Article ; Online: Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.
2021 Volume 12, Issue 1, Page(s) 3061
Abstract: The SARS-CoV-2 pandemic has triggered global efforts to develop therapeutics. The main protease of SARS-CoV-2 ( ... ...
| Abstract | The SARS-CoV-2 pandemic has triggered global efforts to develop therapeutics. The main protease of SARS-CoV-2 (M |
|---|---|
| MeSH term(s) | Antiviral Agents/pharmacology ; Azoles/chemistry ; Azoles/pharmacology ; Catalytic Domain ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/metabolism ; Crystallography, X-Ray ; Cysteine/chemistry ; Hydrolysis ; Models, Molecular ; Organoselenium Compounds/chemistry ; Organoselenium Compounds/pharmacology ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; Reference Standards ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Salicylanilides/chemistry ; Salicylanilides/pharmacology ; Selenium/metabolism |
| Chemical Substances | Antiviral Agents ; Azoles ; Organoselenium Compounds ; Protease Inhibitors ; Salicylanilides ; ebselen (40X2P7DPGH) ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; Selenium (H6241UJ22B) ; Cysteine (K848JZ4886) |
| Language | English |
| Publishing date | 2021-05-24 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2553671-0 |
| ISSN | 2041-1723 ; 2041-1723 |
| ISSN (online) | 2041-1723 |
| ISSN | 2041-1723 |
| DOI | 10.1038/s41467-021-23313-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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