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  1. Article: Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway.

    Jin, Wenyin / Shen, Yinfeng

    Evidence-based complementary and alternative medicine : eCAM

    2019  Volume 2019, Page(s) 3909468

    Abstract: Objective: To investigate the effect of Da-Cheng-Qi decoction (DCQD) on treating intestinal injury in rats with severe acute pancreatitis (SAP), based on the Janus kinase 2 (JAK2)/signal transducers and transcription 3 (STAT3) signaling pathway.: ... ...

    Abstract Objective: To investigate the effect of Da-Cheng-Qi decoction (DCQD) on treating intestinal injury in rats with severe acute pancreatitis (SAP), based on the Janus kinase 2 (JAK2)/signal transducers and transcription 3 (STAT3) signaling pathway.
    Methods: Rats were randomly divided into the SAP group, SAP + ruxolitinib (JAK2 inhibitor) group, SAP + Stattic (STAT3 inhibitor) group, SAP + DCQD group, and sham operation group. They were further divided into 3-hour, 6-hour, 12-hour, and 18-hour subgroups. Levels of amylase and the inflammatory cytokines tumor necrosis factor-
    Results: Rats with SAP had severe changes in plasma levels of amylase and inflammatory cytokines and showed an overexpression of JAK2 mRNA, STAT3 mRNA, p-JAK2 protein, and p-STAT3 protein in the pancreas and terminal ileum. The events could be downregulated by treatment with DCQD, JAK2 inhibitor, and STAT3 inhibitor.
    Conclusions: In rats with SAP, DCQD ameliorated inflammatory cytokines and intestinal injury, which may be closely associated with the inhibition of the JAK2/STAT3 signaling pathway.
    Language English
    Publishing date 2019-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2019/3909468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Early enteral nutrition after pancreatoduodenectomy: a meta-analysis of randomized controlled trials.

    Shen, Yinfeng / Jin, WenYin

    Langenbeck's archives of surgery

    2013  Volume 398, Issue 6, Page(s) 817–823

    Abstract: Purpose: The aim of our study was to evaluate the safety and effectiveness of early enteral nutrition (EN) for patients after pancreatoduodenectomy (PD).: Methods: We performed a comprehensive search of abstracts in the MEDLINE database, OVID ... ...

    Abstract Purpose: The aim of our study was to evaluate the safety and effectiveness of early enteral nutrition (EN) for patients after pancreatoduodenectomy (PD).
    Methods: We performed a comprehensive search of abstracts in the MEDLINE database, OVID database, Springer database, the Science Citation Index, and the Cochrane Library database. Published data of randomized clinical trials (RCTs) comparing the clinically relevant outcomes of early EN and other nutritional routes for patients after PD were analyzed. The analyzed outcome variables included gastroparesis, intra-abdominal complications (gastroparesis excluded), mortality, infection, and postoperative hospital stay. The Cochrane Collaboration's RevMan 5.1 software was used for statistical analysis.
    Results: Four RCTs published in 2000 or later were included in this meta-analysis, in which 246 patients underwent early EN and 238 patients underwent other nutritional routes following PD. In the combined results of early EN versus other nutritional routes, no significant difference could be found in gastroparesis (odds ratio (OR), 0.89; 95 % CI, 0.36-2.18; P = 0.79), intra-abdominal complications (gastroparesis excluded) (OR, 0.82; 95 % CI, 0.53-1.26; P = 0.37), mortality (OR, 0.43; 95 % CI, 0.11-1.62; P = 0.21), infection (OR, 0.55; 95 % CI, 0.29-1.07; P = 0.08), postoperative hospital stay (mean difference, -0.93; 95 % CI, -6.51 to 4.65; P = 0.74).
    Conclusions: Current RCTs suggests that early EN appears safe and tolerated for patients after PD, but does not show advantages in infection and postoperative hospital stay.
    MeSH term(s) Enteral Nutrition/methods ; Evidence-Based Medicine ; Female ; Humans ; Length of Stay ; Male ; Pancreaticoduodenectomy/methods ; Pancreaticoduodenectomy/mortality ; Patient Safety ; Postoperative Care/methods ; Prognosis ; Randomized Controlled Trials as Topic ; Risk Assessment ; Survival Analysis ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2013-05-22
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-013-1089-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.10: Show issues Location:
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  3. Article ; Online: Reconstruction by Pancreaticogastrostomy versus Pancreaticojejunostomy following Pancreaticoduodenectomy: A Meta-Analysis of Randomized Controlled Trials.

    Shen, Yinfeng / Jin, Wenyin

    Gastroenterology research and practice

    2012  Volume 2012, Page(s) 627095

    Abstract: Objectives. The aim of our study was to evaluate and compare the results of pancreaticogastrostomy (PG) and pancreaticojejunostomy (PJ) after pancreaticoduodenectomy (PD). Methods. Published data of randomized clinical trials (RCTs) comparing the ... ...

    Abstract Objectives. The aim of our study was to evaluate and compare the results of pancreaticogastrostomy (PG) and pancreaticojejunostomy (PJ) after pancreaticoduodenectomy (PD). Methods. Published data of randomized clinical trials (RCTs) comparing the clinically relevant outcomes of PG versus PJ after PD were analyzed. Two reviewers assessed the quality of each trial and collected data independently. The Cochrane Collaboration's RevMan 5.0 software was used for statistical analysis. Proportions were combined, and the odds ratio (OR) with its 95% CI was used as the effect size estimate. Results. Four RCTs published in 1995 or later were included in this meta-analysis, in which 276 patients underwent PG and 277 patients underwent PJ followed PD. In the combined results of PG versus PJ, a significant difference in the morbidity of intra-abdominal complications (OR, 0.34; 95% CI, 0.23-0.49; P < 0.00001) was found, but no significant difference could be found for pancreatic fistula (OR, 0.69; 95% CI, 0.42-1.12 , P = 0.13) mortality (OR, 1.09; 95% CI, 0.42-2.83; P = 0.87), recovery with no complications (OR, 1.26; 95% CI, 0.90-1.78; P = 0.18), biliary fistula (OR, 0.55; 95% CI, 0.22-1.35; P = 0.19), or in delayed gastric emptying (OR, 0.55; 95% CI, 0.33-1.01; P = 0.06). Conclusions. Current RCTs suggest that PG is better than PJ for pancreatic reconstruction after PD.
    Language English
    Publishing date 2012-02-19
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2435460-0
    ISSN 1687-630X ; 1687-6121
    ISSN (online) 1687-630X
    ISSN 1687-6121
    DOI 10.1155/2012/627095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The survival outcome and prognostic factors for distal cholangiocarcinoma following surgical resection: a meta-analysis for the 5-year survival.

    Wellner, U F / Shen, YinFeng / Keck, T / Jin, WenYin / Xu, Ze

    Surgery today

    2017  Volume 47, Issue 3, Page(s) 271–279

    Abstract: Purpose: To assess the available evidence on the prognostic factors for the 5-year survival for patients with distal cholangiocarcinoma (DCC) following surgical resection.: Methods: We performed a comprehensive search of abstracts included in ... ...

    Abstract Purpose: To assess the available evidence on the prognostic factors for the 5-year survival for patients with distal cholangiocarcinoma (DCC) following surgical resection.
    Methods: We performed a comprehensive search of abstracts included in databases where relevant studies were published between January 2000 and August 2015. Risk ratios (RRs), 95 % confidence intervals (95 % CIs), and random-effects model were calculated using RevMan 5.3 software.
    Results: A total of 23 observational studies involving 2063 patients with DCC were analyzed. The meta-analysis showed that postoperative adjuvant chemotherapy was not confirmed as a prognostic factor, with similar 5-year survival rates between those receiving and not receiving chemotherapy (RR 0.71; 95 % CI 0.21-2.36; P = 0.57). Perineural invasion (RR 0.51; 95 % CI 0.40-0.64; P < 0.00001), lymph node metastasis (RR 0.51; 95 % CI 0.38-0.70; P < 0.0001), positive resection margin status (RR 2.11; 95 % CI 1.36-3.30; P = 0.001), and not-well-differentiated adenocarcinoma (RR 1.77; 95 % CI 1.39-2.25; P < 0.00001) were associated with shorter survival.
    Conclusions: Perineural invasion, lymph node metastasis, resection margin status, and tumor differentiation were the significant prognostic factors for the 5-year survival.
    MeSH term(s) Aged ; Bile Duct Neoplasms/mortality ; Bile Duct Neoplasms/pathology ; Bile Duct Neoplasms/surgery ; Chemotherapy, Adjuvant ; Cholangiocarcinoma/mortality ; Cholangiocarcinoma/pathology ; Cholangiocarcinoma/surgery ; Female ; Humans ; Lymphatic Metastasis ; Male ; Margins of Excision ; Middle Aged ; Neoplasm Invasiveness ; Neoplasms, Nerve Tissue/pathology ; Prognosis ; Survival Rate ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2017-03
    Publishing country Japan
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1115435-4
    ISSN 1436-2813 ; 0941-1291
    ISSN (online) 1436-2813
    ISSN 0941-1291
    DOI 10.1007/s00595-016-1362-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1077: Show issues Location:
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  5. Article ; Online: Effect of pharmaconutrition-supplemented parenteral nutrition for severe acute pancreatitis: a meta-analysis of randomized controlled trials.

    Shen, Yinfeng / Deng, Xiaochuan / Jin, Wenyin / Zhang, Chenwei / Zhang, Xingwen / Wang, Ying

    JOP : Journal of the pancreas

    2014  Volume 15, Issue 4, Page(s) 371–377

    Abstract: Objective: To evaluate the effectiveness of pharmaconutrition-supplemented parenteral nutrition (PN) for severe acute pancreatitis (SAP).: Methods: A comprehensive search of abstracts was performed in the MEDLINE, OVID, Springer, and Cochrane Library ...

    Abstract Objective: To evaluate the effectiveness of pharmaconutrition-supplemented parenteral nutrition (PN) for severe acute pancreatitis (SAP).
    Methods: A comprehensive search of abstracts was performed in the MEDLINE, OVID, Springer, and Cochrane Library database. Published data of randomized clinical trials (RCTs) comparing the clinically relevant outcomes of pharmaconutrition-supplemented PN versus PN for patients with SAP were analyzed. The analyzed outcome variables included infection, mortality, intensive care unit (ICU) stay, hospital stay, and leukocytes change. Statistical analyses were performed using the Cochrane Collaboration's RevMan 5.1 software.
    Results: Four RCTs published in 1998 or later were included in this meta-analysis, in which 76 patients with pharmaconutrition-supplemented PN and 77 patients with PN. Pharmaconutrition-supplemented PN showed significantly better results in terms of infection (OR, 0.42; 95% CI, 0.20-0.91; P =0.03) and leukocytes change (before treated: mean different, 0.93; 95% CI, 0.21-1.65; P =0.01; after treated: mean different, -0.77; 95% CI, -1.47- -0.08; P =0.03). No significant difference could be found in mortality (OR, 0.30; 95% CI, 0.07-1.19; P =0.09), ICU stay (mean different, -3.65; 95% CI, -9.39-2.10; P =0.21), and hospital stay (mean different, -1.20; 95% CI, -9.89-7.48; P =0.79).
    Conclusions: The current meta-analysis indicates that pharmaconutrition-supplemented PN only show advantages in infection and leukocytes change.
    MeSH term(s) Acute Disease ; Humans ; Intensive Care Units/statistics & numerical data ; Length of Stay/statistics & numerical data ; Outcome Assessment (Health Care) ; Pancreatitis/mortality ; Pancreatitis/pathology ; Pancreatitis/therapy ; Parenteral Nutrition/methods ; Randomized Controlled Trials as Topic ; Severity of Illness Index ; Survival Rate
    Language English
    Publishing date 2014-07-28
    Publishing country Italy
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 2039637-5
    ISSN 1590-8577 ; 1590-8577
    ISSN (online) 1590-8577
    ISSN 1590-8577
    DOI 10.6092/1590-8577/2238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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