; latency ; Medicine ; R
Subject code	570
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research on Uncertainty of audio and Video Information Hiding Based on Semantic and Statistical Moment

Jiexin Zhang

Journal of Software, Vol 6, Iss 6, Pp 1154-

2011 Volume 1162

Abstract: nowadays, audio and video media data is already facilitates generation, transmission, storage and circulation on the global scale. Audio and video data is geometrically fast as the rate of growth, the video data processing and analysis have lagged behind ...

Abstract	nowadays, audio and video media data is already facilitates generation, transmission, storage and circulation on the global scale. Audio and video data is geometrically fast as the rate of growth, the video data processing and analysis have lagged behind the pace of development in the growth of data, resulting in large amounts of data is wasted. Therefore, it becomes an urgent need for efficient retrieval of video data content. Accordingly the SS hiding effectively, verify the presence of the secrete message in an important issue. In this paper we present two statistical analysis algorithms for SS hiding. Both the two methods are based on machine learning theory and discrete wavelet transform (DWT), which adopts the classification technology. In the algorithm I, we introduce Gaussian mixture model (GMM) and generalize Gaussian distribution (GGD) to character the probability distribution of wavelet sub-band. Then the absolute probability distribution function (PDF) moment is extracted as feature vectors. We use GMM to model the probability distribution of wavelet coefficient and calculate the absolute moment of statistical distribution as feature vector of each sub-band for statistical analysis. In the algorithm II, we propose distance metric between GMM and GGD of wavelet sub-band to distinguish cover. The experiment results of both two proposed classification algorithms may obtain better detecting performance. The probability distribution model takes GMM and GGD. We use de-noising method to get the estimation of cover audio, and then use four distances metric to measure the distortion.
Keywords	audio and video,information hiding,semantic,statistical moment ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
Subject code	310
Language	English
Publishing date	2011-06-01T00:00:00Z
Publisher	ACADEMY PUBLISHER
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hypomethylation of the DAZ3 promoter in idiopathic asthenospermia

Shichang Zhang / Li Xu / Mengyao Yu / Jiexin Zhang

Scientific Reports, Vol 10, Iss 1, Pp 1-

a screening tool for liquid biopsy

2020 Volume 7

Abstract: Abstract Given the role of the deleted in azoospermia gene in male infertility, whether the somatic deleted in azoospermia methylation status is associated with idiopathic asthenospermia should be determined. To investigate the methylation levels of the ... ...

Abstract	Abstract Given the role of the deleted in azoospermia gene in male infertility, whether the somatic deleted in azoospermia methylation status is associated with idiopathic asthenospermia should be determined. To investigate the methylation levels of the deleted in azoospermia promoter in peripheral white blood cells from idiopathic asthenospermia patients relative to those in normozoospermia controls, 61 ethylene diamine tetraacetic acid anticoagulant blood samples were drawn from all participants for DNA isolation. The deleted in azoospermia promoter methylation ratio was detected by MassARRAY-based methylation quantification and confirmed by quantitative methylation-specific polymerase chain reaction. A MassARRAY-based methylation analysis showed that the deleted in azoospermia 3 promoter (0 to − 2 kbp) was significantly hypomethylated in peripheral white blood cells from idiopathic asthenospermia males, specifically one CpG site (− 246 to − 247). Quantitative methylation-specific polymerase chain reaction data further confirmed that the methylation level of the deleted in azoospermia 3 promoter region in idiopathic asthenospermia patients was significantly lower than that in normozoospermia males. The area under the receiver operating characteristic curve determined by quantitative methylation-specific polymerase chain reaction was 0.737 (95% confidence interval: 0.552 to 0.924), with a sensitivity of 53.9% and a specificity of 88.2% at a cut-off level of 74.7%. Therefore, our results suggested that methylation ratio detection of the deleted in azoospermia 3 promoter region by real-time polymerase chain reaction assay is a promising and feasible tool for liquid biopsy in the clinical laboratories. The methylation status of other reported infertility-related genes should also be investigated in peripheral white blood cells.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Application of magnetic resonance neurography in neonatal brachial plexus injury

Lili Zang / Tong Yu / Xiaomin Duan / Xiaoyan Zhang / Jiexin Zhang / Jie Wang

Radiology Case Reports, Vol 17, Iss 8, Pp 2859-

A case report and literature review

2022 Volume 2862

Abstract: Neonatal obstetric brachial plexus palsy is common in newborns with fetal macrosomia, especially those who are delivered vaginally with shoulder dystocia or breech delivery. The anatomical structure of brachial plexus in newborns is thin, and it is ... ...

Abstract	Neonatal obstetric brachial plexus palsy is common in newborns with fetal macrosomia, especially those who are delivered vaginally with shoulder dystocia or breech delivery. The anatomical structure of brachial plexus in newborns is thin, and it is neither collinear nor coplanar in space; The location, the type and degree of neonatal brachial plexus injury need to be comprehensively judged by clinical history, neurological and imaging examination. Conventional MR imaging is not sufficient to diagnose brachial plexus injury. In this case report, we describe the clinical and imaging data of a newborn with brachial plexus injury diagnosed by the fat-suppressed T2-weighted sequence and MR myelography and confirmed by surgery. In addition, we review the related literature in an attempt to provide a better understanding of the principles and characteristics of neonatal brachial plexus injury diagnosed by magnetic resonance neurography.
Keywords	Neonatal ; Brachial plexus injury ; Magnetic resonance neurography ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quality Assessment of SAR-to-Optical Image Translation

Jiexin Zhang / Jianjiang Zhou / Minglei Li / Huiyu Zhou / Tianzhu Yu

Remote Sensing, Vol 12, Iss 3472, p

2020 Volume 3472

Abstract: Synthetic aperture radar (SAR) images contain severe speckle noise and weak texture, which are unsuitable for visual interpretation. Many studies have been undertaken so far toward exploring the use of SAR-to-optical image translation to obtain near ... ...

Abstract	Synthetic aperture radar (SAR) images contain severe speckle noise and weak texture, which are unsuitable for visual interpretation. Many studies have been undertaken so far toward exploring the use of SAR-to-optical image translation to obtain near optical representations. However, how to evaluate the translation quality is a challenge. In this paper, we combine image quality assessment (IQA) with SAR-to-optical image translation to pursue a suitable evaluation approach. Firstly, several machine-learning baselines for SAR-to-optical image translation are established and evaluated. Then, extensive comparisons of perceptual IQA models are performed in terms of their use as objective functions for the optimization of image restoration. In order to study feature extraction of the images translated from SAR to optical modes, an application in scene classification is presented. Finally, the attributes of the translated image representations are evaluated using visual inspection and the proposed IQA methods.
Keywords	synthetic aperture radar (SAR) ; generative adversarial networks (GANs) ; SAR-to-optical image translation ; image quality assessment (IQA) ; image restoration ; Science ; Q
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Immune cellular patterns of distribution affect outcomes of patients with non-small cell lung cancer

Edwin Roger Parra / Jiexin Zhang / Mei Jiang / Auriole Tamegnon / Renganayaki Krishna Pandurengan / Carmen Behrens / Luisa Solis / Cara Haymaker / John Victor Heymach / Cesar Moran / Jack J. Lee / Don Gibbons / Ignacio Ivan Wistuba

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 16

Abstract: Abstract Studying the cellular geographic distribution in non-small cell lung cancer is essential to understand the roles of cell populations in this type of tumor. In this study, we characterize the spatial cellular distribution of immune cell ... ...

Abstract	Abstract Studying the cellular geographic distribution in non-small cell lung cancer is essential to understand the roles of cell populations in this type of tumor. In this study, we characterize the spatial cellular distribution of immune cell populations using 23 makers placed in five multiplex immunofluorescence panels and their associations with clinicopathologic variables and outcomes. Our results demonstrate two cellular distribution patterns—an unmixed pattern mostly related to immunoprotective cells and a mixed pattern mostly related to immunosuppressive cells. Distance analysis shows that T-cells expressing immune checkpoints are closer to malignant cells than other cells. Combining the cellular distribution patterns with cellular distances, we can identify four groups related to inflamed and not-inflamed tumors. Cellular distribution patterns and distance are associated with survival in univariate and multivariable analyses. Spatial distribution is a tool to better understand the tumor microenvironment, predict outcomes, and may can help select therapeutic interventions.
Keywords	Science ; Q
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New pattern of individualized management of chronic diseases

Xi Guo / Liyang Cai / Yuchen Cao / Zining Liu / Jiexin Zhang / Danni Liu / Zhujun Jiang / Yanxia Chen / Min Fu / Zhaoxia Xia / Guoguo Yi

Frontiers in Medicine, Vol

focusing on inflammatory bowel diseases and looking to the future

2023 Volume 10

Abstract: Non-infectious chronic diseases, especially inflammatory bowel diseases (IBDs), hypertension, and diabetes mellitus, are characterized by a prolonged and multisystemic course, and their incidence increases annually, usually causing serious economic ... ...

Abstract	Non-infectious chronic diseases, especially inflammatory bowel diseases (IBDs), hypertension, and diabetes mellitus, are characterized by a prolonged and multisystemic course, and their incidence increases annually, usually causing serious economic burden and psychological stress for patients. Therefore, these diseases deserve scientific and consistent disease management. In addition, the lack of a comprehensive “early disease clues tracking—personalized treatment system—follow-up” model in hospitals also exacerbates this dilemma. Based on these facts, we propose an individualized prediction management system for IBDs based on chronic diseases, focusing on the established IBDs-related prediction models and summarizing their advantages and disadvantages. We call on researchers to pay attention to the integration of models with clinical practice and the continuous correction of models to achieve truly individualized medical treatment for chronic diseases, thus providing substantial value for the rapid diagnosis and adequate treatment of chronic diseases such as IBDs, which follow the “relapse-remission” disease model, and realizing long-term drug use and precise disease management for patients. The goal is to achieve a new level of chronic disease management by scientifically improving long-term medication, precise disease management, and individualized medical treatment, effectively prolonging the remission period and reducing morbidity and disability rates.
Keywords	inflammatory bowel disease ; chronic disease management ; closed-loop prediction model ; negative feedback ; diagnostic prediction model ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization

Peier Chen / Xiaodong Ning / Weirun Li / Yuxuan Pan / Ling Wang / Hekai Li / Xianglin Fan / Jiexin Zhang / Tiantian Luo / Yaobin Wu / Caiwen Ou / Minsheng Chen

Bioactive Materials, Vol 14, Iss , Pp 416-

2022 Volume 429

Abstract: Currently, stem cell transplantations in cardiac repair are limited owing to disadvantages, such as immunological rejection and poor cell viability. Although direct injection of exosomes can have a curative effect similar to that of stem cell ... ...

Abstract	Currently, stem cell transplantations in cardiac repair are limited owing to disadvantages, such as immunological rejection and poor cell viability. Although direct injection of exosomes can have a curative effect similar to that of stem cell transplantation, high clearance hinders its application in clinical practice. Previous reports suggested that induction of coronary collateralization can be a desired method of adjunctive therapy for someone who had missed the optimal operation time to attenuate myocardial ischemia. In this study, to mimic the paracrine and biological activity of stem cells, we developed artificial stem cells that can continuously release Tβ4-exosomes (Tβ4-ASCs) by encapsulating specific exosomes within microspheres using microfluidics technology. The results show that Tβ4-ASCs can greatly promote coronary collateralization in the periphery of the myocardial infarcted area, and its therapeutic effect is superior to that of directly injecting the exosomes. In addition, to better understand how it works, we demonstrated that the Tβ4-ASC-derived exosomes can enhance the angiogenic capacity of coronary endothelial cells (CAECs) via the miR-17-5p/PHD3/Hif-1α pathway. In brief, as artificial stem cells, Tβ4-ASCs can constantly release functional exosomes and stimulate the formation of collateral circulation after myocardial infarction, providing a feasible and alternative method for clinical revascularization.
Keywords	Artificial stem cells ; Exosomes ; Myocardial infarction ; Coronary collateralization ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effects of Conditioned Medium Derived from Mesenchymal Stem Cells Cocultured with Hepatocytes on Damaged Hepatocytes and Acute Liver Failure in Rats

Li Chen / Jiexin Zhang / Lu Yang / Guoying Zhang / Yingjie Wang / Shichang Zhang

Stem Cells International, Vol

2018 Volume 2018

Abstract: Mesenchymal stem cells (MSCs) and hepatocytes are two attractive sources of cell-based therapies for acute liver failure (ALF). The cotransplantation of hepatocytes with MSCs can improve the therapeutic performance for the treatment of ALF. However, the ... ...

Abstract	Mesenchymal stem cells (MSCs) and hepatocytes are two attractive sources of cell-based therapies for acute liver failure (ALF). The cotransplantation of hepatocytes with MSCs can improve the therapeutic performance for the treatment of ALF. However, the therapeutic potential of conditioned medium (CM) derived from MSCs cocultured with hepatocytes (MSC-H-CM) remains unclear. The purpose of this study was to investigate the effects of MSC-H-CM on damaged hepatocytes in vitro and on D-galactosamine-induced ALF in vivo. D-Galactosamine-treated L02 cells cultured in MSC-H-CM exhibited higher of cell viability and total protein synthesis than L02 cells cultured in MSC-CM, CM derived from hepatocytes (H-CM), MSC-CM + H-CM, or with nonconditioned medium (NCM). Lactate dehydrogenase and aspartate aminotransferase levels were lower in the supernatant of damaged L02 cells cultured in MSC-H-CM than in that of L02 cells cultured in other types of CM. The lowest percentage of apoptotic cells was observed after the MSC-H-CM treatment. When CM was injected into the tail vein of rats with ALF, MSC-H-CM was the most successful at preventing the release of liver injury biomarkers and in promoting the recovery of liver structure. The greatest survival rate 7 days after the first treatment was observed in the MSC-H-CM-treated rats. Our results reveal that the delivery of MSC-H-CM could be a novel strategy for integrating the therapeutic potentials of hepatocytes and MSCs for the treatment of ALF.
Keywords	Internal medicine ; RC31-1245
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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