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  1. Article ; Online: Continuous monitoring of adverse effects improves surgical outcomes.

    Grande, Luis / Gimeno, Marta / Jimeno, Jaime / Pera, Manuel / Sancho-Insenser, Joan / Pera, Miguel

    Cirugia espanola

    2024  Volume 102, Issue 4, Page(s) 209–215

    Abstract: Background: There has been significant debate about the advantages and disadvantages of using administrative databases or clinical registry in healthcare improvement programs. The aim of this study was to review the implementation and outcomes of an ... ...

    Abstract Background: There has been significant debate about the advantages and disadvantages of using administrative databases or clinical registry in healthcare improvement programs. The aim of this study was to review the implementation and outcomes of an accountability policy through a registry maintained by professionals of the surgical department.
    Materials and methods: All patients admitted to the department between 2003 and 2022 were prospectively included. All adverse events (AEs) occurring during the admission, convalescent care in facilities, or at home for a minimum period of 30 days after discharge were recorded.
    Results: Out of 60,125 records, 24,846 AEs were documented in 16,802 cases (27.9%). There was a progressive increase in the number of AEs recorded per admission (1.17 in 2003 vs. 1.93 in 2022) with a 26% decrease in entries with AEs (from 35.0% in 2003 to 25.8% in 2022), a 57.5% decrease in reoperations (from 8.0% to 3.4%, respectively), and an 80% decrease in mortality (from 1.8% to 1.0%, respectively). It is noteworthy that a significant reduction in severe AEs was observed between 2011 and 2022 (56% vs. 15.6%).
    Conclusion: A prospective registry of AEs created and maintained by health professionals, along with transparent presentation and discussion of the results, leads to sustained improvement in outcomes in a surgical department of a university hospital.
    MeSH term(s) Humans ; Colectomy/methods ; Elective Surgical Procedures ; Treatment Outcome
    Language English
    Publishing date 2024-02-09
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2023.11.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Spanish version of the BREAST-Q® 2.0 questionnaire-breast reduction module-: Linguistic, cross-cultural adaptation and validation.

    Martínez, Paula / Jimeno, Jaime / Hernanz, Fernando / Muñoz, Pedro

    Cirugia espanola

    2022  Volume 101, Issue 3, Page(s) 232–234

    MeSH term(s) Humans ; Cross-Cultural Comparison ; Linguistics ; Surveys and Questionnaires ; Mammaplasty
    Language English
    Publishing date 2022-10-18
    Publishing country Spain
    Document type Case Reports
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2022.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Treatment of symptomatic macromastia in a breast unit. Outcomes analysis of breast reduction using BREAST-Q.

    Hernanz, Fernando / Martínez, Paula / Paz, Lucía / Jimeno, Jaime / Hernan Del Piero, Guillermo / Muñoz, Pedro

    Cirugia espanola

    2022  Volume 101, Issue 4, Page(s) 252–257

    Abstract: Introduction: The BREAST-Q (breast reduction module) is a specific and validated questionnaire to evaluate breast reduction in the treatment of symptomatic macromastia, offering information on their quality of life and degree of satisfaction.: Methods! ...

    Abstract Introduction: The BREAST-Q (breast reduction module) is a specific and validated questionnaire to evaluate breast reduction in the treatment of symptomatic macromastia, offering information on their quality of life and degree of satisfaction.
    Methods: Prospective study of a cohort of 34 patients treated by bilateral breast reduction in a breast unit in 2017-2020 surveyed with the Spanish version of BREAST-Q version 2. The statistical study to assess the effect of reduction, changes from the pre to postoperative scores of the domains were performed using the Wilcoxon signed rank test. Statistical significance was determined with p values ​​<0.05.
    Results: The mean time elapsed from surgery to the postoperative survey was 16 (SD 9) months. Post-surgical complications or sequelae occurred in 14 (42%) patients with 23 events. The preoperative scores, median and interquartile range, in satisfaction with the breasts (28, 26), psychological (33, 14), physical (42, 19) and sexual (34, 14) well-being improved in the postoperative survey to (82, 15), (81.29), (82, 30) and (90, 38), respectively. These changes were statistically significant, p < 0.001.
    Conclusions: The first application of the BREAST-Q in its version in Spanish for Spanish women in patients with symptomatic macromastia treated surgically in a breast unit shows that breast reduction improves the quality of life of patients and that they are very satisfied with the outcome of the surgery and its surgeon, although the information received should clearly be improved.
    MeSH term(s) Female ; Humans ; Quality of Life ; Prospective Studies ; Patient Satisfaction ; Mammaplasty
    Language English
    Publishing date 2022-09-11
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2022.09.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comments on the Clinical Validation of the BREAST-Q Breast-Conserving Therapy Module.

    Hernanz, Fernando / Jimeno, Jaime / Paz, Lucia / Muñoz, Pedro

    Annals of surgical oncology

    2019  Volume 26, Issue Suppl 3, Page(s) 855–856

    MeSH term(s) Mammaplasty ; Mastectomy, Segmental
    Language English
    Publishing date 2019-08-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-019-07754-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies.

    Yélamos, José / Moreno-Lama, Lucia / Jimeno, Jaime / Ali, Syed O

    Cancers

    2020  Volume 12, Issue 2

    Abstract: Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 are enzymes which post-translationally modify proteins through poly(ADP-ribosyl)ation (PARylation)-the transfer of ADP-ribose chains onto amino acid residues-with a resultant modulation of protein ... ...

    Abstract Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 are enzymes which post-translationally modify proteins through poly(ADP-ribosyl)ation (PARylation)-the transfer of ADP-ribose chains onto amino acid residues-with a resultant modulation of protein function. Many targets of PARP-1/2-dependent PARylation are involved in the DNA damage response and hence, the loss of these proteins disrupts a wide range of biological processes, from DNA repair and epigenetics to telomere and centromere regulation. The central role of these PARPs in DNA metabolism in cancer cells has led to the development of PARP inhibitors as new cancer therapeutics, both as adjuvant treatment potentiating chemo-, radio-, and immuno-therapies and as monotherapy exploiting cancer-specific defects in DNA repair. However, a cancer is not just made up of cancer cells and the tumor microenvironment also includes multiple other cell types, particularly stromal and immune cells. Interactions between these cells-cancerous and non-cancerous-are known to either favor or limit tumorigenesis. In recent years, an important role of PARP-1 and PARP-2 has been demonstrated in different aspects of the immune response, modulating both the innate and adaptive immune system. It is now emerging that PARP-1 and PARP-2 may not only impact cancer cell biology, but also modulate the anti-tumor immune response. Understanding the immunomodulatory roles of PARP-1 and PARP-2 may provide invaluable clues to the rational development of more selective PARP-centered therapies which target both the cancer and its microenvironment.
    Language English
    Publishing date 2020-02-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12020392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Reduction mammaplasty technique. The core and the master key of oncoplastic breast surgery.

    Hernanz, Fernando / Jimeno, Jaime Y / Paz, Lucía

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2018  Volume 72, Issue 2, Page(s) 335–354

    MeSH term(s) Breast Neoplasms/surgery ; Female ; Humans ; Mammaplasty/methods
    Language English
    Publishing date 2018-11-13
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2018.10.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Rescue surgery in a patient with metastatic melanoma and BRAF V600E mutation.

    de Miguel, Maite / Jimeno, Jaime / Vidal, Joana / Segura, Sonia / Lorente, Leyre

    Cirugia espanola

    2018  Volume 96, Issue 10, Page(s) 665–666

    Title translation Tratamiento quirúrgico de rescate en paciente con melanoma metastásico con mutación BRAF V600E.
    MeSH term(s) Aged ; Humans ; Intestinal Neoplasms/genetics ; Intestinal Neoplasms/secondary ; Intestinal Neoplasms/surgery ; Male ; Melanoma/genetics ; Melanoma/secondary ; Melanoma/surgery ; Mutation ; Proto-Oncogene Proteins B-raf/genetics
    Chemical Substances BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language Spanish
    Publishing date 2018-07-05
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2018.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Reingreso hospitalario en cirugía general y digestiva: ¿existe asociación con la edad de los pacientes?

    Parés, David / Jimeno, Jaime / Orbeal, Rolando

    Gastroenterologia y hepatologia

    2014  Volume 37, Issue 4, Page(s) 269–270

    Title translation Readmission in general surgery: is there association with patient's age?.
    MeSH term(s) Adult ; Age Factors ; Aged ; Comorbidity ; Digestive System Surgical Procedures ; Female ; General Surgery ; Humans ; Male ; Middle Aged ; Patient Admission/statistics & numerical data ; Postoperative Complications/epidemiology ; Risk Factors ; Surgery Department, Hospital/statistics & numerical data
    Language Spanish
    Publishing date 2014-04
    Publishing country Spain
    Document type Letter
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2013.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Utilización de un recordatorio por SMS para mejorar la asistencia a las consultas externas en cirugía general y digestiva.

    Parés, David / Jimeno, Jaime / Comajuncosas, Jordi

    Gaceta sanitaria

    2013  Volume 27, Issue 4, Page(s) 381

    Title translation Use of SMS reminders in general surgery to improve patient assistance in an outpatient setting.
    MeSH term(s) General Surgery ; Humans ; Outpatients ; Reminder Systems ; Surgical Procedures, Operative ; Text Messaging
    Language Spanish
    Publishing date 2013-07
    Publishing country Spain
    Document type Letter
    ZDB-ID 1038713-4
    ISSN 1578-1283 ; 0213-9111
    ISSN (online) 1578-1283
    ISSN 0213-9111
    DOI 10.1016/j.gaceta.2013.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Carcinoma mucoepidermoide esclerosante con eosinofilia de tiroides.

    Orbeal, Rolando / Jimeno, Jaime / Monroy, Gabriela / Badia, Francesc / Parés, David

    Cirugia espanola

    2015  Volume 93, Issue 10, Page(s) e137–8

    Title translation Sclerosing mucoepidermoid carcinoma of the thyroid gland with eosinophilia.
    MeSH term(s) Carcinoma, Mucoepidermoid ; Eosinophilia ; Humans ; Salivary Gland Neoplasms ; Thyroid Neoplasms ; Viscera
    Language Spanish
    Publishing date 2015-12
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 730701-9
    ISSN 1578-147X ; 0009-739X
    ISSN (online) 1578-147X
    ISSN 0009-739X
    DOI 10.1016/j.ciresp.2014.06.005
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