Article ; Online: Development of On-DNA Thiophene Synthesis for DEL Construction.
2023 Volume 18, Issue 15, Page(s) e202300458
Abstract: Thiophene and its substituted derivatives are a highly important class of heterocyclic compounds, with noteworthy applications in pharmaceutical ingredients. In this study, we leverage the unique reactivity of alkynes to generate thiophenes on-DNA, using ...
| Abstract | Thiophene and its substituted derivatives are a highly important class of heterocyclic compounds, with noteworthy applications in pharmaceutical ingredients. In this study, we leverage the unique reactivity of alkynes to generate thiophenes on-DNA, using a cascade iodination, Cadiot-Chodkiewicz coupling and heterocyclization. This approach, tackling on-DNA thiophene synthesis for the first time, generates diverse, and unprecedented structural and chemical features, which could be significant motifs in DEL screening as molecular recognition agents for drug discovery. |
|---|---|
| Language | English |
| Publishing date | 2023-06-30 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 2233006-9 |
| ISSN | 1861-471X ; 1861-4728 |
| ISSN (online) | 1861-471X |
| ISSN | 1861-4728 |
| DOI | 10.1002/asia.202300458 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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