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  1. Article ; Online: Circulating metabolic markers after surgery identify patients at risk for severe postoperative complications: a prospective cohort study in colorectal cancer.

    Montcusí, Blanca / Madrid-Gambin, Francisco / Pozo, Óscar J / Marco, Santiago / Marin, Silvia / Mayol, Xavier / Pascual, Marta / Alonso, Sandra / Salvans, Silvia / Jiménez-Toscano, Marta / Cascante, Marta / Pera, Miguel

    International journal of surgery (London, England)

    2024  Volume 110, Issue 3, Page(s) 1493–1501

    Abstract: Background: Early detection of postoperative complications after colorectal cancer (CRC) surgery is associated with improved outcomes. The aim was to investigate early metabolomics signatures capable to detect patients at risk for severe postoperative ... ...

    Abstract Background: Early detection of postoperative complications after colorectal cancer (CRC) surgery is associated with improved outcomes. The aim was to investigate early metabolomics signatures capable to detect patients at risk for severe postoperative complications after CRC surgery.
    Materials and methods: Prospective cohort study of patients undergoing CRC surgery from 2015 to 2018. Plasma samples were collected before and after surgery, and analyzed by mass spectrometry obtaining 188 metabolites and 21 ratios. Postoperative complications were registered with Clavien-Dindo Classification and Comprehensive Complication Index.
    Results: One hundred forty-six patients were included. Surgery substantially modified metabolome and metabolic changes after surgery were quantitatively associated with the severity of postoperative complications. The strongest positive relationship with both Clavien-Dindo and Comprehensive Complication Index (β=4.09 and 63.05, P <0.001) corresponded to kynurenine/tryptophan, against an inverse relationship with lysophosphatidylcholines (LPCs) and phosphatidylcholines (PCs). Patients with LPC18:2/PCa36:2 below the cut-off 0.084 µM/µM resulted in a sevenfold higher risk of major complications (OR=7.38, 95% CI: 2.82-21.25, P <0.001), while kynurenine/tryptophan above 0.067 µM/µM a ninefold (OR=9.35, 95% CI: 3.03-32.66, P <0.001). Hexadecanoylcarnitine below 0.093 µM displayed a 12-fold higher risk of anastomotic leakage-related complications (OR=11.99, 95% CI: 2.62-80.79, P =0.004).
    Conclusion: Surgery-induced phospholipids and amino acid dysregulation is associated with the severity of postoperative complications after CRC surgery, including anastomotic leakage-related outcomes. The authors provide quantitative insight on metabolic markers, measuring vulnerability to postoperative morbidity that might help guide early decision-making and improve surgical outcomes.
    MeSH term(s) Humans ; Anastomotic Leak ; Prospective Studies ; Tryptophan ; Kynurenine ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/complications ; Retrospective Studies
    Chemical Substances Tryptophan (8DUH1N11BX) ; Kynurenine (343-65-7)
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Postoperative intra-abdominal infection is an independent prognostic factor of disease-free survival and disease-specific survival in patients with stage II colon cancer.

    Sánchez-Velázquez, P / Pera, M / Jiménez-Toscano, M / Mayol, X / Rogés, X / Lorente, L / Iglesias, M / Gallén, M

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2018  Volume 20, Issue 10, Page(s) 1321–1328

    Abstract: Background: Recurrence occurs in up to 20% of patients with stage II colon cancer operated on for cure. Although postoperative intra-abdominal infection has been linked with an increased risk of recurrence, the association is controversial. The aim was ... ...

    Abstract Background: Recurrence occurs in up to 20% of patients with stage II colon cancer operated on for cure. Although postoperative intra-abdominal infection has been linked with an increased risk of recurrence, the association is controversial. The aim was to investigate the impact of postoperative intra-abdominal infection on disease-free survival and disease-specific survival in patients with stage II colon cancer.
    Methods: Patients undergoing elective surgery for colon cancer stage II, between 2003 and 2014, were included. Patients with anastomotic leak or intra-abdominal abscess were included in the infection group. We used the Kaplan-Meier method to represent the distribution of survival and the Cox proportional hazards model to estimate the contribution of relevant clinicopathological factors with prognosis.
    Results: Postoperative intra-abdominal infection was diagnosed in 37 of 363 (10.2%) patients. Perioperative blood transfusion was more frequent in patients with infection (p = 0.008). Overall 5-year disease-free survival rate was 85.1%. Disease-free survival at 5 years was lower in patients with postoperative intra-abdominal infection (52.8 vs 88.7%; p < 0.001), perineural invasion (p = 0.001), lymphovascular invasion (p = 0.001), pT4 (p = 0.013), and in patients with adjuvant chemotherapy (p = 0.013). Multivariate analysis showed that postoperative intra-abdominal infection (HR 4.275; p < 0.001), perineural invasion (HR 2.230; p = 0.007), and lymphovascular invasion (HR 2.052; p = 0.016) were all significant independent predictors of reduced disease-free survival. Regarding specific survival, independent significant prognostic factors were the number of lymph nodes, lymphovascular invasion, and postoperative intra-abdominal infection.
    Conclusion: In this series of patients with stage II colon cancer, postoperative intra-abdominal infection has an independent negative impact on disease-free survival and disease-specific survival.
    MeSH term(s) Abdominal Abscess/epidemiology ; Adult ; Aged ; Aged, 80 and over ; Anastomotic Leak/epidemiology ; Colonic Neoplasms/mortality ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Disease-Free Survival ; Female ; Humans ; Incidence ; Intraabdominal Infections/epidemiology ; Intraabdominal Infections/etiology ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Prognosis ; Proportional Hazards Models
    Language English
    Publishing date 2018-04-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-018-1866-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Oncological outcome of wide anatomic resection with partial mesorectal excision in patients with upper and middle rectal cancer.

    Jiménez-Toscano, Marta / Montcusí, Blanca / Ansuátegui, Marina / Alonso, Sandra / Salvans, Silvia / Pascual, Marta / Pera, Miguel

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2021  Volume 23, Issue 7, Page(s) 1837–1847

    Abstract: Aim: The aim was to investigate the influence of distal resection margin and extent of mesorectal excision on long-term oncological outcomes.: Method: Consecutive patients with upper and middle third rectal cancer from June 2006 to February 2016 were ...

    Abstract Aim: The aim was to investigate the influence of distal resection margin and extent of mesorectal excision on long-term oncological outcomes.
    Method: Consecutive patients with upper and middle third rectal cancer from June 2006 to February 2016 were reviewed. Patients were divided into four groups depending on the distal margin considered as a surrogate marker of the extension of mesorectal excision (Q1 ≤10 mm, Q2 11-20 mm, Q3 21-30 mm, Q4 ≥31 mm). Local-recurrence-free survival (LRFS), disease-free survival (DFS) and overall survival (OS) were estimated. Cox regression models were used to investigate the influence of surgical and clinicopathological variables on prognosis by adjusting for confounding factors.
    Results: Two hundred and eleven patients with mid (125) and upper (86) rectal cancer underwent wide mesorectal excision. The median follow-up was 48.64 months (interquartile range 28-63). 17.5% patients developed recurrence. The 5-year LRFS, DFS and OS for all patients were 93.20%, 83.89% and 80.1%, respectively, with no statistically significant differences between groups (LRFS, P = 0.601; DFS, P = 0.487; OS, P = 0.468). In the multivariable analysis the recurrences and survival were associated with the quality of the mesorectum (LRFS, hazard ratio 10.629, 95% CI 2.324-48.610, P = 0.002; DFS, hazard ratio 2.789, 95% CI 1.314-5.922, P = 0.008).
    Conclusion: A wide anatomical resection with partial mesorectal excision and shorter distal resection margin does not jeopardize the oncological outcomes.
    MeSH term(s) Disease-Free Survival ; Humans ; Mesocolon ; Neoplasm Recurrence, Local ; Prognosis ; Rectal Neoplasms/surgery ; Rectum/surgery ; Treatment Outcome
    Language English
    Publishing date 2021-06-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chromosomal breaks: another differential gap between early-onset and late-onset colorectal cancers.

    Perea, José / García, Juan Luis / Corchete, Luis A / Martí, Marc / Hernández-Villafranca, Sergio / Alcázar, José A / Álvaro, Edurne / Hurtado, Elena / Jiménez-Toscano, Marta / Balaguer, Francesc / Ballestero, Araceli / López-Rojo, Irene / Jiménez, Fernando / Sanz, Gonzalo / Melone, Sirio / Brandáriz, Lorena / Vivas, Alfredo / Alvarellos, Alicia / González-Sarmiento, Rogelio

    The British journal of surgery

    2024  Volume 111, Issue 3

    MeSH term(s) Humans ; Chromosome Breakage ; Colorectal Neoplasms/genetics
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znae041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Transanal Hartmann reversal: a new technique.

    Bravo, R / Fernández-Hevia, M / Jiménez-Toscano, M / Flores, L F / de Lacy, B / Quaresima, S / Lacy, A M

    Surgical endoscopy

    2016  Volume 30, Issue 6, Page(s) 2628–2631

    Abstract: Background: Hartmann procedure consists in a sigmoidectomy followed by a terminal colostomy. However, the stoma is associated with complications and suboptimal quality of life, so the restoration of colonic continuity should be, at least, considered in ... ...

    Abstract Background: Hartmann procedure consists in a sigmoidectomy followed by a terminal colostomy. However, the stoma is associated with complications and suboptimal quality of life, so the restoration of colonic continuity should be, at least, considered in any case. Open restoration has been associated with significant morbidity and mortality; therefore, many authors have described the advantages of laparoscopic Hartmann reversal. We want to go a step further showing our experience using a combined laparoscopic and transanal approach in an attempt to improve the surgical technique.
    Methods: Patients with an end colostomy due to an emergency Hartmann procedure are selected for this intervention. This approach is performed simultaneously laparoscopically and transanally, with single-port devices, through the colostomy wound in the first case and trough anal canal in the second one. The previous stapler line is resected transanally and the proximal rectum and mesorectum are dissected until the peritoneal reflexion, where both teams work together to complete the adhesiolysis. Finally an end-to-end anastomosis is performed under laparoscopic control.
    Results: As in patients with rectal cancer, dissection of the stump in Hartmann reversal procedure may be better and associated with shorter operative time.
    Conclusions: As with any new surgical procedure, it is probably too early to draw conclusions, but nowadays transanal combined with laparoscopic approach seems to be a safe and feasible technique to perform a Hartmann reversal.
    MeSH term(s) Anastomosis, Surgical ; Colon/surgery ; Colon, Sigmoid/surgery ; Colostomy ; Humans ; Laparoscopy ; Proctoscopy ; Rectal Neoplasms/surgery ; Rectum/surgery
    Keywords covid19
    Language English
    Publishing date 2016-06
    Publishing country Germany
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-015-4504-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Laparoscopic colectomy for transverse colon carcinoma: a surgical challenge but oncologically feasible.

    Fernández-Cebrián, J M / Gil Yonte, P / Jimenez-Toscano, M / Vega, L / Ochando, F

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2013  Volume 15, Issue 2, Page(s) e79–83

    Abstract: Aim: The aim of the study was to assess the safety and feasibility of laparoscopic surgery for transverse colon cancer and to compare the clinicopathological outcome with that of conventional open surgery.: Method: From March 1998 to December 2009, ... ...

    Abstract Aim: The aim of the study was to assess the safety and feasibility of laparoscopic surgery for transverse colon cancer and to compare the clinicopathological outcome with that of conventional open surgery.
    Method: From March 1998 to December 2009, 1253 patients with colorectal tumours were operated on, 564 laparoscopically. There were 154 cases of transverse colon cancer, 86 of which were included in the study. Details were collected on age, sex, body mass index (BMI), operation time, blood loss, time to first flatus, time to resume a liquid diet, postoperative length of hospital stay, complications, TNM stage, tumour size, distal resection margin, proximal resection margin, number of nodes harvested and surgical procedure. Laparoscopic and open surgical removal was compared.
    Results: No significant differences were found between laparoscopic and conventional groups in age, sex, BMI, operation time or postoperative length of hospital stay. The mean blood loss during the operations was significantly less in the laparoscopic group (105.9 ± 140.9 ml vs 305.7 ± 325.3 ml; P = 0.05). The time to the first flatus was shorter (2.1 ± 0.3 days vs 3.8 ± 3.0 days; P = 0.043) and diet was started earlier (3.1 ± 1.4 days vs 3.4 ± 1.5 days) in the laparoscopic group. No significant differences in tumour size, proximal resection margin or number of lymph nodes were observed. The mean distal resection margin was not statistically different (10.3 ± 4.5 cm vs 8.8 ± 4.9 cm). At a mean follow up of 33 ± 2.3 months, nonport-site metastases occurred in eight patients and locoregional recurrence occurred in three, with no significant difference between the groups. The 3-year cumulative overall survival rate was 78%, and the disease-free survival rate was 69%.
    Conclusion: There was no difference in the outcome of laparoscopic and open surgery for transverse colon cancer, including the cancer-specific outcome.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Colectomy/adverse effects ; Colectomy/methods ; Colon, Transverse/pathology ; Colon, Transverse/surgery ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Female ; Humans ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Male ; Middle Aged ; Treatment Outcome
    Language English
    Publishing date 2013-02
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.12067
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  7. Article ; Online: Efficacy and quality of life after transcutaneous posterior tibial neuromodulation for faecal incontinence.

    Jiménez-Toscano, M / Vega, D / Fernandez-Cebrián, J M / Valle Martín, B / Jiménez-Almonacid, P / Rueda Orgaz, J A

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2015  Volume 17, Issue 8, Page(s) 718–723

    Abstract: Aim: The aim of this study was to evaluate the efficacy of transcutaneous neuromodulation of the posterior tibial nerve for faecal incontinence and to assess quality of life after the procedure.: Method: A prospective non-randomized cohort study was ... ...

    Abstract Aim: The aim of this study was to evaluate the efficacy of transcutaneous neuromodulation of the posterior tibial nerve for faecal incontinence and to assess quality of life after the procedure.
    Method: A prospective non-randomized cohort study was conducted in a tertiary centre from September 2010 to May 2013. All patients with faecal incontinence who met the inclusion criteria were included and were treated as outpatients during a 3-month period by unilateral neuromodulation of the posterior tibial nerve. The patients were followed 3-monthly for 1 year. Severity scales, a bowel diary and quality of life scales were evaluated prospectively before and after treatment.
    Results: Twenty-seven patients of median age 67 (interquartile range 60-69) years and a male to female ratio of 1/6 were included. Faecal incontinence was for solid stools in 48.1% of patients with urgency in 55.6%. About one-third (34.6%) had a sphincter defect on ultrasound and reduction of anal canal pressure in 85.2%. There was a significant improvement in episodes of incontinence on the Wexner score and visual analogue scale assessment and a decrease in the number of episodes of incontinence per unit time. The Fecal Incontinence Quality of Life score was improved at the end of the follow-up. No adverse effects were observed. The cost of the treatment was €135 per patient.
    Conclusion: Transcutaneous posterior tibial nerve neuromodulation provides good treatment for faecal incontinence in terms of efficacy and quality of life.
    MeSH term(s) Aged ; Fecal Incontinence/therapy ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Quality of Life ; Severity of Illness Index ; Tibial Nerve ; Transcutaneous Electric Nerve Stimulation/adverse effects ; Transcutaneous Electric Nerve Stimulation/economics ; Treatment Outcome
    Language English
    Publishing date 2015-08
    Publishing country England
    Document type Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.12923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Telomere Length as a New Risk Marker of Early-Onset Colorectal Cancer.

    Martel-Martel, Abel / Corchete, Luis A / Martí, Marc / Vidal-Tocino, Rosario / Hurtado, Elena / Álvaro, Edurne / Jiménez, Fernando / Jiménez-Toscano, Marta / Balaguer, Francesc / Sanz, Gonzalo / López, Irene / Hernández-Villafranca, Sergio / Ballestero, Araceli / Vivas, Alfredo / Melone, Sirio / Pastor, Carlos / Brandáriz, Lorena / Gómez-Marcos, Manuel A / Cruz-Hernández, Juan J /
    Perea, José / González-Sarmiento, Rogelio

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Early-onset colorectal cancer (EOCRC; age younger than 50 years) incidence has been steadily increasing in recent decades worldwide. The need for new biomarkers for EOCRC prevention strategies is undeniable. In this study, we aimed to explore whether an ... ...

    Abstract Early-onset colorectal cancer (EOCRC; age younger than 50 years) incidence has been steadily increasing in recent decades worldwide. The need for new biomarkers for EOCRC prevention strategies is undeniable. In this study, we aimed to explore whether an aging factor, such as telomere length (TL), could be a useful tool in EOCRC screening. The absolute leukocyte TL from 87 microsatellite stable EOCRC patients and 109 healthy controls (HC) with the same range of age, was quantified by Real Time Quantitative PCR (RT-qPCR). Then, leukocyte whole-exome sequencing (WES) was performed to study the status of the genes involved in TL maintenance (
    MeSH term(s) Humans ; Middle Aged ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Incidence ; Telomere/genetics ; Telomere/metabolism ; Biomarkers, Tumor ; Early Detection of Cancer/methods
    Chemical Substances DKC1 protein, human ; Biomarkers, Tumor
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043526
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  9. Article ; Online: Transanal Hartmann's colostomy reversal assisted by laparoscopy: outcomes of the first 10 patients.

    Trépanier, Jean-Sébastien / Arroyave, María Clara / Bravo, Raquel / Jiménez-Toscano, Marta / DeLacy, Francisco B / Fernandez-Hevia, María / Lacy, Antonio M

    Surgical endoscopy

    2017  Volume 31, Issue 12, Page(s) 4981–4987

    Abstract: Introduction: Restoration of intestinal continuity after Hartmann's procedure is a technically difficult surgery associated with significant morbidity and mortality. This study presents the short-term results of a new approach: a transanal Hartmann's ... ...

    Abstract Introduction: Restoration of intestinal continuity after Hartmann's procedure is a technically difficult surgery associated with significant morbidity and mortality. This study presents the short-term results of a new approach: a transanal Hartmann's colostomy reversal assisted by laparoscopy.
    Method: This is a retrospective analysis of data collected in one tertiary hospital, from October 2013 to November 2015.
    Results: During the study period, there were ten cases of transanal Hartmann's reversal. Reasons for Hartmann's procedure were: complicated diverticulitis (4), anastomotic leak (3), and recto-sigmoid cancer (3). Rectal stump length was 10.4 ± 4.5 cm. Reconstruction was achieved in all patients. One low colorectal anastomosis was hand-sewn, the other 9 were stapled. Mean operative time was 204 ± 65 min. Diverting loop ileostomies were created in five patients and all were closed during the following year. One case required hand-assistance but there was no conversion to open surgery. Iatrogenic laparoscopic enterotomies occurred in four patients and all were repaired primarily without consequences. Three patients had a total of four post-operative complications: ileus (2), abdominal abscess and wound infection (1). None required reoperation. Mean length of stay was 7.2 ± 4.3 days. One required readmission.
    Conclusion: A transanal Hartmann's reversal assisted by laparoscopy is a new approach for a difficult surgery. It has the potential to be an additional tool in the case of hostile pelvises or with a rectal stump difficult to identify. The surgery remains challenging and indications need to be clarified.
    MeSH term(s) Aged ; Aged, 80 and over ; Anal Canal/surgery ; Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Colostomy/adverse effects ; Colostomy/methods ; Conversion to Open Surgery ; Female ; Humans ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Operative Time ; Pilot Projects ; Postoperative Complications/epidemiology ; Rectum/surgery ; Retrospective Studies ; Surgical Stomas ; Treatment Outcome
    Language English
    Publishing date 2017-06-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-017-5462-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hernias at the extraction incision after laparoscopic colon and rectal resection: Influence of incision location and use of prophylactic mesh.

    Pereira, José Antonio / Pera, Miguel / López-Cano, Manuel / Pascual, Marta / Alonso, Sandra / Salvans, Silvia / Jiménez-Toscano, Marta / González-Martín, Alba / Grande-Posa, Luis

    Cirugia espanola

    2018  Volume 97, Issue 1, Page(s) 20–26

    Abstract: Objectives: To determine the incidence of incisional hernia (IH) in the extraction incision (EI) in colorectal resection for cancer. To analyze whether the location of the incision has any relationship with the incidence of hernias and whether mesh ... ...

    Title translation Hernias de la incisión de asistencia tras resección colorrectal laparoscópica. Influencia de la localización de la incisión y del uso de una malla profiláctica.
    Abstract Objectives: To determine the incidence of incisional hernia (IH) in the extraction incision (EI) in colorectal resection for cancer. To analyze whether the location of the incision has any relationship with the incidence of hernias and whether mesh could be useful for prevention in high-risk patients.
    Methods: Retrospective review of the colon and rectal surgery database from January 2015 to December 2016. Data were classified into 2groups, transverse (TI) and midline incision (MI), and the latter was divided into 2subgroups (mesh [MIM] and suture [MIS]). Patients were classified using the HERNIAscore. Hernias were diagnosed by clinical and/or CT examination.
    Results: A total of 182 out of 210 surgical patients were included. After a median follow-up of 13.0 months, 39 IH (21.9%) were detected, 23 of which (13.4%) were in the EI; their frequency was lower in the TI group (3.4%) and in the MIM group (5.9%) than in the MIS group (29.5%; p=0.007). The probability of developing IH in the MIS group showed an OR=11.7 (95%CI: 3.3-42.0) compared to the TI group and 4.3 (IC 95%: 1.1-16.3) versus the MIM group.
    Conclusions: The location of the incision is relevant to avoid incisional hernias. Transverse incisions should be used as the first option. When a midline incision is needed, a prophylactic mesh could be considered in high risk patients because it is safe and associated with low morbidity.
    MeSH term(s) Aged ; Colectomy/methods ; Colonic Neoplasms/surgery ; Female ; Humans ; Incidence ; Incisional Hernia/epidemiology ; Incisional Hernia/prevention & control ; Laparoscopy ; Male ; Proctectomy/methods ; Rectal Neoplasms/surgery ; Retrospective Studies ; Surgical Mesh
    Language Spanish
    Publishing date 2018-10-19
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2018.08.002
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