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Article ; Online: Prenatal ultrasound findings and prenatal diagnosis of fetal skeletal dysplasia.

Li, Lili / Jin, Xiaofei / Liu, Suna / Fan, Hui

2024

Abstract: Objective: To analyze the value of prenatal ultrasound and molecular testing in diagnosing fetal skeletal dysplasia (SD).: Methods: Clinical data, prenatal ultrasound data, and molecular results of pregnant women with fetal SD were collected in the ... ...

Abstract	Objective: To analyze the value of prenatal ultrasound and molecular testing in diagnosing fetal skeletal dysplasia (SD). Methods: Clinical data, prenatal ultrasound data, and molecular results of pregnant women with fetal SD were collected in the ultrasound department of our clinic from May 2019 to December 2021. Results: A total of 40 pregnant women with fetal SD were included, with 82.5% exhibiting short limb deformity, followed by 25.0% with central nervous system malformations, 17.50% with facial malformations, 15% with cardiac malformations, and 12.5% with urinary system malformations. The genetic testing positive rate was 70.0% (28/40), with 92.8% (26/28) being single-gene disorders due to mutations in FGFR3, COL1A1, COL1A2, EVC2, FLNB, LBR, and TRPV4 genes. The most common SD subtypes were osteogenesis imperfecta (OI), thanatophoric dysplasia (TD), and achondroplasia (ACH). The gestational age (GA) at initial diagnosis for TD, OI, and ACH was 16.6, 20.9, and 28.3 weeks, respectively (p < 0.05), with no significant difference in femoral shortening between the three groups (p > 0.05). Of the OI cases, 5 out of 12 had a family history. Conclusion: Short limb deformity is the most prevalent phenotype of SD. When fetal SD is suspected, detailed ultrasound screening should be conducted, combined with GA at initial diagnosis, family history, and molecular evidence, to facilitate more accurate diagnosis and enhance prenatal counseling and perinatal management.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.23673
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Zs.A 1186: Show issues

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Article ; Online: Mechanism of astragaloside IV regulating NLRP3 through LOC102555978 to attenuate cerebral ischemia reperfusion induced microglia pyroptosis.

Gao, Ping / Shi, Haowei / Jin, Xiaofei / Guo, Shuhan / Zhou, Xiaohong / Gao, Weijuan

International immunopharmacology

2024 Volume 131, Page(s) 111862

Abstract: Astragaloside IV(ASⅣ), the main component of Radix Astragali, has been used to treat cerebral ischemia reperfusion injury (CIRI). However, the molecular mechanism of ASIV in CIRI needs to be further elucidated. Long non-coding RNA (lncRNA) is considered ... ...

Abstract	Astragaloside IV(ASⅣ), the main component of Radix Astragali, has been used to treat cerebral ischemia reperfusion injury (CIRI). However, the molecular mechanism of ASIV in CIRI needs to be further elucidated. Long non-coding RNA (lncRNA) is considered to be an important kind of regulatory molecule in CIRI. In this work, the biological effect and molecular mechanism of ASIV in CIRI through lncRNA were analyzed by using rat middle cerebral artery occlusion and reperfusion (MCAO/R) model and primary rat microglia (RM) cells oxygen and glucose deprivation/reoxygenation (OGD/R) model. The neurological deficit score was evaluated, the volume of cerebral infarction was calculated, and pyroptosis related molecules were detected by qPCR and western blot. Then, high-throughput sequencing was performed in sham and MCAO/R groups. The competitive endogenous RNA (ceRNA) networks associated with pyroptosis were constructed by functional enrichment analysis. CCK-8 detection of cell survival rate, qPCR and western blot were used to determine the specific molecular mechanism of ASⅣ through ceRNA in vitro. Results showed thatASⅣ could decrease the neurological deficit score, reduce the volume of cerebral infarction, inhibit inflammatory reaction and pyroptosis in MCAO/R model rats. Next, the ceRNA network was established, including the LOC102555978/miR-3584-5p/NLRP3 regulatory network. In vitro experiments showed that LOC102555978 promotes NLRP3 mediated pyroptosis of RM cells through sponge adsorption of miR-3584-5p, which may provide a potential therapeutic target for post-CIRI inflammation regulation. ASⅣ could inhibit pyroptosis of RM cells by down-regulating LOC102555978. LOC102555978/miR-3584-5p/NLRP3 may be the molecular mechanism of ASⅣ's CIRI protective effect.
MeSH term(s)	Rats ; Animals ; Pyroptosis ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/therapeutic use ; Microglia ; MicroRNAs ; Brain Ischemia/genetics ; Reperfusion ; Infarction, Middle Cerebral Artery/complications ; Reperfusion Injury/genetics ; Saponins ; Triterpenes
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; astragaloside A (3A592W8XKE) ; RNA, Long Noncoding ; MicroRNAs ; Saponins ; Triterpenes
Language	English
Publishing date	2024-03-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111862
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Article: [Effect of acupuncture at "Zhibian" (BL 54) through "Shuidao" (ST 28) on the expression of apoptosis-related factors in rats with premature ovarian insufficiency based on oxidative stress].

Yan, Jing / Zhao, Ji-Yu / Yin, Lu-Yun / Yan, Xiao-Qin / Jin, Xiao-Fei

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2023 Volume 43, Issue 4, Page(s) 454–460

Abstract: Objective: To explore the possible mechanism of acupuncture at "Zhibian" (BL 54) through "Shuidao" (ST 28) on premature ovarian insufficiency (POI) from the perspective of oxidative stress.: Methods: Sixty female SD rats were randomly divided into a ... ...

Abstract	Objective: To explore the possible mechanism of acupuncture at "Zhibian" (BL 54) through "Shuidao" (ST 28) on premature ovarian insufficiency (POI) from the perspective of oxidative stress. Methods: Sixty female SD rats were randomly divided into a blank group, a model group, a sham acupuncture group, a medication group, and an acupuncture group, 12 rats in each group. Except the blank group, the rats in the remaining groups were intraperitoneally injected with cyclophosphamide to establish the POI model. After the model was successfully established, the rats in the acupuncture group were treated with acupuncture at "Zhibian" (BL 54) through "Shuidao" (ST 28), with a depth of about 12 mm, and the needle was retained for 30 min; the acupuncture was given once a day, for a total of 4 weeks. The rats in the sham acupuncture group were treated with blunt-head needle to tap the skin surface of "Zhibian" (BL 54), without penetrating the skin, once a day for 4 weeks. The rats in the medication group were treated with estradiol valerate by gastric gavage for 4 weeks. After the intervention, the level of reactive oxygen species (ROS) in the ovarian tissue was detected by fluorescence probe; the expression of c-Jun N-terminal kinase (JNK), forkhead box O1 (FoxO1), tumor suppressor gene protein 53 (p53) and p53 up-regulated modulator of apoptosis (Puma) mRNA and protein in ovarian tissue were detected by real-time fluorescence quantitative PCR and Western blot. Results: Compared with the blank group, the level of ROS and the expression of JNK mRNA, p-JNK protein, FoxO1, p53, Puma mRNA and protein in the ovarian tissue in the model group were increased ( Conclusion: Acupuncture at "Zhibian" (BL 54) through "Shuidao" (ST 28) could improve the level of oxidative stress, down-regulate the expression of apoptosis-related factors JNK, FoxO1, p53 and Puma induced by oxidative stress, and inhibit the premature failure of ovarian reserve function caused by apoptosis of ovarian granulosa cells in POI rats.
MeSH term(s)	Humans ; Rats ; Female ; Animals ; Rats, Sprague-Dawley ; Reactive Oxygen Species ; Tumor Suppressor Protein p53/genetics ; Apoptosis Regulatory Proteins ; Acupuncture Therapy ; Primary Ovarian Insufficiency/genetics ; Primary Ovarian Insufficiency/therapy ; Apoptosis ; RNA, Messenger ; Oxidative Stress ; Acupuncture Points
Chemical Substances	Reactive Oxygen Species ; Tumor Suppressor Protein p53 ; Apoptosis Regulatory Proteins ; RNA, Messenger
Language	Chinese
Publishing date	2023-04-17
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.20220705-k0001
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Article: Origin, development and advantageous disease spectrum of the "Zhibian (BL 54) through Shuidao (ST 28)" needling technique.

Zhang, Yanlin / Wang, Haijun / Cao, Yuxia / Ren, Shuaidi / Duan, Linyu / Hao, Jianheng / Yan, Min / Jin, Xiaofei / Ji, Laixi

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2024 Volume 44, Issue 2, Page(s) 200–203

Abstract: This paper systematically reviews the historical evolution of the "Zhibian (BL 54) through Shuidao (ST 28)" needling technique by examining the history of ... ...

Title translation	“秩边透水道”针法源流探析及优势病谱.
Abstract	This paper systematically reviews the historical evolution of the "Zhibian (BL 54) through Shuidao (ST 28)" needling technique by examining the history of the
MeSH term(s)	Acupuncture Therapy/methods ; Percutaneous Collagen Induction ; Acupuncture Points ; Needles
Language	Chinese
Publishing date	2024-02-12
Publishing country	China
Document type	Journal Article
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.20230619-k0003
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Article ; Online: Expression levels of key immune indicators and immune checkpoints in manganese-exposed rats.

Qi, Yuanmeng / Si, Huifang / Jin, Xiaofei / Guo, Yonghua / Xia, Jiarui / He, Jing / Deng, Xuedan / Deng, Meng / Yao, Wu / Hao, Changfu

Ecotoxicology and environmental safety

2024 Volume 272, Page(s) 116029

Abstract: Manganese is essential trace elements, to participate in the body a variety of biochemical reactions, has important physiological functions, such as stimulate the immune cell proliferation, strengthen the cellular immunity, etc. However, excessive ... ...

Abstract	Manganese is essential trace elements, to participate in the body a variety of biochemical reactions, has important physiological functions, such as stimulate the immune cell proliferation, strengthen the cellular immunity, etc. However, excessive manganese exposure can cause damage to multiple systems of the body.The immune system is extremely vulnerable to external toxicants, however manganese research on the immune system are inadequate and biomarkers are lacking. Therefore, here we applied a manganese-exposed rat model to make preliminary observations on the immunotoxic effects of manganese. We found that manganese exposure inhibited humoral immune function in rats by decreasing peripheral blood IgG (ImmunoglobulinG, IgG), IgM (ImmunoglobulinM, IgM) and complement C3 levels; It also regulates rat cellular immune activity by influencing peripheral blood, spleen, and thymus T cell numbers and immune organ ICs (Immune Checkpoints, ICs) and cytokine expression. Furthermore, it was revealed that the impact of manganese exposure on the immune function of rats exhibited a correlation with both the dosage and duration of exposure. Notably, prolonged exposure to high doses of manganese had the most pronounced influence on rat immune function, primarily manifesting as immunosuppression.The above findings suggest that manganese exposure leads to impaired immune function and related changes in immune indicators, or may provide clues for the discovery of its biomarkers.
MeSH term(s)	Rats ; Animals ; Manganese/toxicity ; T-Lymphocytes ; Immunoglobulin M ; Immunoglobulin G ; Biomarkers
Chemical Substances	Manganese (42Z2K6ZL8P) ; Immunoglobulin M ; Immunoglobulin G ; Biomarkers
Language	English
Publishing date	2024-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.116029
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Article ; Online: Bioinformatics-based dynamics of cuproptosis -related indicators in experimental silicosis.

Xia, Jiarui / Wu, Chenchen / Jin, Xiaofei / Ding, Mingcui / Zhang, Chengpeng / Hou, Guangjie / Hao, Changfu / Yao, Wu

Ecotoxicology and environmental safety

2024 Volume 275, Page(s) 116286

Abstract: Pneumoconiosis is one of the most serious occupational diseases worldwide. Silicosis due to prolonged inhalation of free silica dust during occupational activities is one of the main types. Cuproptosis is a newly discovered mode of programmed cell death ... ...

Abstract	Pneumoconiosis is one of the most serious occupational diseases worldwide. Silicosis due to prolonged inhalation of free silica dust during occupational activities is one of the main types. Cuproptosis is a newly discovered mode of programmed cell death characterized by the accumulation of free copper in the cell, which ultimately leads to cell death. Increased copper in the serum of silicosis patients, suggests that the development of silicosis is accompanied by changes in copper metabolism, but whether cuproptosis is involved in the progression of silicosis is actually to be determined. To test this hypothesis, we screened the genetic changes in patients with idiopathic fibrosis by bioinformatics methods and predicted and functionally annotated the cuproptosis-related genes among them. Subsequently, we established a mouse silicosis model and detected the concentration of copper ions and the activity of ceruloplasmin (CP) in serum, as well as changes of the concentration of copper and cuproptosis related genes in mouse lung tissues. We identified 9 cuproptosis-related genes among the differential genes in patients with IPF at different times and the tissue-specific expression levels of ferredoxin 1 (FDX1) and Lipoyl synthase (LIAS) proteins. Furthermore, serum CP activity and copper ion levels in silicosis mice were elevated on days 7th and 56th after silica exposure. The expression of CP in mouse lung tissue elevated at all stages after silica exposure. The mRNA level of FDX1 decreased on days 7th and 56th, and the protein level remained in accordance with the mRNA level on day 56th. LIAS and Dihydrolipoamide dehydrogenase (DLD) levels were downregulated at all times after silica exposure. In addition, Heatshockprotein70 (HSP70) expression was increased on day 56. In brief, our results demonstrate that there may be cellular cuproptosis during the development of experimental silicosis in mice and show synchronization with enhanced copper loading in mice.
MeSH term(s)	Humans ; Animals ; Mice ; Copper/toxicity ; Silicosis/genetics ; Apoptosis ; Computational Biology ; Disease Models, Animal ; RNA, Messenger ; Silicon Dioxide/toxicity
Chemical Substances	Copper (789U1901C5) ; RNA, Messenger ; Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2024-04-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.116286
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Article ; Online: Manganese accumulation in red blood cells as a biomarker of manganese exposure and neurotoxicity.

Deng, Xuedan / Guo, Yonghua / Jin, Xiaofei / Si, Huifang / Dai, Kai / Deng, Meng / He, Jing / Hao, Changfu / Yao, Wu

Neurotoxicology

2024 Volume 102, Page(s) 1–11

Abstract: Although overexposure to manganese (Mn) is known to cause neurotoxic damage, effective exposure markers for assessing Mn loading in Mn-exposed workers are lacking. Here, we construct a Mn-exposed rat model to perform correlation analysis between Mn- ... ...

Abstract	Although overexposure to manganese (Mn) is known to cause neurotoxic damage, effective exposure markers for assessing Mn loading in Mn-exposed workers are lacking. Here, we construct a Mn-exposed rat model to perform correlation analysis between Mn-induced neurological damage and Mn levels in various biological samples. We combine this analysis with epidemiological investigation to assess whether Mn concentrations in red blood cells (MnRBCs) and urine (MnU) can be used as valid exposure markers. The results show that Mn exposure resulted in neurotoxic damage in rats and that MnRBCs correlated well with neurological damage, showing potential as a novel Mn exposure biomarker. These findings provide a basis for health monitoring of Mn-exposed workers and the development of more appropriate biological exposure limits.
Language	English
Publishing date	2024-03-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800820-6
ISSN	1872-9711 ; 0161-813X
ISSN (online)	1872-9711
ISSN	0161-813X
DOI	10.1016/j.neuro.2024.03.003
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Article ; Online: Evaluation method of

Jin, Xiaofei / Liu, Wenwen / Li, Yiran / Qian, Lu / Zhu, Qiaoqiao / Li, Weitao / Qian, Zhiyu

Biomedizinische Technik. Biomedical engineering

2022 Volume 67, Issue 6, Page(s) 491–501

Abstract: The principle of microwave ablation (MWA) is to cause irreversible damage (protein coagulation, necrosis, etc.) to tumor cells at a certain temperature by heating, thereby destroying the tumor. We have long used functional near-infrared spectroscopy ( ... ...

Abstract	The principle of microwave ablation (MWA) is to cause irreversible damage (protein coagulation, necrosis, etc.) to tumor cells at a certain temperature by heating, thereby destroying the tumor. We have long used functional near-infrared spectroscopy (fNIRs) to monitor clinical thermal ablation efficacy. After a lot of experimental verification, it can be found that there is a clear correlation between the reduced scattering coefficient and the degree of tissue damage. During the MWA process, the reduced scattering coefficient has a stable change. Therefore, both temperature (T) and reduced scattering coefficient (
MeSH term(s)	Swine ; Animals ; Microwaves/therapeutic use ; Temperature ; Liver/surgery ; Hyperthermia, Induced ; Spectrum Analysis ; Catheter Ablation/methods
Language	English
Publishing date	2022-09-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	120817-2
ISSN	1862-278X ; 0013-5585
ISSN (online)	1862-278X
ISSN	0013-5585
DOI	10.1515/bmt-2022-0189
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Article: [Effect of "Zhibian" (BL 54)-to-"Shuidao" (ST 28) needle insertion on the expression of Fas/FADD/Caspase-8 of death receptor pathway in rats with primary ovarian insufficiency].

Yan, Jing / Ma, Meng-Na / Zhao, Ji-Yu / Wang, Hong-Yang / Yin, Lu-Yun / Jin, Xiao-Fei

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2023 Volume 43, Issue 5, Page(s) 537–544

Abstract: Objective: To explore the effect of "Zhibian" (BL 54)-to-"Shuidao" (ST 28) needle insertion on the ovarian function in the rats with primary ovarian insufficiency (POI) and the potential effect mechanism based on the Fas/FADD/Caspase-8 of death receptor ...

Abstract	Objective: To explore the effect of "Zhibian" (BL 54)-to-"Shuidao" (ST 28) needle insertion on the ovarian function in the rats with primary ovarian insufficiency (POI) and the potential effect mechanism based on the Fas/FADD/Caspase-8 of death receptor pathway. Methods: Forty-eight female SD rats were randomly divided into a blank group, a model group, a medication group and an acupuncture group, with 12 rats in each group. Except in the blank group, the rats in the other groups were intraperitoneally injected with cyclophosphamide to establish the POI model. In the acupuncture group, after successful modeling, the intervention was given with "Zhibian" (BL 54)-to- "Shuidao" (ST 28) needle insertion, once daily, 30 min in each intervention; and the duration of intervention was 4 weeks. In the medication group, estradiol valerate tablets were administered intragastrically, 0.09 mg•kg Results: After modeling, except the rats of the blank group, the rats of the other groups had dry fur, lost hair, low spirits, reduced food intake, increased urination and loose stool. After intervention, the stool became regular gradually in the acupuncture group and the medication group. The percentage of estrous cycle disturbance was increased in the rats of the model group when compared with the blank group ( Conclusion: "Zhibian" (BL 54)-to-"Shuidao" (ST 28) needle insertion can effectively improve the ovarian function of POI rats, and its effect mechanism may be related to regulating the serum sex hormone levels, reducing the expression of Fas, FADD and Caspase-8 in ovarian tissue and retarding apoptosis of ovarian cells.
MeSH term(s)	Female ; Animals ; Rats ; Needles ; Signal Transduction ; Receptors, Death Domain/metabolism
Chemical Substances	Fas protein, rat ; Casp8 protein, rat (EC 3.4.22.-) ; Fadd protein, rat ; Receptors, Death Domain
Language	Chinese
Publishing date	2023-05-06
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0255-2930
ISSN	0255-2930
DOI	DOI：10.13703/j.0255-2930.20220301-k0002
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Article ; Online: Changes in serum TIM-3 and complement C3 expression in workers due to Mn exposure.

Qi, Yuanmeng / Si, Huifang / Jin, Xiaofei / Guo, Yonghua / Xia, Jiarui / He, Jing / Deng, Xuedan / Deng, Meng / Yao, Wu / Hao, Changfu

Frontiers in public health

2023 Volume 11, Page(s) 1289838

Abstract: Mn (Manganese, Mn) is an essential trace element involved in various biological processes such as the regulation of immune, nervous and digestive system functions. However, excessive Mn exposure can lead to immune damage. Occupational workers in cement ... ...

Abstract	Mn (Manganese, Mn) is an essential trace element involved in various biological processes such as the regulation of immune, nervous and digestive system functions. However, excessive Mn exposure can lead to immune damage. Occupational workers in cement and ferroalloy manufacturing and other related industries are exposed to low levels of Mn for a long time. Mn exposure is one of the important occupational hazards, but the research on the effect of Mn on the immune system of the occupational population is not complete, and there is no reliable biomarker. Therefore, this study aimed to evaluate the immunotoxicity of Mn from the soluble immune checkpoint TIM-3 (T-cell immunoglobulin and mucin containing protein 3, TIM-3) and complement C3. A total of 144 Mn-exposed workers were recruited from a bus manufacturing company and a railroad company in Henan Province. An inductively coupled plasma mass spectrometer was used to detect the concentration of RBC Mn (Red blood cell Mn, RBC Mn), and ELISA kits were used to detect serum complement C3 and TIM-3. Finally, the subjects were statistically analyzed by dividing them into low and high Mn groups based on the median RBC Mn concentration. We found that Mn exposure resulted in elevated serum TIM-3 expression and decreased complement C3 expression in workers; that serum TIM-3 and complement C3 expression showed a dose-response relationship with RBC Mn; and that the mediating effect of complement C3 between RBC Mn and TIM-3 was found to be significant. The above findings indicate that this study has a preliminary understanding of the effect of Mn exposure on the immune system of the occupational population exposed to Mn, and complement C3 and TIM-3 may be biomarkers of Mn exposure, which may provide clues for the prevention and control of Mn occupational hazards.
MeSH term(s)	Humans ; Complement C3 ; Hepatitis A Virus Cellular Receptor 2 ; Manganese/toxicity ; Biomarkers
Chemical Substances	Complement C3 ; Hepatitis A Virus Cellular Receptor 2 ; Manganese (42Z2K6ZL8P) ; Biomarkers
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1289838
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