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Article: Caveolin-1 in endothelial cells: A potential therapeutic target for atherosclerosis.

Shu, Yan / Jin, Si

2023 Volume 9, Issue 8, Page(s) e18653

Abstract: Atherosclerosis (AS) is a chronic vascular disease characterized by lipid accumulation and the activation of the inflammatory response; it remains the leading nation-wide cause of death. Early in the progression of AS, stimulation by pro-inflammatory ... ...

Abstract	Atherosclerosis (AS) is a chronic vascular disease characterized by lipid accumulation and the activation of the inflammatory response; it remains the leading nation-wide cause of death. Early in the progression of AS, stimulation by pro-inflammatory agonists (TNF-α, LPS, and others), oxidized lipoproteins (ox-LDL), and biomechanical stimuli (low shear stress) lead to endothelial cell activation and dysfunction. Consequently, it is crucial to investigate how endothelial cells respond to different stressors and ways to alter endothelial cell activation in AS development, as they are the earliest cells to respond. Caveolin-1 (Cav1) is a 21-24-kDa membrane protein located in caveolae and highly expressed in endothelial cells, which plays a vital role in regulating lipid transport, inflammatory responses, and various cellular signaling pathways and has atherogenic effects. This review summarizes recent studies on the structure and physiological functions of Cav1 and outlines the potential mechanisms it mediates in AS development. Included are the roles of Cav1 in the regulation of endothelial cell autophagy, response to shear stress, modulation of the eNOS/NO axis, and transduction of inflammatory signaling pathways. This review provides a rationale for proposing Cav1 as a novel target for the prevention of AS, as well as new ideas for therapeutic strategies for early AS.
Language	English
Publishing date	2023-07-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e18653
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Article ; Online: A systematic review and meta-analysis of the comparative curative effects of warm acupuncture and other traditional Chinese medicines in the treatment of knee osteoarthritis.

Jin, Si'an / Guan, Xuefeng

Annals of palliative medicine

2022 Volume 11, Issue 2, Page(s) 708–716

Abstract: Background: Knee osteoarthritis (KOA) is more common in middle-aged and elderly people, and seriously affects the quality of life of those affected. Traditional Chinese medicine (TCM) treatment of KOA has been widely recognized. In recent years, warm ... ...

Abstract	Background: Knee osteoarthritis (KOA) is more common in middle-aged and elderly people, and seriously affects the quality of life of those affected. Traditional Chinese medicine (TCM) treatment of KOA has been widely recognized. In recent years, warm needling acupuncture (WNA) has been used to treat KOA and has achieved good results. However, there is a lack of comparison of the efficacy of WNA and other TCM treatments for KOA. Methods: We conducted a search for reports of WNA and/or TCM treatment of KOA in English- and Chinese-language databases. The data was retrieved from inception of the database until October 2021. The Cochrane risk of bias tool was used to evaluate the quality of the included studies, and the network meta-analysis was performed using the software RevMan 5.20. Results: A total of 8 articles met the inclusion criteria, including 399 patients treated with WNA (WNA group), and 396 patients treated with other TCM (TCM group). The results of meta-analysis showed that compared with patients in the TCM group, the effective rate [relative risk (RR)] was 1.18, 95% confidence interval (CI): 1.06 to 1.33, the last follow-up osteoarthritis index [mean difference (MD)] was -6.93, 95% CI: -12.14 to -1.72, and the last follow-up knee pain visual analogue scale (VAS) MD was -1.06, 95% CI: -1.61 to -0.51, which were all statistically significant. However, the difference in daily activities (MD: -4.31, 95% CI: -10.90 to 2.28) was not statistically significant. Discussion: Compared with other TCM treatments for KOA, WNA has better overall patient efficacy. However, further randomized controlled studies are needed to compare WNA and other TCM treatments individually to confirm the efficacy of WNA.
MeSH term(s)	Acupuncture Therapy/methods ; Aged ; China ; Humans ; Medicine, Chinese Traditional ; Middle Aged ; Osteoarthritis, Knee/therapy ; Quality of Life
Language	English
Publishing date	2022-03-05
Publishing country	China
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-21-3972
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Article: Last Interglacial (MIS 5e) sea surface hydrographic conditions in coastal southern California based on dinoflagellate cysts

Over, Jin-Si / Pospelova, Vera

Palaeogeography, palaeoclimatology, palaeoecology. 2022 Apr. 01, v. 591

2022

Abstract: The first high resolution record of dinoflagellate cysts ∼110–155 kyr over Termination II and the Last Interglacial in the Santa Barbara Basin, California from ODP Hole 893A details a complex paleoceanographic history. Variation in cyst relative ... ...

Abstract	The first high resolution record of dinoflagellate cysts ∼110–155 kyr over Termination II and the Last Interglacial in the Santa Barbara Basin, California from ODP Hole 893A details a complex paleoceanographic history. Variation in cyst relative abundances, concentrations, and diversity reflects climatic and ocean circulation changes, and the assemblages are used to make qualitative reconstructions of sea surface temperature (SST) and annual primary productivity. The dominance of heterotrophic Brigantedinium spp. throughout the section indicates an important influence of coastal upwelling on the basin. Based on the dinoflagellate cyst assemblages, five zones are identified, which approximately correspond to the marine isotope stage boundaries and their associated changes in SST and sea level. Cooler intervals, MIS 6 and MIS 5d, are characterized by cold-water indicator species Selenopemphix undulata whereas thermophilic taxon Spiniferites mirabilis characterizes a warm MIS 5e. In contrast to other studies in the Pacific, the data exhibits a one to two-thousand-year cooling event ∼129 kyr that correlates to the Termination II sea level still-stand of the two-step deglaciation. A significant increase in cyst concentrations in the latest MIS 5e implies enhanced primary production due to increased seasonal upwelling and the warm, nutrient rich waters entering the basin after sea level stabilizes near modern levels. The hydrological evolution and cyst signal of the Last Interglacial is similar to the development of the Holocene in the Santa Barbara Basin, but the sustained presence of Spiniferites mirabilis across MIS 5e indicates SSTs were higher than modern conditions.
Keywords	Holocene epoch ; Miozoa ; basins ; glaciation ; indicator species ; palaeogeography ; paleoceanography ; paleoclimatology ; paleoecology ; primary productivity ; sea level ; surface water temperature ; water ; California
Language	English
Dates of publication	2022-0401
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	417718-6
ISSN	0031-0182
ISSN	0031-0182
DOI	10.1016/j.palaeo.2022.110875
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Article ; Online: Unveiling the Research Landscape and Emerging Trends in Cell Cycle for Cancer Immunotherapy: A Bibliometric Analysis (1990-2022).

Feng, Cheng / Li, Yuan / Zang, Mengya / Jin-Si-Han, E-Er-Man-Bie-Ke / He, Meng / Lu, Zhenhai

Medical science monitor : international medical journal of experimental and clinical research

2023 Volume 29, Page(s) e940556

Abstract: BACKGROUND The direct and indirect roles of the cell cycle in immunology of the tumor microenvironment (TME) are topics of intense scientific interest. Therefore, this study aimed to investigate the knowledge domain and hotspots related to the cell cycle ...

Abstract	BACKGROUND The direct and indirect roles of the cell cycle in immunology of the tumor microenvironment (TME) are topics of intense scientific interest. Therefore, this study aimed to investigate the knowledge domain and hotspots related to the cell cycle for cancer immunology applications. MATERIAL AND METHODS The Web of Science Core Collection (WoSCC) was used as a powerful tool for identifying articles related to cell cycle for cancer immunology applications. Co-occurrence relationships were examined with R, VOSviewer, and CiteSpace software. Related research hotspots and possible future trends were also examined. RESULTS A total of 1844 qualified English-language documents were obtained in WoSCC between 1999 and 2022, with a 7.66% annual growth rate. These eligible studies were co-authored by 2246 institutions in 51 countries/regions, with the greatest article number being published in the United States (36%, 664/1844), followed by China (19%, 351/1844) and Germany (4.5%, 83/1844). The top 3 institutions with the most publications and the top 3 academic journals (n=390 in total) on this topic that published the most articles were identified. Key nodes from the co-cited network were aggregated and identified to reveal the shift in cell cycle for cancer immunology applications. Notably, the current research hotspots in this field include "tumor progression", "chemotherapy", "resistance", "clinical trial", and "target population". CONCLUSIONS This study revealed field profiles, research hotspots, and future directions of cell cycle dysregulation-related immunology, and the findings will offer a vigorous roadmap for further studies in the combination therapy of cell cycle inhibitors and immune checkpoint inhibitors for treating various cancers. Our results can shed more light on relevant research in this field.
MeSH term(s)	Humans ; Cell Cycle ; Cell Division ; Bibliometrics ; Immunotherapy ; Neoplasms/therapy ; Tumor Microenvironment
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.940556
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Zs.A 4924: Show issues

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Article: Editorial: Advances of endocrine and metabolic cardiovascular outcomes: From basic to clinical science, volume II.

Cheng, Wenzhuo / Ding, Ye / Xu, Chengqi / Lu, Qiulun / Jin, Si

Frontiers in endocrinology

2023 Volume 13, Page(s) 1114632

MeSH term(s)	Humans ; Cardiovascular Diseases ; Cardiovascular System ; Heart
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1114632
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Article ; Online: Nipple margin assessment at the time of nipple-sparing mastectomy.

Cadili, Lina / Pao, Jin-Si / McKevitt, Elaine / Dingee, Carol / Bazzarelli, Amy / Warburton, Rebecca

Canadian journal of surgery. Journal canadien de chirurgie

2023 Volume 66, Issue 3, Page(s) E298–E303

Abstract: Background: Documenting negative margins at the nipple-areolar complex (NAC) during nipple-sparing mastectomy (NSM) remains the standard, but how to achieve this and how to manage a positive margin is debated. We sought to review nipple margin ... ...

Abstract	Background: Documenting negative margins at the nipple-areolar complex (NAC) during nipple-sparing mastectomy (NSM) remains the standard, but how to achieve this and how to manage a positive margin is debated. We sought to review nipple margin assessments at our institution and to analyze the risk factors of a positive margin and rate of local recurrence. Methods: Patients who underwent NSM between 2012 and 2018 were reviewed and divided into 3 groups based on indication - cancer, contralateral prophylactic mastectomy (CPM) and bilateral prophylactic mastectomy (BPM). Results: Nipple-sparing mastectomies were performed on 337 patients; 72% for cancer, 20% for CPMs and 8% for BPMs. Nipple margin assessments were performed in 87.8% of patients; 10 patients (3.4%) had a positive margin, 7 of whom underwent NAC excision and 3 were managed with observation. Conclusion: As indications for NSM increase, assessment of nipple margin provides valuable information to manage the NAC in patients with cancer. The routine use of nipple margin biopsies in patients undergoing CPM and BPM may no longer be required, as rates of occult malignant disease are low with no positive biopsies. Further studies with larger sample sizes are needed.
MeSH term(s)	Humans ; Female ; Mastectomy ; Breast Neoplasms/surgery ; Nipples/surgery ; Biopsy ; Risk Factors
Language	English
Publishing date	2023-05-24
Publishing country	Canada
Document type	Journal Article
ZDB-ID	410651-9
ISSN	1488-2310 ; 0008-428X
ISSN (online)	1488-2310
ISSN	0008-428X
DOI	10.1503/cjs.001922
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Article ; Online: Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility.

Wang, Jin-Si / Zhao, Ke-Xin / Zhang, Kun / Pannecouque, Christophe / De Clercq, Erik / Wang, Shuai / Chen, Fen-Er

Bioorganic chemistry

2024 Volume 147, Page(s) 107340

Abstract: In pursuit of enhancing the anti-resistance efficacy and solubility of our previously identified NNRTI 1, a series of biphenyl-quinazoline derivatives were synthesized employing a structure-based drug design strategy. Noteworthy advancements in anti- ... ...

Abstract	In pursuit of enhancing the anti-resistance efficacy and solubility of our previously identified NNRTI 1, a series of biphenyl-quinazoline derivatives were synthesized employing a structure-based drug design strategy. Noteworthy advancements in anti-resistance efficacy were discerned among some of these analogs, prominently exemplified by compound 7ag, which exhibited a remarkable 1.37 to 602.41-fold increase in potency against mutant strains (Y181C, L100I, Y188L, F227L + V106A, and K103N + Y181C) in comparison to compound 1. Compound 7ag also demonstrated comparable anti-HIV activity against both WT HIV and K103N, albeit with a marginal reduction in activity against E138K. Of significance, this analog showed augmented selectivity index (SI > 5368) relative to compound 1 (SI > 37764), Nevirapine (SI > 158), Efavirenz (SI > 269), and Etravirine (SI > 1519). Moreover, it displayed a significant enhancement in water solubility, surpassing that of compound 1, Etravirine, and Rilpivirine. To elucidate the underlying molecular mechanisms, molecular docking studies were undertaken to probe the critical interactions between 7ag and both WT and mutant strains of HIV-1 RT. These findings furnish invaluable insights driving further advancements in the development of DAPYs for HIV therapy.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2024.107340
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Zs.A 4207: Show issues

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Article: Successful endovascular thrombectomy using solitaire FR stent with intermediate catheter assisting technique for acute persistent primitive trigeminal artery and basilar artery occlusion: A case report and literature review.

Chen, Li / Deng, Yu Shi / Wang, Lan Yu / Mao, Xi Quan / Zhang, De Chou / Liu, Zu Tian / Yang, Jin Si

Surgical neurology international

2024 Volume 15, Page(s) 93

Abstract: Background: The persistent primitive trigeminal artery (PPTA) is a persistent embryological carotid-basilar connection. Endovascular thrombectomy (EVT) for hypoplastic PPTA occlusion is a challenge. This case report aims to describe the successful ... ...

Abstract	Background: The persistent primitive trigeminal artery (PPTA) is a persistent embryological carotid-basilar connection. Endovascular thrombectomy (EVT) for hypoplastic PPTA occlusion is a challenge. This case report aims to describe the successful recanalization of simultaneous occlusions in both the PPTA and basilar artery (BA) using the Solitaire FR (RECO SR)/Stent and Intermediate Catheter Assisting (SWIM) technique in a patient with acute cardiogenic cerebral embolism. To the best of our knowledge, this is the first report of such a case. Case description: We present a case of a 70-year-old female patient who presented with acute right-sided hemiparesis and altered consciousness. Digital subtraction angiography confirmed the occlusion of both the distal portion of the PPTA and the BA. The patient underwent EVT using the SWIM technique, resulting in successful recanalization and significant improvement in the patient's condition. Conclusion: This case report demonstrates the successful application of the SWIM technique in achieving recanalization and improving outcomes in a patient with simultaneous occlusion of the acute PPTA and BA. These findings support the potential use of EVT in similar cases.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Case Reports
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_997_2023
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Article ; Online: Paget's disease of the breast: Presentation, treatment, and outcomes in a modern cohort.

Mousa-Doust, Dorsa / Warburton, Rebecca / Pao, Jin-Si / Dingee, Carol / Bazzarelli, Amy / Newman-Bremang, Jieun / McKevitt, Elaine

American journal of surgery

2024 Volume 231, Page(s) 18–23

Abstract: Background: Surgical management for Paget's disease (PD) of the breast is controversial. This study aims to assess outcomes of PD patients based on procedure type and determine the reliability of imaging in estimating disease extent.: Methods: A ... ...

Abstract	Background: Surgical management for Paget's disease (PD) of the breast is controversial. This study aims to assess outcomes of PD patients based on procedure type and determine the reliability of imaging in estimating disease extent. Methods: A retrospective review analyzed clinicopathologic data of PD patients between 2009 and 2022. Pre-operative imaging size (PIS) was compared to post-operative pathology size (PPS) looking at concordance. Results: Thirty patients had PD, 21 underwent total mastectomy (TM) and 9 breast conserving surgery (BCS). Seventeen patients (56.7 %) had a final diagnosis of invasive cancer (14 TM, 3 BCS), with no local recurrences. Only 6/19 (31.6 %) patients with positive findings on ultrasound/mammogram had concordance between PIS and PPS. There were no breast/chest wall recurrences with a median follow up of 35.9 months. Conclusion: Ultrasound and mammogram had poor concordance with pathological size. BCS is feasible in select patients. MRI may help guide management.
MeSH term(s)	Humans ; Female ; Paget's Disease, Mammary/diagnostic imaging ; Paget's Disease, Mammary/surgery ; Mastectomy ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Reproducibility of Results ; Breast/pathology ; Retrospective Studies ; Adenocarcinoma/surgery
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2024.01.026
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Article ; Online: Preoperative depression and anxiety associated with younger age and receipt of immediate breast reconstruction.

Tang, Katelynn / Sutherland, Jason M / Liu, Guiping / Crump, Trafford / Bazzarelli, Amy / Dingee, Carol / Pao, Jin-Si / Warburton, Rebecca / McKevitt, Elaine

American journal of surgery

2024 Volume 231, Page(s) 106–112

Abstract: Background: As survivorship for breast cancer continues to improve, emphasis of care falls upon improving patients' quality of life. Understanding physical and mental health in the preoperative period is needed to aid surgical decision making and ... ...

Abstract	Background: As survivorship for breast cancer continues to improve, emphasis of care falls upon improving patients' quality of life. Understanding physical and mental health in the preoperative period is needed to aid surgical decision making and improve patient experience. Methods: Consecutive patients awaiting total mastectomy (TM), TM with immediate breast reconstruction (IBR) and breast conserving surgery (BCS) were prospectively recruited. Scores for PHQ-9, GAD-7, Breast-Q, EQ5D(5L), PEG were collected preoperatively. Association was measured with multivariate analyses. Results: 477 participants (374 BSC, 46 TM, 84 IBR) were included. Younger patients and those choosing IBR reported worse depression and anxiety symptoms. Clinical tumor features did not affect patient reported outcomes. Higher Breast-Q scores were seen with BCS and lower scores with TM. Conclusions: Patients scheduled for IBR and younger patients reported worse symptoms of depression and anxiety, regardless of clinical features. This will help with surgical decision making and identify patients in need for additional perioperative supports.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/surgery ; Mastectomy/psychology ; Quality of Life ; Depression/epidemiology ; Depression/etiology ; Mammaplasty ; Anxiety/epidemiology ; Anxiety/etiology
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2024.02.012
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