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  1. Article ; Online: Recent advances in natural antifungal flavonoids and their derivatives.

    Jin, Yong-Sheng

    Bioorganic & medicinal chemistry letters

    2019  Volume 29, Issue 19, Page(s) 126589

    Abstract: The resistance of pathogenic fungi and failure of drug therapy increased dramatically. Numerous studies have reported the individual or synergistic antifungal potency of natural and synthesized flavonoids, especially against drug-resistant fungi. This ... ...

    Abstract The resistance of pathogenic fungi and failure of drug therapy increased dramatically. Numerous studies have reported the individual or synergistic antifungal potency of natural and synthesized flavonoids, especially against drug-resistant fungi. This brief review summarizes the structure and individual or synergistic antifungal activity of natural and synthesized flavonoids (literatures mainly cover the past 10 years 2009-2019), with a special focus on the antifungal spectra, structure-activity relationship and mechanisms of actions. These may contribute to a better understanding of flavonoids as multi-target agents in the treatment of mycoses and provide some ideas on the development of novel flavonoids-based antifungals.
    MeSH term(s) Antifungal Agents/pharmacology ; Biological Products/pharmacology ; Flavonoids/pharmacology ; Fungi/drug effects ; Humans ; Mycoses/drug therapy
    Chemical Substances Antifungal Agents ; Biological Products ; Flavonoids
    Language English
    Publishing date 2019-07-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2019.07.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Effect of Dihydromyricetin on the Pharmacokinetics of Fluconazole in Sprague-Dawley Rat Plasma, Based on High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

    Liu, Hongchuan / Dong, Huaihuai / Guo, Liangjun / Jin, Yongsheng / Liu, Lihong

    Drug design, development and therapy

    2023  Volume 17, Page(s) 2657–2667

    Abstract: Background: The synergistic effect of dihydromyricetin (DHM) and fluconazole (FLC) can improve the killing effect of FLC-resistant : Methods: In this study, 12 Sprague-Dawley (SD) rats were randomly divided into two groups as follows: (1) an FLC ... ...

    Abstract Background: The synergistic effect of dihydromyricetin (DHM) and fluconazole (FLC) can improve the killing effect of FLC-resistant
    Methods: In this study, 12 Sprague-Dawley (SD) rats were randomly divided into two groups as follows: (1) an FLC group in which rats were administered FLC only (42 mg/kg orally); (2) an FLC with the combined administration of DHM group, in which rats received an equivalent FLC dose immediately following the administration of DHM (100 mg/kg). Blood samples were collected from the ocular choroid vein of rats and converted into plasma. The concentrations of FLC in the rat plasma were then determined by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), and the related pharmacokinetic parameters were analysed. The initial mobile phase included 0.1% acetonitrile and water with gradient elution. Multiple reaction monitoring modes of m/z 307.2→220.1 for FLC, and m/z 237.1→194.2 for carbamazepine, were utilised to conduct quantitative analysis.
    Results: The calibration curve of FLC in rat plasma demonstrated good linearity in the range of 0.1-30 μg/mL (r > 0.99), and the lower limit of quantification was 0.1 μg/mL. Moreover, the intra- and inter-day precision relative standard deviation of FLC was less than 9.09% and 6.51%, respectively. There were no significant differences in the pharmacokinetic parameters between the two groups.
    Conclusion: The results showed that DHM administration did not significantly alter FLC pharmacokinetics in SD rat plasma.
    MeSH term(s) Rats ; Animals ; Rats, Sprague-Dawley ; Chromatography, High Pressure Liquid ; Fluconazole ; Tandem Mass Spectrometry
    Chemical Substances dihydromyricetin (KD8QND6427) ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2023-08-31
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S415813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Tailoring a N-Doped Nanoporous Carbon Host for a Stable Lithium Metal Anode.

    Lee, In-Hwan / Jin, Yongsheng / Jang, Hyeon-Sik / Whang, Dongmok

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 23

    Abstract: Li metal is a promising anode candidate due to its high theoretical capacity and low electrochemical potential. However, dendrite formation and the resulting dead Li cause continuous Li consumption, which hinders its practical application. In this study, ...

    Abstract Li metal is a promising anode candidate due to its high theoretical capacity and low electrochemical potential. However, dendrite formation and the resulting dead Li cause continuous Li consumption, which hinders its practical application. In this study, we realized N-doped nanoporous carbon for a stable Li metal host composed only of lightweight elements C and N through the simple calcination of a nitrogen-containing metal-organic framework (MOF). During the calcination process, we effectively controlled the amount of lithophilic N and the electrical conductivity of the N-doped porous carbons to optimize their performance as Li metal hosts. As a result, the N-doped porous carbon exhibited excellent electrochemical performances, including 95.8% coulombic efficiency and 91% capacity retention after 150 cycles in a full cell with an LFP cathode. The N-doped nanoporous carbon developed in this study can realize a stable Li metal host without adding lithium ion metals and metal oxides, etc., which is expected to provide an efficient approach for reliable Li metal anodes in secondary battery applications.
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13233007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Enhancing the Stability and Initial Coulombic Efficiency of Silicon Anodes through Coating with Glassy ZIF-4.

    Lee, In-Hwan / Jin, Yongsheng / Jang, Hyeon-Sik / Whang, Dongmok

    Nanomaterials (Basel, Switzerland)

    2023  Volume 14, Issue 1

    Abstract: The high capacity of electrodes allows for a lower mass of electrodes, which is essential for increasing the energy density of the batteries. According to this, silicon is a promising anode candidate for Li-ion batteries due to its high theoretical ... ...

    Abstract The high capacity of electrodes allows for a lower mass of electrodes, which is essential for increasing the energy density of the batteries. According to this, silicon is a promising anode candidate for Li-ion batteries due to its high theoretical capacity. However, its practical application is hampered by the significant volume expansion of silicon during battery operation, resulting in pulverization and contact loss. In this study, we developed a stable Li-ion anode that not only solves the problem of the short lifetime of silicon but also preserves the initial efficiency by using silicon nanoparticles covered with glassy ZIF-4 (SZ-4). SZ-4 suppresses silicon pulverization, contact loss, etc. because the glassy ZIF-4 wrapped around the silicon nanoparticles prevents additional SEI formation outside the silicon surface due to the electrically insulating characteristics of glassy ZIF-4. The SZ-4 realized by a simple heat treatment method showed 74% capacity retention after 100 cycles and a high initial efficiency of 78.7%.
    Language English
    Publishing date 2023-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14010018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Natural Products as Antifungal Agents against Invasive Fungi.

    Dong, Fang-Rui / Gao, Lu / Wang, Liang / Jiang, Yuan-Ying / Jin, Yong-Sheng

    Current topics in medicinal chemistry

    2023  Volume 23, Issue 19, Page(s) 1859–1917

    Abstract: Background: Invasive fungal infections (IFIs) are primarily caused by : Objectives: This review attempts to summarize the origin, structure, and antifungal activity of natural products and their derivatives with MIC ≤ 20 μg/mL or 100 μM, focusing on ... ...

    Abstract Background: Invasive fungal infections (IFIs) are primarily caused by
    Objectives: This review attempts to summarize the origin, structure, and antifungal activity of natural products and their derivatives with MIC ≤ 20 μg/mL or 100 μM, focusing on their MoA and SAR.
    Methods: All pertinent literature databases were searched. The search keywords were antifungal or antifungals, terpenoids, steroidal saponins, alkaloid, phenols, lignans, flavonoids, quinones, macrolide, peptide, tetramic acid glycoside, polyene, polyketide, bithiazole, natural product, and derivatives. All the related literature (covering the past 20 years, 2001-2022) was evaluated.
    Results: In total, 340 natural products and 34 synthesized derivatives with antifungal activity from 301 studies were included in this review. These compounds were derived from terrestrial plants, ocean life, and microorganisms and exhibited
    Conclusion: In this review, we attempted to review the available literature on natural antifungal products and their derivatives. Most of the studied compounds showed potent activity against
    MeSH term(s) Humans ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Biological Products/pharmacology ; Fungi ; Candida ; Aspergillus ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents ; Biological Products
    Language English
    Publishing date 2023-04-18
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1568026623666230417105227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Denitrification Characteristics of the Low-Temperature Tolerant Denitrification Strain

    Gao, Ya-Juan / Zhang, Ting / Hu, Ling-Kang / Liu, Shi-Yuan / Li, Chen-Chen / Jin, Yong-Sheng / Liu, Hong-Bin

    Microorganisms

    2024  Volume 12, Issue 3

    Abstract: The low-temperature environment significantly inhibits the growth and metabolism of denitrifying bacteria, leading to an excessive concentration of ammonia nitrogen and total nitrogen in sewage treatment plants during the cold season. In this study, an ... ...

    Abstract The low-temperature environment significantly inhibits the growth and metabolism of denitrifying bacteria, leading to an excessive concentration of ammonia nitrogen and total nitrogen in sewage treatment plants during the cold season. In this study, an efficient denitrifying strain of heterotrophic nitrification-aerobic denitrification (HN-AD) bacteria named HS2 was isolated and screened from industrial sewage of a chemical factory in Inner Mongolia at 8 °C. The strain was confirmed to be
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12030451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hexafluorotitanic acid-assisted synthesis of large-sized, ultrathin titania nanosheets as multifunctional and high-performance photocatalysts.

    Jin, Yong-Sheng / Wang, Peng / Teng, Shu-Hua

    Nanotechnology

    2020  Volume 31, Issue 40, Page(s) 405605

    Abstract: A fast cyclohexanol solvothermal pathway was developed to prepare highly dispersed anatase titania ( ... ...

    Abstract A fast cyclohexanol solvothermal pathway was developed to prepare highly dispersed anatase titania (TiO
    Language English
    Publishing date 2020-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ab9da6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Exploration of Baicalein-Core Derivatives as Potent Antifungal Agents: SAR and Mechanism Insights.

    Zhou, Heyang / Yang, Niao / Li, Wei / Peng, Xuemi / Dong, Jiaxiao / Jiang, Yuanying / Yan, Lan / Zhang, Dazhi / Jin, Yongsheng

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 17

    Abstract: Baicalein ( ...

    Abstract Baicalein (
    MeSH term(s) Antifungal Agents/pharmacology ; Flavanones/pharmacology ; Flavonoids ; Biological Assay ; Candida albicans
    Chemical Substances Antifungal Agents ; baicalein (49QAH60606) ; Flavanones ; Flavonoids
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28176340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  9. Article ; Online: Morphology-Tailored Hydroxyapatite Nanocarrier for Rhizosphere-Targeted Phosphorus Delivery.

    Tang, Siqi / Liang, Jiaming / Li, Ouyang / Shao, Ningning / Jin, Yongsheng / Ni, Jinren / Fei, Xunchang / Li, Zhenshan

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 14, Page(s) e2206954

    Abstract: High hydrophilicity and soil fixation collectively hamper the delivery of phosphorus (P) released from conventional chemical phosphorus fertilizers (CPFs) to plant rhizosphere for efficient uptake. Here, a phosphorus nutrient nanocarrier (PNC) based on ... ...

    Abstract High hydrophilicity and soil fixation collectively hamper the delivery of phosphorus (P) released from conventional chemical phosphorus fertilizers (CPFs) to plant rhizosphere for efficient uptake. Here, a phosphorus nutrient nanocarrier (PNC) based on morphology-tailored nanohydroxyapatite (HAP) is constructed. By virtue of kinetic control of building blocks with designed calcium phosphate intermediates, rod-like and hexagonal prism-like PNCs are synthesized, both having satisfactory hydrophobicity (water contact angle of 105.4
    MeSH term(s) Phosphorus ; Plant Roots/metabolism ; Rhizosphere ; Soil/chemistry ; Water ; Hydroxyapatites/metabolism
    Chemical Substances Phosphorus (27YLU75U4W) ; Soil ; Water (059QF0KO0R) ; Hydroxyapatites
    Language English
    Publishing date 2023-01-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202206954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Design, synthesis and anti-Chikungunya virus activity of lomerizine derivatives.

    Chen, Chu-Ran / Ma, Ying / Wang, Han-Xuan / Liu, Xin-Yang / Liu, Yan / Meng, Qing-Guo / Jin, Yong-Sheng

    Bioorganic & medicinal chemistry letters

    2023  Volume 83, Page(s) 129188

    Abstract: Chikungunya fever is an acute infectious disease caused by Chikungunya virus (CHIKV) and transmitted by Aedes mosquito. It is characterized by fever, rash and arthralgia with no effective drugs. Lomerizine (Lom) is a new generation calcium antagonist, ... ...

    Abstract Chikungunya fever is an acute infectious disease caused by Chikungunya virus (CHIKV) and transmitted by Aedes mosquito. It is characterized by fever, rash and arthralgia with no effective drugs. Lomerizine (Lom) is a new generation calcium antagonist, which is mainly used in the treatment of migraine. Certain antiviral function of Lom was shown by some research. In our study, a series of new derivatives of Lom were designed and synthesized, and their in-vitro anti-CHIKV activity was tested. The results showed that Lom and its derivatives had potent anti-CHIKV activity and low cytotoxicity. Among them, compounds B1 and B7 showed most potent antiviral activity. Besides, structure-activity relationships, in-silico ADMET properties were also analyzed. Molecular docking study was performed to rationalize the SAR and analyze the possible binding modes between B1 and amino acid residues in the active site of nsP3 protein to enhance the understanding of their action as antiviral agents. These finding provides research basis for the design and synthesis of effective anti-CHIKV drugs with Lom as the lead compound.
    MeSH term(s) Animals ; Humans ; Chikungunya virus ; Molecular Docking Simulation ; Chikungunya Fever/drug therapy ; Antiviral Agents/metabolism ; Virus Replication
    Chemical Substances lomerizine (DEE37CY4VO) ; Antiviral Agents
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2023.129188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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