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  1. Book ; Online ; Thesis: Activation of the tumor suppressor merlin by myosin, moesin phosphatase

    Jin, Hongchuan

    2004  

    Institution Forschungszentrum Karlsruhe
    Author's details Forschungszentrum Karlsruhe GmbH, Karlsruhe. Hongchuan Jin
    Language English
    Size Online-Ressource
    Publisher FZKA
    Publishing place Karlsruhe
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Karlsruhe, Univ., Diss., 2004
    HBZ-ID HT014669314
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Audio / Video ; Thesis: Activation of the tumor suppressor merlin by myosin, moesin phosphatase

    Jin, Hongchuan

    (Wissenschaftliche Berichte / Forschungszentrum Karlsruhe ; 7017)

    2004  

    Author's details Hongchuan Jin. Forschungszentrum Karlsruhe GmbH, Karlsruhe
    Series title Wissenschaftliche Berichte / Forschungszentrum Karlsruhe ; 7017
    Wissenschaftliche Berichte / Forschungszentrum Karlsruhe, Technik und Umwelt
    Collection Wissenschaftliche Berichte / Forschungszentrum Karlsruhe, Technik und Umwelt
    Language English
    Size XI, 105 S., Ill., graph. Darst., 30 cm
    Edition Als Ms. gedr.
    Publisher FZKA
    Publishing place Karlsruhe
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Karlsruhe, Univ., Diss., 2004
    HBZ-ID HT014398803
    Database Catalogue ZB MED Medicine, Health

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    2006 A 1696 order for loan Magazin

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  3. Article ; Online: RNA-based therapeutics: an overview and prospectus.

    Zhu, Yiran / Zhu, Liyuan / Wang, Xian / Jin, Hongchuan

    Cell death & disease

    2022  Volume 13, Issue 7, Page(s) 644

    Abstract: The growing understanding of RNA functions and their crucial roles in diseases promotes the application of various RNAs to selectively function on hitherto "undruggable" proteins, transcripts and genes, thus potentially broadening the therapeutic targets. ...

    Abstract The growing understanding of RNA functions and their crucial roles in diseases promotes the application of various RNAs to selectively function on hitherto "undruggable" proteins, transcripts and genes, thus potentially broadening the therapeutic targets. Several RNA-based medications have been approved for clinical use, while others are still under investigation or preclinical trials. Various techniques have been explored to promote RNA intracellular trafficking and metabolic stability, despite significant challenges in developing RNA-based therapeutics. In this review, the mechanisms of action, challenges, solutions, and clinical application of RNA-based therapeutics have been comprehensively summarized.
    MeSH term(s) RNA Interference ; RNA, Small Interfering/genetics
    Chemical Substances RNA, Small Interfering
    Language English
    Publishing date 2022-07-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-022-05075-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Effect of glutamine metabolism on chemoresistance and its mechanism in tumors.

    Hu, Xinyang / Jin, Hongchuan / Zhu, Liyuan

    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

    2021  Volume 50, Issue 1, Page(s) 32–40

    Abstract: The metabolic reprogramming of tumor cells is characterized by increased uptake of various nutrients including glutamine. Glutamine metabolism provides the required substances for glycolysis and oxidative phosphorylation and affects the homeostasis of ... ...

    Abstract The metabolic reprogramming of tumor cells is characterized by increased uptake of various nutrients including glutamine. Glutamine metabolism provides the required substances for glycolysis and oxidative phosphorylation and affects the homeostasis of carbohydrate，fat and protein metabolism to induce the chemoresistance of tumor cells. Combination of chemotherapeutic agents with inhibitors specific to different components of glutamine metabolic pathway has obtained favorable clinical results on various tumors. Glutamine metabolic pathway plays a role in drug resistance of tumor cells in various ways. Firstly，the dynamic change of glutamine transporters can directly affect intracellular glutamine content thereby causing drug resistance; secondly，tumor stromal cells including adipocyte，fibroblast and metabolite from tumor microenvironment would give rise to immune-mediated drug resistance; thirdly，the expression and activity of key enzymes in glutamine metabolism also has a critical role in drug resistance of tumors. This article reviews the effects of glutamine metabolic pathway in the development of tumor chemoresistance，in terms of transporters，tumor microenvironment and metabolic enzymes，to provide insight for improving the therapeutic efficacy for drug-resistant tumors.
    MeSH term(s) Cell Line, Tumor ; Drug Resistance, Neoplasm ; Glutamine/metabolism ; Glycolysis ; Humans ; Neoplasms/drug therapy ; Oxidative Phosphorylation ; Tumor Microenvironment
    Chemical Substances Glutamine (0RH81L854J)
    Language English
    Publishing date 2021-06-08
    Publishing country China
    Document type Journal Article ; Review
    ISSN 1008-9292
    ISSN 1008-9292
    DOI 10.3724/zdxbyxb-2021-0040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Epigenetic Modifications in Mesothelioma.

    Cheng, Yuen Yee / Yuen, Man Lee / Jin, Hongchuan

    Frontiers in oncology

    2021  Volume 11, Page(s) 650136

    Language English
    Publishing date 2021-02-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.650136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The regulation of protein translation and its implications for cancer.

    Song, Ping / Yang, Fan / Jin, Hongchuan / Wang, Xian

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 68

    Abstract: In addition to the deregulation of gene transcriptions and post-translational protein modifications, the aberrant translation from mRNAs to proteins plays an important role in the pathogenesis of various cancers. Targeting mRNA translation are expected ... ...

    Abstract In addition to the deregulation of gene transcriptions and post-translational protein modifications, the aberrant translation from mRNAs to proteins plays an important role in the pathogenesis of various cancers. Targeting mRNA translation are expected to become potential approaches for anticancer treatments. Protein translation is affected by many factors including translation initiation factors and RNA-binding proteins. Recently, modifications of mRNAs mainly N6-methyladenine (m
    MeSH term(s) Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Neoplasms/genetics ; Protein Biosynthesis ; RNA, Messenger/genetics ; RNA, Untranslated/genetics ; RNA-Binding Proteins/biosynthesis ; RNA-Binding Proteins/genetics
    Chemical Substances MicroRNAs ; Neoplasm Proteins ; RNA, Messenger ; RNA, Untranslated ; RNA-Binding Proteins
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-020-00444-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Appraising the role of circulating concentrations of micro-nutrients in epithelial ovarian cancer risk: A Mendelian randomization analysis.

    Guo, Yan / Lu, Yunlong / Jin, Hongchuan

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 7356

    Abstract: To determine the causality of micro-nutrients concentrations and risk of ovarian cancer using the Mendelian randomization approach. Analyses were conducted using summary statistics data for SNPs robustly associated with concentrations of thirteen micro- ... ...

    Abstract To determine the causality of micro-nutrients concentrations and risk of ovarian cancer using the Mendelian randomization approach. Analyses were conducted using summary statistics data for SNPs robustly associated with concentrations of thirteen micro-nutrients (iron, copper, zinc, calcium, magnesium, phosphorus, selenium, vitamin A, β-carotene, vitamin B6, vitamin B12, vitamin E, folate). The corresponding data for ovarian cancer were obtained from the Ovarian Cancer Association Consortium (25,509 cases and 40,941 controls). In standard Mendelian randomization analysis, the odds ratios (OR) of invasive epithelial ovarian cancer were 0.14 (95% CI, 0.03-0.70; P = 0.02) per 0.1 mmol/L (about one standard deviation, SD) increase in genetically predicted magnesium concentration, 1.04 (95% CI, 1.00-1.09; P = 0.03) per 0.3 μmol/liter (about one SD) increase in genetically predicted β-carotene concentration. The OR of low malignant potential tumours were 0.82 (95% CI, 0.76-0.90; P = 1.01 × 10
    MeSH term(s) Carcinoma, Ovarian Epithelial/blood ; Carcinoma, Ovarian Epithelial/epidemiology ; Case-Control Studies ; Female ; Humans ; Magnesium/blood ; Mendelian Randomization Analysis ; Odds Ratio ; Ovarian Neoplasms/blood ; Ovarian Neoplasms/epidemiology ; Polymorphism, Single Nucleotide/genetics ; Vitamin B 12/blood ; beta Carotene/blood
    Chemical Substances beta Carotene (01YAE03M7J) ; Magnesium (I38ZP9992A) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-63909-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Recent advances of SIRT1 and implications in chemotherapeutics resistance in cancer.

    Yousafzai, Neelum Aziz / Jin, Hongchuan / Ullah, Mujib / Wang, Xian

    American journal of cancer research

    2021  Volume 11, Issue 11, Page(s) 5233–5248

    Abstract: Cancer is a big group of diseases and one of the leading causes of mortality worldwide. Despite enormous studies and efforts are being carried out in understanding the cancer and developing drugs against tumorigenesis, drug resistance is the main ... ...

    Abstract Cancer is a big group of diseases and one of the leading causes of mortality worldwide. Despite enormous studies and efforts are being carried out in understanding the cancer and developing drugs against tumorigenesis, drug resistance is the main obstacle in cancer treatments. Chemotherapeutic treatment is an important part of cancer treatment and drug resistance is getting gradually multidimensional with the advancement of studies in cancer. The underlying mechanisms of drug resistance are largely unknown. Sirtuin1 (SIRT1) is a type of the Class III histone deacetylase family that is distinctively dependent on nicotinamide adenine dinucleotide (NAD+) for catalysis reaction. SIRT1 is a molecule which upon upregulation directly influences tumor progression, metastasis, tumor cell apoptosis, autophagy, DNA repair, as well as other interlinked tumorigenesis mechanism. It is involved in drug metabolism, apoptosis, DNA damage, DNA repair, and autophagy, which are key hallmarks of drug resistance and may contribute to multidrug resistance. Thus, understanding the role of SIRT1 in drug resistance could be important. This study focuses on the SIRT1 based mechanisms that might be a potential underlying approach in the development of cancer drug resistance and could be a potential target for drug development.
    Language English
    Publishing date 2021-11-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Guanosine primes acute myeloid leukemia for differentiation via guanine nucleotide salvage synthesis.

    Wang, Hanying / He, Xin / Li, Zheng / Jin, Hongchuan / Wang, Xian / Li, Ling

    American journal of cancer research

    2022  Volume 12, Issue 1, Page(s) 427–444

    Abstract: Differentiation arrest represents a distinct hallmark of acute myeloid leukemia (AML). Identification of differentiation-induction agents that are effective across various subtypes remains an unmet challenge. GTP biosynthesis is elevated in several types ...

    Abstract Differentiation arrest represents a distinct hallmark of acute myeloid leukemia (AML). Identification of differentiation-induction agents that are effective across various subtypes remains an unmet challenge. GTP biosynthesis is elevated in several types of cancers, considered to support uncontrolled tumor growth. Here we report that GTP overload by supplementation of guanosine, the nucleoside precursor of GTP, poises AML cells for differentiation and growth inhibition. Transcriptome profiling of guanosine-treated AML cells reveals a myeloid differentiation pattern. Importantly, the treatment compromises leukemia progression in AML xenograft models. Mechanistically, GTP overproduction requires sequential metabolic conversions executed by the purine salvage biosynthesis pathway including the involvement of purine nucleoside phosphorylase (PNP) and hypoxanthine phosphoribosyltransferase 1 (HPRT1). Taken together, our study offers novel metabolic insights tethering GTP homeostasis to myeloid differentiation and provides an experimental basis for further clinical investigations of guanosine or guanine nucleotides in the treatment of AML patients.
    Language English
    Publishing date 2022-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Novel Defined PANoptosis-Related miRNA Signature for Predicting the Prognosis and Immune Characteristics in Clear Cell Renal Cell Carcinoma: A miRNA Signature for the Prognosis of ccRCC.

    Wang, Yanmei / Zhou, Jia / Zhang, Nan / Zhu, Yiran / Zhong, Yiming / Wang, Zhuo / Jin, Hongchuan / Wang, Xian

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent cancers, and PANoptosis is a distinct, inflammatory-programmed cell death regulated by the PANoptosome. The essential regulators of cancer occurrence and progression are microRNAs ( ... ...

    Abstract Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent cancers, and PANoptosis is a distinct, inflammatory-programmed cell death regulated by the PANoptosome. The essential regulators of cancer occurrence and progression are microRNAs (miRNAs). However, the potential function of PANoptosis-related microRNAs (PRMs) in ccRCC remains obscure. This study retrieved ccRCC samples from The Cancer Genome Atlas database and three Gene Expression Omnibus datasets. PRMs were recognized based on previous reports in the scientific literature. Regression analyses were used to identify the prognosis PRMs and construct a PANoptosis-related miRNA prognostic signature based on the risk score. We discovered that high-risk patients had poorer survival prognoses and were significantly linked to high-grade and advanced-stage tumors, using a variety of R software packages and web analysis tools. Furthermore, we demonstrated that the low-risk group had significant changes in their metabolic pathways. In contrast, the high-risk group was characterized by high immune cell infiltration, immune checkpoint expression, and low half-maximum inhibition concentration (IC50) values of chemotherapeutic agents. This suggests that high-risk patients may benefit more from immunotherapy and chemotherapy. In conclusion, we constructed a PANoptosis-related microRNA signature and revealed its potential significance in clinicopathological features and tumor immunity, thereby providing new precise treatment strategies.
    MeSH term(s) Humans ; MicroRNAs/genetics ; Carcinoma, Renal Cell/genetics ; Carcinoma ; Apoptosis ; Kidney Neoplasms/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-05-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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