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  1. Article: [Preliminary observation of wearable balance diagnosis and treatment system in evaluating dynamic and static balance function in patients with vestibular vertigo].

    Gao, N / Jin, F / Meng, Y / Yang, C / Wang, J

    Zhonghua yi xue za zhi

    2024  Volume 104, Issue 14, Page(s) 1180–1183

    Abstract: A newly developed wearable balance diagnosis and treatment system was studied to evaluate the indexes of the abnormal balance function in patients with vestibular vertigo. A cross-sectional study was carried out. A total of 30 patients diagnosed with non- ...

    Abstract A newly developed wearable balance diagnosis and treatment system was studied to evaluate the indexes of the abnormal balance function in patients with vestibular vertigo. A cross-sectional study was carried out. A total of 30 patients diagnosed with non-acute vestibular vertigo in the outpatient department of Eye, Ear, Nose and Throat Hospital Affiliated to Fudan University from July 2022 to May 2023 were selected as the vertigo group, including 13 males and 17 females, and aged (45.7±13.9) years. Meanwhile, 20 healthy controls (8 males and 12 females) were included as the control group, with a mean age of (43.6±8.0) years. The static balance and limits of stability (LOS) function of all subjects were assessed with wearable balance diagnosis and treatment system developed under the leadership of Eye & ENT Hospital of Fudan University. In the static balance test, the ratio of eyes open with cushions to eyes open without cushions in the vertigo group was less than that of the control group[1.20% (0.92%, 1.53%) vs 1.49% (1.22%, 1.81%),
    MeSH term(s) Male ; Female ; Humans ; Adult ; Middle Aged ; Cross-Sectional Studies ; Vertigo/diagnosis ; Vertigo/therapy ; Outpatients ; Wearable Electronic Devices ; Postural Balance
    Language Chinese
    Publishing date 2024-04-07
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.cn112137-20240111-00085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Technologies for Prenatal Diagnosis and Assessment of Genetic Disorders

    Jin, Fan / Tan, Yueqiu / Rajcan-Separovic, Evica / Leung, Peter C. K.

    2020  

    Keywords Science: general issues ; Medical genetics ; Prenatal chromosomal abnormalities ; Single gene disorders ; Molecular technologies ; Prenatal screening/diagnosis ; Carrier screening
    Size 1 electronic resource (117 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230178
    ISBN 9782889637393 ; 2889637395
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: The transmembrane supercomplex mediating the biogenesis of OMPs in Gram-negative bacteria assumes a circular conformational change upon activation.

    Jin, Feng

    FEBS open bio

    2020  Volume 10, Issue 8, Page(s) 1698–1715

    Abstract: The cell envelope of Gram-negative bacteria is composed of the inner (plasma) and the outer membrane. In the outer membrane, the outer membrane β-barrel proteins (OMPs) serve multiple functions. They are synthesized in the cytoplasm and finally inserted ... ...

    Abstract The cell envelope of Gram-negative bacteria is composed of the inner (plasma) and the outer membrane. In the outer membrane, the outer membrane β-barrel proteins (OMPs) serve multiple functions. They are synthesized in the cytoplasm and finally inserted into the outer membrane through a critical and complex pathway facilitated by many protein factors. Recently, a new model for the biogenesis of OMPs in Gram-negative bacteria was proposed, in which a supercomplex containing multiple proteins spans the inner and outer membrane, to mediate the biogenesis of OMPs. The core part of the transmembrane supercomplex is the inner membrane protein translocon and the outer membrane β-barrel assembly machinery (BAM) complex. Some components of the supercomplex, such as the BamA subunit of the BAM complex, are essential and conserved across species. The other components, for example, the BamB subunit and the primary periplasmic chaperone SurA, are also required for the supercomplex to gain complete function and full efficiency. How BamB and SurA behave in the supercomplex, however, is less well understood. Therefore, the crosstalk between BamA, BamB and SurA was investigated mainly through in vivo protein photo-cross-linking experiments and protein modeling. Moreover, theoretical structures for part of the supercomplex consisting of SurA and the BAM complex were constructed. The modeling data are consistent with the experimental results. The theoretical structures computed in this work provide a more comprehensive view of the mechanism of the supercomplex, demonstrating a circular conformational change of the supercomplex when it is active.
    MeSH term(s) Bacterial Outer Membrane Proteins/chemistry ; Bacterial Outer Membrane Proteins/metabolism ; Carrier Proteins/chemistry ; Carrier Proteins/metabolism ; Escherichia coli/chemistry ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Models, Molecular ; Peptidylprolyl Isomerase/chemistry ; Peptidylprolyl Isomerase/metabolism ; Protein Conformation
    Chemical Substances Bacterial Outer Membrane Proteins ; BamA protein, E coli ; BamB protein, E coli ; Carrier Proteins ; Escherichia coli Proteins ; SurA protein, E coli (EC 5.2.1.-) ; Peptidylprolyl Isomerase (EC 5.2.1.8)
    Language English
    Publishing date 2020-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2651702-4
    ISSN 2211-5463 ; 2211-5463
    ISSN (online) 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.12922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Structural insights into the mechanism of a novel protein targeting pathway in Gram-negative bacteria.

    Jin, Feng

    FEBS open bio

    2020  Volume 10, Issue 4, Page(s) 561–579

    Abstract: Many nascent polypeptides synthesized in the cytoplasm are translocated across membranes via a specific 'translocon' composed of protein complexes. Recently, a novel targeting pathway for the outer membrane β-barrel proteins (OMPs) in Gram-negative ... ...

    Abstract Many nascent polypeptides synthesized in the cytoplasm are translocated across membranes via a specific 'translocon' composed of protein complexes. Recently, a novel targeting pathway for the outer membrane β-barrel proteins (OMPs) in Gram-negative bacteria was discovered. The cell envelope of Gram-negative bacteria is composed of the inner (plasma) membrane (IM) and the outer membrane (OM). In this new pathway, a SecA
    MeSH term(s) Algorithms ; Amino Acid Motifs/genetics ; Bacterial Outer Membrane/metabolism ; Bacterial Outer Membrane Proteins/metabolism ; Cytoplasm/metabolism ; Gram-Negative Bacteria/enzymology ; Models, Chemical ; Mutation ; Protein Conformation, beta-Strand ; Protein Multimerization ; Protein Transport ; SEC Translocation Channels/chemistry ; SEC Translocation Channels/metabolism ; SecA Proteins/chemistry ; SecA Proteins/genetics ; SecA Proteins/metabolism ; Signal Transduction
    Chemical Substances Bacterial Outer Membrane Proteins ; SEC Translocation Channels ; SecA Proteins (EC 7.4.2.4)
    Language English
    Publishing date 2020-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2651702-4
    ISSN 2211-5463 ; 2211-5463
    ISSN (online) 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.12813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Analysis of the differences in the characteristics of mesenchymal stem cells derived from jaw and long bones based on single-cell RNA-sequencing].

    Wang, H / Zhou, Z K / Sui, B D / Jin, F / Zhou, J / Zheng, C X

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

    2024  Volume 59, Issue 3, Page(s) 247–254

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) RNA/metabolism ; Mesenchymal Stem Cells/physiology ; Bone Marrow Cells/metabolism ; Cell Differentiation
    Chemical Substances RNA (63231-63-0)
    Language Chinese
    Publishing date 2024-03-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1027950-7
    ISSN 1002-0098
    ISSN 1002-0098
    DOI 10.3760/cma.j.cn112144-20230824-00109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: [Functional synergism of pyoverdine and the S-type pyocins of

    Chen, Wenhui / Jin, Fan

    Sheng wu gong cheng xue bao = Chinese journal of biotechnology

    2023  Volume 39, Issue 4, Page(s) 1562–1577

    Abstract: Pyocin S2 and S4 ... ...

    Abstract Pyocin S2 and S4 in
    MeSH term(s) Pyocins/metabolism ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/metabolism
    Chemical Substances Pyocins
    Language Chinese
    Publishing date 2023-05-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1042206-7
    ISSN 1872-2075 ; 1042-749X
    ISSN (online) 1872-2075
    ISSN 1042-749X
    DOI 10.13345/j.cjb.220608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Association between serum estradiol level and appendicular lean mass index in middle-aged postmenopausal women.

    Jin, Fang / Wang, Yan-Fei / Zhu, Zhong-Xin

    World journal of orthopedics

    2024  Volume 15, Issue 1, Page(s) 45–51

    Abstract: Background: Previous studies investigating the association between loss of estrogen at menopause and skeletal muscle mass came to contradictory conclusions.: Aim: To evaluate the association between serum estradiol level and appendicular lean mass ... ...

    Abstract Background: Previous studies investigating the association between loss of estrogen at menopause and skeletal muscle mass came to contradictory conclusions.
    Aim: To evaluate the association between serum estradiol level and appendicular lean mass index in middle-aged postmenopausal women using population-based data.
    Methods: This study included 673 postmenopausal women, aged 40-59 years, from the National Health and Nutrition Examination Survey between 2013 and 2016. Weighted multivariable linear regression models were used to evaluate the association between serum E2 Level and appendicular lean mass index (ALMI). When non-linear associations were found by using weighted generalized additive model and smooth curve fitting, two-piecewise linear regression models were further applied to examine the threshold effects.
    Results: There was a positive association between serum E2 level and ALMI. Compared to individuals in quartile 1 group, those in other quartiles had higher ALMI levels. An inverted U-shaped curve relationship between serum E2 Level and ALMI was found on performing weighted generalized additive model and smooth curve fitting, and the inflection point was identified as a serum E2 level of 85 pg/mL.
    Conclusion: Our results demonstrated an inverted U-shaped curve relationship between serum E2 levels and ALMI in middle-aged postmenopausal women, suggesting that low serum E2 levels play an important in the loss of muscle mass in middle-aged postmenopausal women.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649712-8
    ISSN 2218-5836
    ISSN 2218-5836
    DOI 10.5312/wjo.v15.i1.45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clinical application of Yang-Supplementing acupuncture therapy in the treatment of chronic heart failure combined with chronic kidney disease.

    Deng, Xiaozheng / Wang, Wenhai / Wen, Shaojin / Jin, Feng

    Asian journal of surgery

    2024  Volume 47, Issue 4, Page(s) 1949–1950

    MeSH term(s) Humans ; Acupuncture Therapy ; Chronic Disease ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Heart Failure/therapy
    Language English
    Publishing date 2024-01-19
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.12.159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Conference proceedings ; Online: Investigation of weather-band sea-level variability along North-West Australia

    Jin, F. / Pattiaratchi, C. / Cosoli, S. / Hetzel, Y.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: Sea-level oscillations and associated current variability, responding to meteorological forcing with periods in the range of 3-15 days (“weather-band”), are ubiquitous along continental shelves globally. However, the investigation of these weather-band ... ...

    Abstract Sea-level oscillations and associated current variability, responding to meteorological forcing with periods in the range of 3-15 days (“weather-band”), are ubiquitous along continental shelves globally. However, the investigation of these weather-band sea-level (WBSL) variations over a long period (~10 years) and the understanding their forcing are limited, particularly along North-West Australia. The aims of this research were to: (1) investigate WBSL along North-West Australia from 2009 to 2018; (2) assess the different types of meteorological forcing that contribute to WBSL; and (3) evaluate different meteorological drivers that contribute to the generation of continental shelf waves (CSWs). These aims were achieved through the analysis of long-term sea level records from 7 tide gauge stations, between Port Hedland and Geraldton, separated by 1400 km, together with concurrent meteorological data. The most energetic weather events occurred during the cyclone season (Nov-Apr) and other strong weather events were present during austral winter, particularly along the southern stations. WBSL was linked to five different meteorological forcing conditions: tropical storms (cyclones and depressions); frontal systems, west coast trough and sub-tropical high pressure systems. Over the period of analysis, ~50% of WBSL were attributed to propagating signals and were identified as continental shelf waves (CSW). These waves had mean phase speeds of 4.92±0.6m/s within the study region. CSW’s occurred throughout the year with the most energetic being generated by tropical cyclones. Other WBSL signals were generated by large scale weather systems that resulted in simultaneous sea level changes over the study region.
    Subject code 551 ; 333
    Language English
    Publishing date 2023-07-11
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: The transmembrane supercomplex mediating the biogenesis of OMPs in Gram‐negative bacteria assumes a circular conformational change upon activation

    Jin, Feng

    FEBS Open Bio. 2020 Aug., v. 10, no. 8

    2020  

    Abstract: The cell envelope of Gram‐negative bacteria is composed of the inner (plasma) and the outer membrane. In the outer membrane, the outer membrane β‐barrel proteins (OMPs) serve multiple functions. They are synthesized in the cytoplasm and finally inserted ... ...

    Abstract The cell envelope of Gram‐negative bacteria is composed of the inner (plasma) and the outer membrane. In the outer membrane, the outer membrane β‐barrel proteins (OMPs) serve multiple functions. They are synthesized in the cytoplasm and finally inserted into the outer membrane through a critical and complex pathway facilitated by many protein factors. Recently, a new model for the biogenesis of OMPs in Gram‐negative bacteria was proposed, in which a supercomplex containing multiple proteins spans the inner and outer membrane, to mediate the biogenesis of OMPs. The core part of the transmembrane supercomplex is the inner membrane protein translocon and the outer membrane β‐barrel assembly machinery (BAM) complex. Some components of the supercomplex, such as the BamA subunit of the BAM complex, are essential and conserved across species. The other components, for example, the BamB subunit and the primary periplasmic chaperone SurA, are also required for the supercomplex to gain complete function and full efficiency. How BamB and SurA behave in the supercomplex, however, is less well understood. Therefore, the crosstalk between BamA, BamB and SurA was investigated mainly through in vivo protein photo‐cross‐linking experiments and protein modeling. Moreover, theoretical structures for part of the supercomplex consisting of SurA and the BAM complex were constructed. The modeling data are consistent with the experimental results. The theoretical structures computed in this work provide a more comprehensive view of the mechanism of the supercomplex, demonstrating a circular conformational change of the supercomplex when it is active.
    Keywords biogenesis ; cytoplasm ; membrane proteins ; models
    Language English
    Dates of publication 2020-08
    Size p. 1698-1715.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2651702-4
    ISSN 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.12922
    Database NAL-Catalogue (AGRICOLA)

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