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Article ; Online: Biohydrogenation of 1,3-Butadiene to 1-Butene under Acetogenic Conditions by

Yang, Yi / Jin, Huijuan / Li, Xiuying / Yan, Jun

Environmental science & technology

2023 Volume 57, Issue 4, Page(s) 1637–1645

Abstract: The environmental fate and transformation mechanism(s) of 1,3-butadiene (BD) under anoxic conditions remain largely unexplored. Anaerobic consortia that can biohydrogenate BD to stoichiometric amounts of 1-butene at a maximum rate of 205.7 ± 38.6 μM ... ...

Abstract	The environmental fate and transformation mechanism(s) of 1,3-butadiene (BD) under anoxic conditions remain largely unexplored. Anaerobic consortia that can biohydrogenate BD to stoichiometric amounts of 1-butene at a maximum rate of 205.7 ± 38.6 μM day
MeSH term(s)	Acetobacterium/genetics ; RNA, Ribosomal, 16S
Chemical Substances	1,3-butadiene (JSD5FGP5VD) ; 1-butene (LY001N554L) ; RNA, Ribosomal, 16S
Language	English
Publishing date	2023-01-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.2c05683
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Article ; Online: Neuron Derived Cold-Inducible RNA-Binding Protein Promotes NETs Formation to Exacerbate Brain Endothelial Barrier Disruption after Ischemic Stroke.

Li, Zhifang / Sun, Shuai / Xiao, Qinghui / Tan, Senwei / Jin, Huijuan / Hu, Bo

Aging and disease

2024

Abstract: In ischemic stroke, neutrophils are the first-line peripheral immune cells infiltrating the brain tissue to form neutrophil extracellular traps (NETs). The present study aimed to investigate the role of neuronal cold-inducible RNA-binding protein (CIRP) ... ...

Abstract	In ischemic stroke, neutrophils are the first-line peripheral immune cells infiltrating the brain tissue to form neutrophil extracellular traps (NETs). The present study aimed to investigate the role of neuronal cold-inducible RNA-binding protein (CIRP) in promoting NETs-induced brain endothelial barrier destruction and cerebral edema after ischemic stroke. We found that the expression of NETs and neuronal CIRP in the penumbra increased at 6 hours after transient middle cerebral artery occlusion (tMCAO) and increased significantly at 24 hours, reaching a peak at 3 days. NETs degradation or CIRP inhibition can alleviate the leakage of brain endothelial barrier and reverse the decreased expression of tight junction proteins (zonula occludens-1, claudin-5 and occludin) in tMCAO mice. Oxygen-glucose deprivation/reperfusion treated primary neurons or recombinant CIRP could induce NETs formation via TLR4/p38 signaling pathway in vitro. Transcription factor specificity protein 1 (sp1) was responsible for the increased neuronal CIRP expression and the inhibition of sp1 could suppress the increased CIRP expression, reduce NETs formation, and diminish brain endothelial barrier leakage in tMCAO mice. We also found the upregulated CIRP level was associated with severe cerebral edema in patients with acute ischemic stroke. In conclusion, the increased expression of transcription factor sp1 after ischemic stroke can lead to elevated CIRP expression and release from the neurons, which subsequently interacts with neutrophils and promotes NETs formation, resulting in brain endothelial barrier destruction and cerebral edema.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625789-0
ISSN	2152-5250 ; 2152-5250
ISSN (online)	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2024.0204-1
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Article ; Online: Tektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella.

Geng, Xin-Yan / Jin, Hui-Juan / Xia, Lan / Wang, Bin-Bin / Chen, Su-Ren

Cellular and molecular life sciences : CMLS

2024 Volume 81, Issue 1, Page(s) 118

Abstract: Tektins are microtubule inner proteins (MIPs) and localize at the inside lumen of doublet microtubules (DMTs) of cilia/flagella. TEKTIP1, a newly identified protein by cryo-electron microscopy (cryo-EM), is proposed to be localized at the center of the ... ...

Abstract	Tektins are microtubule inner proteins (MIPs) and localize at the inside lumen of doublet microtubules (DMTs) of cilia/flagella. TEKTIP1, a newly identified protein by cryo-electron microscopy (cryo-EM), is proposed to be localized at the center of the tektin bundle and hypothesized to recruit tektins or stabilize the bundle. However, the physiological role of TEKTIP1 is unknown. In this study, we generated Tektip1-knockout (Tektip1
MeSH term(s)	Humans ; Male ; Animals ; Mice ; Female ; Axoneme ; Cryoelectron Microscopy ; Semen ; Sperm Motility ; Spermatozoa ; Flagella ; Microtubule Proteins
Chemical Substances	tektins ; Microtubule Proteins
Language	English
Publishing date	2024-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-023-05081-3
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Article ; Online: An updated review on prediction and preventive treatment of post-stroke depression.

Sun, Shuai / Li, Zhifang / Xiao, Qinghui / Tan, Senwei / Hu, Bo / Jin, Huijuan

Expert review of neurotherapeutics

2023 Volume 23, Issue 8, Page(s) 721–739

Abstract: Introduction: Post-stroke depression (PSD), one of the most common complications following stroke, affects approximately one-third of stroke patients and is significantly associated with increased disability and mortality as well as decreased quality of ...

Abstract	Introduction: Post-stroke depression (PSD), one of the most common complications following stroke, affects approximately one-third of stroke patients and is significantly associated with increased disability and mortality as well as decreased quality of life, which makes it an important public health concern. Treatment of PSD significantly ameliorates depressive symptoms and improves the prognosis of stroke. Areas covered: The authors discuss the critical aspects of the clinical application of prediction and preventive treatment of PSD. Then, the authors update the biological factors associated with the onset of PSD. Furthermore, they summarize the recent progress in pharmacological preventive treatment in clinical trials and propose potential treatment targets. The authors also discuss the current roadblocks in the preventive treatment of PSD. Finally, the authors put postulate potential directions for future studies so as to discover accurate predictors and provide individualized preventive treatment. Expert opinion: Sorting out high-risk PSD patients using reliable predictors will greatly assist PSD management. Indeed, some predictors not only predict the incidence of PSD but also predict prognosis, which indicates that they might also aid the development of an individualized treatment scheme. Preventive application of antidepressants may also be considered.
MeSH term(s)	Humans ; Depression/etiology ; Depression/prevention & control ; Quality of Life ; Risk Factors ; Stroke/drug therapy ; Antidepressive Agents/therapeutic use
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2112534-X
ISSN	1744-8360 ; 1473-7175
ISSN (online)	1744-8360
ISSN	1473-7175
DOI	10.1080/14737175.2023.2234081
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Article ; Online: Roles of N-terminal Annexin A2 phosphorylation sites and miR-206 in colonic adenocarcinoma.

Xiao, Li / Jin, Huijuan / Duan, Wei / Hou, Yingchun

Life sciences

2020 Volume 253, Page(s) 117740

Abstract: Aims: Annexin A2 (ANXA2) is closely associated with tumor malignancy and its N-terminus includes a vital domain for its function. The aims are to explore the correlation between the sites (Tyr23, Ser1, Ser11 and Ser25) in the domain and its roles.: ... ...

Abstract	Aims: Annexin A2 (ANXA2) is closely associated with tumor malignancy and its N-terminus includes a vital domain for its function. The aims are to explore the correlation between the sites (Tyr23, Ser1, Ser11 and Ser25) in the domain and its roles. Main methods: We re-expressed ANXA2 with mutated sites in ANXA2-deleted human colonic adenocarcinoma cell line caco2 (ANXA2-/-caco2). A series of analyses were used to determine the correlation of each site with ANXA2 activation, cell malignancy enhancement and motility-associated microstructural development. Bioinformatics and luciferase reporter assays were employed to validate ANXA2-targeted miRNAs. Key findings: The in vitro results showed that all single and multiple mutations of the ANXA2 N-terminal sites inhibited ANXA2 phosphorylation at different levels and subsequently inhibited the proliferation, motility, and polymerization of F-actin and β-tubulin in caco2 cells. Motility-associated microstructures were significantly remodeled when these sites were mutated. The forced expression of miR-206 significantly suppressed the proliferation, motility and epithelial-mesenchymal transition (EMT) of caco2 cells. The in vivo results showed that all the ANXA2 N-terminal site mutations and forced expression of miR-206 significantly inhibited tumor growth. Overall, this study demonstrated that the sites of the ANXA2 N-terminus, especially Tyr23, play crucial roles in maintaining the high malignancy of colonic adenocarcinoma. Furthermore, miR-206 targets ANXA2 and plays a role as a cancer suppressor in colonic adenocarcinoma. Significance: Our study provided evidence that further elucidates the molecular mechanism of ANXA2 and its roles in colonic adenocarcinoma and suggested potential targets of ANXA2 for colonic adenocarcinoma therapy by using miR-206 as a novel strategy.
MeSH term(s)	Actins/metabolism ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Animals ; Annexin A2/genetics ; Caco-2 Cells ; Cell Movement/genetics ; Cell Proliferation/genetics ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Epithelial-Mesenchymal Transition/genetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/genetics ; Phosphorylation/genetics ; Tubulin/metabolism ; Xenograft Model Antitumor Assays
Chemical Substances	ANXA2 protein, human ; Actins ; Annexin A2 ; MIRN206 microRNA, human ; MicroRNAs ; Tubulin
Language	English
Publishing date	2020-05-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.117740
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Article ; Online: Roles of N-terminal Annexin A2 phosphorylation sites and miR-206 in colonic adenocarcinoma

Xiao, Li / Jin, Huijuan / Duan, Wei / Hou, Yingchun

Life Sciences. 2020 July, v. 253 p.117740-

2020

Abstract: Annexin A2 (ANXA2) is closely associated with tumor malignancy and its N-terminus includes a vital domain for its function. The aims are to explore the correlation between the sites (Tyr23, Ser1, Ser11 and Ser25) in the domain and its roles. We re- ... ...

Abstract	Annexin A2 (ANXA2) is closely associated with tumor malignancy and its N-terminus includes a vital domain for its function. The aims are to explore the correlation between the sites (Tyr23, Ser1, Ser11 and Ser25) in the domain and its roles. We re-expressed ANXA2 with mutated sites in ANXA2-deleted human colonic adenocarcinoma cell line caco2 (ANXA2-/-caco2). A series of analyses were used to determine the correlation of each site with ANXA2 activation, cell malignancy enhancement and motility-associated microstructural development. Bioinformatics and luciferase reporter assays were employed to validate ANXA2-targeted miRNAs. The in vitro results showed that all single and multiple mutations of the ANXA2 N-terminal sites inhibited ANXA2 phosphorylation at different levels and subsequently inhibited the proliferation, motility, and polymerization of F-actin and β-tubulin in caco2 cells. Motility-associated microstructures were significantly remodeled when these sites were mutated. The forced expression of miR-206 significantly suppressed the proliferation, motility and epithelial-mesenchymal transition (EMT) of caco2 cells. The in vivo results showed that all the ANXA2 N-terminal site mutations and forced expression of miR-206 significantly inhibited tumor growth. Overall, this study demonstrated that the sites of the ANXA2 N-terminus, especially Tyr23, play crucial roles in maintaining the high malignancy of colonic adenocarcinoma. Furthermore, miR-206 targets ANXA2 and plays a role as a cancer suppressor in colonic adenocarcinoma. Our study provided evidence that further elucidates the molecular mechanism of ANXA2 and its roles in colonic adenocarcinoma and suggested potential targets of ANXA2 for colonic adenocarcinoma therapy by using miR-206 as a novel strategy.
Keywords	actin ; adenocarcinoma ; bioinformatics ; cell lines ; humans ; luciferase ; microRNA ; neoplasm cells ; phosphorylation ; polymerization ; therapeutics ; ANXA2 ; Phosphorylation sites ; miR-206 ; Colonic cancer ; Cancer malignancy
Language	English
Dates of publication	2020-07
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.117740
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Article ; Online: The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.

Zhang, Xiao-Zhen / Wei, Lin-Lin / Jin, Hui-Juan / Zhang, Xiao-Hui / Chen, Su-Ren

Cell reports

2022 Volume 40, Issue 1, Page(s) 111049

Abstract: The perinuclear theca (PT) is a cytoskeletal element encapsulating the sperm nucleus; however, our understanding of the physiological roles of PT in sperm is very limited. We show that Calicin interacts with itself and many other PT components, ... ...

Abstract	The perinuclear theca (PT) is a cytoskeletal element encapsulating the sperm nucleus; however, our understanding of the physiological roles of PT in sperm is very limited. We show that Calicin interacts with itself and many other PT components, indicating it may serve as an organizing center of the PT assembly. Calicin is detectable first when surrounding the acrosome, then detected around the entire nucleus, and finally translocated to the postacrosomal region of spermatid heads. Intriguingly, loss of Calicin specifically causes surface subsidence of sperm heads in the nuclear condensation stage. Calicin interacts with inner acrosomal membrane (IAM) protein Spaca1 and nuclear envelope (NE) components to form an "IAM-PT-NE" structure. Intriguingly, Ccin-knockout sperm also exhibit DNA damage and failure of fertilization. Our study provides solid animal evidence to suggest that the PT encapsulating sperm nucleus helps shape the sperm head and maintain the nuclear structure.
MeSH term(s)	Animals ; Cytoskeletal Proteins/metabolism ; Cytoskeleton/physiology ; Male ; Mice ; Semen/metabolism ; Sperm Head/metabolism ; Sperm Head/physiology
Chemical Substances	Cytoskeletal Proteins ; calicin
Language	English
Publishing date	2022-07-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2022.111049
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Article ; Online: Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.

Zhang, Xiao-Zhen / Wei, Lin-Lin / Zhang, Xiao-Hui / Jin, Hui-Juan / Chen, Su-Ren

Development (Cambridge, England)

2022 Volume 149, Issue 12

Abstract: The perinuclear theca (PT) is a cytoskeletal element encapsulating the sperm nucleus; however, the physiological roles of the PT in sperm are largely uncertain. Here, we reveal that ACTRT1, ACTRT2, ACTL7A and ACTL9 proteins interact to form a multimeric ... ...

Abstract	The perinuclear theca (PT) is a cytoskeletal element encapsulating the sperm nucleus; however, the physiological roles of the PT in sperm are largely uncertain. Here, we reveal that ACTRT1, ACTRT2, ACTL7A and ACTL9 proteins interact to form a multimeric complex and localize to the subacrosomal region of spermatids. Furthermore, we engineered Actrt1-knockout (KO) mice to define the functions of ACTRT1. Despite normal sperm count and motility, Actrt1-KO males were severely subfertile owing to a deficiency in fertilization. Loss of ACTRT1 caused a high incidence of malformed heads and detachment of acrosomes from sperm nuclei, caused by loosened acroplaxome structure during spermiogenesis. Furthermore, Actrt1-KO sperm showed reduced ACTL7A and PLCζ protein content as a potential cause of fertilization defects. Moreover, we reveal that ACTRT1 anchors developing acrosomes to the nucleus, likely by interacting with the inner acrosomal membrane protein SPACA1 and the nuclear envelope proteins PARP11 and SPATA46. Loss of ACTRT1 weakened the interaction between ACTL7A and SPACA1. Our study and recent findings of ACTL7A/ACTL9-deficient sperm together reveal that the sperm PT-specific ARP complex mediates the acrosome-nucleus connection.
MeSH term(s)	Acrosome/metabolism ; Animals ; Humans ; Infertility, Male/genetics ; Infertility, Male/metabolism ; Male ; Membrane Proteins/metabolism ; Mice ; Mice, Knockout ; Microfilament Proteins/metabolism ; Spermatids/metabolism ; Spermatogenesis/genetics ; Spermatozoa/metabolism
Chemical Substances	ACTRT1 protein, human ; Membrane Proteins ; Microfilament Proteins
Language	English
Publishing date	2022-06-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.200489
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Article ; Online: The Role of Oxidative Stress in Acute Ischemic Stroke-Related Thrombosis.

Li, Zhifang / Bi, Rentang / Sun, Shuai / Chen, Shengcai / Chen, Jiefang / Hu, Bo / Jin, Huijuan

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 8418820

Abstract: Acute ischemic stroke is a serious life-threatening disease that affects almost 600 million people each year throughout the world with a mortality of more than 10%, while two-thirds of survivors remain disabled. However, the available treatments for ... ...

Abstract	Acute ischemic stroke is a serious life-threatening disease that affects almost 600 million people each year throughout the world with a mortality of more than 10%, while two-thirds of survivors remain disabled. However, the available treatments for ischemic stroke are still limited to thrombolysis and/or mechanical thrombectomy, and there is an urgent need for developing new therapeutic target. Recently, intravascular oxidative stress, derived from endothelial cells, platelets, and leukocytes, has been found to be tightly associated with stroke-related thrombosis. It not only promotes primary thrombus formation by damaging endothelial cells and platelets but also affects thrombus maturation and stability by modifying fibrin components. Thus, oxidative stress is expected to be a novel target for the prevention and treatment of ischemic stroke. In this review, we first discuss the mechanisms by which oxidative stress promotes stroke-related thrombosis, then summarize the oxidative stress biomarkers of stroke-related thrombosis, and finally put forward an antithrombotic therapy targeting oxidative stress in ischemic stroke.
MeSH term(s)	Humans ; Ischemic Stroke/complications ; Brain Ischemia/complications ; Brain Ischemia/drug therapy ; Endothelial Cells ; Thrombosis/complications ; Stroke/drug therapy ; Oxidative Stress
Language	English
Publishing date	2022-11-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/8418820
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Article ; Online: Identification of CFAP52 as a novel diagnostic target of male infertility with defects of sperm head-tail connection and flagella development.

Jin, Hui-Juan / Ruan, Tiechao / Dai, Siyu / Geng, Xin-Yan / Yang, Yihong / Shen, Ying / Chen, Su-Ren

eLife

2023 Volume 12

Abstract: Male infertility is a worldwide population health concern. Asthenoteratozoospermia is a common cause of male infertility, but its etiology remains incompletely understood. No evidence indicates the relevance ... ...

Abstract	Male infertility is a worldwide population health concern. Asthenoteratozoospermia is a common cause of male infertility, but its etiology remains incompletely understood. No evidence indicates the relevance of
MeSH term(s)	Animals ; Humans ; Male ; Mice ; Cytoskeletal Proteins ; Flagella ; Infertility, Male/diagnosis ; Infertility, Male/genetics ; Mice, Knockout ; Microtubule Proteins ; Semen ; Sperm Head ; Sperm Tail
Chemical Substances	Cytoskeletal Proteins ; Microtubule Proteins ; CFAP52 protein, human
Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.92769
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