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  1. Article ; Online: Plug-in Models: A Promising Direction for Molecular Generation.

    Liu, Ningfeng / Jin, Hongwei / Zhang, Liangren / Liu, Zhenming

    Health data science

    2023  Volume 3, Page(s) 92

    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2765-8783
    ISSN (online) 2765-8783
    DOI 10.34133/hds.0092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A combination of the modified catalytic core and conjugation of 3'-inverted deoxythymidine for a more efficient and nuclease-resistant 10-23 DNAzyme.

    Li, Yang / Du, Shanshan / Jin, Hongwei / He, Junlin

    Bioorganic & medicinal chemistry letters

    2022  Volume 62, Page(s) 128633

    Abstract: 10-23 DNAzyme is a catalytic DNA molecule capable of cleaving complementary RNA. Its high cleavage efficiency is being pursued by chemical modifications, for realizing its genetic therapeutics potential. The most efficient and nuclease-resistant DNAzyme ... ...

    Abstract 10-23 DNAzyme is a catalytic DNA molecule capable of cleaving complementary RNA. Its high cleavage efficiency is being pursued by chemical modifications, for realizing its genetic therapeutics potential. The most efficient and nuclease-resistant DNAzyme was obtained in this study combined two modifications - 7-aminopropyl-8-aza-7-deaza-2'-deoxyadenosine (residue 1) at A9 and 3'-inverted deoxythymidine residue (
    MeSH term(s) Catalytic Domain ; DNA ; DNA, Catalytic/chemistry ; Endonucleases ; RNA ; Thymidine
    Chemical Substances DNA, Catalytic ; RNA (63231-63-0) ; DNA (9007-49-2) ; Endonucleases (EC 3.1.-) ; Thymidine (VC2W18DGKR)
    Language English
    Publishing date 2022-02-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2022.128633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Immune checkpoints expression patterns in early-stage triple-negative breast cancer predict prognosis and remodel the tumor immune microenvironment.

    Zhang, Jinguo / Jin, Hongwei / Pan, Shuaikang / Han, Chaoqiang / Sun, Qingqing / Han, Xinghua

    Frontiers in immunology

    2023  Volume 14, Page(s) 1073550

    Abstract: Background: Currently, targeting immune checkpoint molecules holds great promise for triple-negative breast cancer (TNBC). However, the expression landscape of immune checkpoint genes (ICGs) in TNBC remains largely unknown.: Method: Herein, we ... ...

    Abstract Background: Currently, targeting immune checkpoint molecules holds great promise for triple-negative breast cancer (TNBC). However, the expression landscape of immune checkpoint genes (ICGs) in TNBC remains largely unknown.
    Method: Herein, we systematically investigated the ICGs expression patterns in 422 TNBC samples. We evaluated the ICGs molecular typing based on the ICGs expression profile and explored the associations between ICGs molecular subtypes and tumor immune characteristics, clinical significance, and response to immune checkpoint inhibitors (ICIs).
    Results: Two ICGs clusters and two ICGs-related gene clusters were determined, which were involved in different survival outcomes, biological roles and infiltration levels of immune cells. We established a quantification system ICGs riskscore (named IRS) to assess the ICGs expression patterns for individuals. TNBC patients with lower IRS were characterized by increased immune cell infiltration, favorable clinical outcomes and high sensitivity to ICIs therapy. We also developed a nomogram model combining clinicopathological variables to predict overall survival in TNBC. Genomic feature analysis revealed that high IRS group presented an increased tumor mutation burden compared with the low IRS group.
    Conclusion: Collectively, dissecting the ICGs expression patterns not only provides a new insight into TNBC subtypes but also deepens the understanding of ICGs in the tumor immune microenvironment.
    MeSH term(s) Humans ; Triple Negative Breast Neoplasms ; Prognosis ; Nomograms ; Clinical Relevance ; Genomics ; Immune Checkpoint Proteins ; Tumor Microenvironment
    Chemical Substances Immune Checkpoint Proteins
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1073550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nickel-catalyzed divergent formylation and carboxylation of aryl halides with isocyanides.

    Mao, Haoying / Qian, Hongwei / He, Zhichang / Zhang, Zhiguo / Jin, Hongwei / Liu, Yunkui / Zhou, Bingwei

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 16, Page(s) 3360–3364

    Abstract: Herein, we describe a nickel-catalyzed divergent formylation and carboxylation reaction of aryl halides with isocyanides. A rich array of aromatic aldehydes and carboxylic acids can be, respectively, accessed in moderate to good yields. Some sensitive ... ...

    Abstract Herein, we describe a nickel-catalyzed divergent formylation and carboxylation reaction of aryl halides with isocyanides. A rich array of aromatic aldehydes and carboxylic acids can be, respectively, accessed in moderate to good yields. Some sensitive functional groups such as hydroxyl, iodine, cyano, and indolyl are fairly tolerant of nickel catalysis. In the carboxylation reactions, the combination of isocyanide and H
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob00327b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Induced Self-Assembly of Vitamin E-Spermine/siRNA Nanocomplexes via Spermine/Helix Groove-Specific Interaction for Efficient siRNA Delivery and Antitumor Therapy.

    Zhao, Xiaoran / Xu, Qi / Wang, Qian / Liang, Xingxing / Wang, Jing / Jin, Hongwei / Man, Yizhi / Guo, Dongyang / Gao, Feng / Tang, Xinjing

    Advanced healthcare materials

    2024  Volume 13, Issue 11, Page(s) e2303186

    Abstract: Gene therapy has been one of potential strategies for the treatment of different diseases, where efficient and safe gene delivery systems are also extremely in need. Current lipid nanoparticles (LNP) technology highly depends on the packing and ... ...

    Abstract Gene therapy has been one of potential strategies for the treatment of different diseases, where efficient and safe gene delivery systems are also extremely in need. Current lipid nanoparticles (LNP) technology highly depends on the packing and condensation of nucleic acids with amine moieties. Here, an attempt to covalently link two natural compounds, spermine and vitamin E, is made to develop self-assembled nucleic acid delivery systems. Among them, the spermine moieties specifically interact with the major groove of siRNA helix through salt bridge interaction, while vitamin E moieties are located around siRNA duplex. Such amphiphilic vitamin E-spermine/siRNA complexes can further self-assemble into nanocomplexes like multiblade wheels. Further studies indicate that these siRNA nanocomplexes with the neutrally charged surface of vitamin E can enter cells via caveolin/lipid raft mediated endocytosis pathway and bypass lysosome trapping. With these self-assembled delivery systems, efficient siRNA delivery is successfully achieved for Eg5 and Survivin gene silencing as well as DNA plasmid delivery. Further in vivo study indicates that VE-Su-Sper/DSPE-PEG
    MeSH term(s) RNA, Small Interfering/chemistry ; Spermine/chemistry ; Animals ; Humans ; Vitamin E/chemistry ; Nanoparticles/chemistry ; Mice ; Cell Line, Tumor ; Mice, Nude ; Gene Transfer Techniques ; Mice, Inbred BALB C ; Survivin/genetics ; Survivin/metabolism ; Neoplasms/therapy
    Chemical Substances RNA, Small Interfering ; Spermine (2FZ7Y3VOQX) ; Vitamin E (1406-18-4) ; Survivin
    Language English
    Publishing date 2024-01-26
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202303186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
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  6. Article ; Online: Structural characteristics and biological activity of lactic acid bacteria exopolysaccharides separated by ethanol/(NH4)2SO4 ATPS

    Jiang, Bin / Chen, Peifeng / Guo, Jiaxuan / Han, Bing / Jin, Hongwei / Li, Dongmei / Liu, Chunhong / Feng, Zhibiao

    International Journal of Biological Macromolecules. 2023 July, v. 244 p.125451-

    2023  

    Abstract: Exopolysaccharides (EPS) from lactic acid bacteria (LAB) as edible and safe bioproducts with health benefits have become an interesting topic. In this study, aqueous two-phase system (ATPS) was established using ethanol and (NH₄)₂SO₄ as phase-forming ... ...

    Abstract Exopolysaccharides (EPS) from lactic acid bacteria (LAB) as edible and safe bioproducts with health benefits have become an interesting topic. In this study, aqueous two-phase system (ATPS) was established using ethanol and (NH₄)₂SO₄ as phase-forming substances to separate and purify LAB EPS from Lactobacillus plantarum 1.0665. The operating conditions were optimized by a single factor and response surface method (RSM). The results indicated that an effectively selective separation of LAB EPS was achieved by the ATPS consisted of 28 % (w/w) ethanol and 18 % (w/w) (NH₄)₂SO₄ at pH 4.0. Under optimized conditions, the partition coefficient (K) and recovery rate (Y) were well matched with the predicted value of 3.83 ± 0.019 and 74.66 ± 1.05 %. The physicochemical properties of purified LAB EPS were characterized by various technologies. According to the results, LAB EPS was a complex polysaccharide with a triple helix structure mainly composed of mannose, glucose and galactose in the molar ratio of 1.00: 0.32: 0.14, and it proved that the ethanol/(NH₄)₂SO₄ system had good selectivity for LAB EPS. In addition, LAB EPS displayed excellent antioxidant activity, antihypertension activity, anti-gout capacity and hypoglycemic activity in vitro analysis. The results suggested that LAB EPS could be a dietary supplement applied in functional foods.
    Keywords Lactobacillus plantarum ; antioxidant activity ; biobased products ; dietary supplements ; ethanol ; exopolysaccharides ; galactose ; glucose ; glycemic effect ; lactic acid ; mannose ; pH ; response surface methodology ; Aqueous two-phase system ; Physicochemical properties ; Biologic activity
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.125451
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    Zs.B 2374: Show issues Location:
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  7. Book ; Online: Orthogonal Gromov-Wasserstein Discrepancy with Efficient Lower Bound

    Jin, Hongwei / Yu, Zishun / Zhang, Xinhua

    2022  

    Abstract: Comparing structured data from possibly different metric-measure spaces is a fundamental task in machine learning, with applications in, e.g., graph classification. The Gromov-Wasserstein (GW) discrepancy formulates a coupling between the structured data ...

    Abstract Comparing structured data from possibly different metric-measure spaces is a fundamental task in machine learning, with applications in, e.g., graph classification. The Gromov-Wasserstein (GW) discrepancy formulates a coupling between the structured data based on optimal transportation, tackling the incomparability between different structures by aligning the intra-relational geometries. Although efficient \emph{local} solvers such as conditional gradient and Sinkhorn are available, the inherent non-convexity still prevents a tractable evaluation, and the existing lower bounds are not tight enough for practical use. To address this issue, we take inspiration from the connection with the quadratic assignment problem, and propose the orthogonal Gromov-Wasserstein (OGW) discrepancy as a surrogate of GW. It admits an efficient and \emph{closed-form} lower bound with $\mathcal{O}(n^3)$ complexity, and directly extends to the fused Gromov-Wasserstein (FGW) distance, incorporating node features into the coupling. Extensive experiments on both the synthetic and real-world datasets show the tightness of our lower bounds, and both OGW and its lower bounds efficiently deliver accurate predictions and satisfactory barycenters for graph sets.

    Comment: Published as a conference paper in UAI 2022
    Keywords Computer Science - Machine Learning ; Statistics - Machine Learning
    Subject code 006
    Publishing date 2022-05-11
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Synthesis and "DNA Interlocks" Formation of Small Circular Oligodeoxynucleotides.

    Gubu, Amu / Wang, Jing / Jin, Hongwei / Tang, Xinjing

    ACS applied materials & interfaces

    2020  Volume 12, Issue 11, Page(s) 12584–12590

    Abstract: Circular oligodeoxynucleotides (c-ODNs) have their particular characteristics in topological properties. However, different from oligoribonucleotides, enzymatic synthesis of small c-ODNs is still challenging using conventional methods. Herein, we ... ...

    Abstract Circular oligodeoxynucleotides (c-ODNs) have their particular characteristics in topological properties. However, different from oligoribonucleotides, enzymatic synthesis of small c-ODNs is still challenging using conventional methods. Herein, we successfully achieved highly efficient cyclization of linear single-stranded ODNs using T4 DNA ligase simply through the frozen/lyophilization/cyclization (FLC) method. We successfully shortened the cyclization length of linear ODNs to 20 nt (l-ODN 20) with up to 63% yield, which was never achieved before through normal enzymatic methods. With the efficient FLC method, we further developed "DNA interlocks" which were intercross-linked with multiple c-ODNs using the one-pot FLC method. This FLC strategy provides a powerful, cheap, and convenient method to synthesize small c-ODNs for studying DNA nanotechnology and paves the way to achieve future deciphering of c-ODN functions.
    MeSH term(s) Cyclization ; DNA Ligases/metabolism ; DNA, Single-Stranded/metabolism ; Freeze Drying ; Nanotechnology ; Oligodeoxyribonucleotides/chemistry ; Oligodeoxyribonucleotides/metabolism
    Chemical Substances DNA, Single-Stranded ; Oligodeoxyribonucleotides ; DNA Ligases (EC 6.5.1.-)
    Language English
    Publishing date 2020-03-09
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c00923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Synthesis and “DNA Interlocks” Formation of Small Circular Oligodeoxynucleotides

    Gubu, Amu / Wang, Jing / Jin, Hongwei / Tang, Xinjing

    ACS applied materials & interfaces. 2020 Feb. 26, v. 12, no. 11

    2020  

    Abstract: Circular oligodeoxynucleotides (c-ODNs) have their particular characteristics in topological properties. However, different from oligoribonucleotides, enzymatic synthesis of small c-ODNs is still challenging using conventional methods. Herein, we ... ...

    Abstract Circular oligodeoxynucleotides (c-ODNs) have their particular characteristics in topological properties. However, different from oligoribonucleotides, enzymatic synthesis of small c-ODNs is still challenging using conventional methods. Herein, we successfully achieved highly efficient cyclization of linear single-stranded ODNs using T4 DNA ligase simply through the frozen/lyophilization/cyclization (FLC) method. We successfully shortened the cyclization length of linear ODNs to 20 nt (l-ODN 20) with up to 63% yield, which was never achieved before through normal enzymatic methods. With the efficient FLC method, we further developed “DNA interlocks” which were intercross-linked with multiple c-ODNs using the one-pot FLC method. This FLC strategy provides a powerful, cheap, and convenient method to synthesize small c-ODNs for studying DNA nanotechnology and paves the way to achieve future deciphering of c-ODN functions.
    Keywords DNA ; enzymatic treatment ; freeze drying ; ligases ; nanotechnology ; oligodeoxyribonucleotides ; oligoribonucleotides ; topology
    Language English
    Dates of publication 2020-0226
    Size p. 12584-12590.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1944-8252
    DOI 10.1021/acsami.0c00923
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  10. Article: An Essential NRP1-Mediated Role for Tagln2 in Gastric Cancer Angiogenesis.

    Jin, Hongwei / Zheng, Wei / Hou, Jingjing / Peng, Huifang / Zhuo, Huiqin

    Frontiers in oncology

    2021  Volume 11, Page(s) 653246

    Abstract: Knowledge about the precise biological role and underlying mechanism of Tagln2 in tumor progression is relatively limited, especially in angiogenesis focused on tumor derived endothelial cells (ECs) has rarely been reported. Here, the function, molecular ...

    Abstract Knowledge about the precise biological role and underlying mechanism of Tagln2 in tumor progression is relatively limited, especially in angiogenesis focused on tumor derived endothelial cells (ECs) has rarely been reported. Here, the function, molecular mechanism and potential clinical value of Tagln2 in gastric cancer (GC) angiogenesis were investigated. GC tissue microarrays were used to assess the expression of Tagln2 in ECs. The relationships between expression and clinicopathological features were analyzed to evaluate the clinical value of Tagln2. Gain- and loss-of-function approaches were performed in ECs to investigate the functions of Tagln2 in angiogenesis. A combination of angiogenesis antibody array, RNA-Seq analyses and a series of
    Language English
    Publishing date 2021-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.653246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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