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Article: CCL7 and olfactory transduction pathway activation play an important role in the formation of CaOx and CaP kidney stones.

Zhang, Qiankun / Wei, Hhuiling / Huang, Gang / Jin, Lie

2024 Volume 14, Page(s) 1267545

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1267545
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Article ; Online: Calculated plasma volume status in hemodialysis patients.

Zhang, Qiankun / Fang, Hang / Jin, Lie

Renal failure

2024 Volume 46, Issue 1, Page(s) 2322685

Abstract: Background: Plasma volume (PV) calculated from hematocrit and body weight has applications in cardiovascular disease. The current study investigated the validity of the calculated PV for predicting volume overload and its prognostic utility in patients ... ...

Abstract	Background: Plasma volume (PV) calculated from hematocrit and body weight has applications in cardiovascular disease. The current study investigated the validity of the calculated PV for predicting volume overload and its prognostic utility in patients undergoing hemodialysis (HD). Patients and methods: Fifty-four HD patients were prospectively enrolled, and their actual PV (aPV) and relative PV status (PVS) were calculated. Bioelectrical impedance analysis (BIA) with assessment of and total body water (TBW), intracellular water (ICW), extracellular water (ECW), and overhydration (OH) and routine blood examinations were performed before dialysis. A second cohort of 164 HD patients was retrospectively enrolled to evaluate the relationship between the calculated PVS and the outcome, with an endpoint of all-cause mortality. Results: aPV was significantly associated with TBW, ICW, ECW, OH, and ECW/TBW (all Conclusions: aPV was most strongly associated with ECW measured using BIA. HD patients with higher time-averaged PVS had a higher rate of all-cause mortality.
MeSH term(s)	Humans ; Plasma Volume ; Retrospective Studies ; Body Water ; Renal Dialysis/adverse effects ; Water ; Electric Impedance
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2024.2322685
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Article ; Online: Performance and mechanism of a bioelectrochemical system for reduction of heavy metal cadmium ions.

Wang, XiaXia / Zhao, Yu / Jin, Li'E / Liu, Bin

RSC advances

2024 Volume 14, Issue 8, Page(s) 5390–5399

Abstract: This study explores the removal of Cd(ii) from wastewater using a microbial electrolysis cell (MEC) to investigate the electrochemical performance and removal kinetics of an anodic polarity reversal biocathode and the mechanism of action of ... ...

Abstract	This study explores the removal of Cd(ii) from wastewater using a microbial electrolysis cell (MEC) to investigate the electrochemical performance and removal kinetics of an anodic polarity reversal biocathode and the mechanism of action of electrochemically active bacteria. Comparative electrochemical methods showed that using an anodic polarity reversal biocathode resulted in greater than 90% removal of different concentrations of Cd(ii) within three days, which may be related to the catalytic effect of anodic electrochemically active bacteria. However, due to the ability of bacteria to regulate, up to nearly 2 mg L
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra07771c
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Article: Upadacitinib sustained-release tablets for the treatment of chronic refractory gouty arthritis: a case report and literature review.

Yu, Lishi / Huang, Weidong / Lv, Honghua / Jin, Lie / Lei, Wenhui

Frontiers in medicine

2024 Volume 11, Page(s) 1357117

Abstract: Background: Gouty arthritis (GA) is a crystal-related joint disease caused by the deposition of monosodium urate (MSU) crystals, directly associated with hyperuricemia resulting from purine metabolism disorder and/or reduced uric acid excretion. Acute ... ...

Abstract	Background: Gouty arthritis (GA) is a crystal-related joint disease caused by the deposition of monosodium urate (MSU) crystals, directly associated with hyperuricemia resulting from purine metabolism disorder and/or reduced uric acid excretion. Acute attacks of typical gouty arthritis are generally relieved through the clinical use of NSAIDs, colchicine, or glucocorticoids. However, managing patients with chronic refractory gout poses challenges due to complications such as multiple tophi, gouty nephropathy, diabetes, and gastrointestinal bleeding. While there have been numerous studies on gout in recent years, research specifically regarding chronic refractory gout remains limited. The management of such cases still faces several unresolved issues, including recurrent disease flare-ups and poor patient compliance leading to inadequate drug utilization and increased risk of side effects. In this report, we present a case of successful improvement in chronic refractory gouty arthritis using the biologic agent upadacitinib sustained-release tablets. Case presentation: Our case report involves a 53 years-old Asian patient with recurrent gouty arthritis who had a history of over 20 years without regular treatment, presenting with tophi and an increasing number of painful episodes. During hospitalization, various analgesics and anti-inflammatory drugs provided inadequate relief, requiring the use of steroids to alleviate symptoms. However, tapering off steroids proved challenging. We decided to add upadacitinib sustained-release tablets to the treatment regimen, which ultimately improved the patient's condition. After 6 months of follow-up, the patient has not experienced any further acute pain episodes. Conclusion: This case highlights the potential therapeutic effect of upadacitinib sustained-release tablets during the acute phase of chronic refractory gouty arthritis.
Language	English
Publishing date	2024-03-28
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1357117
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Article ; Online: Association of beta-2-microglobulin with cardiovascular and all-cause mortality in the general and non-CKD population.

Fang, Hang / Zhang, Qiankun / Jin, Lie

Medicine

2023 Volume 102, Issue 11, Page(s) e33202

Abstract: β-2 microglobulin, a light chain in the major histocompatibility complex Class 1 molecule, is associated with mortality in dialysis or uremic patients. Current evidence on the relationship between beta-2-microglobulin (B2M) and mortality in the general ... ...

Abstract	β-2 microglobulin, a light chain in the major histocompatibility complex Class 1 molecule, is associated with mortality in dialysis or uremic patients. Current evidence on the relationship between beta-2-microglobulin (B2M) and mortality in the general and non-chronic kidney disease (CKD) population are limited and controversial. Data from the nutrition and health examination survey database and the nutrition and health examination survey linked mortality file were used. In total, 10,388 adults who had complete data for B2M were included. Weighted multivariable Cox proportional hazards regression models and regression splines were employed to evaluate the relationship between B2M with mortality. Moreover, subgroup and sensitivity analyses were performed. During a median follow up of 17.9 years (interquartile range 15.2-18.7), 2780 people died, 902 (32%) from cardiovascular disease. Restricted cubic splines showed that B2M is J-shaped nonlinear positively associated with all-cause mortality and cardiovascular disease mortality in the non-CKD and general population. Based on the multivariable adjustment model, the adjusted hazard ratios comparing the highest versus lowest quartile of the distribution of B2M were 2.50 (95% confidence interval: 1.90, 3.28) for all-cause mortality in the general population, 2.58 (95% confidence interval: 1.52, 4.37) for cardiovascular disease mortality in the general population, 2.58 (1.91, 3.49) for all-cause mortality in the non-CKD population and 2.62 (1.52, 4.53) for cardiovascular disease mortality in the non-CKD population. The positive associations between B2M and outcomes remained broadly significant across subgroups and sensitivity analyses. Higher B2M levels were associated with cardiovascular and all-cause mortality in the general and non-CKD population.
MeSH term(s)	Adult ; Humans ; Cardiovascular Diseases/epidemiology ; Biomarkers ; Renal Dialysis/adverse effects ; Risk Factors
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033202
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Article ; Online: Engineering metallenes for boosting electrocatalytic biomass-oxidation-assisted hydrogen evolution reaction.

Yang, Lida / Wang, Kun / Jin, Lie / Xu, Hui / Chen, Haiqun

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 33, Page(s) 11378–11389

Abstract: Metallenes exhibit great potential for catalytic reaction, particularly for the hydrogen evolution reaction (HER) and biomass oxidation reaction, due to their favorable electronic configurations, ultrahigh specific surface areas, and highly accessible ... ...

Abstract	Metallenes exhibit great potential for catalytic reaction, particularly for the hydrogen evolution reaction (HER) and biomass oxidation reaction, due to their favorable electronic configurations, ultrahigh specific surface areas, and highly accessible surface atoms. Therefore, metallenes can function as bifunctional electrocatalysts to boost the energy-saving biomass-oxidation-assisted HER, and have attracted great interest. Given the growing importance of green hydrogen as an alternative energy source in recent years, it is timely and imperative to summarize the recent progress and current status of metallene-based catalysts for the biomass-oxidation-assisted HER. Here, we review the recent advances in metallenes in terms of composition and structural regulations including alloying, nonmetal doping, defect engineering, surface functionalization, and heterostructure engineering strategies and their applications in driving electrocatalytic HER, with special focus on biomass-oxidation-assisted hydrogen production. The underlying structure-activity relationship and mechanisms are also comprehensively discussed. Finally, we also propose the challenges and future directions of metallene-based catalysts for the applications in biomass-oxidation-assisted HER.
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt01562a
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Article: Synthesis and properties of L(AS)3-type low-molecular-mass organic gelators based on citryl aromatic amino acid cholesteryl ester

Huo, Li / Zhang, Haixia / Wang, Ying / Wang, Yaxiong / Deng, Bo / Jin, Li’e

Colloids and surfaces. 2022 Sept. 05, v. 648

2022

Abstract: Three types of L(AS)₃ gelators have been synthesized by the reaction of phenylalanine, tyrosine and tryptophan，whose amino were protected and reacted with cholesterol under the condition of citric acid as a linker, respectively. The synthetic gelators ... ...

Abstract	Three types of L(AS)₃ gelators have been synthesized by the reaction of phenylalanine, tyrosine and tryptophan，whose amino were protected and reacted with cholesterol under the condition of citric acid as a linker, respectively. The synthetic gelators performed strong gelation ability in cyclohexane and isopropanol. The structure, thermal stability and mechanical properties of the gels were observed; the gel formation mechanism was analyzed with XRD and SEM and the results showed that the hydrogen bonding and the π-π interaction force remarkably increased due to the existence of a great deal of amide bonds, ester bonds and aromatic rings in gelators. The gels are packed in a layered structure and are stable against temperature change. Among three gelators, citric acid tyrosine cholesterol ester displays a good gel-solution conversion under trifluoroacetic acid-triethylamine simulation in isopropanol. The study is expected to have application in the detection of organic amines in the field of sensing.
Keywords	cholesterol ; citric acid ; cyclohexanes ; gelation ; gels ; hydrogen ; isopropyl alcohol ; phenylalanine ; temperature ; thermal stability ; tyrosine
Language	English
Dates of publication	2022-0905
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2022.129197
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A nomogram to predict hyperkalemia in patients with hemodialysis: a retrospective cohort study.

Mei, Ziwei / Chen, Jun / Chen, Peipei / Luo, Songmei / Jin, Lie / Zhou, Limei

BMC nephrology

2022 Volume 23, Issue 1, Page(s) 351

Abstract: Background: Hyperkalemia increases the risk of mortality and cardiovascular-related hospitalizations in patients with hemodialysis. Predictors of hyperkalemia are yet to be identified. We aimed at developing a nomogram able to predict hyperkalemia in ... ...

Abstract	Background: Hyperkalemia increases the risk of mortality and cardiovascular-related hospitalizations in patients with hemodialysis. Predictors of hyperkalemia are yet to be identified. We aimed at developing a nomogram able to predict hyperkalemia in patients with hemodialysis. Methods: We retrospectively screened patients with end-stage renal disease (ESRD) who had regularly received hemodialysis between Jan 1, 2017, and Aug 31, 2021, at Lishui municipal central hospital in China. The outcome for the nomogram was hyperkalemia, defined as serum potassium [K Results: A total of 401 patients were enrolled in this study. 159 (39.65%) patients were hyperkalemia. All participants were divided into development (n = 256) and validation (n = 145) cohorts randomly. Predictors in this nomogram were the number of hemodialysis session, blood urea nitrogen (BUN), serum sodium, serum calcium, serum phosphorus, and diabetes. The ROC curve of the training set was 0.82 (95%CI 0.77, 0.88). Similar ROC curve was achieved at validation set 0.81 (0.74, 0.88). The calibration curve demonstrated that the prediction outcome was correlated with the observed outcome. Conclusion: This nomogram helps clinicians in predicting the risk of PEW and managing serum potassium in the patients with hemodialysis.
MeSH term(s)	Humans ; Nomograms ; Retrospective Studies ; Hyperkalemia ; Cohort Studies ; Renal Dialysis ; Potassium
Chemical Substances	Potassium (RWP5GA015D)
Language	English
Publishing date	2022-11-01
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-022-02976-4
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Article ; Online: Comparative efficacy of intravenous and oral iron supplements for the treatment of iron deficiency in patients with heart failure: A network meta-analysis of randomized controlled trials.

Mei, Ziwei / Chen, Jun / Luo, Songmei / Jin, Lie / Liu, Qiang / Chen, Yijie

Pharmacological research

2022 Volume 182, Page(s) 106345

Abstract: Objective: We aimed at comparing the efficacy of intravenous and oral iron supplementations for the treatment of iron deficiency (ID) in patients with heart failure (HF).: Methods: We searched the PubMed, Cochrane, and Embase databases from inception ...

Abstract	Objective: We aimed at comparing the efficacy of intravenous and oral iron supplementations for the treatment of iron deficiency (ID) in patients with heart failure (HF). Methods: We searched the PubMed, Cochrane, and Embase databases from inception to January 15, 2022. We included randomized controlled trials enrolling patients with HF who were treated for ID with intravenous iron supplements, oral iron supplements, or placebo. The primary outcomes were all-cause death, cardiovascular mortality, and hospitalization for heart failure. The secondary outcomes were evaluated through the six-minute walking test (6MWT) and the Kansas City Cardiomyopathy Questionnaire (KCCQ). Results: The network meta-analysis included sixteen studies. Compared to placebo/control groups, intravenous iron supplements did not decrease all-cause death (0.69, 0.39-1.23) or cardiovascular mortality (0.89, 0.66-1.20). After 12 weeks, a reduced hospitalization for heart failure was associated with the administration of intravenous iron supplementations (0.58, 0.34-0.97). The most significant improvements regarding 6MWT (44.44, 6.10-82.79) and KCCQ (5.96, 3.19-8.73) were observed with intravenous iron supplements. Oral iron supplements reduced hospitalization for heart failure (0.36, 0.14-0.96) and all-cause death (0.34, 0.12-0.95), but did not influence the 6MWT (29.74, -47.36 to 106.83) and KCCQ (0.10, -10.95 to 11.15). Conclusions: Administering intravenous iron supplements for ID in patients with HF improves their exercise capacity and quality of life. In order to reduce hospitalizations for heart failure, the supplementation should be administered for more than 12 weeks. Although oral iron supplements did not improve exercise capacity and quality of life, they could reduce all-cause death and hospitalizations for heart failure.
MeSH term(s)	Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/drug therapy ; Dietary Supplements ; Heart Failure/drug therapy ; Humans ; Iron/therapeutic use ; Iron Deficiencies ; Maltose/therapeutic use ; Network Meta-Analysis ; Quality of Life ; Randomized Controlled Trials as Topic ; Treatment Outcome
Chemical Substances	Maltose (69-79-4) ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-07-08
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2022.106345
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Article ; Online: A network meta-analysis of the efficacy of hypoxia-inducible factor prolyl-hydroxylase inhibitors in dialysis chronic kidney disease.

Chen, Jun / Shou, Xinyang / Xu, Yanyan / Jin, Lie / Zhu, Chaoyong / Ye, Xiaolan / Mei, Ziwei / Chen, Peipei

Aging

2023 Volume 15, Issue 6, Page(s) 2237–2274

Abstract: Background: Five types of HIF-PHIs have been authorized for anemia treatment in CKD patients in China and Japan. These are enarodustat, roxadustat, daprodustat, vadadustat, and molidustat. How effectively they compare to ESAs about clinical results in ... ...

Abstract	Background: Five types of HIF-PHIs have been authorized for anemia treatment in CKD patients in China and Japan. These are enarodustat, roxadustat, daprodustat, vadadustat, and molidustat. How effectively they compare to ESAs about clinical results in CKD-DD patients is uncertain. This study examined the RCT evidence about the benefits and risks of HIF-PHIs and ESAs in dialysis CKD patients. Methods: We conducted an extensive investigation and network meta-analysis of RCTs. In these RCTs, patients with CKD-DD received one of five different HIF-PHI or ESAs, a placebo, and no medical intervention. Outcomes included hemoglobin, iron parameters, and adverse events, and there were four weeks of follow-up at least. A frequentist framework for multivariate random effects meta-analyzed the results. The effect sizes of categorical variables were displayed as odds ratios. Mean differences were employed for computing continuous outcomes with common units; otherwise, standardized mean differences were applied. The Cochrane tool evaluated the bias risk in RCTs. Results: 26 RCTs with 14945 patients were qualified for inclusion. Compared to the placebo, HIF-PHIs and ESAs dramatically boosted hemoglobin without affecting serum iron. Roxadustat performed better hemoglobin levels than ESAs (MD 0.32, 95% CI 0.10 to 0.53) and daprodustat (0.46, 0.09 to 0.84). Roxadustat (91.8%) was the top hemoglobin treatment among all medical interventions, as determined by the SUCRA ranking. However, roxadustat caused more thrombosis and hypertension than ESAs (1.61, 1.22 to 2.12) and vadadustat (1.36, 1.01 to 1.82). The lowest rates of hypertension and thrombosis were seen in molidustat (80.7%) and ESAs (88.5%). Compared with a placebo, ESAs and HIF-PHIs all affected TSAT levels. Except for molidustat, the other four HIF-PHIs impact different iron parameters. Regarding ferritin reduction, roxadustat (90.9%) and daprodustat (60.9%) came out on top. Enarodustat (80.9%) and roxadustat (74%) placed best and second in lowering hepcidin levels. The former two medicines for TIBC improvement were vadadustat (98.7%) and enarodustat (80.9%). Conclusion: The most effective treatment for hemoglobin correction is roxadustat. The superior efficacy of reducing hepcidin makes roxadustat and enarodustat appropriate for patients with inflammation. However, the increased risk of hypertension and thrombosis associated with roxadustat should be noted. In patients at risk for hypertension and thrombosis, molidustat and ESAs may be preferable options. When administering roxadustat and daprodustat, clinicians should check ferritin to assess iron storage. Lower TSAT in patients receiving HIF-PHIs and ESAs treatment suggests intravenous iron supplements are needed.
MeSH term(s)	Humans ; Hepcidins ; Prolyl-Hydroxylase Inhibitors/therapeutic use ; Prolyl Hydroxylases ; Network Meta-Analysis ; Renal Dialysis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Hemoglobins/metabolism ; Iron ; Hypertension/complications ; Procollagen-Proline Dioxygenase ; Ferritins ; Hypoxia/complications
Chemical Substances	Hepcidins ; Prolyl-Hydroxylase Inhibitors ; Prolyl Hydroxylases (EC 1.14.11.-) ; Hemoglobins ; Iron (E1UOL152H7) ; Procollagen-Proline Dioxygenase (EC 1.14.11.2) ; Ferritins (9007-73-2)
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204611
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