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Article ; Online: Probing Protein Corona Formation around Gold Nanoparticles: Effects of Surface Coating.

Dridi, Narjes / Jin, Zhicheng / Perng, Woody / Mattoussi, Hedi

ACS nano

2024 Volume 18, Issue 12, Page(s) 8649–8662

Abstract: There has been much interest in integrating various inorganic nanoparticles (nanoscale colloids) in biology and medicine. However, buildup of a protein corona around the nanoparticles in biological media, driven by nonspecific interactions, remains a ... ...

Abstract	There has been much interest in integrating various inorganic nanoparticles (nanoscale colloids) in biology and medicine. However, buildup of a protein corona around the nanoparticles in biological media, driven by nonspecific interactions, remains a major hurdle for the translation of nanomedicine into clinical applications. In this study, we investigate the interactions between gold nanoparticles and serum proteins using a series of dihydrolipoic acid (DHLA)-based ligands. We employed gel electrophoresis combined with UV-vis absorption and dynamic light scattering to correlate protein adsorption with the nature and size of the ligand used. For instance, we found that AuNPs capped with DHLA alone promote nonspecific protein adsorption. In comparison, capping AuNPs with polyethylene glycol- or zwitterion-appended DHLA essentially prevents corona formation, regardless of ligand charge and size. Our results highlight the crucial role of surface chemistry and core material in protein corona formation and offer valuable information for the design of colloidal nanomaterials for biological applications.
MeSH term(s)	Protein Corona ; Gold ; Metal Nanoparticles ; Ligands ; Nanoparticles ; Proteins
Chemical Substances	Protein Corona ; Gold (7440-57-5) ; Ligands ; Proteins
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c08005
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Article ; Online: Cardiac substructures dosimetric predicts cardiac toxicity and prognosis in esophageal squamous cell cancer treated by radiotherapy.

Jin, Zhicheng / Sun, Xuefeng / Zhou, Chao / Yang, Haihua / Zhou, Suna

Neoplasia (New York, N.Y.)

2024 Volume 48, Page(s) 100969

Abstract: Purpose: To look into the relationship between cardiac substructures (CS) dosimetric parameters and cardiac events (CE) or overall survival (OS) in patients undergoing radiation therapy (RT) for esophageal squamous cell carcinoma (ESCC).: Methods and ... ...

Abstract	Purpose: To look into the relationship between cardiac substructures (CS) dosimetric parameters and cardiac events (CE) or overall survival (OS) in patients undergoing radiation therapy (RT) for esophageal squamous cell carcinoma (ESCC). Methods and materials: A retrospective study included 350 patients with ESCC receiving definitive chemoradiotherapy or radiotherapy (d-CRT/d-RT) or neoadjuvant chemoradiotherapy (NCRT) from March 2013 to May 2022. Our study examined the adverse cardiac events of any grade or G3+, as defined by the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Competing risk analysis and Cox regression analysis were used to assess the relationship between CS doses and CEs or OS. Results: 201 (57.4 %) patients received any grade CEs over a median follow-up time of 22.50 months (IQR, 12.40-45.60), and 24 (6.86 %) patients suffered G3+ CEs. On landmark analysis, patients with any grade CEs had significantly lower OS (P = 0.003). Multivariable analysis revealed that any grade CEs were predicted by the dose of CSs in all populations. In addition, for G3+ cardiac events, arrhythmic and small probability of cardiac events, LAD V20 ((HR: 1.02, 95 % CI: 1.00-1.03, P = 0.012; HR: 1.01, 95 % CI: 1.00-1.02, P = 0.005; HR; 1.01, 95 % CI: 1.00-1.02, P = 0.012) was also an independent predictive factor. LAD V50 (HR: 1.07, 95 % CI: 1.03-1.10, P <0.001) predicted pericardium effusion events. Moreover, the multivariable analysis revealed that OS was predicted by LAD V30 (HR: 1.03; 95 % CI, 1.01-1.05, P = 0.015). Conclusions: In the population of ESCC patients receiving RT, we showed that the CS factors had a substantial predictive value for the various types and grades of CEs. The elevated radiation dose of LAD was a significant contributor to a higher rate of cardiac events and a worse prognosis.
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/diagnosis ; Esophageal Squamous Cell Carcinoma/drug therapy ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/drug therapy ; Cardiotoxicity/diagnosis ; Cardiotoxicity/etiology ; Cardiotoxicity/drug therapy ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/radiotherapy ; Esophageal Neoplasms/drug therapy ; Retrospective Studies ; Prognosis ; Chemoradiotherapy/adverse effects ; Epithelial Cells/pathology
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483840-0
ISSN	1476-5586 ; 1522-8002
ISSN (online)	1476-5586
ISSN	1522-8002
DOI	10.1016/j.neo.2024.100969
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Article ; Online: Assessment of Iohexol Serum Clearance by LC-MS/MS with Isotopically Labeled Internal Standard.

Jin, Zhicheng / Bertholf, Roger L / Yi, Xin

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2737, Page(s) 319–327

Abstract: Accurate measurement of the glomerular filtration rate (GFR) is essential for detecting renal insufficiency in living kidney donors. Iohexol is a "near-ideal" exogenous filtration marker for GFR measurement that has attracted increasing interest in ... ...

Abstract	Accurate measurement of the glomerular filtration rate (GFR) is essential for detecting renal insufficiency in living kidney donors. Iohexol is a "near-ideal" exogenous filtration marker for GFR measurement that has attracted increasing interest in clinical practice because it is non-toxic, non-radioactive, readily available, and easy to measure. In this chapter, we describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to measure iohexol in serum and to calculate GFR based on the rate of iohexol clearance. In this procedure, the contrast agent iohexol is administrated to the study subject in an outpatient setting, and three timed blood samples are collected. The serum proteins are precipitated, and the supernatant containing iohexol and the internal standard
MeSH term(s)	Humans ; Iohexol/analysis ; Iohexol/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry/methods ; Kidney Function Tests ; Contrast Media/metabolism ; Renal Insufficiency
Chemical Substances	Iohexol (4419T9MX03) ; Contrast Media
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3541-4_29
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Article: Markedly Elevated Liver Enzymes in a Young COVID-19 Positive Patient.

Jin, Zhicheng / Liu, Yongjun / Cui, Min

The journal of applied laboratory medicine

2023 Volume 8, Issue 6, Page(s) 1184–1189

MeSH term(s)	Humans ; COVID-19 ; Liver ; Alanine Transaminase
Chemical Substances	Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article
ISSN	2576-9456
ISSN	2576-9456
DOI	10.1093/jalm/jfad046
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Article ; Online: Advances and challenges in the measurement of 1,25-dihydroxyvitamin D: a comprehensive review.

Jin, Zhicheng / Bertholf, Roger L / Yi, Xin

Critical reviews in clinical laboratory sciences

2023 Volume 60, Issue 7, Page(s) 535–548

Abstract: Vitamin D has received significant attention from clinical societies, researchers, and the general population in recent years. While 25-hydroxyvitamin D (25(OH)D) is the most commonly-used biomarker of vitamin D status, 1α,25-dihydroxyvitamin D (1,25(OH) ...

Abstract	Vitamin D has received significant attention from clinical societies, researchers, and the general population in recent years. While 25-hydroxyvitamin D (25(OH)D) is the most commonly-used biomarker of vitamin D status, 1α,25-dihydroxyvitamin D (1,25(OH)
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	280641-1
ISSN	1549-781X ; 1040-8363 ; 0590-8191
ISSN (online)	1549-781X
ISSN	1040-8363 ; 0590-8191
DOI	10.1080/10408363.2023.2212765
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Article ; Online: Molar excess of coordinating N-heterocyclic carbene ligands triggers kinetic digestion of gold nanocrystals.

Arabzadeh Nosratabad, Neda / Jin, Zhicheng / Arabzadeh, Hesam / Chen, Banghao / Huang, Cheng / Mattoussi, Hedi

Dalton transactions (Cambridge, England : 2003)

2024 Volume 53, Issue 2, Page(s) 467–483

Abstract: There has been much interest in evaluating the strength of the coordination interactions between N-heterocyclic carbene (NHC) molecules and transition metal ions, nanocolloids and surfaces. We implement a top-down core digestion test of Au nanoparticles ( ...

Abstract	There has been much interest in evaluating the strength of the coordination interactions between N-heterocyclic carbene (NHC) molecules and transition metal ions, nanocolloids and surfaces. We implement a top-down core digestion test of Au nanoparticles (AuNPs) triggered by incubation with a large molar excess of poly(ethylene glycol)-appended NHC molecules, where kinetic dislodging of surface atoms and formation of NHC-Au complexes progressively take place. We characterize the structure and chemical nature of the generated PEG-NHC-Au complexes using 1D and 2D
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt02961a
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Article ; Online: Endostar acts as a pneumonitis protectant in patients with locally advanced non-small cell lung cancer receiving concurrent chemoradiotherapy.

Chen, Kuifei / Li, Shuling / Chen, Meng / Jin, Zhicheng / Sun, Xuefeng / Zhou, Suna / Yang, Haihua

BMC cancer

2024 Volume 24, Issue 1, Page(s) 257

Abstract: Background: CCRT is presently the standard treatment for LA-NSCLC. RP is one of the main obstacles to the completion of thoracic radiation therapy, resulting in limited survival benefits in NSCLC patients. This research aims to explore the role of ... ...

Abstract	Background: CCRT is presently the standard treatment for LA-NSCLC. RP is one of the main obstacles to the completion of thoracic radiation therapy, resulting in limited survival benefits in NSCLC patients. This research aims to explore the role of Endostar in the occurrence of grade≥2 RP and clinical curative effect in LA-NSCLC patients. Methods: This study retrospectively analyzed 122 patients with stage III NSCLC who received CCRT from December 2008 to December 2017, or Endostar intravenous drip concurrently with chemoradiotherapy (Endostar + CCRT group). Standard toxicity of the pneumonitis endpoint was also collected by CTCAE V5.0. We further summarized other available studies on the role of Endostar in the prognosis of NSCLC patients and the incidence of RP. Results: There were 76 cases in the CCRT group and 46 cases in the CCRT+ Endostar group. In the CCRT+ Endostar group, the occurrence of grade ≥2 RP in patients with V20Gy ≥25% was significantly higher than that in patients with V20Gy < 25% (p = 0.001). In the cohorts with V20Gy < 25%, 0 cases of 29 patients treated with Endostar developed grade ≥2 RP was lower than in the CCRT group (p = 0.026). The re-analysis of data from other available studies indicated that Endostar plus CCRT could be more efficient and safely in the occurrence of grade≥2 RP with LA-NSCLC. Conclusions: When receiving CCRT for LA-NSCLC patients, simultaneous combination of Endostar is recommended to enhance clinical benefit and reduce pulmonary toxicity.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/drug therapy ; Retrospective Studies ; Chemoradiotherapy/adverse effects ; Chemoradiotherapy/methods ; Pneumonia/chemically induced ; Pneumonia/epidemiology ; Radiation Pneumonitis/epidemiology ; Radiation Pneumonitis/etiology ; Recombinant Proteins ; Endostatins
Chemical Substances	endostar protein (GVG18ZDN65) ; Recombinant Proteins ; Endostatins
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-12001-6
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Article ; Online: Esophageal carcinoma with SMARCA4 mutation: Unique diagnostic challenges.

Cui, Min / Lemmon, Kayla / Jin, Zhicheng / Uboha, Nataliya V

Pathology, research and practice

2023 Volume 248, Page(s) 154692

Abstract: Esophageal carcinoma with SMARCA4 deficiency or dysfunction is a recently recognized entity. This study describes the clinicopathologic features of four cases of esophageal carcinoma with SMARCA4 mutation, three with deep deletion and one with missense ... ...

Abstract	Esophageal carcinoma with SMARCA4 deficiency or dysfunction is a recently recognized entity. This study describes the clinicopathologic features of four cases of esophageal carcinoma with SMARCA4 mutation, three with deep deletion and one with missense mutation. Patients include 3 males and 1 female, with an age range of 45-68 years old. Histologically, the neoplasms showed frequent mitotic activity, large nucleus and prominent nucleoli. Glandular differentiation was variable from not identifiable to approximately 20% in the biopsy material. Percentage of rhabdoid morphology was also variable from not identifiable to 20% of the biopsy material. For these cases, one case was diagnosed SMARCA4 deficient esophageal carcinoma based on the biopsy of a retroperitoneal lymph node showing loss of BRG1 by immunostain, and next generation sequencing confirmed deep deletion of SMARCA4. The other three cases had diagnosis of undifferentiated carcinoma or poorly differentiated carcinoma, and the SMARCA4 deep deletion or mutation was discovered by next generation sequencing. Molecular analysis showed TP53 mutation in all the three cases with SMARCA4 deep deletion. Two of the patients deceased 72 and 78 days after diagnosis, and the other two patients showed limited or no treatment response to chemotherapy. In conclusion, esophageal carcinoma with SMARCA4 mutation may pose significant diagnostic challenge for surgical pathologists due to its variable morphology and immunoprofile, and accurate classification of this entity requires recognition of the spectrum of morphology and utilization of BRG1 immunostain and next generating sequencing.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Aged ; Carcinoma/genetics ; Carcinoma/pathology ; Mutation ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/genetics ; Cell Nucleus/pathology ; Mutation, Missense ; Biomarkers, Tumor/genetics ; DNA Helicases/genetics ; Nuclear Proteins/genetics ; Transcription Factors/genetics
Chemical Substances	Biomarkers, Tumor ; SMARCA4 protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-) ; Nuclear Proteins ; Transcription Factors
Language	English
Publishing date	2023-07-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154692
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Article ; Online: Evaluation of the effect of regional collaborative management of water pollution in Nanjing-Zhenjiang-Yangzhou metropolitan area based on grey theory

Jin Zhicheng / Li Ruxuan / Zheng Nanxi

E3S Web of Conferences, Vol 257, p

2021 Volume 03009

Abstract: This paper mainly focuses on the current situation of collaborative water pollution management in the Nanjing-Zhenjiang-Yangzhou Region metropolitan area. For this purpose, a synthetical, innovative and more comprehensive indicator system, based on PSR ... ...

Abstract	This paper mainly focuses on the current situation of collaborative water pollution management in the Nanjing-Zhenjiang-Yangzhou Region metropolitan area. For this purpose, a synthetical, innovative and more comprehensive indicator system, based on PSR theory and the degree of regional synergy, which is also suitable for further evaluations towards regional collaborative water pollution management, was constructed by analyzing the existing theories and programs of collaborative regional management. The indicator weights are determined by fuzzy hierarchical analysis. The current situation of water pollution cooperative management in Nanjing-Zhenjiang-Yangzhou metropolitan area is evaluated as good with a probability of 0.9453 in the third grey class by a grey clustering model combining the data from the annual environmental bulletin of the Environmental Protection Bureau of the three cities and 2018 Nanjing Yearbook etc. Finally, several policy suggestions are given.
Keywords	Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Significance of Monoclonal Band in Cerebral Spinal Fluid.

Jin, Zhicheng / Bertholf, Roger L / Yi, Xin

Clinical chemistry

2022 Volume 68, Issue 2, Page(s) 276–281

MeSH term(s)	Antibodies, Monoclonal ; Humans
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2022-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1093/clinchem/hvab258
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